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Entry version 125 (17 Jun 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Esterase OVCA2

Gene

OVCA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Encoded in an intron of the gene DPH1/OVCA1 (same strand).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei119Charge relay systemBy similarity1
Active sitei179Charge relay systemBy similarity1
Active sitei206Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-OVCA2 FSH1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Esterase OVCA2 (EC:3.1.2.-Curated)
Alternative name(s):
Ovarian cancer-associated gene 2 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OVCA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000262664.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24203 OVCA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607896 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WZ82

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
124641

Open Targets

More...
OpenTargetsi
ENSG00000262664

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165432281

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WZ82 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OVCA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731010

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003008761 – 227Esterase OVCA2Add BLAST227

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WZ82

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WZ82

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WZ82

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WZ82

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WZ82

PeptideAtlas

More...
PeptideAtlasi
Q8WZ82

PRoteomics IDEntifications database

More...
PRIDEi
Q8WZ82

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75237

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WZ82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WZ82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000262664 Expressed in body of stomach and 86 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WZ82 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000262664 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125881, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WZ82, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000461388

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WZ82 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WZ82

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LovG family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2551 Eukaryota
ENOG4111JYH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003541

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_051938_2_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WZ82

Identification of Orthologs from Complete Genome Data

More...
OMAi
EEPTVCR

Database of Orthologous Groups

More...
OrthoDBi
1190789at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WZ82

TreeFam database of animal gene trees

More...
TreeFami
TF313006

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR005645 FSH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03959 FSH1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WZ82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD
60 70 80 90 100
PPGPEGARSD FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG
110 120 130 140 150
MVAQALNRLG PFDGLLGFSQ GAALAALVCA LGQAGDPRFP LPRFILLVSG
160 170 180 190 200
FCPRGIGFKE SILQRPLSLP SLHVFGDTDK VIPSQESVQL ASQFPGAITL
210 220
THSGGHFIPA AAPQRQAYLK FLDQFAE
Length:227
Mass (Da):24,418
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4A4694A7E30FBD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84S → C in AAH40696 (PubMed:15489334).Curated1
Sequence conflicti150G → S in AAC62628 (PubMed:8616839).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF073528 mRNA Translation: AAC62628.1
AF321875 mRNA Translation: AAL35713.1
AF335321 Genomic DNA Translation: AAN04659.1
BC040696 mRNA Translation: AAH40696.1
BC041170 mRNA Translation: AAH41170.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11015.1

NCBI Reference Sequences

More...
RefSeqi
NP_543012.1, NM_080822.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000572195; ENSP00000461388; ENSG00000262664

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
124641

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:124641

UCSC genome browser

More...
UCSCi
uc002ftx.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073528 mRNA Translation: AAC62628.1
AF321875 mRNA Translation: AAL35713.1
AF335321 Genomic DNA Translation: AAN04659.1
BC040696 mRNA Translation: AAH40696.1
BC041170 mRNA Translation: AAH41170.1
CCDSiCCDS11015.1
RefSeqiNP_543012.1, NM_080822.2

3D structure databases

SMRiQ8WZ82
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125881, 3 interactors
IntActiQ8WZ82, 2 interactors
STRINGi9606.ENSP00000461388

Protein family/group databases

ESTHERihuman-OVCA2 FSH1

PTM databases

iPTMnetiQ8WZ82
PhosphoSitePlusiQ8WZ82

Polymorphism and mutation databases

BioMutaiOVCA2
DMDMi74731010

Proteomic databases

EPDiQ8WZ82
jPOSTiQ8WZ82
MassIVEiQ8WZ82
MaxQBiQ8WZ82
PaxDbiQ8WZ82
PeptideAtlasiQ8WZ82
PRIDEiQ8WZ82
ProteomicsDBi75237

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
69773 56 antibodies

The DNASU plasmid repository

More...
DNASUi
124641

Genome annotation databases

EnsembliENST00000572195; ENSP00000461388; ENSG00000262664
GeneIDi124641
KEGGihsa:124641
UCSCiuc002ftx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
124641
DisGeNETi124641
EuPathDBiHostDB:ENSG00000262664.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OVCA2
HGNCiHGNC:24203 OVCA2
HPAiENSG00000262664 Low tissue specificity
MIMi607896 gene
neXtProtiNX_Q8WZ82
OpenTargetsiENSG00000262664
PharmGKBiPA165432281

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2551 Eukaryota
ENOG4111JYH LUCA
GeneTreeiENSGT00390000003541
HOGENOMiCLU_051938_2_3_1
InParanoidiQ8WZ82
OMAiEEPTVCR
OrthoDBi1190789at2759
PhylomeDBiQ8WZ82
TreeFamiTF313006

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
124641 33 hits in 787 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
124641
PharosiQ8WZ82 Tdark

Protein Ontology

More...
PROi
PR:Q8WZ82
RNActiQ8WZ82 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000262664 Expressed in body of stomach and 86 other tissues
GenevisibleiQ8WZ82 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR005645 FSH_dom
PfamiView protein in Pfam
PF03959 FSH1, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOVCA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WZ82
Secondary accession number(s): Q86XN3, Q8IW87, Q9UCX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: June 17, 2020
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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