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Entry version 158 (17 Jun 2020)
Sequence version 3 (05 May 2009)
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Protein

Kelch-like protein 6

Gene

KLHL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch-like protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHL6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000172578.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18653 KLHL6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614214 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WZ60

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89857

Open Targets

More...
OpenTargetsi
ENSG00000172578

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38621

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WZ60 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLHL6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462964

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001191061 – 621Kelch-like protein 6Add BLAST621

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WZ60

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WZ60

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WZ60

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WZ60

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WZ60

PeptideAtlas

More...
PeptideAtlasi
Q8WZ60

PRoteomics IDEntifications database

More...
PRIDEi
Q8WZ60

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75222

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8WZ60

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WZ60

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WZ60

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in germinal center B-cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172578 Expressed in bronchial epithelial cell and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WZ60 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WZ60 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000172578 Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124622, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WZ60, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341342

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WZ60 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WZ60

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 139BTBPROSITE-ProRule annotationAdd BLAST68
Domaini174 – 276BACKAdd BLAST103
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati320 – 367Kelch 1Add BLAST48
Repeati378 – 421Kelch 2Add BLAST44
Repeati422 – 468Kelch 3Add BLAST47
Repeati470 – 516Kelch 4Add BLAST47
Repeati517 – 558Kelch 5Add BLAST42
Repeati560 – 606Kelch 6Add BLAST47

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4441 Eukaryota
ENOG410XNX8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154345

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004253_14_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WZ60

KEGG Orthology (KO)

More...
KOi
K10444

Identification of Orthologs from Complete Genome Data

More...
OMAi
PIETKCT

Database of Orthologous Groups

More...
OrthoDBi
279729at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WZ60

TreeFam database of animal gene trees

More...
TreeFami
TF351654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR029851 KLHL6
IPR011333 SKP1/BTB/POZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24412:SF428 PTHR24412:SF428, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8WZ60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD
60 70 80 90 100
DAGLSLILQN GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM
110 120 130 140 150
FCNDLKEKYE KRIIIKGVDA ETMHTLLDYT YTSKALITKQ NVQRVLEAAN
160 170 180 190 200
LFQFLRMVDA CASFLTEALN PENCVGILRL ADTHSLDSLK KQVQSYIIQN
210 220 230 240 250
FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM SWVRHKPSER
260 270 280 290 300
LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS
310 320 330 340 350
GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV
360 370 380 390 400
AKLPLTEHEL ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK
410 420 430 440 450
WIQIEYLNIG RWRHKMVVLG GKVYVIGGFD GLQRINNVET YDPFHNCWSE
460 470 480 490 500
AAPLLVHVSS FAATSHKKKL YVIGGGPNGK LATDKTQCYD PSTNKWSLKA
510 520 530 540 550
AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL VTQLSHERAS
560 570 580 590 600
CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG
610 620
SVTIRKSYTH IRRIVPGAVS V
Length:621
Mass (Da):70,359
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i267FD90AEC6629E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGF2A0A0C4DGF2_HUMAN
Kelch-like protein 6
KLHL6
610Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32348 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL35594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37078 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11T → R in AAL35594 (PubMed:12617994).Curated1
Sequence conflicti94S → G in BAG37078 (PubMed:14702039).Curated1
Sequence conflicti112R → G in BAG37078 (PubMed:14702039).Curated1
Sequence conflicti363E → G in AAL35594 (PubMed:12617994).Curated1
Sequence conflicti495K → R in BAG37078 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056125518I → V. Corresponds to variant dbSNP:rs35354575Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097125 mRNA Translation: BAC04957.1
AK314473 mRNA Translation: BAG37078.1 Different initiation.
AC092960 Genomic DNA No translation available.
AC069211 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78324.1
CH471052 Genomic DNA Translation: EAW78325.1
BC032348 mRNA Translation: AAH32348.1 Different initiation.
AF441792 mRNA Translation: AAL35594.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3245.2

NCBI Reference Sequences

More...
RefSeqi
NP_569713.2, NM_130446.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341319; ENSP00000341342; ENSG00000172578

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89857

UCSC genome browser

More...
UCSCi
uc003flr.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097125 mRNA Translation: BAC04957.1
AK314473 mRNA Translation: BAG37078.1 Different initiation.
AC092960 Genomic DNA No translation available.
AC069211 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78324.1
CH471052 Genomic DNA Translation: EAW78325.1
BC032348 mRNA Translation: AAH32348.1 Different initiation.
AF441792 mRNA Translation: AAL35594.1 Different initiation.
CCDSiCCDS3245.2
RefSeqiNP_569713.2, NM_130446.2

3D structure databases

SMRiQ8WZ60
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124622, 14 interactors
IntActiQ8WZ60, 12 interactors
STRINGi9606.ENSP00000341342

PTM databases

iPTMnetiQ8WZ60
PhosphoSitePlusiQ8WZ60

Polymorphism and mutation databases

BioMutaiKLHL6
DMDMi229462964

Proteomic databases

EPDiQ8WZ60
jPOSTiQ8WZ60
MassIVEiQ8WZ60
MaxQBiQ8WZ60
PaxDbiQ8WZ60
PeptideAtlasiQ8WZ60
PRIDEiQ8WZ60
ProteomicsDBi75222
TopDownProteomicsiQ8WZ60

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18928 101 antibodies

The DNASU plasmid repository

More...
DNASUi
89857

Genome annotation databases

EnsembliENST00000341319; ENSP00000341342; ENSG00000172578
GeneIDi89857
KEGGihsa:89857
UCSCiuc003flr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89857
DisGeNETi89857
EuPathDBiHostDB:ENSG00000172578.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KLHL6
HGNCiHGNC:18653 KLHL6
HPAiENSG00000172578 Tissue enhanced (lymphoid)
MIMi614214 gene
neXtProtiNX_Q8WZ60
OpenTargetsiENSG00000172578
PharmGKBiPA38621

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00940000154345
HOGENOMiCLU_004253_14_2_1
InParanoidiQ8WZ60
KOiK10444
OMAiPIETKCT
OrthoDBi279729at2759
PhylomeDBiQ8WZ60
TreeFamiTF351654

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89857 4 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KLHL6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89857
PharosiQ8WZ60 Tbio

Protein Ontology

More...
PROi
PR:Q8WZ60
RNActiQ8WZ60 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172578 Expressed in bronchial epithelial cell and 144 other tissues
ExpressionAtlasiQ8WZ60 baseline and differential
GenevisibleiQ8WZ60 HS

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR029851 KLHL6
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF428 PTHR24412:SF428, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLHL6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WZ60
Secondary accession number(s): B2RB31
, D3DNS8, Q8N5I1, Q8N892
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 5, 2009
Last modified: June 17, 2020
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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