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Entry version 106 (16 Oct 2019)
Sequence version 3 (24 Nov 2009)
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Protein

Putative cellulose synthase operon protein C

Gene

bcsC

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for maximal bacterial cellulose synthesis.By similarity

Caution

Could be the product of a pseudogene.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: bacterial cellulose biosynthesis

This protein is involved in the pathway bacterial cellulose biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway bacterial cellulose biosynthesis and in Glycan metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCellulose biosynthesis

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00694

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative cellulose synthase operon protein C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bcsC
Ordered Locus Names:Z4944/Z4945, ECs4410
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O157:H7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83334 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000558 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000010643024 – 1154Putative cellulose synthase operon protein CAdd BLAST1131

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8X5M0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
155864.EDL933_4784

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 95TPR 1Add BLAST34
Repeati266 – 299TPR 2Add BLAST34
Repeati300 – 333TPR 3Add BLAST34
Repeati348 – 381TPR 4Add BLAST34
Repeati382 – 415TPR 5Add BLAST34
Repeati458 – 491TPR 6Add BLAST34
Repeati600 – 633TPR 7Add BLAST34
Repeati707 – 741TPR 8Add BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AcsC/BcsC family.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105EJG Bacteria
COG0457 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000125935

KEGG Orthology (KO)

More...
KOi
K20543

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008410 BCSC_C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05420 BCSC_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8X5M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKFTLNIFT LSLGLAVMPM VEAAPTAQQQ LLEQVRLGEA THREDLVQQS
60 70 80 90 100
LYRLELIDPN NPDVVAARFR SLLRQGDIDG AQKQLDRLSQ LAPSSNAYKS
110 120 130 140 150
SRTTMLLSTP DGRQALQQAR LQATTGHAEE AVANLFNGAP PEGDIAVEYW
160 170 180 190 200
STVAKIPARR GEAINQLKRI NADEPGNTGL QNNLALLLFS SDRRDEGFAV
210 220 230 240 250
LEQMAKSNAG REGASKIWYG QIKDMPVSDA SVSALKKYLS IFSDGDSVAA
260 270 280 290 300
AQSQLAEQQK QLADPAFRAR AQGLAAVDSG MAGKAIPELQ QAVRANPKDS
310 320 330 340 350
EALGALGQAY SQKGDRANAV ANLEKALALD PHSSNNDKWN SLLKVNRYWL
360 370 380 390 400
AIQQGDAALK ANNPDRAERL FQQARNVDNT DSYAVLGLGD VAMARKDYPA
410 420 430 440 450
AERYYQQTLR MDSGNTNAVR GLANIYRQQS PEKAEAFIAS LSASQRRSID
460 470 480 490 500
DIERSLQNDR LAQQAEALEN QGKWAQAAAL QRQRLALDPG SVWITYRLSQ
510 520 530 540 550
DLWQAGQRSQ ADTLMRNLAQ QKPNDPEQVY AYGLYLSGHD QDRAALAHIN
560 570 580 590 600
SLPRAQWSSN IQELVNRLQS DQVLETANRL RESGKEAEAE AMLRQQPPST
610 620 630 640 650
RIDLTLADWA LQRRDYTAAR AAYQNVLTRE PTNADAILGL TEVDIAAGDT
660 670 680 690 700
AAARSQLAKL PATDNASLNT QRRVALAQAQ LGDTAAAQQT FNKLIPQAKS
710 720 730 740 750
QPPSMESAMV LRDGAKFEAQ AGDPKQALET YKDAMVASGV TTTRPQDNDT
760 770 780 790 800
FTRLTRNDEK DDWLKRGVRS DAADLYRQQD LNVTLEHDYW GSSGTGGYSD
810 820 830 840 850
LKAHTTMLQV DAPYSDGRMF FRSDFVNMNV GSFSTNADGK WDDNWGTCTL
860 870 880 890 900
RDCSGNRSQS DSGASVAVGW RNDVWSWDIG TTPMGFNVVD VVGGISYSDD
910 920 930 940 950
IGPLGYTVNA HRRPISSSLL AFGGQKDFPS NTGKKWGGVR ADGVGLSLSY
960 970 980 990 1000
DKGEANGVWA SLSGDQLTGK NVEDNWRVRW MTGYYYKVIN QNNRRVTIGL
1010 1020 1030 1040 1050
NNMIWHYDKD LSGYSLGQGG YYSPQEYLSF AIPVMWRERT ENWSWELGAS
1060 1070 1080 1090 1100
GSWSHSRTKT MPRYPLMNLI PTDWQEEAAR QSNDGGSSQG FGYTARALLE
1110 1120 1130 1140 1150
RRVTSNWFVG TAIDIQQAKD YAPSHFLLYV RYSAAGWQGD MDLPPQPLIP

YADW
Length:1,154
Mass (Da):127,462
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7288C6479AAA23C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG58671 differs from that shown. Reason: Frameshift.Curated
The sequence AAG58671 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAG58672 differs from that shown. Reason: Frameshift.Curated
The sequence BAB37833 differs from that shown. Reason: Frameshift.Curated
The sequence BAB37833 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58672.1 Frameshift.
AE005174 Genomic DNA Translation: AAG58671.1 Sequence problems.
BA000007 Genomic DNA Translation: BAB37833.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
B91180
C86026
D86026

NCBI Reference Sequences

More...
RefSeqi
NP_312437.1, NC_002695.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG58671; AAG58671; Z4944
AAG58672; AAG58672; Z4945
BAB37833; BAB37833; BAB37833

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
915729

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ece:Z4944
ece:Z4945
ecs:ECs4410

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|386585.9.peg.4610

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58672.1 Frameshift.
AE005174 Genomic DNA Translation: AAG58671.1 Sequence problems.
BA000007 Genomic DNA Translation: BAB37833.1 Sequence problems.
PIRiB91180
C86026
D86026
RefSeqiNP_312437.1, NC_002695.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi155864.EDL933_4784

Proteomic databases

PRIDEiQ8X5M0

Genome annotation databases

EnsemblBacteriaiAAG58671; AAG58671; Z4944
AAG58672; AAG58672; Z4945
BAB37833; BAB37833; BAB37833
GeneIDi915729
KEGGiece:Z4944
ece:Z4945
ecs:ECs4410
PATRICifig|386585.9.peg.4610

Phylogenomic databases

eggNOGiENOG4105EJG Bacteria
COG0457 LUCA
HOGENOMiHOG000125935
KOiK20543

Enzyme and pathway databases

UniPathwayiUPA00694

Family and domain databases

Gene3Di1.25.40.10, 5 hits
InterProiView protein in InterPro
IPR008410 BCSC_C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF05420 BCSC_C, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCSC_ECO57
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8X5M0
Secondary accession number(s): Q8X3J4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 24, 2009
Last modified: October 16, 2019
This is version 106 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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