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UniProtKB - Q8WZ74 (CTTB2_HUMAN)

Entry version 144 (29 Sep 2021)
Sequence version 1 (01 Mar 2002)
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Protein

Cortactin-binding protein 2

Gene

CTTNBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WZ74

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTTNBP2
Synonyms:C7orf8, CORTBP2, KIAA1758
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15679, CTTNBP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609772, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WZ74

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000077063

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		83992

Open Targets

More...OpenTargetsi		ENSG00000077063

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26774

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WZ74, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CTTNBP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002270021 – 1663Cortactin-binding protein 2Add BLAST1663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei498Asymmetric dimethylarginineBy similarity1
Modified residuei1524PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WZ74

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WZ74

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WZ74

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WZ74

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WZ74

PeptideAtlas

More...PeptideAtlasi		Q8WZ74

PRoteomics IDEntifications database

More...PRIDEi		Q8WZ74

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75231

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8WZ74, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WZ74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WZ74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000077063, Expressed in cortical plate and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WZ74, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WZ74, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000077063, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTTN/cortactin SH3 domain.

Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123842, 39 interactors

Protein interaction database and analysis system

More...IntActi		Q8WZ74, 36 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000160373

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WZ74, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WZ74

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati709 – 739ANK 1Add BLAST31
Repeati743 – 772ANK 2Add BLAST30
Repeati776 – 805ANK 3Add BLAST30
Repeati809 – 838ANK 4Add BLAST30
Repeati842 – 871ANK 5Add BLAST30
Repeati912 – 942ANK 6Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni203 – 222DisorderedSequence analysisAdd BLAST20
Regioni367 – 440DisorderedSequence analysisAdd BLAST74
Regioni454 – 478DisorderedSequence analysisAdd BLAST25
Regioni498 – 616DisorderedSequence analysisAdd BLAST119
Regioni1449 – 1482DisorderedSequence analysisAdd BLAST34
Regioni1581 – 1663DisorderedSequence analysisAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 276Sequence analysisAdd BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi393 – 407Pro residuesSequence analysisAdd BLAST15
Compositional biasi408 – 440Polar residuesSequence analysisAdd BLAST33
Compositional biasi455 – 478Polar residuesSequence analysisAdd BLAST24
Compositional biasi540 – 557Pro residuesSequence analysisAdd BLAST18
Compositional biasi567 – 607Polar residuesSequence analysisAdd BLAST41
Compositional biasi1464 – 1482Polar residuesSequence analysisAdd BLAST19
Compositional biasi1581 – 1605Polar residuesSequence analysisAdd BLAST25
Compositional biasi1617 – 1649Polar residuesSequence analysisAdd BLAST33

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWG2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004926_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WZ74

Identification of Orthologs from Complete Genome Data

More...OMAi		WNLHKHE

Database of Orthologous Groups

More...OrthoDBi		264951at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WZ74

TreeFam database of animal gene trees

More...TreeFami		TF325130

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR019131, Cortactin-binding_p2_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF09727, CortBP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q8WZ74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG 
        60         70         80         90        100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK 
       110        120        130        140        150
KPVCTNPLSI LEAVMAHCKK MQERMSAQLA AAESRQKKLE MEKLQLQALE 
       160        170        180        190        200
QEHKKLAARL EEERGKNKQV VLMLVKECKQ LSGKVIEEAQ KLEDVMAKLE 
       210        220        230        240        250
EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ LRAKLNREEA 
       260        270        280        290        300
HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT 
       310        320        330        340        350
VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT 
       360        370        380        390        400
MARPGIDRQA SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP 
       410        420        430        440        450
LPSNAAPPTA QTPGIAPQNS QAPPMHSLHS PCANTSLHPG LNPRIQAARF 
       460        470        480        490        500
RFQGNANDPD QNGNTTQSPP SRDVSPTSRD NLVAKQLARN TVTQALSRFT 
       510        520        530        540        550
SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG NPPPIPPKKP 
       560        570        580        590        600
GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE 
       610        620        630        640        650
ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA 
       660        670        680        690        700
CSDSSLVIPT TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM 
       710        720        730        740        750
SGGPAPLAGR PTLLQQAAAQ GNVTLLSMLL NEEGLDINYS CEDGHSALYS 
       760        770        780        790        800
AAKNGHTDCV RLLLSAEAQV NAADKNGFTP LCAAAAQGHF ECVELLISYD 
       810        820        830        840        850
ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT TDGWTPVHAA 
       860        870        880        890        900
VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV 
       910        920        930        940        950
VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV 
       960        970        980        990       1000
HDVATDDCKH LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI 
      1010       1020       1030       1040       1050
RKQTSWDDFS KAVSQALTNH FQAISSDGWW SLEDVTCNNT TDSNIGLSAR 
      1060       1070       1080       1090       1100
SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK AEHITVLLSG PQEGCLSSVT 
      1110       1120       1130       1140       1150
YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL ALCLKHRQMA 
      1160       1170       1180       1190       1200
AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL 
      1210       1220       1230       1240       1250
EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA 
      1260       1270       1280       1290       1300
KACLQGSDLL VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP 
      1310       1320       1330       1340       1350
CDPVCKIVDW ALSVWRQLNS CLARLGTPEA LLGPKYFLSC PVVPGHAQVT 
      1360       1370       1380       1390       1400
VKWMSKLWNG VIAPRVQEAI LSRASVKRQP GFGQTTAKRH PSQGQQAVVK 
      1410       1420       1430       1440       1450
AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS SYNTCNKKKG 
      1460       1470       1480       1490       1500
ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL 
      1510       1520       1530       1540       1550
SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA 
      1560       1570       1580       1590       1600
DSRDDLRMFD SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS 
      1610       1620       1630       1640       1650
KTELGVSRVK SFLPVPRSKV TQCSQNTKRS SSSSNTRQIE INNNSKEVNW 
      1660 
NLHKNEHLEK PNK
Length:1,663
Mass (Da):181,051
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i367B933A177D6E3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y448H0Y448_HUMAN
Cortactin-binding protein 2
CTTNBP2
1,151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB16F8WB16_HUMAN
Cortactin-binding protein 2
CTTNBP2
640Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFC9C9JFC9_HUMAN
Cortactin-binding protein 2
CTTNBP2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J720C9J720_HUMAN
Cortactin-binding protein 2
CTTNBP2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVQ6C9JVQ6_HUMAN
Cortactin-binding protein 2
CTTNBP2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0N3H7C0N3_HUMAN
Cortactin-binding protein 2
CTTNBP2
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2I0H7C2I0_HUMAN
Cortactin-binding protein 2
CTTNBP2
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZH0H7BZH0_HUMAN
Cortactin-binding protein 2
CTTNBP2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0482941148Q → K. Corresponds to variant dbSNP:rs10274022Ensembl.1
Natural variantiVAR_0255351213L → V1 PublicationCorresponds to variant dbSNP:rs62617115Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF377960 mRNA Translation: AAL32176.1
DQ354388 Genomic DNA Translation: ABC79049.1
DQ354389 Genomic DNA Translation: ABC79051.1
DQ354390 Genomic DNA Translation: ABC79053.1
DQ354391 Genomic DNA Translation: ABC79055.1
DQ356257 Genomic DNA Translation: ABC87052.1
DQ356259 Genomic DNA Translation: ABC87056.1
DQ356260 Genomic DNA Translation: ABC87058.1
DQ356261 Genomic DNA Translation: ABC87060.1
DQ356262 Genomic DNA Translation: ABC87062.1
DQ356264 Genomic DNA Translation: ABC87066.1
AC004240 Genomic DNA Translation: AAC04501.2
BC106000 mRNA Translation: AAI06001.1
AB051545 mRNA Translation: BAB21849.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5774.1

