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UniProtKB - Q8XB24 (MDTL_ECO57)
Protein
Multidrug resistance protein MdtL
Gene
mdtL
Organism
Escherichia coli O157:H7
Status
Functioni
Confers resistance to chloramphenicol.
By similarityGO - Molecular functioni
- transmembrane transporter activity Source: UniProtKB-UniRule
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Biological process | Antibiotic resistance, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein MdtL |
Gene namesi | Name:mdtL Ordered Locus Names:Z5205, ECs4647 |
Organismi | Escherichia coli O157:H7 |
Taxonomic identifieri | 83334 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 41 | PeriplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 68 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 90 – 92 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 114 – 130 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 152 – 157 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 198 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 199 – 221 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 222 – 244 | PeriplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 245 – 265 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 266 – 268 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 292 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 293 – 313 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 314 – 330 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 331 – 351 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 352 – 355 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 377 – 391 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173356 | 1 – 391 | Multidrug resistance protein MdtLAdd BLAST | 391 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_47_1_6 |
OMAi | AGSCYVV |
Family and domain databases
HAMAPi | MF_01530, MFS_MdtL, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023697, Multidrug-R_MdtL |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8XB24-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRFLICSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG
60 70 80 90 100
MAAAMLFAGK VADRSGRKPV AIPGAALFII TSVFCSLAET STLFLAGRFL
110 120 130 140 150
QGLGAGCCYV VAFAILRDTL DDRRRAKVLS LLNGITCIIP VLAPVLGHLI
160 170 180 190 200
MLKFPWQSLF WTMAIMGIAV LMLSLFILKE TRPAAPAASD KSRENSESLL
210 220 230 240 250
NRFFLSRVVI TTLSVSVILT FVNTSPVLLM EIMGFERGEY ATIMALTAGV
260 270 280 290 300
SMTVSFSTPF ALGIFKPRTL MITSQVLFLA AGITLTVSPS HAVSLFGITL
310 320 330 340 350
ICAGFSVGFG VAMSQALGPF SLRAGVASST LGIAQVCGSS LWIWLAAVVG
360 370 380 390
ISAWNMLIGI LIACSIVSLL LIMFVAPGRP VTAHEEIHHH A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG58910.1 BA000007 Genomic DNA Translation: BAB38070.1 |
PIRi | B86056 G91209 |
RefSeqi | NP_312674.1, NC_002695.1 WP_000086017.1, NZ_SEKU01000014.1 |
Genome annotation databases
EnsemblBacteriai | AAG58910; AAG58910; Z5205 BAB38070; BAB38070; ECs_4647 |
GeneIDi | 915390 |
KEGGi | ece:Z5205 ecs:ECs4647 |
PATRICi | fig|386585.9.peg.4856 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG58910.1 BA000007 Genomic DNA Translation: BAB38070.1 |
PIRi | B86056 G91209 |
RefSeqi | NP_312674.1, NC_002695.1 WP_000086017.1, NZ_SEKU01000014.1 |
3D structure databases
AlphaFoldDBi | Q8XB24 |
SMRi | Q8XB24 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 155864.EDL933_5035 |
Genome annotation databases
EnsemblBacteriai | AAG58910; AAG58910; Z5205 BAB38070; BAB38070; ECs_4647 |
GeneIDi | 915390 |
KEGGi | ece:Z5205 ecs:ECs4647 |
PATRICi | fig|386585.9.peg.4856 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_47_1_6 |
OMAi | AGSCYVV |
Family and domain databases
HAMAPi | MF_01530, MFS_MdtL, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023697, Multidrug-R_MdtL |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MDTL_ECO57 | |
Accessioni | Q8XB24Primary (citable) accession number: Q8XB24 Secondary accession number(s): Q7A9I9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families