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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Gene

ARAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri700 – 723C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Alternative name(s):
Centaurin-delta-1
Short name:
Cnt-d1
Protein PARX
Gene namesi
Name:ARAP2
Synonyms:CENTD1, KIAA0580
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000047365.11
HGNCiHGNC:16924 ARAP2
MIMi606645 gene
neXtProtiNX_Q8WZ64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi116984
OpenTargetsiENSG00000047365
PharmGKBiPA164715938

Polymorphism and mutation databases

BioMutaiARAP2
DMDMi308153629

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742121 – 1704Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2Add BLAST1704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphotyrosineBy similarity1
Modified residuei1632PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WZ64
MaxQBiQ8WZ64
PaxDbiQ8WZ64
PeptideAtlasiQ8WZ64
PRIDEiQ8WZ64
ProteomicsDBi75223

PTM databases

iPTMnetiQ8WZ64
PhosphoSitePlusiQ8WZ64

Expressioni

Tissue specificityi

Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000047365 Expressed in 206 organ(s), highest expression level in corpus callosum
CleanExiHS_ARAP2
ExpressionAtlasiQ8WZ64 baseline and differential
GenevisibleiQ8WZ64 HS

Organism-specific databases

HPAiHPA035925

Interactioni

Protein-protein interaction databases

BioGridi125547, 1 interactor
IntActiQ8WZ64, 3 interactors
MINTiQ8WZ64
STRINGi9606.ENSP00000302895

Structurei

Secondary structure

11704
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WZ64
SMRiQ8WZ64
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WZ64

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 70SAMPROSITE-ProRule annotationAdd BLAST65
Domaini482 – 574PH 1PROSITE-ProRule annotationAdd BLAST93
Domaini587 – 679PH 2PROSITE-ProRule annotationAdd BLAST93
Domaini676 – 811Arf-GAPPROSITE-ProRule annotationAdd BLAST136
Domaini878 – 1003PH 3PROSITE-ProRule annotationAdd BLAST126
Domaini1014 – 1114PH 4PROSITE-ProRule annotationAdd BLAST101
Domaini1116 – 1297Rho-GAPPROSITE-ProRule annotationAdd BLAST182
Domaini1326 – 1420Ras-associatingPROSITE-ProRule annotationAdd BLAST95
Domaini1434 – 1537PH 5PROSITE-ProRule annotationAdd BLAST104

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri700 – 723C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1117 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00930000150886
HOGENOMiHOG000246988
HOVERGENiHBG095947
InParanoidiQ8WZ64
KOiK18440
OMAiIKHYNER
OrthoDBiEOG091G00AN
PhylomeDBiQ8WZ64
TreeFamiTF105769

