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Entry version 129 (08 May 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Cortactin-binding protein 2

Gene

CTTNBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTTNBP2
Synonyms:C7orf8, CORTBP2, KIAA1758
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15679 CTTNBP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609772 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WZ74

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83992

Open Targets

More...
OpenTargetsi
ENSG00000077063

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26774

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTTNBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002270021 – 1663Cortactin-binding protein 2Add BLAST1663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei498Asymmetric dimethylarginineBy similarity1
Modified residuei1524PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WZ74

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WZ74

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WZ74

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WZ74

PeptideAtlas

More...
PeptideAtlasi
Q8WZ74

PRoteomics IDEntifications database

More...
PRIDEi
Q8WZ74

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75231

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WZ74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WZ74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000077063 Expressed in 184 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WZ74 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WZ74 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009151
HPA044654

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123842, 27 interactors

Protein interaction database and analysis system

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IntActi
Q8WZ74, 33 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000160373

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WZ74

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati709 – 739ANK 1Add BLAST31
Repeati743 – 772ANK 2Add BLAST30
Repeati776 – 805ANK 3Add BLAST30
Repeati809 – 838ANK 4Add BLAST30
Repeati842 – 871ANK 5Add BLAST30
Repeati912 – 942ANK 6Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 276Sequence analysisAdd BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi371 – 561Pro-richAdd BLAST191

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGN3 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112055

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WZ74

Identification of Orthologs from Complete Genome Data

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OMAi
QYRNVIF

Database of Orthologous Groups

More...
OrthoDBi
264951at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WZ74

TreeFam database of animal gene trees

More...
TreeFami
TF325130

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR019131 Cortactin-binding_p2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF09727 CortBP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q8WZ74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG
60 70 80 90 100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK
110 120 130 140 150
KPVCTNPLSI LEAVMAHCKK MQERMSAQLA AAESRQKKLE MEKLQLQALE
160 170 180 190 200
QEHKKLAARL EEERGKNKQV VLMLVKECKQ LSGKVIEEAQ KLEDVMAKLE
210 220 230 240 250
EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ LRAKLNREEA
260 270 280 290 300
HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT
310 320 330 340 350
VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT
360 370 380 390 400
MARPGIDRQA SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP
410 420 430 440 450
LPSNAAPPTA QTPGIAPQNS QAPPMHSLHS PCANTSLHPG LNPRIQAARF
460 470 480 490 500
RFQGNANDPD QNGNTTQSPP SRDVSPTSRD NLVAKQLARN TVTQALSRFT
510 520 530 540 550
SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG NPPPIPPKKP
560 570 580 590 600
GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE
610 620 630 640 650
ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA
660 670 680 690 700
CSDSSLVIPT TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM
710 720 730 740 750
SGGPAPLAGR PTLLQQAAAQ GNVTLLSMLL NEEGLDINYS CEDGHSALYS
760 770 780 790 800
AAKNGHTDCV RLLLSAEAQV NAADKNGFTP LCAAAAQGHF ECVELLISYD
810 820 830 840 850
ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT TDGWTPVHAA
860 870 880 890 900
VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV
910 920 930 940 950
VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV
960 970 980 990 1000
HDVATDDCKH LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI
1010 1020 1030 1040 1050
RKQTSWDDFS KAVSQALTNH FQAISSDGWW SLEDVTCNNT TDSNIGLSAR
1060 1070 1080 1090 1100
SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK AEHITVLLSG PQEGCLSSVT
1110 1120 1130 1140 1150
YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL ALCLKHRQMA
1160 1170 1180 1190 1200
AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL
1210 1220 1230 1240 1250
EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA
1260 1270 1280 1290 1300
KACLQGSDLL VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP
1310 1320 1330 1340 1350
CDPVCKIVDW ALSVWRQLNS CLARLGTPEA LLGPKYFLSC PVVPGHAQVT
1360 1370 1380 1390 1400
VKWMSKLWNG VIAPRVQEAI LSRASVKRQP GFGQTTAKRH PSQGQQAVVK
1410 1420 1430 1440 1450
AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS SYNTCNKKKG
1460 1470 1480 1490 1500
ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL
1510 1520 1530 1540 1550
SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA
1560 1570 1580 1590 1600
DSRDDLRMFD SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS
1610 1620 1630 1640 1650
KTELGVSRVK SFLPVPRSKV TQCSQNTKRS SSSSNTRQIE INNNSKEVNW
1660
NLHKNEHLEK PNK
Length:1,663
Mass (Da):181,051
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i367B933A177D6E3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y448H0Y448_HUMAN
Cortactin-binding protein 2
CTTNBP2
1,151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB16F8WB16_HUMAN
Cortactin-binding protein 2
CTTNBP2
640Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFC9C9JFC9_HUMAN
Cortactin-binding protein 2
CTTNBP2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J720C9J720_HUMAN
Cortactin-binding protein 2
CTTNBP2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVQ6C9JVQ6_HUMAN
Cortactin-binding protein 2
CTTNBP2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2I0H7C2I0_HUMAN
Cortactin-binding protein 2
CTTNBP2
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZH0H7BZH0_HUMAN
Cortactin-binding protein 2
CTTNBP2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0N3H7C0N3_HUMAN
Cortactin-binding protein 2
CTTNBP2
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0482941148Q → K. Corresponds to variant dbSNP:rs10274022Ensembl.1
Natural variantiVAR_0255351213L → V1 PublicationCorresponds to variant dbSNP:rs62617115Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF377960 mRNA Translation: AAL32176.1
DQ354388 Genomic DNA Translation: ABC79049.1
DQ354389 Genomic DNA Translation: ABC79051.1
DQ354390 Genomic DNA Translation: ABC79053.1
DQ354391 Genomic DNA Translation: ABC79055.1
DQ356257 Genomic DNA Translation: ABC87052.1
DQ356259 Genomic DNA Translation: ABC87056.1
DQ356260 Genomic DNA Translation: ABC87058.1
DQ356261 Genomic DNA Translation: ABC87060.1
DQ356262 Genomic DNA Translation: ABC87062.1
DQ356264 Genomic DNA Translation: ABC87066.1
AC004240 Genomic DNA Translation: AAC04501.2
BC106000 mRNA Translation: AAI06001.1
AB051545 mRNA Translation: BAB21849.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5774.1

