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UniProtKB - Q8WZ71 (TM158_HUMAN)

Entry version 115 (23 Feb 2022)
Sequence version 2 (03 Oct 2012)
Previous versions | rss
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Protein

Transmembrane protein 158

Gene

TMEM158

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • peptide binding Source: GO_Central
Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WZ71

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8WZ71

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 158
Alternative name(s):
40 kDa BINP-binding protein
Short name:
p40BBP
Ras-induced senescence protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM158
Synonyms:HBBP, RIS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30293, TMEM158

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WZ71

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000249992

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		25907

Open Targets

More...OpenTargetsi		ENSG00000249992

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128395777

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WZ71, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM158

Domain mapping of disease mutations (DMDM)

More...DMDMi		408360199

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028512821 – 300Transmembrane protein 158Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WZ71

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WZ71

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WZ71

PeptideAtlas

More...PeptideAtlasi		Q8WZ71

PRoteomics IDEntifications database

More...PRIDEi		Q8WZ71

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75226 [Q8WZ71-1]
75227 [Q8WZ71-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8WZ71, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WZ71

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WZ71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during Ras-induced senescence.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000249992, Expressed in brain and 189 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WZ71, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000249992, Tissue enhanced (brain, endometrium)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117413, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q8WZ71, 2 interactors

Molecular INTeraction database

More...MINTi		Q8WZ71

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000422431

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WZ71, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM158 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RYJ7, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009719

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_085099_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WZ71

Identification of Orthologs from Complete Genome Data

More...OMAi		QGEPRHF

Database of Orthologous Groups

More...OrthoDBi		1276094at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WZ71

TreeFam database of animal gene trees

More...TreeFami		TF339241

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038962, TMEM158

The PANTHER Classification System

More...PANTHERi		PTHR38324, PTHR38324, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WZ71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SADEPIAPRL 
        60         70         80         90        100
LASAAPGPPE RPGPEEAAAA AAPCNISVQR QMLSSLLVRW GRPRGFQCDL 
       110        120        130        140        150
LLFSTNAHGR AFFAAAFHRV GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR 
       160        170        180        190        200
GRRTGRLRPA AAPSAAAATA GAPTALPAYP AAEPPGPLWL QGEPLHFCCL 
       210        220        230        240        250
DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIVVWSVAA LIWPVPIIAG 
       260        270        280        290        300
FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AAVTSGVATK
Length:300
Mass (Da):30,404
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA555CC499B7FE0DC
GO
Isoform 2 (identifier: Q8WZ71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-286: Missing.

Show »
Length:286
Mass (Da):29,309
Checksum:iD375F4A2482F19D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67A → T in AAL30845 (PubMed:11822868).Curated1
Sequence conflicti67A → T in BAC05687 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024826273 – 286Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF438313 mRNA Translation: AAL30845.1
AB078417 mRNA Translation: BAC05687.1
AC010170 Genomic DNA No translation available.
BC057390 mRNA Translation: AAH57390.1
AL080235 mRNA Translation: CAB45781.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS54573.1 [Q8WZ71-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T12547

NCBI Reference Sequences

More...RefSeqi		NP_056259.2, NM_015444.2 [Q8WZ71-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000503771; ENSP00000422431; ENSG00000249992

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25907

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25907

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000503771.2; ENSP00000422431.1; NM_015444.3; NP_056259.2

UCSC genome browser

More...UCSCi		uc011baf.3, human [Q8WZ71-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438313 mRNA Translation: AAL30845.1
AB078417 mRNA Translation: BAC05687.1
AC010170 Genomic DNA No translation available.
BC057390 mRNA Translation: AAH57390.1
AL080235 mRNA Translation: CAB45781.1
CCDSiCCDS54573.1 [Q8WZ71-1]
PIRiT12547
RefSeqiNP_056259.2, NM_015444.2 [Q8WZ71-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117413, 1 interactor
IntActiQ8WZ71, 2 interactors
MINTiQ8WZ71
STRINGi9606.ENSP00000422431

PTM databases

GlyGeniQ8WZ71, 1 site
iPTMnetiQ8WZ71
PhosphoSitePlusiQ8WZ71

Genetic variation databases

BioMutaiTMEM158
DMDMi408360199

Proteomic databases

jPOSTiQ8WZ71
MassIVEiQ8WZ71
PaxDbiQ8WZ71
PeptideAtlasiQ8WZ71
PRIDEiQ8WZ71
ProteomicsDBi75226 [Q8WZ71-1]
75227 [Q8WZ71-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45715, 79 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		25907

Genome annotation databases

EnsembliENST00000503771; ENSP00000422431; ENSG00000249992
GeneIDi25907
KEGGihsa:25907
MANE-SelectiENST00000503771.2; ENSP00000422431.1; NM_015444.3; NP_056259.2
UCSCiuc011baf.3, human [Q8WZ71-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25907
DisGeNETi25907

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM158
HGNCiHGNC:30293, TMEM158
HPAiENSG00000249992, Tissue enhanced (brain, endometrium)
neXtProtiNX_Q8WZ71
OpenTargetsiENSG00000249992
PharmGKBiPA128395777
VEuPathDBiHostDB:ENSG00000249992

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RYJ7, Eukaryota
GeneTreeiENSGT00390000009719
HOGENOMiCLU_085099_0_0_1
InParanoidiQ8WZ71
OMAiQGEPRHF
OrthoDBi1276094at2759
PhylomeDBiQ8WZ71
TreeFamiTF339241

Enzyme and pathway databases

PathwayCommonsiQ8WZ71
SignaLinkiQ8WZ71

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25907, 8 hits in 1052 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM158, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TMEM158

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25907
PharosiQ8WZ71, Tbio

Protein Ontology

More...PROi		PR:Q8WZ71
RNActiQ8WZ71, protein

Gene expression databases

BgeeiENSG00000249992, Expressed in brain and 189 other tissues
GenevisibleiQ8WZ71, HS

Family and domain databases

InterProiView protein in InterPro
IPR038962, TMEM158
PANTHERiPTHR38324, PTHR38324, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM158_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WZ71
Secondary accession number(s): Q6PFW5, Q9Y4M1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 3, 2012
Last modified: February 23, 2022
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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