UniProtKB - Q8WZ74 (CTTB2_HUMAN)
Protein
Cortactin-binding protein 2
Gene
CTTNBP2
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.By similarity
GO - Molecular functioni
- SH3 domain binding Source: Ensembl
GO - Biological processi
- brain development Source: Ensembl
- regulation of synapse organization Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q8WZ74 |
Names & Taxonomyi
Protein namesi | Recommended name: Cortactin-binding protein 2Short name: CortBP2 |
Gene namesi | Name:CTTNBP2 Synonyms:C7orf8, CORTBP2, KIAA1758 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000077063.10 |
HGNCi | HGNC:15679, CTTNBP2 |
MIMi | 609772, gene |
neXtProti | NX_Q8WZ74 |
Subcellular locationi
Other locations
- cell cortex By similarity
- dendritic spine By similarity
Note: Remains associated with dendritic spines even after glutamate stimulation.By similarity
Other locations
- cell cortex Source: UniProtKB-SubCell
- dendritic spine Source: UniProtKB-SubCell
- glutamatergic synapse Source: Ensembl
- synaptic vesicle Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 83992 |
OpenTargetsi | ENSG00000077063 |
PharmGKBi | PA26774 |
Miscellaneous databases
Pharosi | Q8WZ74, Tbio |
Polymorphism and mutation databases
BioMutai | CTTNBP2 |
DMDMi | 74751641 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227002 | 1 – 1663 | Cortactin-binding protein 2Add BLAST | 1663 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 498 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1524 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q8WZ74 |
jPOSTi | Q8WZ74 |
MassIVEi | Q8WZ74 |
MaxQBi | Q8WZ74 |
PaxDbi | Q8WZ74 |
PeptideAtlasi | Q8WZ74 |
PRIDEi | Q8WZ74 |
ProteomicsDBi | 75231 |
PTM databases
iPTMneti | Q8WZ74 |
PhosphoSitePlusi | Q8WZ74 |
Expressioni
Tissue specificityi
Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000077063, Expressed in cortical plate and 198 other tissues |
ExpressionAtlasi | Q8WZ74, baseline and differential |
Genevisiblei | Q8WZ74, HS |
Organism-specific databases
HPAi | ENSG00000077063, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CTTN/cortactin SH3 domain.
Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
By similarityBinary interactionsi
Hide detailsQ8WZ74
GO - Molecular functioni
- SH3 domain binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 123842, 37 interactors |
IntActi | Q8WZ74, 36 interactors |
STRINGi | 9606.ENSP00000160373 |
Miscellaneous databases
RNActi | Q8WZ74, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 709 – 739 | ANK 1Add BLAST | 31 | |
Repeati | 743 – 772 | ANK 2Add BLAST | 30 | |
Repeati | 776 – 805 | ANK 3Add BLAST | 30 | |
Repeati | 809 – 838 | ANK 4Add BLAST | 30 | |
Repeati | 842 – 871 | ANK 5Add BLAST | 30 | |
Repeati | 912 – 942 | ANK 6Add BLAST | 31 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 119 – 276 | Sequence analysisAdd BLAST | 158 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 371 – 561 | Pro-richAdd BLAST | 191 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG502QWG2, Eukaryota |
GeneTreei | ENSGT00940000158293 |
HOGENOMi | CLU_004926_0_0_1 |
InParanoidi | Q8WZ74 |
OMAi | AYQIAAC |
OrthoDBi | 264951at2759 |
PhylomeDBi | Q8WZ74 |
TreeFami | TF325130 |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR019131, Cortactin-binding_p2_N |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF09727, CortBP2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q8WZ74-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG
60 70 80 90 100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK
110 120 130 140 150
KPVCTNPLSI LEAVMAHCKK MQERMSAQLA AAESRQKKLE MEKLQLQALE