NCBI Reference Sequences

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RefSeqi
NP_219499.1, NM_033427.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000160373; ENSP00000160373; ENSG00000077063

Database of genes from NCBI RefSeq genomes

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GeneIDi
83992

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83992

UCSC genome browser

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UCSCi
uc003vjf.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF377960 mRNA Translation: AAL32176.1
DQ354388 Genomic DNA Translation: ABC79049.1
DQ354389 Genomic DNA Translation: ABC79051.1
DQ354390 Genomic DNA Translation: ABC79053.1
DQ354391 Genomic DNA Translation: ABC79055.1
DQ356257 Genomic DNA Translation: ABC87052.1
DQ356259 Genomic DNA Translation: ABC87056.1
DQ356260 Genomic DNA Translation: ABC87058.1
DQ356261 Genomic DNA Translation: ABC87060.1
DQ356262 Genomic DNA Translation: ABC87062.1
DQ356264 Genomic DNA Translation: ABC87066.1
AC004240 Genomic DNA Translation: AAC04501.2
BC106000 mRNA Translation: AAI06001.1
AB051545 mRNA Translation: BAB21849.1
CCDSiCCDS5774.1
RefSeqiNP_219499.1, NM_033427.2

3D structure databases

SMRiQ8WZ74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123842, 27 interactors
IntActiQ8WZ74, 33 interactors
STRINGi9606.ENSP00000160373

PTM databases

iPTMnetiQ8WZ74
PhosphoSitePlusiQ8WZ74

Polymorphism and mutation databases

BioMutaiCTTNBP2
DMDMi74751641

Proteomic databases

EPDiQ8WZ74
jPOSTiQ8WZ74
MaxQBiQ8WZ74
PaxDbiQ8WZ74
PeptideAtlasiQ8WZ74
PRIDEiQ8WZ74
ProteomicsDBi75231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000160373; ENSP00000160373; ENSG00000077063
GeneIDi83992
KEGGihsa:83992
UCSCiuc003vjf.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83992
DisGeNETi83992

GeneCards: human genes, protein and diseases

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GeneCardsi
CTTNBP2
HGNCiHGNC:15679 CTTNBP2
HPAiCAB009151
HPA044654
MIMi609772 gene
neXtProtiNX_Q8WZ74
OpenTargetsiENSG00000077063
PharmGKBiPA26774

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGN3 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000158293
HOGENOMiHOG000112055
InParanoidiQ8WZ74
OMAiQYRNVIF
OrthoDBi264951at2759
PhylomeDBiQ8WZ74
TreeFamiTF325130

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CTTNBP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CTTNBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83992

Protein Ontology

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PROi
PR:Q8WZ74

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000077063 Expressed in 184 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ8WZ74 baseline and differential
GenevisibleiQ8WZ74 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF09727 CortBP2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTTB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WZ74
Secondary accession number(s): O43389, Q7LG11, Q9C0A5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2002
Last modified: May 8, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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