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Protein

Deoxyribonuclease-2-beta

Gene

DNASE2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.2 Publications

Catalytic activityi

Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BRENDAi3.1.22.1 2681
SIGNORiQ8WZ79

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease-2-beta (EC:3.1.22.1)
Alternative name(s):
DNase II-like acid DNase
DNase2-like acid DNase
Deoxyribonuclease II beta
Short name:
DNase II beta
Endonuclease DLAD
Gene namesi
Name:DNASE2B
Synonyms:DLAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000137976.7
HGNCiHGNC:28875 DNASE2B
MIMi608057 gene
neXtProtiNX_Q8WZ79

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi58511
OpenTargetsiENSG00000137976
PharmGKBiPA134993904

Polymorphism and mutation databases

BioMutaiDNASE2B
DMDMi46395921

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000729528 – 361Deoxyribonuclease-2-betaAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8WZ79
PaxDbiQ8WZ79
PRIDEiQ8WZ79
ProteomicsDBi75235
75236 [Q8WZ79-2]

PTM databases

iPTMnetiQ8WZ79
PhosphoSitePlusiQ8WZ79

Expressioni

Tissue specificityi

Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific.3 Publications

Gene expression databases

BgeeiENSG00000137976
CleanExiHS_DNASE2B
GenevisibleiQ8WZ79 HS

Interactioni

Protein-protein interaction databases

BioGridi121838, 37 interactors
STRINGi9606.ENSP00000359699

Structurei

3D structure databases

ProteinModelPortaliQ8WZ79
SMRiQ8WZ79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNase II family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3825 Eukaryota
ENOG4111G8U LUCA
GeneTreeiENSGT00390000002634
HOGENOMiHOG000261682
HOVERGENiHBG051387
InParanoidiQ8WZ79
KOiK01158
OMAiLPYHVYN
OrthoDBiEOG091G08N7
PhylomeDBiQ8WZ79
TreeFamiTF314536

Family and domain databases

InterProiView protein in InterPro
IPR004947 DNase_II
PANTHERiPTHR10858 PTHR10858, 1 hit
PfamiView protein in Pfam
PF03265 DNase_II, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WZ79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQKMMARLL RTSFALLFLG LFGVLGAATI SCRNEEGKAV DWFTFYKLPK
60 70 80 90 100
RQNKESGETG LEYLYLDSTT RSWRKSEQLM NDTKSVLGRT LQQLYEAYAS
110 120 130 140 150
KSNNTAYLIY NDGVPKPVNY SRKYGHTKGL LLWNRVQGFW LIHSIPQFPP
160 170 180 190 200
IPEEGYDYPP TGRRNGQSGI CITFKYNQYE AIDSQLLVCN PNVYSCSIPA
210 220 230 240 250
TFHQELIHMP QLCTRASSSE IPGRLLTTLQ SAQGQKFLHF AKSDSFLDDI
260 270 280 290 300
FAAWMAQRLK THLLTETWQR KRQELPSNCS LPYHVYNIKA IKLSRHSYFS
310 320 330 340 350
SYQDHAKWCI SQKGTKNRWT CIGDLNRSPH QAFRSGGFIC TQNWQIYQAF
360
QGLVLYYESC K
Length:361
Mass (Da):41,713
Last modified:March 1, 2002 - v1
Checksum:iC6FDD3F58F62CAC0
GO
Isoform 2 (identifier: Q8WZ79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:153
Mass (Da):17,816
Checksum:iABF4ED379AFA9FCF
GO

Sequence cautioni

The sequence AAF76893 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0592503Q → H. Corresponds to variant dbSNP:rs3738573Ensembl.1
Natural variantiVAR_04887247K → R. Corresponds to variant dbSNP:rs3754274Ensembl.1
Natural variantiVAR_05925151R → K. Corresponds to variant dbSNP:rs3754274Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0098121 – 208Missing in isoform 2. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333389 mRNA Translation: AAL34448.1
AF334602 Genomic DNA Translation: AAL34449.1
AF274571 mRNA Translation: AAF76893.1 Different initiation.
AL359273 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73238.1
CH471097 Genomic DNA Translation: EAW73239.1
CCDSiCCDS44167.1 [Q8WZ79-1]
CCDS694.1 [Q8WZ79-2]
RefSeqiNP_067056.2, NM_021233.2 [Q8WZ79-1]
NP_490649.1, NM_058248.1 [Q8WZ79-2]
XP_011540180.1, XM_011541878.2 [Q8WZ79-2]
UniGeneiHs.129142

Genome annotation databases

EnsembliENST00000370662; ENSP00000359696; ENSG00000137976 [Q8WZ79-2]
ENST00000370665; ENSP00000359699; ENSG00000137976 [Q8WZ79-1]
GeneIDi58511
KEGGihsa:58511
UCSCiuc001djt.2 human [Q8WZ79-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDNS2B_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ79
Secondary accession number(s): Q5VXD0
, Q5VXD1, Q8WZ80, Q9NQW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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