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Protein

Urease subunit beta

Gene

ureB1

more
Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Neither O157 strain expresses urease due to a truncation of ureD, the last gene of the probable operon. Urease activity is restored in O157 / Sakai upon complementation with wild-type ureD.Curated
This region of the chromosome is duplicated in strain O157:H7 / EDL933 but not in O157:H7 / Sakai.Curated

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit beta (ureB1), Urease subunit gamma (ureA1), Urease subunit alpha (ureC1)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit betaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit betaUniRule annotation
Gene namesi
Name:ureB1UniRule annotation
Ordered Locus Names:Z1144, ECs1323
AND
Name:ureB2UniRule annotation
Ordered Locus Names:Z1583
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002342481 – 106Urease subunit betaAdd BLAST106

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z1583

Structurei

3D structure databases

ProteinModelPortaliQ8XAG1
SMRiQ8XAG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease beta subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KI2 Bacteria
COG0832 LUCA
HOGENOMiHOG000077770
KOiK01429
OMAiHFAETNA

Family and domain databases

CDDicd00407 Urease_beta, 1 hit
Gene3Di2.10.150.10, 1 hit
HAMAPiMF_01954 Urease_beta, 1 hit
InterProiView protein in InterPro
IPR002019 Urease_beta
IPR036461 Urease_betasu_sf
PfamiView protein in Pfam
PF00699 Urease_beta, 1 hit
SUPFAMiSSF51278 SSF51278, 1 hit
TIGRFAMsiTIGR00192 urease_beta, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XAG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGEYKVKP GYIELNIGRA TCSIIVENHG DRPIQVGSHY HFAEVNPALK
60 70 80 90 100
FDRQKARGYR LNIAAGTAVR FEPGQKREVE LVALSGARIV HGFRGDIMGE

LEANDE
Length:106
Mass (Da):11,761
Last modified:March 1, 2002 - v1
Checksum:i8DEF15030AAA78AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55289.1
AE005174 Genomic DNA Translation: AAG55698.1
BA000007 Genomic DNA Translation: BAB34746.1
PIRiC90794
E85603
RefSeqiNP_309350.1, NC_002695.1
WP_000612150.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55289; AAG55289; Z1144
AAG55698; AAG55698; Z1583
BAB34746; BAB34746; BAB34746
GeneIDi913707
KEGGiece:Z1144
ece:Z1583
ecs:ECs1323
PATRICifig|386585.9.peg.1428

Similar proteinsi

Entry informationi

Entry nameiURE2_ECO57
AccessioniPrimary (citable) accession number: Q8XAG1
Secondary accession number(s): Q7AFH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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