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Protein

Histidinol-phosphate aminotransferase 1

Gene

hisC1

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 1 (hisC1), Histidinol-phosphate aminotransferase 2 (hisC2)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase 1 (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase 1
Gene namesi
Name:hisC1
Ordered Locus Names:RSc2951
ORF Names:RS00135
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000001436 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534301 – 374Histidinol-phosphate aminotransferase 1Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ8XV80

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi267608.RSc2951

Structurei

3D structure databases

ProteinModelPortaliQ8XV80
SMRiQ8XV80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiTYGMYKV
OrthoDBiPOG091H05S1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XV80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNANAPVQPS LDDLLGRIVR DDVRAMGAYH VPDASGMVKL DAMENPYHLP
60 70 80 90 100
AMLRDALGKR LAEVALNRYP VPTADALKAQ LKRVMRVPAG ADVLLGNGSD
110 120 130 140 150
EIISLIAIAA AKPGATVLAP VPGFVMYAMS AQLMGLKFVG VPLRADLTLD
160 170 180 190 200
REAMLAAMAE HQPAVIYLAY PNNPTGNLFD AADMDALLRA ARGPVCQSLV
210 220 230 240 250
VVDEAYQPFA QHSWMPRLPE FDHLLVMRTV SKLGLAGIRL GYVAGHPKWI
260 270 280 290 300
AELDKVRPPY NVNVLTEATA AFVLDHVDVL DAQAATLRAE RTRLIDALSA
310 320 330 340 350
QPGVTVFPSA ANFLLLRVPD AAGLFERLLK RRVLVKNVSK MHPLLANCLR
360 370
VTVSNPEENA QFLDAFAASL QDTP
Length:374
Mass (Da):40,441
Last modified:March 1, 2002 - v1
Checksum:i0B39486908D44E93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA Translation: CAD16658.1
RefSeqiWP_011002856.1, NC_003295.1

Genome annotation databases

EnsemblBacteriaiCAD16658; CAD16658; RSc2951
GeneIDi1221805
KEGGirso:RSc2951

Similar proteinsi

Entry informationi

Entry nameiHIS81_RALSO
AccessioniPrimary (citable) accession number: Q8XV80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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