We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8WZ71 (TM158_HUMAN)
Protein
Transmembrane protein 158
Gene
TMEM158
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
By similarityGO - Molecular functioni
- peptide binding Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q8WZ71 |
SignaLinki | Q8WZ71 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 158Alternative name(s): 40 kDa BINP-binding protein Short name: p40BBP Ras-induced senescence protein 1 |
Gene namesi | Name:TMEM158 Synonyms:HBBP, RIS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30293, TMEM158 |
neXtProti | NX_Q8WZ71 |
VEuPathDBi | HostDB:ENSG00000249992 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 273 – 293 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 25907 |
OpenTargetsi | ENSG00000249992 |
PharmGKBi | PA128395777 |
Miscellaneous databases
Pharosi | Q8WZ71, Tbio |
Genetic variation databases
BioMutai | TMEM158 |
DMDMi | 408360199 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000285128 | 21 – 300 | Transmembrane protein 158Add BLAST | 280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q8WZ71 |
MassIVEi | Q8WZ71 |
PaxDbi | Q8WZ71 |
PeptideAtlasi | Q8WZ71 |
PRIDEi | Q8WZ71 |
ProteomicsDBi | 75226 [Q8WZ71-1] 75227 [Q8WZ71-2] |
PTM databases
GlyGeni | Q8WZ71, 1 site |
iPTMneti | Q8WZ71 |
PhosphoSitePlusi | Q8WZ71 |
Expressioni
Inductioni
Up-regulated during Ras-induced senescence.1 Publication
Gene expression databases
Bgeei | ENSG00000249992, Expressed in brain and 189 other tissues |
Genevisiblei | Q8WZ71, HS |
Organism-specific databases
HPAi | ENSG00000249992, Tissue enhanced (brain, endometrium) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117413, 1 interactor |
IntActi | Q8WZ71, 2 interactors |
MINTi | Q8WZ71 |
STRINGi | 9606.ENSP00000422431 |
Miscellaneous databases
RNActi | Q8WZ71, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM158 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYJ7, Eukaryota |
GeneTreei | ENSGT00390000009719 |
HOGENOMi | CLU_085099_0_0_1 |
InParanoidi | Q8WZ71 |
OMAi | QGEPRHF |
OrthoDBi | 1276094at2759 |
PhylomeDBi | Q8WZ71 |
TreeFami | TF339241 |
Family and domain databases
InterProi | View protein in InterPro IPR038962, TMEM158 |
PANTHERi | PTHR38324, PTHR38324, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8WZ71-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SADEPIAPRL
60 70 80 90 100
LASAAPGPPE RPGPEEAAAA AAPCNISVQR QMLSSLLVRW GRPRGFQCDL
110 120 130 140 150
LLFSTNAHGR AFFAAAFHRV GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR
160 170 180 190 200
GRRTGRLRPA AAPSAAAATA GAPTALPAYP AAEPPGPLWL QGEPLHFCCL
210 220 230 240 250
DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIVVWSVAA LIWPVPIIAG
260 270 280 290 300
FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AAVTSGVATK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 67 | A → T in AAL30845 (PubMed:11822868).Curated | 1 | |
Sequence conflicti | 67 | A → T in BAC05687 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024826 | 273 – 286 | Missing in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF438313 mRNA Translation: AAL30845.1 AB078417 mRNA Translation: BAC05687.1 AC010170 Genomic DNA No translation available. BC057390 mRNA Translation: AAH57390.1 AL080235 mRNA Translation: CAB45781.1 |
CCDSi | CCDS54573.1 [Q8WZ71-1] |
PIRi | T12547 |
RefSeqi | NP_056259.2, NM_015444.2 [Q8WZ71-1] |
Genome annotation databases
Ensembli | ENST00000503771; ENSP00000422431; ENSG00000249992 |
GeneIDi | 25907 |
KEGGi | hsa:25907 |
MANE-Selecti | ENST00000503771.2; ENSP00000422431.1; NM_015444.3; NP_056259.2 |
UCSCi | uc011baf.3, human [Q8WZ71-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF438313 mRNA Translation: AAL30845.1 AB078417 mRNA Translation: BAC05687.1 AC010170 Genomic DNA No translation available. BC057390 mRNA Translation: AAH57390.1 AL080235 mRNA Translation: CAB45781.1 |
CCDSi | CCDS54573.1 [Q8WZ71-1] |
PIRi | T12547 |
RefSeqi | NP_056259.2, NM_015444.2 [Q8WZ71-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117413, 1 interactor |
IntActi | Q8WZ71, 2 interactors |
MINTi | Q8WZ71 |
STRINGi | 9606.ENSP00000422431 |
PTM databases
GlyGeni | Q8WZ71, 1 site |
iPTMneti | Q8WZ71 |
PhosphoSitePlusi | Q8WZ71 |
Genetic variation databases
BioMutai | TMEM158 |
DMDMi | 408360199 |
Proteomic databases
jPOSTi | Q8WZ71 |
MassIVEi | Q8WZ71 |
PaxDbi | Q8WZ71 |
PeptideAtlasi | Q8WZ71 |
PRIDEi | Q8WZ71 |
ProteomicsDBi | 75226 [Q8WZ71-1] 75227 [Q8WZ71-2] |
Protocols and materials databases
Antibodypediai | 45715, 79 antibodies from 18 providers |
DNASUi | 25907 |
Genome annotation databases
Ensembli | ENST00000503771; ENSP00000422431; ENSG00000249992 |
GeneIDi | 25907 |
KEGGi | hsa:25907 |
MANE-Selecti | ENST00000503771.2; ENSP00000422431.1; NM_015444.3; NP_056259.2 |
UCSCi | uc011baf.3, human [Q8WZ71-1] |
Organism-specific databases
CTDi | 25907 |
DisGeNETi | 25907 |
GeneCardsi | TMEM158 |
HGNCi | HGNC:30293, TMEM158 |
HPAi | ENSG00000249992, Tissue enhanced (brain, endometrium) |
neXtProti | NX_Q8WZ71 |
OpenTargetsi | ENSG00000249992 |
PharmGKBi | PA128395777 |
VEuPathDBi | HostDB:ENSG00000249992 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYJ7, Eukaryota |
GeneTreei | ENSGT00390000009719 |
HOGENOMi | CLU_085099_0_0_1 |
InParanoidi | Q8WZ71 |
OMAi | QGEPRHF |
OrthoDBi | 1276094at2759 |
PhylomeDBi | Q8WZ71 |
TreeFami | TF339241 |
Enzyme and pathway databases
PathwayCommonsi | Q8WZ71 |
SignaLinki | Q8WZ71 |
Miscellaneous databases
BioGRID-ORCSi | 25907, 8 hits in 1052 CRISPR screens |
ChiTaRSi | TMEM158, human |
GeneWikii | TMEM158 |
GenomeRNAii | 25907 |
Pharosi | Q8WZ71, Tbio |
PROi | PR:Q8WZ71 |
RNActi | Q8WZ71, protein |
Gene expression databases
Bgeei | ENSG00000249992, Expressed in brain and 189 other tissues |
Genevisiblei | Q8WZ71, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038962, TMEM158 |
PANTHERi | PTHR38324, PTHR38324, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM158_HUMAN | |
Accessioni | Q8WZ71Primary (citable) accession number: Q8WZ71 Secondary accession number(s): Q6PFW5, Q9Y4M1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families