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Entry version 169 (17 Jun 2020)
Sequence version 3 (05 Oct 2010)
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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Gene

ARAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri700 – 723C4-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Alternative name(s):
Centaurin-delta-1
Short name:
Cnt-d1
Protein PARX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARAP2
Synonyms:CENTD1, KIAA0580
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000047365.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16924 ARAP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606645 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WZ64

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116984

Open Targets

More...
OpenTargetsi
ENSG00000047365

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164715938

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WZ64 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARAP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153629

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000742121 – 1704Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2Add BLAST1704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei77PhosphotyrosineBy similarity1
Modified residuei1632PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WZ64

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WZ64

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WZ64

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WZ64

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WZ64

PeptideAtlas

More...
PeptideAtlasi
Q8WZ64

PRoteomics IDEntifications database

More...
PRIDEi
Q8WZ64

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75223

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WZ64

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WZ64

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000047365 Expressed in corpus callosum and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WZ64 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WZ64 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000047365 Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125547, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WZ64, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8WZ64

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302895

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WZ64 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11704
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WZ64

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WZ64

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 70SAMPROSITE-ProRule annotationAdd BLAST65
Domaini482 – 574PH 1PROSITE-ProRule annotationAdd BLAST93
Domaini587 – 679PH 2PROSITE-ProRule annotationAdd BLAST93
Domaini676 – 811Arf-GAPPROSITE-ProRule annotationAdd BLAST136
Domaini878 – 1003PH 3PROSITE-ProRule annotationAdd BLAST126
Domaini1014 – 1114PH 4PROSITE-ProRule annotationAdd BLAST101
Domaini1116 – 1297Rho-GAPPROSITE-ProRule annotationAdd BLAST182
Domaini1326 – 1420Ras-associatingPROSITE-ProRule annotationAdd BLAST95
Domaini1434 – 1537PH 5PROSITE-ProRule annotationAdd BLAST104

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri700 – 723C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1117 Eukaryota
COG5347 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160197

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002900_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WZ64

KEGG Orthology (KO)

More...
KOi
K18440

Identification of Orthologs from Complete Genome Data

More...
OMAi
TVEECFH

Database of Orthologous Groups

More...
OrthoDBi
98944at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WZ64

