UniProtKB - Q8XDI5 (ULAE_ECO57)
Protein
L-ribulose-5-phosphate 3-epimerase UlaE
Gene
ulaE
Organism
Escherichia coli O157:H7
Status
Functioni
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization.UniRule annotation
Catalytic activityi
- EC:5.1.3.22UniRule annotation
: L-ascorbate degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes D-xylulose 5-phosphate from L-ascorbate.UniRule annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Probable L-ascorbate-6-phosphate lactonase UlaG (ulaG), Probable L-ascorbate-6-phosphate lactonase UlaG (ulaG)
- 3-keto-L-gulonate-6-phosphate decarboxylase UlaD (ulaD), 3-keto-L-gulonate-6-phosphate decarboxylase UlaD (ulaD)
- L-ribulose-5-phosphate 3-epimerase UlaE (ulaE), L-ribulose-5-phosphate 3-epimerase UlaE (ulaE), L-ribulose-5-phosphate 3-epimerase UlaE (ulaE), L-ribulose-5-phosphate 3-epimerase UlaE (ulaE), L-ribulose-5-phosphate 3-epimerase UlaE (ulaE)
- L-ribulose-5-phosphate 4-epimerase UlaF (ulaF), L-ribulose-5-phosphate 4-epimerase UlaF (ulaF)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-xylulose 5-phosphate from L-ascorbate, the pathway L-ascorbate degradation and in Cofactor degradation.
GO - Molecular functioni
- intramolecular oxidoreductase activity, interconverting aldoses and ketoses Source: InterPro
- L-ribulose-5-phosphate 3-epimerase activity Source: UniProtKB-UniRule
GO - Biological processi
- L-ascorbic acid catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Enzyme and pathway databases
UniPathwayi | UPA00263;UER00379 |
Names & Taxonomyi
Protein namesi | Recommended name: L-ribulose-5-phosphate 3-epimerase UlaEUniRule annotation (EC:5.1.3.22UniRule annotation)Alternative name(s): L-ascorbate utilization protein EUniRule annotation L-xylulose-5-phosphate 3-epimeraseUniRule annotation |
Gene namesi | Name:ulaEUniRule annotation Ordered Locus Names:Z5806, ECs5173 |
Organismi | Escherichia coli O157:H7 |
Taxonomic identifieri | 83334 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233251 | 1 – 284 | L-ribulose-5-phosphate 3-epimerase UlaEAdd BLAST | 284 |
Expressioni
Inductioni
Induced by L-ascorbate. Repressed by UlaR.UniRule annotation
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8XDI5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8XDI5 |
Family & Domainsi
Sequence similaritiesi
Belongs to the L-ribulose-5-phosphate 3-epimerase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG3623, Bacteria |
HOGENOMi | CLU_082738_0_0_6 |
Family and domain databases
HAMAPi | MF_01951, UlaE, 1 hit |
InterProi | View protein in InterPro IPR004560, L-Ru-5P_3-Epase IPR023492, L-Ru-5P_3-Epase_Enterobacteria IPR036237, Xyl_isomerase-like_sf IPR013022, Xyl_isomerase-like_TIM-brl |
Pfami | View protein in Pfam PF01261, AP_endonuc_2, 1 hit |
SUPFAMi | SSF51658, SSF51658, 1 hit |
TIGRFAMsi | TIGR00542, hxl6Piso_put, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8XDI5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSKQIPLGI YEKALPAGEC WLERLQLAKT LGFDFVEMSV DETDERLSRL
60 70 80 90 100
DWSREQRLAL VNAIVETGVR VPSMCLSAHR RFPLGSEDDA VRAQGLEIMR
110 120 130 140 150
KAIQFAQDVG IRVIQLAGYD VYYQEANNET RRRFRDGLKE SVEMASRAQV
160 170 180 190 200
TLAMEIMDYP LMNSISKALG YAHYLNNPWF QLYPDIGNLS AWDNDVQMEL
210 220 230 240 250
QAGIGHIVAV HVKDTKPGVF KNVPFGEGVV DFERCFETLK QSGYCGPYLI
260 270 280
EMWSETAEDP AAEVAKARDW VKARMAKAGM VEAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG59393.1 BA000007 Genomic DNA Translation: BAB38596.1 |
PIRi | E86116 E91275 |
RefSeqi | NP_313200.1, NC_002695.1 WP_000949511.1, NZ_SWKA01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAG59393; AAG59393; Z5806 BAB38596; BAB38596; ECs_5173 |
GeneIDi | 57730092 913998 |
KEGGi | ece:Z5806 ecs:ECs5173 |
PATRICi | fig|386585.9.peg.5407 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG59393.1 BA000007 Genomic DNA Translation: BAB38596.1 |
PIRi | E86116 E91275 |
RefSeqi | NP_313200.1, NC_002695.1 WP_000949511.1, NZ_SWKA01000005.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3CQH | X-ray | 2.08 | A/B | 2-284 | [»] | |
3CQI | X-ray | 2.10 | A/B | 2-284 | [»] | |
3CQJ | X-ray | 2.04 | A/B | 2-284 | [»] | |
3CQK | X-ray | 2.33 | A/B | 2-284 | [»] | |
SMRi | Q8XDI5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 155864.EDL933_5542 |
Genome annotation databases
EnsemblBacteriai | AAG59393; AAG59393; Z5806 BAB38596; BAB38596; ECs_5173 |
GeneIDi | 57730092 913998 |
KEGGi | ece:Z5806 ecs:ECs5173 |
PATRICi | fig|386585.9.peg.5407 |
Phylogenomic databases
eggNOGi | COG3623, Bacteria |
HOGENOMi | CLU_082738_0_0_6 |
Enzyme and pathway databases
UniPathwayi | UPA00263;UER00379 |
Miscellaneous databases
EvolutionaryTracei | Q8XDI5 |
Family and domain databases
HAMAPi | MF_01951, UlaE, 1 hit |
InterProi | View protein in InterPro IPR004560, L-Ru-5P_3-Epase IPR023492, L-Ru-5P_3-Epase_Enterobacteria IPR036237, Xyl_isomerase-like_sf IPR013022, Xyl_isomerase-like_TIM-brl |
Pfami | View protein in Pfam PF01261, AP_endonuc_2, 1 hit |
SUPFAMi | SSF51658, SSF51658, 1 hit |
TIGRFAMsi | TIGR00542, hxl6Piso_put, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ULAE_ECO57 | |
Accessioni | Q8XDI5Primary (citable) accession number: Q8XDI5 Secondary accession number(s): Q7A8U6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families