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Protein

Argininosuccinate lyase

Gene

argH

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciRSOL267608:RS_RS11865-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:RSc2363
ORF Names:RS01183
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000001436 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001378091 – 471Argininosuccinate lyaseAdd BLAST471

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc2363

Structurei

3D structure databases

ProteinModelPortaliQ8XWV7
SMRiQ8XWV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XWV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQLAKKAE AWSARFNEPM SDLVKRYTAS VFFDKRLALF DIQGSLAHAA
60 70 80 90 100
MLAKQGIIAE ADRAAIEQGM AQIRQEIEAG TFEWKLDLED VHLNIEARLT
110 120 130 140 150
AMAGDAGKRL HTGRSRNDQV ATDIRLWLRS EIDNIVGLLR ALRGALLDLA
160 170 180 190 200
EQHTNTIVPG FTHLQVAQPV VFGHHLLAYV EMFTRDTERM LDARKRVNRL
210 220 230 240 250
PLGAAALAGT SYPIDREFVA QQLGFDGVCR NSLDAVSDRD FAIEFCAAAA
260 270 280 290 300
LVMTHISRFS EELVLWMSPR VGFIDIADRF CTGSSIMPQK KNPDVPELAR
310 320 330 340 350
GKTGRVNGHL IGLLTLMKGQ PLAYNKDNQE DKEPLFDTVD TVVDTLRIFA
360 370 380 390 400
DMVPGITVKA DAMRAAALQG YATATDLADY LVKRGLPFRD AHEAVAHAVR
410 420 430 440 450
ACDDLRCDLA DLSVTQLREI SGLGDKANLI GDDVHAVLTL EGSVASRNHI
460 470
GGTAPEQVRL AIVAARAGLA G
Length:471
Mass (Da):51,488
Last modified:March 1, 2002 - v1
Checksum:i8926CC855F86FA56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA Translation: CAD16070.1
RefSeqiWP_011002286.1, NC_003295.1

Genome annotation databases

EnsemblBacteriaiCAD16070; CAD16070; RSc2363
GeneIDi1221209
KEGGirso:RSc2363
PATRICifig|267608.8.peg.2402

Similar proteinsi

Entry informationi

Entry nameiARLY_RALSO
AccessioniPrimary (citable) accession number: Q8XWV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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