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Protein

CDP-diacylglycerol pyrophosphatase

Gene

cdh

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

CDP-diacylglycerol + H2O = CMP + phosphatidate.UniRule annotation

Pathwayi: CDP-diacylglycerol degradation

This protein is involved in step 1 of the subpathway that synthesizes phosphatidate from CDP-diacylglycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. CDP-diacylglycerol pyrophosphatase (cdh)
This subpathway is part of the pathway CDP-diacylglycerol degradation, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidate from CDP-diacylglycerol, the pathway CDP-diacylglycerol degradation and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayi
UPA00609;UER00664

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol pyrophosphataseUniRule annotation (EC:3.6.1.26UniRule annotation)
Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolaseUniRule annotation
CDP-diglyceride hydrolaseUniRule annotation
Gene namesi
Name:cdhUniRule annotation
Ordered Locus Names:Z5463, ECs4843
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001985751 – 251CDP-diacylglycerol pyrophosphataseAdd BLAST251

Proteomic databases

PRIDEiQ8X7A5

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5463

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8X7A5
SMRiQ8X7A5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8X7A5

Family & Domainsi

Sequence similaritiesi

Belongs to the Cdh family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EAF Bacteria
COG2134 LUCA
HOGENOMiHOG000048713
KOiK01521
OMAiSPFIMLA

Family and domain databases

Gene3Di3.30.428.30, 1 hit
HAMAPiMF_00319 Cdh, 1 hit
InterProiView protein in InterPro
IPR003763 CDP-diacylglyc_Pase
IPR015993 CDP-diacylglyc_Pase_proteobac
IPR038433 CDP-diacylglyc_Pase_sf
IPR036265 HIT-like_sf
PfamiView protein in Pfam
PF02611 CDH, 1 hit
PIRSFiPIRSF001273 CDH, 1 hit
SUPFAMiSSF54197 SSF54197, 1 hit
TIGRFAMsiTIGR00672 cdh, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X7A5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ
60 70 80 90 100
NPSPCAEVKP NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF
110 120 130 140 150
FWLAWQARDF MSKKYGQPVP DRAVSLAINS RTGRTQNHFH IHISCIRPDV
160 170 180 190 200
REQLDNNLAN ISSRWLPLPG GLRGHEYLAR RVTESELVQR SPFMMLAEEV
210 220 230 240 250
PEAREHMGSY GLAMVRQSDN SFVLLATQRN LLTLNRASAE EIQDHQCEIL

R
Length:251
Mass (Da):28,383
Last modified:March 1, 2002 - v1
Checksum:iC987D3A4B12BE5F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59111.1
BA000007 Genomic DNA Translation: BAB38266.1
PIRiC86081
C91234
RefSeqiNP_312870.1, NC_002695.1
WP_000708998.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59111; AAG59111; Z5463
BAB38266; BAB38266; BAB38266
GeneIDi915054
KEGGiece:Z5463
ecs:ECs4843
PATRICifig|386585.9.peg.5065

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59111.1
BA000007 Genomic DNA Translation: BAB38266.1
PIRiC86081
C91234
RefSeqiNP_312870.1, NC_002695.1
WP_000708998.1, NZ_NOKN01000002.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2POFX-ray1.40A/B27-251[»]
ProteinModelPortaliQ8X7A5
SMRiQ8X7A5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z5463

Proteomic databases

PRIDEiQ8X7A5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG59111; AAG59111; Z5463
BAB38266; BAB38266; BAB38266
GeneIDi915054
KEGGiece:Z5463
ecs:ECs4843
PATRICifig|386585.9.peg.5065

Phylogenomic databases

eggNOGiENOG4105EAF Bacteria
COG2134 LUCA
HOGENOMiHOG000048713
KOiK01521
OMAiSPFIMLA

Enzyme and pathway databases

UniPathwayi
UPA00609;UER00664

Miscellaneous databases

EvolutionaryTraceiQ8X7A5

Family and domain databases

Gene3Di3.30.428.30, 1 hit
HAMAPiMF_00319 Cdh, 1 hit
InterProiView protein in InterPro
IPR003763 CDP-diacylglyc_Pase
IPR015993 CDP-diacylglyc_Pase_proteobac
IPR038433 CDP-diacylglyc_Pase_sf
IPR036265 HIT-like_sf
PfamiView protein in Pfam
PF02611 CDH, 1 hit
PIRSFiPIRSF001273 CDH, 1 hit
SUPFAMiSSF54197 SSF54197, 1 hit
TIGRFAMsiTIGR00672 cdh, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDH_ECO57
AccessioniPrimary (citable) accession number: Q8X7A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2002
Last modified: October 10, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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