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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation1 Publication

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation1 Publication

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  • phosphoenolpyruvate carboxylase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarbon dioxide fixation
LigandMagnesium

Enzyme and pathway databases

BRENDAi4.1.1.31 1503

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:CPE1094
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095931 – 537Phosphoenolpyruvate carboxylaseAdd BLAST537

Proteomic databases

PRIDEiQ8XLE8

Interactioni

Subunit structurei

Homodimer or homotetramer.1 Publication

Structurei

Secondary structure

1537
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8XLE8
SMRiQ8XLE8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8XLE8

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009826
KOiK01595
OMAiPAMNYGL
OrthoDBiPOG091H040O

Family and domain databases

HAMAPiMF_01904 PEPcase_type2, 1 hit
InterProiView protein in InterPro
IPR007566 PEP_COase_arc-type
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
PfamiView protein in Pfam
PF14010 PEPcase_2, 1 hit
PIRSFiPIRSF006677 UCP006677, 1 hit
SUPFAMiSSF51621 SSF51621, 1 hit
TIGRFAMsiTIGR02751 PEPCase_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XLE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIPCSMMTQ HPDNVETYIS IQQEPAEAIK GLTPQDKGGL GIEEVMIDFE
60 70 80 90 100
GKLTPYHQTS QIALGLISNG IIPGKDVRVT PRIPNANKES VFRQLMSIMS
110 120 130 140 150
IIETNVQSKE LTGTPAISEV VVPMIETGKE ISEFQDRVNS VVDMGNKNYK
160 170 180 190 200
TKLDLNSVRI IPLVEDVPAL ANIDRILDEH YEIEKSKGHI LKDLRIMIAR
210 220 230 240 250
SDTAMSYGLI SGVLSVLMAV DGAYKWGEKH GVTISPILGC GSLPFRGHFS
260 270 280 290 300
EENIDEILAT YSGIKTFTFQ SALRYDHGEE ATKHAVRELK EKIAQSKPRN
310 320 330 340 350
FSEEDKDLMK EFIGICSKHY LQTFLKVIDT VSFVSDFIPK NRDRLTKAKT
360 370 380 390 400
GLEYNREVAN LDNVADLVKD EVLKQEILSI DNSKEYAVPR AISFTGAMYT
410 420 430 440 450
LGMPPELMGM GRALNEIKTK YGQEGIDKLL EIYPILRKDL AFAARFANGG
460 470 480 490 500
VSKKIIDEEA RQEYKEDMKY VNEILNLGLD YDFLNENEFY HTLLKTTKPI
510 520 530
IMHLMGLEEN VMRNSTEELK ILNEWIVRMG KVRGSIG
Length:537
Mass (Da):60,494
Last modified:March 1, 2002 - v1
Checksum:iBCDD97C4E8EC8B8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA Translation: BAB80800.1
RefSeqiWP_011010232.1, NC_003366.1

Genome annotation databases

EnsemblBacteriaiBAB80800; BAB80800; BAB80800
KEGGicpe:CPE1094

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA Translation: BAB80800.1
RefSeqiWP_011010232.1, NC_003366.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ODMX-ray2.95A/B/C/D/E/F/G/H1-537[»]
ProteinModelPortaliQ8XLE8
SMRiQ8XLE8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8XLE8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB80800; BAB80800; BAB80800
KEGGicpe:CPE1094

Phylogenomic databases

HOGENOMiHOG000009826
KOiK01595
OMAiPAMNYGL
OrthoDBiPOG091H040O

Enzyme and pathway databases

BRENDAi4.1.1.31 1503

Miscellaneous databases

EvolutionaryTraceiQ8XLE8

Family and domain databases

HAMAPiMF_01904 PEPcase_type2, 1 hit
InterProiView protein in InterPro
IPR007566 PEP_COase_arc-type
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
PfamiView protein in Pfam
PF14010 PEPcase_2, 1 hit
PIRSFiPIRSF006677 UCP006677, 1 hit
SUPFAMiSSF51621 SSF51621, 1 hit
TIGRFAMsiTIGR02751 PEPCase_arch, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAPPA_CLOPE
AccessioniPrimary (citable) accession number: Q8XLE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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