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Protein

Potassium-transporting ATPase ATP-binding subunit

Gene

kdpB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + K+(Out) = ADP + phosphate + K+(In).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3074-aspartylphosphate intermediateUniRule annotation1
Binding sitei344ATPUniRule annotation1
Binding sitei348ATPUniRule annotation1
Binding sitei395ATPUniRule annotation1
Metal bindingi518MagnesiumUniRule annotation1
Metal bindingi522MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi377 – 384ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase ATP-binding subunitUniRule annotation (EC:3.6.3.12UniRule annotation)
Alternative name(s):
ATP phosphohydrolase [potassium-transporting] B chainUniRule annotation
Potassium-binding and translocating subunit BUniRule annotation
Potassium-translocating ATPase B chainUniRule annotation
Gene namesi
Name:kdpBUniRule annotation
Ordered Locus Names:Z0844, ECs0725
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalUniRule annotationAdd BLAST21
Transmembranei62 – 82HelicalUniRule annotationAdd BLAST21
Transmembranei219 – 239HelicalUniRule annotationAdd BLAST21
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21
Transmembranei588 – 608HelicalUniRule annotationAdd BLAST21
Transmembranei616 – 636HelicalUniRule annotationAdd BLAST21
Transmembranei656 – 676HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461161 – 682Potassium-transporting ATPase ATP-binding subunitAdd BLAST682

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8X9F9

Interactioni

Subunit structurei

The system is composed of three essential subunits: KdpA, KdpB and KdpC.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z0844

Structurei

3D structure databases

ProteinModelPortaliQ8X9F9
SMRiQ8X9F9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C8X Bacteria
COG2216 LUCA
HOGENOMiHOG000244113
KOiK01547
OMAiILWLWFT

Family and domain databases

CDDicd02078 P-type_ATPase_K, 1 hit
Gene3Di3.40.1110.10, 1 hit
HAMAPiMF_00285 KdpB, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006391 P-type_ATPase_bsu_IA
IPR001757 P_typ_ATPase
PANTHERiPTHR43743 PTHR43743, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
TIGR01497 kdpB, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X9F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKQLALFE PTLVVQALKE AVKKLNPQAQ WRNPVMFIVW IGSLLTTCIS
60 70 80 90 100
IAMASGAMPG NALFSVAISG WLWVTVLFAN FAEALAEGRS KAQANSLKGV
110 120 130 140 150
KKTAFARKLR EPKYGAAADK VPADQLRKGD IVLVEAGDII PCDGEVIEGG
160 170 180 190 200
ASVDESAITG ESAPVIRESG GDFASVTGGT RILSDWLVIE CSVNPGETFL
210 220 230 240 250
DRMIAMVEGA QRRKTPNEIA LTILLIALTI VFLLATATLW PFSAWGGNAV
260 270 280 290 300
SVTVLVALLV CLIPTTIGGL LSAIGVAGMS RMLGANVVAT SGRAVEAAGD
310 320 330 340 350
VDVLLLDKTG TITLGNRQAS EFIPAQGVDE KTLADAAQLA SLADETPEGR
360 370 380 390 400
SIVILAKQRF NLRERDVQSL HATFVPFTAQ SRMSGINIDN RMIRKGSVDA
410 420 430 440 450
IRRHVEANGG HFPADVDQKV DQVARQGATP LVVVEGSRVL GVIALKDIVK
460 470 480 490 500
GGIKERFAQL RKMGIKTVMI TGDNRLTAAA IAAEAGVDDF LAEATPEAKL
510 520 530 540 550
ALIRQYQAEG RLVAMTGDGT NDAPALAQAD VAVAMNSGTQ AAKEAGNMVD
560 570 580 590 600
LDSNPTKLIE VVHIGKQMLM TRGSLTTFSI ANDVAKYFAI IPAAFAVTYP
610 620 630 640 650
QLNALNIMRL HSPDSAILSA VIFNALIIVF LIPLALKGVS YKPLTASAML
660 670 680
RRNLWIYGLG GLLVPFIGIK VIDLLLTVCG LV
Length:682
Mass (Da):72,250
Last modified:March 1, 2002 - v1
Checksum:iD8E8604852373178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55018.1
BA000007 Genomic DNA Translation: BAB34148.1
PIRiE90719
F85569
RefSeqiNP_308752.1, NC_002695.1
WP_000087992.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55018; AAG55018; Z0844
BAB34148; BAB34148; BAB34148
GeneIDi917094
KEGGiece:Z0844
ecs:ECs0725
PATRICifig|386585.9.peg.841

Similar proteinsi

Entry informationi

Entry nameiKDPB_ECO57
AccessioniPrimary (citable) accession number: Q8X9F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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