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Protein

Ribose 1,5-bisphosphate phosphokinase PhnN

Gene

phnN

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).UniRule annotation

Catalytic activityi

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. Ribose 1,5-bisphosphate phosphokinase PhnN (phnN)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00087; UER00175

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose 1,5-bisphosphate phosphokinase PhnNUniRule annotation (EC:2.7.4.23UniRule annotation)
Alternative name(s):
Ribose 1,5-bisphosphokinaseUniRule annotation
Gene namesi
Name:phnNUniRule annotation
Ordered Locus Names:Z5697, ECs5077
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004127851 – 185Ribose 1,5-bisphosphate phosphokinase PhnNAdd BLAST185

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5697

Structurei

3D structure databases

ProteinModelPortaliQ8X5P4
SMRiQ8X5P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribose 1,5-bisphosphokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105MFQ Bacteria
COG3709 LUCA
HOGENOMiHOG000037637
KOiK05774
OMAiMARLIWL

Family and domain databases

HAMAPiMF_00836 PhnN, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR027417 P-loop_NTPase
IPR012699 PhnN
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02322 phosphon_PhnN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X5P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGKLIWLMG PSGSGKDSLL AELRLREQTQ LLVAHRYITR DASAGSENHI
60 70 80 90 100
ALSEQEFFTR AGQNLLALSW HANGLYYGVG VEIDLWLHAG FDVLVNGSRA
110 120 130 140 150
HLPQARARYQ SALLPICLQV SPEILRQRLE NRGRENASEI NARLARAARY
160 170 180
TPQDCHTLNN DGSLRQSVDT LLTLIHQKEK HHACL
Length:185
Mass (Da):20,744
Last modified:March 1, 2002 - v1
Checksum:i21217D57C785D1B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59294.1
BA000007 Genomic DNA Translation: BAB38500.1
PIRiB86104
E91263
RefSeqiNP_313104.1, NC_002695.1
WP_000971883.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59294; AAG59294; Z5697
BAB38500; BAB38500; BAB38500
GeneIDi914257
KEGGiece:Z5697
ecs:ECs5077
PATRICifig|386585.9.peg.5307

Similar proteinsi

Entry informationi

Entry nameiPHNN_ECO57
AccessioniPrimary (citable) accession number: Q8X5P4
Secondary accession number(s): Q7A901
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health