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UniProtKB - Q8X9D3 (DTPD_ECO57)

Entry version 113 (07 Apr 2021)
Sequence version 3 (13 Jul 2010)
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Protein

Dipeptide permease D

Gene

dtpD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable proton-dependent permease that transports dipeptides.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dipeptide permease D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dtpD
Ordered Locus Names:Z0860, ECs0734
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O157:H7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83334 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000558 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 48PeriplasmicSequence analysisAdd BLAST14
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 77CytoplasmicSequence analysis8
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 100PeriplasmicSequence analysis2
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 137CytoplasmicSequence analysisAdd BLAST16
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 166PeriplasmicSequence analysis8
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 211CytoplasmicSequence analysisAdd BLAST24
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 234PeriplasmicSequence analysis2
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 268CytoplasmicSequence analysisAdd BLAST13
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 311PeriplasmicSequence analysisAdd BLAST22
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 343CytoplasmicSequence analysisAdd BLAST11
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 378PeriplasmicSequence analysisAdd BLAST14
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 412CytoplasmicSequence analysisAdd BLAST13
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 461PeriplasmicSequence analysisAdd BLAST28
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 493CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003952951 – 493Dipeptide permease DAdd BLAST493

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer in solution. Exhibits a doughnut-like shape with a central, shallow depression and has a diameter of 8 nm.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		155864.EDL933_0775

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG3104, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004790_0_0_6

Family and domain databases

Conserved Domains Database

More...CDDi		cd17346, MFS_DtpA_like, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01880, PTR2_DtpD_subfam, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023777, AA/pep_transptr_DtpD
IPR005279, Dipep/tripep_permease
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS

The PANTHER Classification System

More...PANTHERi		PTHR11654, PTHR11654, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00854, PTR2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00924, yjdL_sub1_fam, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850, MFS, 1 hit
PS01022, PTR2_1, 1 hit
PS01023, PTR2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8X9D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKHASQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYNDTHAYEL 
        60         70         80         90        100
FSAYCSLVYV TPILGGFLAD KVLGNRMAVM LGALLMAIGH VVLGASEIHP 
       110        120        130        140        150
SFLYLSLAII VCGYGLFKSN VSCLLGELYE PTDPRRDGGF SLMYAAGNVG 
       160        170        180        190        200
SIIAPIACGY AQEEYSWAMG FGLAAVGMIA GLVIFLCGNR HFTHTRGVNK 
       210        220        230        240        250
KVLRATNFLL PNWGWLLVLL VATPALITVL FWKEWSVYAL IVATIIGLGV 
       260        270        280        290        300
LAKIYRKAEN QKQRKELRLI VTLTFFSMLF WAFAQQGGSS ISLYIDRFVN 
       310        320        330        340        350
RDMFGYTVPT AMFQSINAFA VMLCGVFLAW VVKESVAGNR TVRIWGKFAL 
       360        370        380        390        400
GLGLMSAGFC ILTLSARWSA MYGHSSLPLM VLGLAVMGFA ELFIDPVAMS 
       410        420        430        440        450
QITRIEIPGV TGVLTGIYML LSGAIANYLA GVIADQTSQA SFDASGAINY 
       460        470        480        490 
SINAYIEVFD QITWGALACV GVVLMIWLYQ ALKFRNRALA LES
Length:493
Mass (Da):54,230
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FF2F29DBD3C4B61
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55032.1
BA000007 Genomic DNA Translation: BAB34157.1

Protein sequence database of the Protein Information Resource

More...PIRi		D85571
F90720

NCBI Reference Sequences

More...RefSeqi		NP_308761.1, NC_002695.1
WP_001032707.1, NZ_SWKA01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAG55032; AAG55032; Z0860
BAB34157; BAB34157; ECs_0734

Database of genes from NCBI RefSeq genomes

More...GeneIDi		917103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ece:Z0860
ecs:ECs0734

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|386585.9.peg.850

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55032.1
BA000007 Genomic DNA Translation: BAB34157.1
PIRiD85571
F90720
RefSeqiNP_308761.1, NC_002695.1
WP_001032707.1, NZ_SWKA01000005.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi155864.EDL933_0775

Genome annotation databases

EnsemblBacteriaiAAG55032; AAG55032; Z0860
BAB34157; BAB34157; ECs_0734
GeneIDi917103
KEGGiece:Z0860
ecs:ECs0734
PATRICifig|386585.9.peg.850

Phylogenomic databases

eggNOGiCOG3104, Bacteria
HOGENOMiCLU_004790_0_0_6

Family and domain databases

CDDicd17346, MFS_DtpA_like, 1 hit
HAMAPiMF_01880, PTR2_DtpD_subfam, 1 hit
InterProiView protein in InterPro
IPR023777, AA/pep_transptr_DtpD
IPR005279, Dipep/tripep_permease
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS
PANTHERiPTHR11654, PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854, PTR2, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00924, yjdL_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS01022, PTR2_1, 1 hit
PS01023, PTR2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTPD_ECO57
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8X9D3
Secondary accession number(s): Q7AGL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 7, 2021
This is version 113 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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