TreeFam database of animal gene trees

More...
TreeFami
TF105769

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04385 RhoGAP_ARAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 4 hits
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 4 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF00536 SAM_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405 REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8WZ64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVSEVNVD IKDFLMSINL EQYLLHFHES GFTTVKDCAA INDSLLQKIG
60 70 80 90 100
ISPTGHRRRI LKQLQIILSK MQDIPIYANV HKTKKNDDPS KDYHVPSSDQ
110 120 130 140 150
NICIELSNSG SVQTSSPPQL ETVRKNLEDS DASVERSQYP QSDDKLSPPK
160 170 180 190 200
RDFPTAEEPH LNLGSLNDSL FGSDNIKIES LITKKTVDHT VEEQQTEKVK
210 220 230 240 250
LITENLSKLP NADSECLSFV GCSTSGTNSG NGTNGLLEGS PPSPFFKFQG
260 270 280 290 300
EMIVNDLYVP SSPILAPVRS RSKLVSRPSR SFLLRHRPVP EIPGSTKGVS
310 320 330 340 350
GSYFRERRNV ATSTEKSVAW QNSNEENSSS IFPYGETFLF QRLENSKKRS
360 370 380 390 400
IKNEFLTQGE ALKGEAATAT NSFIIKSSIY DNRKEKISED KVEDIWIPRE
410 420 430 440 450
DKNNFLIDTA SESEYSTVEE CFQSLRRKNS KASKSRTQKA LILDSVNRHS
460 470 480 490 500
YPLSSTSGNA DSSAVSSQAI SPYACFYGAS AKKVKSGWLD KLSPQGKRMF
510 520 530 540 550
QKRWVKFDGL SISYYNNEKE MYSKGIIPLS AISTVRVQGD NKFEVVTTQR
560 570 580 590 600
TFVFRVEKEE ERNDWISILL NALKSQSLTS QSQAVVTPEK CGYLELRGYK
610 620 630 640 650
AKIFTVLSGN SVWLCKNEQD FKSGLGITII PMNVANVKQV DRTVKQSFEI
660 670 680 690 700
ITPYRSFSFT AETEKEKQDW IEAVQQSIAE TLSDYEVAEK IWFNESNRSC
710 720 730 740 750
ADCKAPDPDW ASINLCVVIC KKCAGQHRSL GPKDSKVRSL KMDASIWSNE
760 770 780 790 800
LIELFIVIGN KRANDFWAGN LQKDEELHMD SPVEKRKNFI TQKYKEGKFR
810 820 830 840 850
KTLLASLTKE ELNKALCAAV VKPDVLETMA LLFSGADVMC ATGDPVHSTP
860 870 880 890 900
YLLAKKAGQS LQMEFLYHNK FSDFPQHDIH SEGVLSQESS QSTFLCDFLY
910 920 930 940 950
QAPSAASKLS SEKKLLEETN KKWCVLEGGF LSYYENDKST TPNGTININE
960 970 980 990 1000
VICLAIHKED FYLNTGPIFI FEIYLPSERV FLFGAETSQA QRKWTEAIAK
1010 1020 1030 1040 1050
HFVPLFAENL TEADYDLIGQ LFYKDCHALD QWRKGWFAMD KSSLHFCLQM
1060 1070 1080 1090 1100
QEVQGDRMHL RRLQELTIST MVQNGEKLDV LLLVEKGRTL YIHGHTKLDF
1110 1120 1130 1140 1150
TVWHTAIEKA AGTDGNALQD QQLSKNDVPI IVNSCIAFVT QYGLGCKYIY
1160 1170 1180 1190 1200
QKNGDPLHIS ELLESFKKDA RSFKLRAGKH QLEDVTAVLK SFLSDIDDAL
1210 1220 1230 1240 1250
LTKELYPYWI SALDTQDDKE RIKKYGAFIR SLPGVNRATL AAIIEHLYRV
1260 1270 1280 1290 1300
QKCSEINHMN AHNLALVFSS CLFQTKGQTS EEVNVIEDLI NNYVEIFEVK
1310 1320 1330 1340 1350
EDQVKQMDIE NSFITKWKDT QVSQAGDLLI EVYVERKEPD CSIIIRISPV
1360 1370 1380 1390 1400
MEAEELTNDI LAIKNIIPTK GDIWATFEVI ENEELERPLH YKENVLEQVL
1410 1420 1430 1440 1450
RWSSLAEPGS AYLVVKRFLT ADTIKHCSDR STLGSIKEGI LKIKEEPSKI
1460 1470 1480 1490 1500
LSGNKFQDRY FVLRDGFLFL YKDVKSSKHD KMFSLSSMKF YRGVKKKMKP
1510 1520 1530 1540 1550
PTSWGLTAYS EKHHWHLCCD SSRTQTEWMT SIFIAQHEYD IWPPAGKERK
1560 1570 1580 1590 1600
RSITKNPKIG GLPLIPIQHE GNATLARKNI ESARAELERL RLSEKCDKES
1610 1620 1630 1640 1650
VDSSLKERAS MVAHCLEHKD DKLRNRPRKH RSFNCLEDTE PEAPLGQPKG
1660 1670 1680 1690 1700
HKGLKTLRKT EDRNSKATLD SDHKLPSRVI EELNVVLQRS RTLPKELQDE

