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Protein

Ribosomal RNA large subunit methyltransferase I

Gene

rlmI

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1962) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1962) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase IUniRule annotation (EC:2.1.1.191UniRule annotation)
Alternative name(s):
23S rRNA m5C1962 methyltransferaseUniRule annotation
rRNA (cytosine-C(5)-)-methyltransferase RlmIUniRule annotation
Gene namesi
Name:rlmIUniRule annotation
Ordered Locus Names:Z1319, ECs1051
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003662281 – 396Ribosomal RNA large subunit methyltransferase IAdd BLAST396

Interactioni

Protein-protein interaction databases

STRINGi155864.Z1319

Structurei

3D structure databases

ProteinModelPortaliQ8XD85
SMRiQ8XD85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81PUAUniRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DR4 Bacteria
COG1092 LUCA
HOGENOMiHOG000266009
KOiK06969
OMAiFDYFKYA

Family and domain databases

Gene3Di2.30.130.10, 1 hit
HAMAPiMF_01857 23SrRNA_methyltr_I, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR023542 rRNA_lsu_MeTfrase_I
IPR019614 SAM-dep_methyl-trfase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10672 Methyltrans_SAM, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XD85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVRLVLAKG REKSLLRRHP WVFSGAVARM EGKASLGETI DIVDHQGKWL
60 70 80 90 100
ARGAYSPASQ IRARVWTFDP SESIDIAFFS RRLQQAQKWR DWLAQKDGLD
110 120 130 140 150
SYRLIAGESD GLPGITIDRF GNFLVLQLLS AGAEYQRAAL ISALQTLYPE
160 170 180 190 200
CAIYDRSDVA VRKKEGMELT QGLVTGELPP ALLPIEEHGM KLLVDIQHGH
210 220 230 240 250
KTGYYLDQRD SRLATRRYVE NKRVLNCFSY TGGFAVSALM GGCSQVVSVD
260 270 280 290 300
TSQEALDIAR QNVELNKLDL SKAEFVRDDV FKLLRTYRDR GEKFDVIVMD
310 320 330 340 350
PPKFVENKSQ LMGACRGYKD INMLAIQLLN EGGILLTFSC SGLMTSDLFQ
360 370 380 390
KIIADAAIDA GRDVQFIEQF RQAADHPVIA TYPEGLYLKG FACRVM
Length:396
Mass (Da):44,357
Last modified:March 3, 2009 - v2
Checksum:i413E90026B7C2B7D
GO

Sequence cautioni

The sequence AAG55453 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB34474 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55453.1 Different initiation.
BA000007 Genomic DNA Translation: BAB34474.1 Different initiation.
PIRiA85624
C90760
RefSeqiNP_309078.2, NC_002695.1
WP_000116288.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55453; AAG55453; Z1319
BAB34474; BAB34474; BAB34474
GeneIDi916915
KEGGiece:Z1319
ecs:ECs1051
PATRICifig|386585.9.peg.1176

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55453.1 Different initiation.
BA000007 Genomic DNA Translation: BAB34474.1 Different initiation.
PIRiA85624
C90760
RefSeqiNP_309078.2, NC_002695.1
WP_000116288.1, NZ_NOKN01000002.1

3D structure databases

ProteinModelPortaliQ8XD85
SMRiQ8XD85
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z1319

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55453; AAG55453; Z1319
BAB34474; BAB34474; BAB34474
GeneIDi916915
KEGGiece:Z1319
ecs:ECs1051
PATRICifig|386585.9.peg.1176

Phylogenomic databases

eggNOGiENOG4105DR4 Bacteria
COG1092 LUCA
HOGENOMiHOG000266009
KOiK06969
OMAiFDYFKYA

Family and domain databases

Gene3Di2.30.130.10, 1 hit
HAMAPiMF_01857 23SrRNA_methyltr_I, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR023542 rRNA_lsu_MeTfrase_I
IPR019614 SAM-dep_methyl-trfase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10672 Methyltrans_SAM, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRLMI_ECO57
AccessioniPrimary (citable) accession number: Q8XD85
Secondary accession number(s): Q7AG23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 10, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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