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Protein

Olfactory receptor 1E3

Gene

OR1E3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1E3
Alternative name(s):
Olfactory receptor 17-210
Short name:
OR17-210
Olfactory receptor OR17-7
Gene namesi
Name:OR1E3
Synonyms:OR1E3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8191 OR1E3
neXtProtiNX_Q8WZA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 107CytoplasmicSequence analysisAdd BLAST58
Transmembranei108 – 128Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini129 – 141ExtracellularSequence analysisAdd BLAST13
Transmembranei142 – 162Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini163 – 195CytoplasmicSequence analysisAdd BLAST33
Transmembranei196 – 216Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini217 – 242ExtracellularSequence analysisAdd BLAST26
Transmembranei243 – 263Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini264 – 271CytoplasmicSequence analysis8
Transmembranei272 – 292Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini293 – 310ExtracellularSequence analysisAdd BLAST18
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 343CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215840

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003159431 – 343Olfactory receptor 1E3Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8WZA6
ProteomicsDBi75246

Structurei

3D structure databases

ProteinModelPortaliQ8WZA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiQ8WZA6
PhylomeDBiQ8WZA6

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WZA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKKNQTMIS EFLLLGLPIQ PEQQNLFYAL FLAVYLTTLL GNLLVIVLIR
60 70 80 90 100
LDSHLHMPMY LCLSNLSFSD LCFSSVTMPK LLQNMQSQNP SIPFADCLAQ
110 120 130 140 150
MYFHLFYGVL ESFLLVVMAY HCYVAICFPL HYTTIMSPKC CLGLLTLSWL
160 170 180 190 200
LTTAHATLHT LLMARLSFCA ENVIPHFFCD TSTLLKLACS NTQVNGWVMF
210 220 230 240 250
FMGGLILVIP FLLLIMSCAR IVSTILRVPS TGGIQKAFST CGPHLSVVSL
260 270 280 290 300
FYGTIIGLYL CPLTNHNTVK DTVMAVMYTG VTHMLNPFIY SLRNRDMRGN
310 320 330 340
PGQSLQHKEN FFVFKIVIVG ILPLLNLVGV VKLIMKYHSK SVA
Length:343
Mass (Da):38,518
Last modified:January 15, 2008 - v2
Checksum:iD20294E28EF1A787
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Q → R in AF087929 (PubMed:10673334).Curated1
Sequence conflicti141 – 143CLG → WLA in AAA18353 (PubMed:8004088).Curated3
Sequence conflicti164 – 165AR → GS in AAA18353 (PubMed:8004088).Curated2

Polymorphismi

A single nucleotide deletion at position Leu-17 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097370 Genomic DNA No translation available.
AF087929 Genomic DNA No translation available.
U04690 Genomic DNA Translation: AAA18353.1
AF399437 Genomic DNA No translation available.
BK004549 Genomic DNA No translation available.
PIRiI38482

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1E3_HUMAN
AccessioniPrimary (citable) accession number: Q8WZA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 20, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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