Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8X654 (Q8X654_ECO57)

Entry version 143 (02 Dec 2020)
Sequence version 2 (10 Oct 2018)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

LysR family transcriptional regulator

Gene

E3149_14515

Organism
Escherichia coli O157:H7
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LysR family transcriptional regulatorImported
Submitted name:
Regulatory proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:E3149_14515Imported, E3150_08965Imported, E3151_08590Imported, E3152_08595Imported, E3153_08605Imported, E3154_08580Imported, E3155_09120Imported, E3156_09085Imported, E3157_08730Imported, E3158_09175Imported, E3159_19430Imported, E3160_18670Imported, E3161_08600Imported, E3162_08960Imported, E3163_08605Imported, E3164_09185Imported, E3165_09180Imported, E3166_08520Imported, E3167_08490Imported, E3168_08610Imported, E3169_08600Imported, E3170_08695Imported, E3171_08685Imported, E3172_08975Imported, E3173_08605Imported, E4T53_08920Imported, E4U08_08610Imported, E4U62_08600Imported, E4U63_08520Imported, E4U64_08590Imported, E4U65_08590Imported, E4U66_08635Imported, E4U67_09080Imported, E4U68_08940Imported, E4U69_08630Imported, E4U70_08615Imported, E4U72_09105Imported, E4U73_09225Imported, E4U74_08610Imported, E4U76_08590Imported, E4U77_09110Imported, E4U78_08900Imported, E4U79_08615Imported, E4U80_08900Imported, E4U81_09070Imported, E4U84_08590Imported, E4U86_08620Imported, E4U87_08670Imported, E4U89_08635Imported, E4U90_09145Imported, ECs_3032Imported, EVY27_15785Imported, FCV42_08540Imported, FDZ86_08555Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O157:H7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83334 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000558 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		155864.EDL933_3301

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 65HTH lysR-typeInterPro annotationAdd BLAST58

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LysR transcriptional regulatory family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0583, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039613_6_0_6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005119, LysR_subst-bd
IPR000847, Tscrpt_reg_HTH_LysR
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00126, HTH_1, 1 hit
PF03466, LysR_substrate, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00039, HTHLYSR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50931, HTH_LYSR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8X654-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANWAQKLKL HHLEMLVALG EQGNLTHVAR MMNITQPALS KWLSQLEDEI 
        60         70         80         90        100
GITLFERHSK GLRPTEGGKL LLQHAQRLIN DMERSQHELA RFKQGGLVGS 
       110        120        130        140        150
LKIGCSPVAT DCVSQAILHL LTKMPTLHLN IEEKVMTPLL QDLLAGSVDV 
       160        170        180        190        200
VVGRIGGRAL QLPLNYQVLY TEPVCFVARP EHPLAKYATL SWNDLANWRW 
       210        220        230        240        250
IVWPTGTPIR ISIDNALVDH GVMLPENTIE SASMNVSTNL LQSSDMISIL 
       260        270        280        290        300
SLRLAQRYAS QGQLVILNLP KIEQKGSVGV FWRNNETPSY ALSQFLHFLQ 

QN
Length:302
Mass (Da):33,800
Last modified:October 10, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDEEED9240BE3A64B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BA000007 Genomic DNA Translation: BAB36455.2
SEKQ01000012 Genomic DNA Translation: NEV31989.1
CP038282 Genomic DNA Translation: QJZ34228.1
CP038284 Genomic DNA Translation: QJZ39535.1
CP038287 Genomic DNA Translation: QJZ44926.1
CP038290 Genomic DNA Translation: QJZ50324.1
CP038292 Genomic DNA Translation: QJZ55786.1
CP038295 Genomic DNA Translation: QJZ61147.1
CP038300 Genomic DNA Translation: QJZ66136.1
CP038302 Genomic DNA Translation: QJZ71545.1
CP038305 Genomic DNA Translation: QJZ77147.1
CP038309 Genomic DNA Translation: QJZ82495.1
CP038313 Genomic DNA Translation: QJZ88035.1
CP038316 Genomic DNA Translation: QJZ93311.1
CP038319 Genomic DNA Translation: QJZ98513.1
CP038321 Genomic DNA Translation: QKA03791.1
CP038324 Genomic DNA Translation: QKA09287.1
CP038328 Genomic DNA Translation: QKA14888.1
CP038333 Genomic DNA Translation: QKA20429.1
CP038336 Genomic DNA Translation: QKA25906.1
CP038339 Genomic DNA Translation: QKA31296.1
CP038342 Genomic DNA Translation: QKA36558.1
CP038344 Genomic DNA Translation: QKA41880.1
CP038346 Genomic DNA Translation: QKA47153.1
CP038349 Genomic DNA Translation: QKA52569.1
CP038351 Genomic DNA Translation: QKA57768.1
CP038353 Genomic DNA Translation: QKA63291.1
CP038357 Genomic DNA Translation: QKA73952.1
CP038360 Genomic DNA Translation: QKA79363.1
CP038363 Genomic DNA Translation: QKA84567.1
CP038366 Genomic DNA Translation: QKA89975.1
CP038369 Genomic DNA Translation: QKA95340.1
CP038372 Genomic DNA Translation: QKB00657.1
CP038374 Genomic DNA Translation: QKB07807.1
CP038376 Genomic DNA Translation: QKB13144.1
CP038380 Genomic DNA Translation: QKB16817.1
CP038383 Genomic DNA Translation: QKB22233.1
CP038386 Genomic DNA Translation: QKB27549.1
CP038389 Genomic DNA Translation: QKB32460.1
CP038394 Genomic DNA Translation: QKB37592.1
CP038398 Genomic DNA Translation: QKB42506.1
CP038402 Genomic DNA Translation: QKB47665.1
CP038405 Genomic DNA Translation: QKB53126.1
CP038408 Genomic DNA Translation: QKB58425.1
CP038412 Genomic DNA Translation: QKB63796.1
CP038414 Genomic DNA Translation: QKB69094.1
CP038416 Genomic DNA Translation: QKB74528.1
CP038419 Genomic DNA Translation: QKB79836.1
CP038421 Genomic DNA Translation: QKB85239.1
CP038423 Genomic DNA Translation: QKB90503.1
CP038425 Genomic DNA Translation: QKB95908.1
CP038428 Genomic DNA Translation: QKC02258.1
CP039834 Genomic DNA Translation: QKQ79605.1
CP040107 Genomic DNA Translation: QKQ84919.1

