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Protein

Deoxyribonuclease-2-beta

Gene

DNASE2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products. EC:3.1.22.1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • deoxyribonuclease II activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.22.1 2681

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8WZ79

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxyribonuclease-2-beta (EC:3.1.22.1)
Alternative name(s):
DNase II-like acid DNase
DNase2-like acid DNase
Deoxyribonuclease II beta
Short name:
DNase II beta
Endonuclease DLAD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNASE2B
Synonyms:DLAD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137976.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28875 DNASE2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608057 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WZ79

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
58511

Open Targets

More...
OpenTargetsi
ENSG00000137976

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134993904

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNASE2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46395921

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000729528 – 361Deoxyribonuclease-2-betaAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WZ79

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WZ79

PRoteomics IDEntifications database

More...
PRIDEi
Q8WZ79

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75235
75236 [Q8WZ79-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WZ79

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WZ79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137976 Expressed in 59 organ(s), highest expression level in saliva-secreting gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_DNASE2B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WZ79 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121838, 37 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359699

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WZ79

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WZ79

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNase II family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3825 Eukaryota
ENOG4111G8U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002634

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261682

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051387

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WZ79

KEGG Orthology (KO)

More...
KOi
K01158

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHVYNIK

Database of Orthologous Groups

More...
OrthoDBi
605654at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WZ79

TreeFam database of animal gene trees

More...
TreeFami
TF314536

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004947 DNase_II

The PANTHER Classification System

More...
PANTHERi
PTHR10858 PTHR10858, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03265 DNase_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WZ79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKQKMMARLL RTSFALLFLG LFGVLGAATI SCRNEEGKAV DWFTFYKLPK
60 70 80 90 100
RQNKESGETG LEYLYLDSTT RSWRKSEQLM NDTKSVLGRT LQQLYEAYAS
110 120 130 140 150
KSNNTAYLIY NDGVPKPVNY SRKYGHTKGL LLWNRVQGFW LIHSIPQFPP
160 170 180 190 200
IPEEGYDYPP TGRRNGQSGI CITFKYNQYE AIDSQLLVCN PNVYSCSIPA
210 220 230 240 250
TFHQELIHMP QLCTRASSSE IPGRLLTTLQ SAQGQKFLHF AKSDSFLDDI
260 270 280 290 300
FAAWMAQRLK THLLTETWQR KRQELPSNCS LPYHVYNIKA IKLSRHSYFS
310 320 330 340 350
SYQDHAKWCI SQKGTKNRWT CIGDLNRSPH QAFRSGGFIC TQNWQIYQAF
360
QGLVLYYESC K
Length:361
Mass (Da):41,713
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6FDD3F58F62CAC0
GO
Isoform 2 (identifier: Q8WZ79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:153
Mass (Da):17,816
Checksum:iABF4ED379AFA9FCF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF76893 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0592503Q → H. Corresponds to variant dbSNP:rs3738573Ensembl.1
Natural variantiVAR_04887247K → R. Corresponds to variant dbSNP:rs3754274Ensembl.1
Natural variantiVAR_05925151R → K. Corresponds to variant dbSNP:rs3754274Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0098121 – 208Missing in isoform 2. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF333389 mRNA Translation: AAL34448.1
AF334602 Genomic DNA Translation: AAL34449.1
AF274571 mRNA Translation: AAF76893.1 Different initiation.
AL359273 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73238.1
CH471097 Genomic DNA Translation: EAW73239.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44167.1 [Q8WZ79-1]
CCDS694.1 [Q8WZ79-2]

NCBI Reference Sequences

More...
RefSeqi
NP_067056.2, NM_021233.2 [Q8WZ79-1]
NP_490649.1, NM_058248.1 [Q8WZ79-2]
XP_011540180.1, XM_011541878.2 [Q8WZ79-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.129142

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370662; ENSP00000359696; ENSG00000137976 [Q8WZ79-2]
ENST00000370665; ENSP00000359699; ENSG00000137976 [Q8WZ79-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58511

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:58511

UCSC genome browser

More...
UCSCi
uc001djt.2 human [Q8WZ79-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333389 mRNA Translation: AAL34448.1
AF334602 Genomic DNA Translation: AAL34449.1
AF274571 mRNA Translation: AAF76893.1 Different initiation.
AL359273 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73238.1
CH471097 Genomic DNA Translation: EAW73239.1
CCDSiCCDS44167.1 [Q8WZ79-1]
CCDS694.1 [Q8WZ79-2]
RefSeqiNP_067056.2, NM_021233.2 [Q8WZ79-1]
NP_490649.1, NM_058248.1 [Q8WZ79-2]
XP_011540180.1, XM_011541878.2 [Q8WZ79-2]
UniGeneiHs.129142

3D structure databases

ProteinModelPortaliQ8WZ79
SMRiQ8WZ79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121838, 37 interactors
STRINGi9606.ENSP00000359699

PTM databases

iPTMnetiQ8WZ79
PhosphoSitePlusiQ8WZ79

Polymorphism and mutation databases

BioMutaiDNASE2B
DMDMi46395921

Proteomic databases

EPDiQ8WZ79
PaxDbiQ8WZ79
PRIDEiQ8WZ79
ProteomicsDBi75235
75236 [Q8WZ79-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
58511
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370662; ENSP00000359696; ENSG00000137976 [Q8WZ79-2]
ENST00000370665; ENSP00000359699; ENSG00000137976 [Q8WZ79-1]
GeneIDi58511
KEGGihsa:58511
UCSCiuc001djt.2 human [Q8WZ79-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
58511
DisGeNETi58511
EuPathDBiHostDB:ENSG00000137976.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNASE2B
HGNCiHGNC:28875 DNASE2B
MIMi608057 gene
neXtProtiNX_Q8WZ79
OpenTargetsiENSG00000137976
PharmGKBiPA134993904

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3825 Eukaryota
ENOG4111G8U LUCA
GeneTreeiENSGT00390000002634
HOGENOMiHOG000261682
HOVERGENiHBG051387
InParanoidiQ8WZ79
KOiK01158
OMAiYHVYNIK
OrthoDBi605654at2759
PhylomeDBiQ8WZ79
TreeFamiTF314536

Enzyme and pathway databases

BRENDAi3.1.22.1 2681
SIGNORiQ8WZ79

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
58511

Protein Ontology

More...
PROi
PR:Q8WZ79

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137976 Expressed in 59 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_DNASE2B
GenevisibleiQ8WZ79 HS

Family and domain databases

InterProiView protein in InterPro
IPR004947 DNase_II
PANTHERiPTHR10858 PTHR10858, 1 hit
PfamiView protein in Pfam
PF03265 DNase_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNS2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WZ79
Secondary accession number(s): Q5VXD0
, Q5VXD1, Q8WZ80, Q9NQW3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: January 16, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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