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Protein

NAD kinase

Gene

nadK

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton acceptorUniRule annotation1
Binding sitei181NADUniRule annotation1
Binding sitei183NADUniRule annotation1
Binding sitei218NAD; via carbonyl oxygenUniRule annotation1
Binding sitei252NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 80NADUniRule annotation2
Nucleotide bindingi153 – 154NADUniRule annotation2
Nucleotide bindingi194 – 199NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:RSc2650
ORF Names:RS04566
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000001436 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206491 – 302NAD kinaseAdd BLAST302

Proteomic databases

PRIDEiQ8XW25

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc2650

Structurei

3D structure databases

ProteinModelPortaliQ8XW25
SMRiQ8XW25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XW25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRANATSP FKTVALVGRY SAANIAAPLL ELASCIAARG HDIVFERETA
60 70 80 90 100
LNIGVQDYPA LPPDEMARHA DVAVVLGGDG TLLGIGRHLA GASVPVIGVN
110 120 130 140 150
HGRLGFMTDI PFEDVHNVLP DMLAGQYEAE TRSLLQAQVV RDDETIFSAL
160 170 180 190 200
AFNDVVVNRS GFSGMVELAV SVDGFFMYNQ RSDGLIVSTP TGSTAYALSA
210 220 230 240 250
GGPILHPALS GLVLVPIAPH ALSNRPIVIP HDAEVVIQVT SGRDASVNFD
260 270 280 290 300
MQSLTSLLPG DRIVVRRSER TVRLLHPVGY NYYATLRKKL HWHEYPTEDN

RL
Length:302
Mass (Da):32,528
Last modified:March 1, 2002 - v1
Checksum:i1C4ADC5D6402CE5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA Translation: CAD16357.1

Genome annotation databases

EnsemblBacteriaiCAD16357; CAD16357; RSc2650
KEGGirso:RSc2650

Similar proteinsi

Entry informationi

Entry nameiNADK_RALSO
AccessioniPrimary (citable) accession number: Q8XW25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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