160 170 180 190 200
QEHKKLAARL EEERGKNKQV VLMLVKECKQ LSGKVIEEAQ KLEDVMAKLE
210 220 230 240 250
EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ LRAKLNREEA
260 270 280 290 300
HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT
310 320 330 340 350
VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT
360 370 380 390 400
MARPGIDRQA SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP
410 420 430 440 450
LPSNAAPPTA QTPGIAPQNS QAPPMHSLHS PCANTSLHPG LNPRIQAARF
460 470 480 490 500
RFQGNANDPD QNGNTTQSPP SRDVSPTSRD NLVAKQLARN TVTQALSRFT
510 520 530 540 550
SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG NPPPIPPKKP
560 570 580 590 600
GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE
610 620 630 640 650
ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA
660 670 680 690 700
CSDSSLVIPT TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM
710 720 730 740 750
SGGPAPLAGR PTLLQQAAAQ GNVTLLSMLL NEEGLDINYS CEDGHSALYS
760 770 780 790 800
AAKNGHTDCV RLLLSAEAQV NAADKNGFTP LCAAAAQGHF ECVELLISYD
810 820 830 840 850
ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT TDGWTPVHAA
860 870 880 890 900
VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV
910 920 930 940 950
VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV
960 970 980 990 1000
HDVATDDCKH LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI
1010 1020 1030 1040 1050
RKQTSWDDFS KAVSQALTNH FQAISSDGWW SLEDVTCNNT TDSNIGLSAR
1060 1070 1080 1090 1100
SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK AEHITVLLSG PQEGCLSSVT
1110 1120 1130 1140 1150
YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL ALCLKHRQMA
1160 1170 1180 1190 1200
AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL
1210 1220 1230 1240 1250
EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA
1260 1270 1280 1290 1300
KACLQGSDLL VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP
1310 1320 1330 1340 1350
CDPVCKIVDW ALSVWRQLNS CLARLGTPEA LLGPKYFLSC PVVPGHAQVT
1360 1370 1380 1390 1400
VKWMSKLWNG VIAPRVQEAI LSRASVKRQP GFGQTTAKRH PSQGQQAVVK
1410 1420 1430 1440 1450
AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS SYNTCNKKKG
1460 1470 1480 1490 1500
ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL
1510 1520 1530 1540 1550
SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA
1560 1570 1580 1590 1600
DSRDDLRMFD SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS
1610 1620 1630 1640 1650
KTELGVSRVK SFLPVPRSKV TQCSQNTKRS SSSSNTRQIE INNNSKEVNW
1660
NLHKNEHLEK PNK
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y448 | H0Y448_HUMAN | Cortactin-binding protein 2 | CTTNBP2 | 1,151 | Annotation score: | ||
F8WB16 | F8WB16_HUMAN | Cortactin-binding protein 2 | CTTNBP2 | 640 | Annotation score: | ||
C9JFC9 | C9JFC9_HUMAN | Cortactin-binding protein 2 | CTTNBP2 | 161 | Annotation score: | ||
C9J720 | C9J720_HUMAN | Cortactin-binding protein 2 | CTTNBP2 | 136 | Annotation score: | ||
C9JVQ6 | C9JVQ6_HUMAN | Cortactin-binding protein 2 | CTTNBP2 | 95 | Annotation score: | ||
H7C0N3 | H7C0N3_HUMAN | Cortactin-binding protein 2 | CTTNBP2 | 193 | Annotation score: | ||
H7C2I0 | H7C2I0_HUMAN | Cortactin-binding protein 2 | CTTNBP2 | 120 | Annotation score: | ||
H7BZH0 | H7BZH0_HUMAN | Cortactin-binding protein 2 | CTTNBP2 | 47 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048294 | 1148 | Q → K. Corresponds to variant dbSNP:rs10274022Ensembl. | 1 | |