QILK
Length:1,704
Mass (Da):193,452
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5A13EE08D43A9A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGW1A0A0C4DGW1_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP2
863Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAD6D6RAD6_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC39D6RC39_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP2
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL04166 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227T → I in AAL32459 (Ref. 2) Curated1
Sequence conflicti532I → V in AAL32459 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055530384K → N. Corresponds to variant dbSNP:rs35468501Ensembl.1
Natural variantiVAR_0555311006F → L. Corresponds to variant dbSNP:rs35218548Ensembl.1
Natural variantiVAR_0279521523R → Q3 PublicationsCorresponds to variant dbSNP:rs4833069Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY049733 mRNA Translation: AAL12170.1
AF439781 mRNA Translation: AAL32459.1
AC098827 Genomic DNA No translation available.
AC104078 Genomic DNA No translation available.
AC108033 Genomic DNA Translation: AAY40927.1
AC109818 Genomic DNA No translation available.
AC116623 Genomic DNA No translation available.
AB011152 mRNA Translation: BAA25506.2
AF411982 mRNA Translation: AAL04166.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3441.1

Protein sequence database of the Protein Information Resource

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PIRi
T00342

NCBI Reference Sequences

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RefSeqi
NP_056045.2, NM_015230.3
XP_016863188.1, XM_017007699.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000303965; ENSP00000302895; ENSG00000047365

Database of genes from NCBI RefSeq genomes

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GeneIDi
116984

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:116984

UCSC genome browser

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UCSCi
uc003gsq.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049733 mRNA Translation: AAL12170.1
AF439781 mRNA Translation: AAL32459.1
AC098827 Genomic DNA No translation available.
AC104078 Genomic DNA No translation available.
AC108033 Genomic DNA Translation: AAY40927.1
AC109818 Genomic DNA No translation available.
AC116623 Genomic DNA No translation available.
AB011152 mRNA Translation: BAA25506.2
AF411982 mRNA Translation: AAL04166.1 Frameshift.
CCDSiCCDS3441.1
PIRiT00342
RefSeqiNP_056045.2, NM_015230.3
XP_016863188.1, XM_017007699.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X40NMR-A1-78[»]
2CODNMR-A483-584[»]
SMRiQ8WZ64
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125547, 3 interactors
IntActiQ8WZ64, 8 interactors
MINTiQ8WZ64
STRINGi9606.ENSP00000302895

PTM databases

iPTMnetiQ8WZ64
PhosphoSitePlusiQ8WZ64

Polymorphism and mutation databases

BioMutaiARAP2
DMDMi308153629

Proteomic databases

EPDiQ8WZ64
jPOSTiQ8WZ64
MassIVEiQ8WZ64
MaxQBiQ8WZ64
PaxDbiQ8WZ64
PeptideAtlasiQ8WZ64
PRIDEiQ8WZ64
ProteomicsDBi75223

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23290 96 antibodies

The DNASU plasmid repository

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DNASUi
116984

Genome annotation databases

EnsembliENST00000303965; ENSP00000302895; ENSG00000047365
GeneIDi116984
KEGGihsa:116984
UCSCiuc003gsq.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
116984
DisGeNETi116984
EuPathDBiHostDB:ENSG00000047365.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ARAP2
HGNCiHGNC:16924 ARAP2
HPAiENSG00000047365 Tissue enhanced (bone)
MIMi606645 gene
neXtProtiNX_Q8WZ64
OpenTargetsiENSG00000047365
PharmGKBiPA164715938

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1117 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00940000160197
HOGENOMiCLU_002900_1_0_1
InParanoidiQ8WZ64
KOiK18440
OMAiTVEECFH
OrthoDBi98944at2759
PhylomeDBiQ8WZ64
TreeFamiTF105769

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
116984 6 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARAP2 human
EvolutionaryTraceiQ8WZ64

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CENTD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
116984
PharosiQ8WZ64 Tbio

Protein Ontology

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PROi
PR:Q8WZ64
RNActiQ8WZ64 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000047365 Expressed in corpus callosum and 205 other tissues
ExpressionAtlasiQ8WZ64 baseline and differential
GenevisibleiQ8WZ64 HS

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 4 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 4 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARAP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WZ64
Secondary accession number(s): Q4W5D2
, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 5, 2010
Last modified: June 17, 2020
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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