NCBI Reference Sequences

More...RefSeqi		NP_311059.2, NC_002695.1
WP_000024633.1, NZ_SWKA01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAG57278; AAG57278; Z3395
BAB36455; BAB36455; BAB36455

Database of genes from NCBI RefSeq genomes

More...GeneIDi		916736

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecs:ECs3032

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|386585.9.peg.3157

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000007 Genomic DNA Translation: BAB36455.2
SEKQ01000012 Genomic DNA Translation: NEV31989.1
CP038282 Genomic DNA Translation: QJZ34228.1
CP038284 Genomic DNA Translation: QJZ39535.1
CP038287 Genomic DNA Translation: QJZ44926.1
CP038290 Genomic DNA Translation: QJZ50324.1
CP038292 Genomic DNA Translation: QJZ55786.1
CP038295 Genomic DNA Translation: QJZ61147.1
CP038300 Genomic DNA Translation: QJZ66136.1
CP038302 Genomic DNA Translation: QJZ71545.1
CP038305 Genomic DNA Translation: QJZ77147.1
CP038309 Genomic DNA Translation: QJZ82495.1
CP038313 Genomic DNA Translation: QJZ88035.1
CP038316 Genomic DNA Translation: QJZ93311.1
CP038319 Genomic DNA Translation: QJZ98513.1
CP038321 Genomic DNA Translation: QKA03791.1
CP038324 Genomic DNA Translation: QKA09287.1
CP038328 Genomic DNA Translation: QKA14888.1
CP038333 Genomic DNA Translation: QKA20429.1
CP038336 Genomic DNA Translation: QKA25906.1
CP038339 Genomic DNA Translation: QKA31296.1
CP038342 Genomic DNA Translation: QKA36558.1
CP038344 Genomic DNA Translation: QKA41880.1
CP038346 Genomic DNA Translation: QKA47153.1
CP038349 Genomic DNA Translation: QKA52569.1
CP038351 Genomic DNA Translation: QKA57768.1
CP038353 Genomic DNA Translation: QKA63291.1
CP038357 Genomic DNA Translation: QKA73952.1
CP038360 Genomic DNA Translation: QKA79363.1
CP038363 Genomic DNA Translation: QKA84567.1
CP038366 Genomic DNA Translation: QKA89975.1
CP038369 Genomic DNA Translation: QKA95340.1
CP038372 Genomic DNA Translation: QKB00657.1
CP038374 Genomic DNA Translation: QKB07807.1
CP038376 Genomic DNA Translation: QKB13144.1
CP038380 Genomic DNA Translation: QKB16817.1
CP038383 Genomic DNA Translation: QKB22233.1
CP038386 Genomic DNA Translation: QKB27549.1
CP038389 Genomic DNA Translation: QKB32460.1
CP038394 Genomic DNA Translation: QKB37592.1
CP038398 Genomic DNA Translation: QKB42506.1
CP038402 Genomic DNA Translation: QKB47665.1
CP038405 Genomic DNA Translation: QKB53126.1
CP038408 Genomic DNA Translation: QKB58425.1
CP038412 Genomic DNA Translation: QKB63796.1
CP038414 Genomic DNA Translation: QKB69094.1
CP038416 Genomic DNA Translation: QKB74528.1
CP038419 Genomic DNA Translation: QKB79836.1
CP038421 Genomic DNA Translation: QKB85239.1
CP038423 Genomic DNA Translation: QKB90503.1
CP038425 Genomic DNA Translation: QKB95908.1
CP038428 Genomic DNA Translation: QKC02258.1
CP039834 Genomic DNA Translation: QKQ79605.1
CP040107 Genomic DNA Translation: QKQ84919.1
RefSeqiNP_311059.2, NC_002695.1
WP_000024633.1, NZ_SWKA01000005.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi155864.EDL933_3301

Genome annotation databases

EnsemblBacteriaiAAG57278; AAG57278; Z3395
BAB36455; BAB36455; BAB36455
GeneIDi916736
KEGGiecs:ECs3032
PATRICifig|386585.9.peg.3157

Phylogenomic databases

eggNOGiCOG0583, Bacteria
HOGENOMiCLU_039613_6_0_6

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119, LysR_subst-bd
IPR000847, Tscrpt_reg_HTH_LysR
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126, HTH_1, 1 hit
PF03466, LysR_substrate, 1 hit
PRINTSiPR00039, HTHLYSR
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931, HTH_LYSR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8X654_ECO57
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8X654
Secondary accession number(s): A0A6M0JKP2, Q7AC96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: October 10, 2018
Last modified: December 2, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again