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UniProtKB - Q8X743 (CAPP_ECO57)
Protein
Phosphoenolpyruvate carboxylase
Gene
ppc
Organism
Escherichia coli O157:H7
Status
Functioni
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
UniRule annotationCatalytic activityi
- EC:4.1.1.31UniRule annotation
Cofactori
Mg2+UniRule annotation
Activity regulationi
The enzyme has distinct binding sites for each of the allosteric effectors such as acetyl-CoA, fructose 1,6-bisphosphate, guanosine 3'-diphosphate 5'-diphosphate, long chain fatty acids, and L-aspartate.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 138 | UniRule annotation | 1 | |
Active sitei | 546 | UniRule annotation | 1 |
GO - Molecular functioni
- magnesium ion binding Source: UniProtKB-UniRule
- phosphoenolpyruvate carboxylase activity Source: UniProtKB-UniRule
GO - Biological processi
- carbon fixation Source: UniProtKB-UniRule
- oxaloacetate metabolic process Source: UniProtKB-UniRule
- tricarboxylic acid cycle Source: InterPro
Keywordsi
Molecular function | Allosteric enzyme, Lyase |
Biological process | Carbon dioxide fixation |
Ligand | Magnesium |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)Short name: PEPCUniRule annotation Short name: PEPCaseUniRule annotation |
Gene namesi | Name:ppcUniRule annotation Ordered Locus Names:Z5514, ECs4885 |
Organismi | Escherichia coli O157:H7 |
Taxonomic identifieri | 83334 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000166594 | 1 – 883 | Phosphoenolpyruvate carboxylaseAdd BLAST | 883 |
Interactioni
Subunit structurei
Homotetramer.
UniRule annotationProtein-protein interaction databases
STRINGi | 386585.gene:10367983 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PEPCase type 1 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG2352, Bacteria |
HOGENOMi | CLU_006557_2_0_6 |
Family and domain databases
HAMAPi | MF_00595, PEPcase_type1, 1 hit |
InterProi | View protein in InterPro IPR021135, PEP_COase IPR022805, PEP_COase_bac/pln-type IPR018129, PEP_COase_Lys_AS IPR033129, PEPCASE_His_AS IPR015813, Pyrv/PenolPyrv_Kinase-like_dom |
PANTHERi | PTHR30523, PTHR30523, 1 hit |
Pfami | View protein in Pfam PF00311, PEPcase, 1 hit |
PRINTSi | PR00150, PEPCARBXLASE |
SUPFAMi | SSF51621, SSF51621, 1 hit |
PROSITEi | View protein in PROSITE PS00781, PEPCASE_1, 1 hit PS00393, PEPCASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8X743-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNEQYSALRS NVSMLGKVLG ETIKDALGEH ILERVETIRK LSKSSRAGND
60 70 80 90 100
ANRQELLTTL QNLSNDELLP VARAFSQFLN LANTAEQYHS ISPKGEAASN
110 120 130 140 150
PEVIARTLRK LKNQPELSED TIKKAVESLS LELVLTAHPT EITRRTLIHK
160 170 180 190 200
MVEVNACLKQ LDNKDIADYE HNQLMRRLRQ LIAQSWHTDE IRKLRPSPVD
210 220 230 240 250
EAKWGFAVVE NSLWQGVPNY LRELNEQLEE NLGYKLPVEF VPVRFTSWMG
260 270 280 290 300
GDRDGNPNVT ADITRHVLLL SRWKATDLFL KDIQVLVSEL SMVEATPELL
310 320 330 340 350
ALVGEEGAAE PYRYLMKNLR SRLMATQAWL EARLKGEELP KPEGLLTQNE
360 370 380 390 400
ELWEPLYACY QSLQACGMGI IANGDLLDTL RRVKCFGVPL VRIDIRQEST
410 420 430 440 450
RHTEALGELT RYLGIGDYES WSEADKQAFL IRELNSKRPL LPRNWQPSAE
460 470 480 490 500
TREVLDTCQV IAEAPQGSIA AYVISMAKTP SDVLAVHLLL KEAGIGFAMP
510 520 530 540 550
VAPLFETLDD LNNANDVMTQ LLNIDWYRGL IQGKQMVMIG YSDSAKDAGV
560 570 580 590 600
MAASWAQYQA QDALIKTCEK AGIELTLFHG RGGSIGRGGA PAHAALLSQP
610 620 630 640 650
PGSLKGGLRV TEQGEMIRFK YGLPEITVSS LSLYTGAILE ANLLPPPEPK
660 670 680 690 700
ESWRRIMDEL SVISCDLYRG YVRENKDFVP YFRSATPEQE LGKLPLGSRP
710 720 730 740 750
AKRRPTGGVE SLRAIPWIFA WTQNRLMLPA WLGAGTALQK VVEDGKQSEL
760 770 780 790 800
EAMCRDWPFF STRLGMLEMV FAKADLWLAE YYDQRLVDKT LWPLGKELRN
810 820 830 840 850
LQEEDIKVVL AIANDSHLMA DLPWIAESIQ LRNIYTDPLN VLQAELLHRS
860 870 880
RQAEKEGQEP DPRVEQALMV TIAGIAAGMR NTG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG59158.1 BA000007 Genomic DNA Translation: BAB38308.1 |
PIRi | B86087 E91239 |
RefSeqi | NP_312912.1, NC_002695.1 WP_001005582.1, NZ_SEKU01000028.1 |
Genome annotation databases
EnsemblBacteriai | AAG59158; AAG59158; Z5514 BAB38308; BAB38308; ECs_4885 |
GeneIDi | 915001 |
KEGGi | ece:Z5514 ecs:ECs4885 |
PATRICi | fig|386585.9.peg.5109 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG59158.1 BA000007 Genomic DNA Translation: BAB38308.1 |
PIRi | B86087 E91239 |
RefSeqi | NP_312912.1, NC_002695.1 WP_001005582.1, NZ_SEKU01000028.1 |
3D structure databases
SMRi | Q8X743 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 386585.gene:10367983 |
Genome annotation databases
EnsemblBacteriai | AAG59158; AAG59158; Z5514 BAB38308; BAB38308; ECs_4885 |
GeneIDi | 915001 |
KEGGi | ece:Z5514 ecs:ECs4885 |
PATRICi | fig|386585.9.peg.5109 |
Phylogenomic databases
eggNOGi | COG2352, Bacteria |
HOGENOMi | CLU_006557_2_0_6 |
Family and domain databases
HAMAPi | MF_00595, PEPcase_type1, 1 hit |
InterProi | View protein in InterPro IPR021135, PEP_COase IPR022805, PEP_COase_bac/pln-type IPR018129, PEP_COase_Lys_AS IPR033129, PEPCASE_His_AS IPR015813, Pyrv/PenolPyrv_Kinase-like_dom |
PANTHERi | PTHR30523, PTHR30523, 1 hit |
Pfami | View protein in Pfam PF00311, PEPcase, 1 hit |
PRINTSi | PR00150, PEPCARBXLASE |
SUPFAMi | SSF51621, SSF51621, 1 hit |
PROSITEi | View protein in PROSITE PS00781, PEPCASE_1, 1 hit PS00393, PEPCASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAPP_ECO57 | |
Accessioni | Q8X743Primary (citable) accession number: Q8X743 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families