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 4 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 4 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8WZ64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVSEVNVD IKDFLMSINL EQYLLHFHES GFTTVKDCAA INDSLLQKIG
60 70 80 90 100
ISPTGHRRRI LKQLQIILSK MQDIPIYANV HKTKKNDDPS KDYHVPSSDQ
110 120 130 140 150
NICIELSNSG SVQTSSPPQL ETVRKNLEDS DASVERSQYP QSDDKLSPPK
160 170 180 190 200
RDFPTAEEPH LNLGSLNDSL FGSDNIKIES LITKKTVDHT VEEQQTEKVK
210 220 230 240 250
LITENLSKLP NADSECLSFV GCSTSGTNSG NGTNGLLEGS PPSPFFKFQG
260 270 280 290 300
EMIVNDLYVP SSPILAPVRS RSKLVSRPSR SFLLRHRPVP EIPGSTKGVS
310 320 330 340 350
GSYFRERRNV ATSTEKSVAW QNSNEENSSS IFPYGETFLF QRLENSKKRS
360 370 380 390 400
IKNEFLTQGE ALKGEAATAT NSFIIKSSIY DNRKEKISED KVEDIWIPRE
410 420 430 440 450
DKNNFLIDTA SESEYSTVEE CFQSLRRKNS KASKSRTQKA LILDSVNRHS
460 470 480 490 500
YPLSSTSGNA DSSAVSSQAI SPYACFYGAS AKKVKSGWLD KLSPQGKRMF
510 520 530 540 550
QKRWVKFDGL SISYYNNEKE MYSKGIIPLS AISTVRVQGD NKFEVVTTQR
560 570 580 590 600
TFVFRVEKEE ERNDWISILL NALKSQSLTS QSQAVVTPEK CGYLELRGYK
610 620 630 640 650
AKIFTVLSGN SVWLCKNEQD FKSGLGITII PMNVANVKQV DRTVKQSFEI
660 670 680 690 700
ITPYRSFSFT AETEKEKQDW IEAVQQSIAE TLSDYEVAEK IWFNESNRSC
710 720 730 740 750
ADCKAPDPDW ASINLCVVIC KKCAGQHRSL GPKDSKVRSL KMDASIWSNE
760 770 780 790 800
LIELFIVIGN KRANDFWAGN LQKDEELHMD SPVEKRKNFI TQKYKEGKFR
810 820 830 840 850
KTLLASLTKE ELNKALCAAV VKPDVLETMA LLFSGADVMC ATGDPVHSTP
860 870 880 890 900
YLLAKKAGQS LQMEFLYHNK FSDFPQHDIH SEGVLSQESS QSTFLCDFLY
910 920 930 940 950
QAPSAASKLS SEKKLLEETN KKWCVLEGGF LSYYENDKST TPNGTININE
960 970 980 990 1000
VICLAIHKED FYLNTGPIFI FEIYLPSERV FLFGAETSQA QRKWTEAIAK
1010 1020 1030 1040 1050
HFVPLFAENL TEADYDLIGQ LFYKDCHALD QWRKGWFAMD KSSLHFCLQM
1060 1070 1080 1090 1100
QEVQGDRMHL RRLQELTIST MVQNGEKLDV LLLVEKGRTL YIHGHTKLDF
1110 1120 1130 1140 1150
TVWHTAIEKA AGTDGNALQD QQLSKNDVPI IVNSCIAFVT QYGLGCKYIY
1160 1170 1180 1190 1200
QKNGDPLHIS ELLESFKKDA RSFKLRAGKH QLEDVTAVLK SFLSDIDDAL
1210 1220 1230 1240 1250
LTKELYPYWI SALDTQDDKE RIKKYGAFIR SLPGVNRATL AAIIEHLYRV
1260 1270 1280 1290 1300
QKCSEINHMN AHNLALVFSS CLFQTKGQTS EEVNVIEDLI NNYVEIFEVK
1310 1320 1330 1340 1350
EDQVKQMDIE NSFITKWKDT QVSQAGDLLI EVYVERKEPD CSIIIRISPV
1360 1370 1380 1390 1400
MEAEELTNDI LAIKNIIPTK GDIWATFEVI ENEELERPLH YKENVLEQVL
1410 1420 1430 1440 1450
RWSSLAEPGS AYLVVKRFLT ADTIKHCSDR STLGSIKEGI LKIKEEPSKI
1460 1470 1480 1490 1500
LSGNKFQDRY FVLRDGFLFL YKDVKSSKHD KMFSLSSMKF YRGVKKKMKP
1510 1520 1530 1540 1550
PTSWGLTAYS EKHHWHLCCD SSRTQTEWMT SIFIAQHEYD IWPPAGKERK
1560 1570 1580 1590 1600
RSITKNPKIG GLPLIPIQHE GNATLARKNI ESARAELERL RLSEKCDKES
1610 1620 1630 1640 1650
VDSSLKERAS MVAHCLEHKD DKLRNRPRKH RSFNCLEDTE PEAPLGQPKG
1660 1670 1680 1690 1700
HKGLKTLRKT EDRNSKATLD SDHKLPSRVI EELNVVLQRS RTLPKELQDE

QILK
Length:1,704
Mass (Da):193,452
Last modified:October 5, 2010 - v3
Checksum:iA5A13EE08D43A9A0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGW1A0A0C4DGW1_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP2
863Annotation score:
D6RAD6D6RAD6_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP2
47Annotation score:
D6RC39D6RC39_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP2
50Annotation score:

Sequence cautioni

The sequence AAL04166 differs from that shown. Reason: Frameshift at position 1579.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227T → I in AAL32459 (Ref. 2) Curated1
Sequence conflicti532I → V in AAL32459 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055530384K → N. Corresponds to variant dbSNP:rs35468501Ensembl.1
Natural variantiVAR_0555311006F → L. Corresponds to variant dbSNP:rs35218548Ensembl.1
Natural variantiVAR_0279521523R → Q3 PublicationsCorresponds to variant dbSNP:rs4833069Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049733 mRNA Translation: AAL12170.1
AF439781 mRNA Translation: AAL32459.1
AC098827 Genomic DNA No translation available.
AC104078 Genomic DNA No translation available.
AC108033 Genomic DNA Translation: AAY40927.1
AC109818 Genomic DNA No translation available.
AC116623 Genomic DNA No translation available.
AB011152 mRNA Translation: BAA25506.2
AF411982 mRNA Translation: AAL04166.1 Frameshift.
CCDSiCCDS3441.1
PIRiT00342
RefSeqiNP_056045.2, NM_015230.3
XP_016863188.1, XM_017007699.1
UniGeneiHs.479451
Hs.591071
Hs.739008

Genome annotation databases

EnsembliENST00000303965; ENSP00000302895; ENSG00000047365
GeneIDi116984
KEGGihsa:116984
UCSCiuc003gsq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049733 mRNA Translation: AAL12170.1
AF439781 mRNA Translation: AAL32459.1
AC098827 Genomic DNA No translation available.
AC104078 Genomic DNA No translation available.
AC108033 Genomic DNA Translation: AAY40927.1
AC109818 Genomic DNA No translation available.
AC116623 Genomic DNA No translation available.
AB011152 mRNA Translation: BAA25506.2
AF411982 mRNA Translation: AAL04166.1 Frameshift.
CCDSiCCDS3441.1
PIRiT00342
RefSeqiNP_056045.2, NM_015230.3
XP_016863188.1, XM_017007699.1
UniGeneiHs.479451
Hs.591071
Hs.739008

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X40NMR-A1-78[»]
2CODNMR-A483-584[»]
ProteinModelPortaliQ8WZ64
SMRiQ8WZ64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125547, 1 interactor
IntActiQ8WZ64, 3 interactors
MINTiQ8WZ64
STRINGi9606.ENSP00000302895

PTM databases

iPTMnetiQ8WZ64
PhosphoSitePlusiQ8WZ64

Polymorphism and mutation databases

BioMutaiARAP2
DMDMi308153629

Proteomic databases

EPDiQ8WZ64
MaxQBiQ8WZ64
PaxDbiQ8WZ64
PeptideAtlasiQ8WZ64
PRIDEiQ8WZ64
ProteomicsDBi75223

Protocols and materials databases

DNASUi116984
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303965; ENSP00000302895; ENSG00000047365
GeneIDi116984
KEGGihsa:116984
UCSCiuc003gsq.3 human

Organism-specific databases

CTDi116984
DisGeNETi116984
EuPathDBiHostDB:ENSG00000047365.11
GeneCardsiARAP2
H-InvDBiHIX0004149
HGNCiHGNC:16924 ARAP2
HPAiHPA035925
MIMi606645 gene
neXtProtiNX_Q8WZ64
OpenTargetsiENSG00000047365
PharmGKBiPA164715938
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1117 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00930000150886
HOGENOMiHOG000246988
HOVERGENiHBG095947
InParanoidiQ8WZ64
KOiK18440
OMAiIKHYNER
OrthoDBiEOG091G00AN
PhylomeDBiQ8WZ64
TreeFamiTF105769

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiARAP2 human
EvolutionaryTraceiQ8WZ64
GeneWikiiCENTD1
GenomeRNAii116984
PROiPR:Q8WZ64
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000047365 Expressed in 206 organ(s), highest expression level in corpus callosum
CleanExiHS_ARAP2
ExpressionAtlasiQ8WZ64 baseline and differential
GenevisibleiQ8WZ64 HS

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 4 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 4 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARAP2_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ64
Secondary accession number(s): Q4W5D2
, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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