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Protein

Urease subunit gamma

Gene

ureA1

more
Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Neither O157 strain expresses urease due to a truncation of ureD, the last gene of the probable operon. Urease activity is restored in O157 / Sakai upon complementation with wild-type ureD.Curated
This region of the chromosome is duplicated in strain O157:H7 / EDL933 but not in O157:H7 / Sakai.Curated

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA1), Urease subunit alpha (ureC1), Urease subunit beta (ureB1)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayi
UPA00258;UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit gammaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit gammaUniRule annotation
Gene namesi
Name:ureA1UniRule annotation
Ordered Locus Names:Z1143, ECs1322
AND
Name:ureA2UniRule annotation
Ordered Locus Names:Z1582
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000980111 – 100Urease subunit gammaAdd BLAST100

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z1582

Structurei

3D structure databases

ProteinModelPortaliQ8XAG2
SMRiQ8XAG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease gamma subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YZ9 Bacteria
COG0831 LUCA
HOGENOMiHOG000075053
KOiK01430
OMAiMIHEVQV

Family and domain databases

CDDicd00390 Urease_gamma, 1 hit
Gene3Di3.30.280.10, 1 hit
HAMAPiMF_00739 Urease_gamma, 1 hit
InterProiView protein in InterPro
IPR012010 Urease_gamma
IPR002026 Urease_gamma/gamma-beta_su
IPR036463 Urease_gamma_sf
PANTHERiPTHR45301 PTHR45301, 1 hit
PfamiView protein in Pfam
PF00547 Urease_gamma, 1 hit
PIRSFiPIRSF001223 Urease_gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002319 Urease_gamma_reg, 1 hit
SUPFAMiSSF54111 SSF54111, 1 hit
TIGRFAMsiTIGR00193 urease_gam, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XAG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELTPREKDK LLLFTAALLA ERRLARGLKL NYPESVALIS AFIMEGARDG
60 70 80 90 100
KSVAALMEEG RHVLSREQVM EGIPEMIPDI QVEATFPDGS KLVTVHNPII
Length:100
Mass (Da):11,085
Last modified:March 1, 2002 - v1
Checksum:i8A492D5A2662DCF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55288.1
AE005174 Genomic DNA Translation: AAG55697.1
BA000007 Genomic DNA Translation: BAB34745.1
PIRiB90794
D85603
RefSeqiNP_309349.1, NC_002695.1
WP_000424145.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55288; AAG55288; Z1143
AAG55697; AAG55697; Z1582
BAB34745; BAB34745; BAB34745
GeneIDi913824
KEGGiece:Z1143
ece:Z1582
ecs:ECs1322
PATRICifig|386585.9.peg.1427

Similar proteinsi

Entry informationi

Entry nameiURE3_ECO57
AccessioniPrimary (citable) accession number: Q8XAG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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