NCBI Reference Sequences

More...RefSeqi		NP_219499.1, NM_033427.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000160373; ENSP00000160373; ENSG00000077063

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83992

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83992

UCSC genome browser

More...UCSCi		uc003vjf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF377960 mRNA Translation: AAL32176.1
DQ354388 Genomic DNA Translation: ABC79049.1
DQ354389 Genomic DNA Translation: ABC79051.1
DQ354390 Genomic DNA Translation: ABC79053.1
DQ354391 Genomic DNA Translation: ABC79055.1
DQ356257 Genomic DNA Translation: ABC87052.1
DQ356259 Genomic DNA Translation: ABC87056.1
DQ356260 Genomic DNA Translation: ABC87058.1
DQ356261 Genomic DNA Translation: ABC87060.1
DQ356262 Genomic DNA Translation: ABC87062.1
DQ356264 Genomic DNA Translation: ABC87066.1
AC004240 Genomic DNA Translation: AAC04501.2
BC106000 mRNA Translation: AAI06001.1
AB051545 mRNA Translation: BAB21849.1
CCDSiCCDS5774.1
RefSeqiNP_219499.1, NM_033427.2

3D structure databases

SMRiQ8WZ74
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123842, 39 interactors
IntActiQ8WZ74, 36 interactors
STRINGi9606.ENSP00000160373

PTM databases

GlyGeniQ8WZ74, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ8WZ74
PhosphoSitePlusiQ8WZ74

Genetic variation databases

BioMutaiCTTNBP2
DMDMi74751641

Proteomic databases

EPDiQ8WZ74
jPOSTiQ8WZ74
MassIVEiQ8WZ74
MaxQBiQ8WZ74
PaxDbiQ8WZ74
PeptideAtlasiQ8WZ74
PRIDEiQ8WZ74
ProteomicsDBi75231

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3970, 92 antibodies

The DNASU plasmid repository

More...DNASUi		83992

Genome annotation databases

EnsembliENST00000160373; ENSP00000160373; ENSG00000077063
GeneIDi83992
KEGGihsa:83992
UCSCiuc003vjf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83992
DisGeNETi83992

GeneCards: human genes, protein and diseases

More...GeneCardsi		CTTNBP2
HGNCiHGNC:15679, CTTNBP2
HPAiENSG00000077063, Low tissue specificity
MIMi609772, gene
neXtProtiNX_Q8WZ74
OpenTargetsiENSG00000077063
PharmGKBiPA26774
VEuPathDBiHostDB:ENSG00000077063

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWG2, Eukaryota
GeneTreeiENSGT00940000158293
HOGENOMiCLU_004926_0_0_1
InParanoidiQ8WZ74
OMAiWNLHKHE
OrthoDBi264951at2759
PhylomeDBiQ8WZ74
TreeFamiTF325130

Enzyme and pathway databases

PathwayCommonsiQ8WZ74

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83992, 3 hits in 1008 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CTTNBP2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CTTNBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83992
PharosiQ8WZ74, Tbio

Protein Ontology

More...PROi		PR:Q8WZ74
RNActiQ8WZ74, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000077063, Expressed in cortical plate and 198 other tissues
ExpressionAtlasiQ8WZ74, baseline and differential
GenevisibleiQ8WZ74, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR019131, Cortactin-binding_p2_N
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF09727, CortBP2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTTB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WZ74
Secondary accession number(s): O43389, Q7LG11, Q9C0A5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2002
Last modified: September 29, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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