Natural variantiVAR_025535 | 1213 | L → V1 PublicationCorresponds to variant dbSNP:rs62617115Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF377960 mRNA Translation: AAL32176.1 DQ354388 Genomic DNA Translation: ABC79049.1 DQ354389 Genomic DNA Translation: ABC79051.1 DQ354390 Genomic DNA Translation: ABC79053.1 DQ354391 Genomic DNA Translation: ABC79055.1 DQ356257 Genomic DNA Translation: ABC87052.1 DQ356259 Genomic DNA Translation: ABC87056.1 DQ356260 Genomic DNA Translation: ABC87058.1 DQ356261 Genomic DNA Translation: ABC87060.1 DQ356262 Genomic DNA Translation: ABC87062.1 DQ356264 Genomic DNA Translation: ABC87066.1 AC004240 Genomic DNA Translation: AAC04501.2 BC106000 mRNA Translation: AAI06001.1 AB051545 mRNA Translation: BAB21849.1 |
CCDSi | CCDS5774.1 |
RefSeqi | NP_219499.1, NM_033427.2 |
Genome annotation databases
Ensembli | ENST00000160373; ENSP00000160373; ENSG00000077063 |
GeneIDi | 83992 |
KEGGi | hsa:83992 |
UCSCi | uc003vjf.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF377960 mRNA Translation: AAL32176.1 DQ354388 Genomic DNA Translation: ABC79049.1 DQ354389 Genomic DNA Translation: ABC79051.1 DQ354390 Genomic DNA Translation: ABC79053.1 DQ354391 Genomic DNA Translation: ABC79055.1 DQ356257 Genomic DNA Translation: ABC87052.1 DQ356259 Genomic DNA Translation: ABC87056.1 DQ356260 Genomic DNA Translation: ABC87058.1 DQ356261 Genomic DNA Translation: ABC87060.1 DQ356262 Genomic DNA Translation: ABC87062.1 DQ356264 Genomic DNA Translation: ABC87066.1 AC004240 Genomic DNA Translation: AAC04501.2 BC106000 mRNA Translation: AAI06001.1 AB051545 mRNA Translation: BAB21849.1 |
CCDSi | CCDS5774.1 |
RefSeqi | NP_219499.1, NM_033427.2 |
3D structure databases
SMRi | Q8WZ74 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123842, 37 interactors |
IntActi | Q8WZ74, 36 interactors |
STRINGi | 9606.ENSP00000160373 |
PTM databases
iPTMneti | Q8WZ74 |
PhosphoSitePlusi | Q8WZ74 |
Polymorphism and mutation databases
BioMutai | CTTNBP2 |
DMDMi | 74751641 |
Proteomic databases
EPDi | Q8WZ74 |
jPOSTi | Q8WZ74 |
MassIVEi | Q8WZ74 |
MaxQBi | Q8WZ74 |
PaxDbi | Q8WZ74 |
PeptideAtlasi | Q8WZ74 |
PRIDEi | Q8WZ74 |
ProteomicsDBi | 75231 |
Protocols and materials databases
Antibodypediai | 3970, 88 antibodies |
Genome annotation databases
Ensembli | ENST00000160373; ENSP00000160373; ENSG00000077063 |
GeneIDi | 83992 |
KEGGi | hsa:83992 |
UCSCi | uc003vjf.4, human |
Organism-specific databases
CTDi | 83992 |
DisGeNETi | 83992 |
EuPathDBi | HostDB:ENSG00000077063.10 |
GeneCardsi | CTTNBP2 |
HGNCi | HGNC:15679, CTTNBP2 |
HPAi | ENSG00000077063, Low tissue specificity |
MIMi | 609772, gene |
neXtProti | NX_Q8WZ74 |
OpenTargetsi | ENSG00000077063 |
PharmGKBi | PA26774 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWG2, Eukaryota |
GeneTreei | ENSGT00940000158293 |
HOGENOMi | CLU_004926_0_0_1 |
InParanoidi | Q8WZ74 |
OMAi | AYQIAAC |
OrthoDBi | 264951at2759 |
PhylomeDBi | Q8WZ74 |
TreeFami | TF325130 |
Enzyme and pathway databases
PathwayCommonsi | Q8WZ74 |
Miscellaneous databases
BioGRID-ORCSi | 83992, 1 hit in 844 CRISPR screens |
ChiTaRSi | CTTNBP2, human |
GeneWikii | CTTNBP2 |
GenomeRNAii | 83992 |
Pharosi | Q8WZ74, Tbio |
PROi | PR:Q8WZ74 |
RNActi | Q8WZ74, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077063, Expressed in cortical plate and 198 other tissues |
ExpressionAtlasi | Q8WZ74, baseline and differential |
Genevisiblei | Q8WZ74, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR019131, Cortactin-binding_p2_N |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF09727, CortBP2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTTB2_HUMAN | |
Accessioni | Q8WZ74Primary (citable) accession number: Q8WZ74 Secondary accession number(s): O43389, Q7LG11, Q9C0A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations