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Entry version 201 (23 Feb 2022)
Sequence version 4 (18 Apr 2012)
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Homo sapiens (Human)
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

1 Publication


In some isoforms, after the PEVK repeat region there is a long PEVK duplicated region. On account of this region, it has been very difficult to sequence the whole protein. The length of this region (ranging from 183 to 2174 residues), may be a key elastic element of titin.

<p>This subsection of the <a href="">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori


<p>This subsection of the <a href="">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Full activation of the protein kinase domain requires both phosphorylation of Tyr-32341, preventing it from blocking the catalytic aspartate residue, and binding of Ca/CALM to the C-terminal regulatory tail of the molecule which results in ATP binding to the kinase.1 Publication


Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32207ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei32298Proton acceptorPROSITE-ProRule annotation1


Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi32184 – 32192ATPPROSITE-ProRule annotation9

<p>The <a href="">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

BRENDAi, 2681

Pathway Commons web resource for biological pathway data


Reactome - a knowledgebase of biological pathways and processes

R-HSA-114608, Platelet degranulation
R-HSA-390522, Striated Muscle Contraction

SignaLink: a signaling pathway resource with multi-layered regulatory networks


SIGNOR Signaling Network Open Resource


Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

Q8WZ42, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Titin (EC:
Alternative name(s):
Rhabdomyosarcoma antigen MU-RMS-40.14
<p>This subsection of the <a href="">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="">Names and taxonomy</a> section is present for entries that are part of a <a href="">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

HGNC:12403, TTN

Online Mendelian Inheritance in Man (OMIM)

188840, gene

neXtProt; the human protein knowledge platform


Eukaryotic Pathogen, Vector and Host Database Resources


<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="">OMIM</a> database are represented with a <a href="">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy, myofibrillar, 9, with early respiratory failure (MFM9)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant myopathy characterized by adulthood onset of weakness in proximal, distal, axial and respiratory muscles. Pelvic girdle weakness, foot drop and neck weakness are the main symptoms at onset, but ultimately the weakness usually involves the proximal compartment of both upper and lower limbs. Additional features include variable degrees of Achilles tendon contractures, spinal rigidity and muscle hypertrophy. Respiratory involvement often leads to requirement for non-invasive ventilation support.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026634279R → W in MFM9; disrupts NBR1-binding. 1 PublicationCorresponds to variant dbSNP:rs138060032EnsemblClinVar.1
Cardiomyopathy, familial hypertrophic 9 (CMH9)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026687740R → L in CMH9. 1 PublicationCorresponds to variant dbSNP:rs28933405EnsemblClinVar.1
Cardiomyopathy, dilated 1G (CMD1G)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02668554V → M in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs139517732EnsemblClinVar.1
Natural variantiVAR_026688743A → V in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs267607157EnsemblClinVar.1
Natural variantiVAR_026689976W → R in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs267607155EnsemblClinVar.1
Natural variantiVAR_0266903799S → Y in CMD1G. 1 Publication1
Natural variantiVAR_0266924465S → N in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs281864908Ensembl.1
Natural variantiVAR_02669332996R → Q in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs199642423Ensembl.1
Tardive tibial muscular dystrophy (TMD)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal dominant, late-onset distal myopathy. Muscle weakness and atrophy are usually confined to the anterior compartment of the lower leg, in particular the tibialis anterior muscle. Clinical symptoms usually occur at age 35-45 years or much later.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02669434306I → N in TMD. 1 PublicationCorresponds to variant dbSNP:rs281864928Ensembl.1
Natural variantiVAR_02669534315L → P in TMD. 1 PublicationCorresponds to variant dbSNP:rs267607156Ensembl.1
Muscular dystrophy, limb-girdle, autosomal recessive 10 (LGMDR10)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive degenerative myopathy characterized by progressive weakness of the pelvic and shoulder girdle muscles. Severe disability is observed within 20 years of onset.
Related information in OMIM
Salih myopathy (SALMY)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, early-onset muscular disorder characterized by dilated cardiomyopathy, delayed motor development with generalized muscle weakness predominantly affecting proximal and distal lower limbs. Skeletal muscle biopsies show minicore-like lesions with mitochondrial depletion and sarcomere disorganization, centralized nuclei, and type 1 fiber predominance. Dystrophic changes become apparent in the second decade. Cardiac muscle biopsies show disruption of myocardial architecture, nuclear hypertrophy, and endomysial fibrosis. Sudden death may occurr due to cardiomyopathy.
Related information in OMIM


Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32207K → A: Disrupts catalytic activity. 1 Publication1
Mutagenesisi32341Y → E: No phosphorylation on tyrosine. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease variant, Limb-girdle muscular dystrophy, Myofibrillar myopathy

Organism-specific databases



GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.


MalaCards human disease database

MIMi600334, phenotype
603689, phenotype
604145, phenotype
608807, phenotype
611705, phenotype
613765, phenotype

Open Targets


Orphanet; a database dedicated to information on rare diseases and orphan drugs

169186, Autosomal recessive centronuclear myopathy
466921, Childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome
324604, Classic multiminicore myopathy
289377, Early-onset myopathy with fatal cardiomyopathy
334, Familial atrial fibrillation
293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
154, Familial isolated dilated cardiomyopathy
178464, Hereditary myopathy with early respiratory failure
155, NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
609, Tibial muscular dystrophy
140922, Titin-related limb-girdle muscular dystrophy R10

The Pharmacogenetics and Pharmacogenomics Knowledge Base


Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

Q8WZ42, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database


<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002393111 – 34350TitinAdd BLAST34350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="">lipids</a>, <a href="">glycans</a> and <a href="">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei267PhosphothreonineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi964 ↔ 1015PROSITE-ProRule annotation
Disulfide bondi1724 ↔ 1777PROSITE-ProRule annotation
Disulfide bondi2109 ↔ 2134PROSITE-ProRule annotation1 Publication
Disulfide bondi2196 ↔ 2246PROSITE-ProRule annotation
Disulfide bondi3259 ↔ 3311PROSITE-ProRule annotation
Disulfide bondi4404 ↔ 4455PROSITE-ProRule annotation
Disulfide bondi4499 ↔ 4550PROSITE-ProRule annotation
Disulfide bondi4592 ↔ 4643PROSITE-ProRule annotation
Disulfide bondi4686 ↔ 4737PROSITE-ProRule annotation
Disulfide bondi4779 ↔ 4830PROSITE-ProRule annotation
Disulfide bondi5061 ↔ 5112PROSITE-ProRule annotation
Disulfide bondi5248 ↔ 5299PROSITE-ProRule annotation
Disulfide bondi5623 ↔ 5674PROSITE-ProRule annotation
Disulfide bondi5810 ↔ 5861PROSITE-ProRule annotation
Disulfide bondi5903 ↔ 5954PROSITE-ProRule annotation
Disulfide bondi6185 ↔ 6236PROSITE-ProRule annotation
Disulfide bondi6372 ↔ 6423PROSITE-ProRule annotation
Disulfide bondi6465 ↔ 6516PROSITE-ProRule annotation
Disulfide bondi6748 ↔ 6799PROSITE-ProRule annotation
Modified residuei6920PhosphoserineBy similarity1
Disulfide bondi7027 ↔ 7078PROSITE-ProRule annotation
Disulfide bondi7123 ↔ 7174PROSITE-ProRule annotation
Disulfide bondi7219 ↔ 7270PROSITE-ProRule annotation
Disulfide bondi7313 ↔ 7364PROSITE-ProRule annotation
Disulfide bondi7406 ↔ 7457PROSITE-ProRule annotation
Disulfide bondi7689 ↔ 7740PROSITE-ProRule annotation
Disulfide bondi7968 ↔ 8019PROSITE-ProRule annotation
Disulfide bondi8064 ↔ 8115PROSITE-ProRule annotation
Disulfide bondi8160 ↔ 8211PROSITE-ProRule annotation
Disulfide bondi8254 ↔ 8305PROSITE-ProRule annotation
Disulfide bondi8347 ↔ 8398PROSITE-ProRule annotation
Disulfide bondi8630 ↔ 8681PROSITE-ProRule annotation
Disulfide bondi8909 ↔ 8960PROSITE-ProRule annotation
Disulfide bondi9005 ↔ 9056PROSITE-ProRule annotation
Disulfide bondi9101 ↔ 9152PROSITE-ProRule annotation
Modified residuei9122PhosphoserineBy similarity1
Disulfide bondi9294 ↔ 9345PROSITE-ProRule annotation
Disulfide bondi9693 ↔ 9743PROSITE-ProRule annotation
Modified residuei11503PhosphoserineBy similarity1
Modified residuei12007PhosphothreonineBy similarity1
Modified residuei12009PhosphoserineBy similarity1
Modified residuei12022PhosphoserineBy similarity1
Disulfide bondi12067 ↔ 12117PROSITE-ProRule annotation
Disulfide bondi12611 ↔ 12660PROSITE-ProRule annotation
Disulfide bondi12966 ↔ 13016PROSITE-ProRule annotation
Disulfide bondi13233 ↔ 13283PROSITE-ProRule annotation
Disulfide bondi13322 ↔ 13372PROSITE-ProRule annotation
Disulfide bondi13411 ↔ 13461PROSITE-ProRule annotation
Disulfide bondi13771 ↔ 13821PROSITE-ProRule annotation
Modified residuei30443PhosphothreonineBy similarity1
Disulfide bondi31481 ↔ 31532PROSITE-ProRule annotation
Modified residuei32341Phosphotyrosine1 Publication1
Disulfide bondi32516 ↔ 32568PROSITE-ProRule annotation
Modified residuei33245PhosphoserineBy similarity1
Modified residuei33247PhosphoserineBy similarity1
Modified residuei33602PhosphoserineBy similarity1
Modified residuei33614PhosphoserineBy similarity1
Disulfide bondi33664 ↔ 33718PROSITE-ProRule annotation

<p>This subsection of the <a href="">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics


jPOST - Japan Proteome Standard Repository/Database


MassIVE - Mass Spectrometry Interactive Virtual Environment


MaxQB - The MaxQuant DataBase


PaxDb, a database of protein abundance averages across all three domains of life




PRoteomics IDEntifications database


ProteomicsDB: a multi-organism proteome resource

75209 [Q8WZ42-1]
75210 [Q8WZ42-10]
75211 [Q8WZ42-11]
75212 [Q8WZ42-2]
75213 [Q8WZ42-3]
75214 [Q8WZ42-4]
75215 [Q8WZ42-5]
75216 [Q8WZ42-6]
75217 [Q8WZ42-7]
75218 [Q8WZ42-8]
75219 [Q8WZ42-9]

PTM databases

CarbonylDB database of protein carbonylation sites


GlyGen: Computational and Informatics Resources for Glycoscience

Q8WZ42, 11 sites, 2 O-linked glycans (11 sites)

iPTMnet integrated resource for PTMs in systems biology context


MetOSite database of methionine sulfoxide sites


Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.


SwissPalm database of S-palmitoylation events


<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="">P92958</a>, <a href="">Q8TDN4</a>, <a href="">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

ENSG00000155657, Expressed in biceps brachii and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

Q8WZ42, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

Q8WZ42, HS

Organism-specific databases

Human Protein Atlas

ENSG00000155657, Group enriched (skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYOM1, MYOM2, tropomyosin and myosin.

Interacts with actin, primarily via the PEVK domains and with MYPN (By similarity).

Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B.

Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains.

Interacts with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142.

Interacts with ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via immunoglobulin domain 79.

Interacts with NBR1 through the protein kinase domain.

Interacts with CALM/calmodulin.

Isoform 6 interacts with OBSCN isoform 3.

Interacts with CMYA5.

By similarity13 Publications

<p>This subsection of the '<a href="">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="">IntAct database</a>. It is updated at every <a href="">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

113124, 176 interactors

ComplexPortal: manually curated resource of macromolecular complexes

CPX-101, Titin-Telethonin complex

CORUM comprehensive resource of mammalian protein complexes


Database of interacting proteins


Protein interaction database and analysis system

Q8WZ42, 128 interactors

Molecular INTeraction database


STRING: functional protein association networks


<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank


SWISS-MODEL Repository - a database of annotated 3D protein structure models


Database of comparative protein structure models


Protein Data Bank in Europe - Knowledge Base


Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence


<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 96Ig-like 1Add BLAST91
Domaini104 – 192Ig-like 2Add BLAST89
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati417 – 462Z-repeat 1Add BLAST46
Repeati466 – 511Z-repeat 2Add BLAST46
Repeati512 – 554Z-repeat 3Add BLAST43
Repeati555 – 600Z-repeat 4Add BLAST46
Repeati601 – 646Z-repeat 5Add BLAST46
Repeati647 – 691Z-repeat 6Add BLAST45
Repeati692 – 740Z-repeat 7Add BLAST49
Domaini943 – 1031Ig-like 3Add BLAST89
Domaini1082 – 1172Ig-like 4Add BLAST91
Domaini1291 – 1382Ig-like 5Add BLAST92
Domaini1457 – 1546Ig-like 6Add BLAST90
Domaini1556 – 1646Ig-like 7Add BLAST91
Domaini1703 – 1793Ig-like 8Add BLAST91
Domaini1841 – 1928Ig-like 9Add BLAST88
Domaini2078 – 2167Ig-like 10Add BLAST90
Domaini2171 – 2262Ig-like 11Add BLAST92
Domaini2264 – 2354Ig-like 12Add BLAST91
Domaini2353 – 2443Ig-like 13Add BLAST91
Domaini2430 – 2529Ig-like 14Add BLAST100
Domaini2620 – 2703Ig-like 15Add BLAST84
Domaini2880 – 2965Ig-like 16Add BLAST86
Domaini2968 – 3050Ig-like 17Add BLAST83
Domaini3058 – 3141Ig-like 18Add BLAST84
Domaini3239 – 3327Ig-like 19Add BLAST89
Domaini3344 – 3432Ig-like 20Add BLAST89
Domaini3503 – 3586Ig-like 21Add BLAST84
Domaini3621 – 3712Ig-like 22Add BLAST92
Domaini4289 – 4376Ig-like 23Add BLAST88
Domaini4383 – 4471Ig-like 24Add BLAST89
Domaini4478 – 4566Ig-like 25Add BLAST89
Domaini4571 – 4659Ig-like 26Add BLAST89
Domaini4664 – 4753Ig-like 27Add BLAST90
Domaini4758 – 4846Ig-like 28Add BLAST89
Domaini4851 – 4936Ig-like 29Add BLAST86
Domaini4943 – 5032Ig-like 30Add BLAST90
Domaini5040 – 5128Ig-like 31Add BLAST89
Domaini5133 – 5221Ig-like 32Add BLAST89
Domaini5225 – 5314Ig-like 33Add BLAST90
Domaini5320 – 5408Ig-like 34Add BLAST89
Domaini5413 – 5501Ig-like 35Add BLAST89
Domaini5505 – 5594Ig-like 36Add BLAST90
Domaini5602 – 5690Ig-like 37Add BLAST89
Domaini5695 – 5783Ig-like 38Add BLAST89
Domaini5788 – 5877Ig-like 39Add BLAST90
Domaini5882 – 5970Ig-like 40Add BLAST89
Domaini5975 – 6063Ig-like 41Add BLAST89
Domaini6067 – 6156Ig-like 42Add BLAST90
Domaini6164 – 6252Ig-like 43Add BLAST89
Domaini6257 – 6347Ig-like 44Add BLAST91
Domaini6350 – 6440Ig-like 45Add BLAST91
Domaini6444 – 6534Ig-like 46Add BLAST91
Domaini6537 – 6626Ig-like 47Add BLAST90
Domaini6630 – 6721Ig-like 48Add BLAST92
Domaini6727 – 6815Ig-like 49Add BLAST89
Domaini6820 – 6908Ig-like 50Add BLAST89
Domaini6912 – 7001Ig-like 51Add BLAST90
Domaini7005 – 7093Ig-like 52Add BLAST89
Domaini7102 – 7190Ig-like 53Add BLAST89
Domaini7198 – 7286Ig-like 54Add BLAST89
Domaini7291 – 7380Ig-like 55Add BLAST90
Domaini7385 – 7473Ig-like 56Add BLAST89
Domaini7478 – 7567Ig-like 57Add BLAST90
Domaini7571 – 7662Ig-like 58Add BLAST92
Domaini7668 – 7756Ig-like 59Add BLAST89
Domaini7761 – 7849Ig-like 60Add BLAST89
Domaini7853 – 7942Ig-like 61Add BLAST90
Domaini7946 – 8035Ig-like 62Add BLAST90
Domaini8042 – 8133Ig-like 63Add BLAST92
Domaini8138 – 8229Ig-like 64Add BLAST92
Domaini8232 – 8321Ig-like 65Add BLAST90
Domaini8326 – 8414Ig-like 66Add BLAST89
Domaini8419 – 8508Ig-like 67Add BLAST90
Domaini8512 – 8603Ig-like 68Add BLAST92
Domaini8609 – 8697Ig-like 69Add BLAST89
Domaini8702 – 8790Ig-like 70Add BLAST89
Domaini8794 – 8883Ig-like 71Add BLAST90
Domaini8888 – 8976Ig-like 72Add BLAST89
Domaini8984 – 9074Ig-like 73Add BLAST91
Domaini9079 – 9168Ig-like 74Add BLAST90
Domaini9176 – 9265Ig-like 75Add BLAST90
Domaini9272 – 9361Ig-like 76Add BLAST90
Domaini9366 – 9470Ig-like 77Add BLAST105
Domaini9660 – 9755Ig-like 78Add BLAST96
Domaini9760 – 9851Ig-like 79Add BLAST92
Repeati10216 – 10242PEVK 1Add BLAST27
Repeati10244 – 10270PEVK 2Add BLAST27
Repeati10272 – 10298PEVK 3Add BLAST27
Repeati10300 – 10326PEVK 4Add BLAST27
Repeati10327 – 10353PEVK 5Add BLAST27
Repeati10355 – 10381PEVK 6Add BLAST27
Repeati10508 – 10534PEVK 7Add BLAST27
Repeati10536 – 10562PEVK 8Add BLAST27
Repeati10592 – 10618PEVK 9Add BLAST27
Repeati10878 – 10904PEVK 10Add BLAST27
Repeati10906 – 10930PEVK 11Add BLAST25
Repeati10932 – 10958PEVK 12Add BLAST27
Repeati10960 – 10986PEVK 13Add BLAST27
Repeati10987 – 11014PEVK 14Add BLAST28
Repeati11363 – 11396PEVK 15Add BLAST34
Repeati11397 – 11421PEVK 16Add BLAST25
Repeati11453 – 11479PEVK 17Add BLAST27
Repeati11481 – 11507PEVK 18Add BLAST27
Repeati11509 – 11535PEVK 19Add BLAST27
Repeati11537 – 11563PEVK 20Add BLAST27
Repeati11565 – 11591PEVK 21Add BLAST27
Repeati11657 – 11683PEVK 22Add BLAST27
Repeati11703 – 11729PEVK 23Add BLAST27
Repeati11745 – 11771PEVK 24Add BLAST27
Repeati11775 – 11801PEVK 25Add BLAST27
Repeati11836 – 11862PEVK 26Add BLAST27
Repeati11864 – 11890PEVK 27Add BLAST27
Repeati11893 – 11919PEVK 28Add BLAST27
Repeati11929 – 11955PEVK 29Add BLAST27
Repeati11966 – 11992PEVK 30Add BLAST27
Repeati11996 – 12022PEVK 31Add BLAST27
Domaini12041 – 12133Ig-like 80Add BLAST93
Domaini12138 – 12222Ig-like 81Add BLAST85
Domaini12233 – 12318Ig-like 82Add BLAST86
Domaini12499 – 12584Ig-like 83Add BLAST86
Domaini12590 – 12672Ig-like 84Add BLAST83
Domaini12766 – 12850Ig-like 85Add BLAST85
Domaini12945 – 13032Ig-like 86Add BLAST88
Domaini13120 – 13206Ig-like 87Add BLAST87
Domaini13210 – 13295Ig-like 88Add BLAST86
Domaini13299 – 13384Ig-like 89Add BLAST86
Domaini13388 – 13478Ig-like 90Add BLAST91
Domaini13479 – 13562Ig-like 91Add BLAST84
Domaini13565 – 13655Ig-like 92Add BLAST91
Domaini13659 – 13748Ig-like 93Add BLAST90
Domaini13749 – 13833Ig-like 94Add BLAST85
Domaini13927 – 14012Ig-like 95Add BLAST86
Domaini14019 – 14114Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini14120 – 14215Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini14221 – 14316Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini14417 – 14513Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini14517 – 14614Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST98
Domaini14615 – 14708Ig-like 96Add BLAST94
Domaini14713 – 14806Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini14812 – 14907Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini14913 – 15007Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini15010 – 15107Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini15113 – 15207Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST95
Domaini15214 – 15310Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini15314 – 15402Ig-like 97Add BLAST89
Domaini15409 – 15503Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST95
Domaini15509 – 15604Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST96
Domaini15608 – 15724Ig-like 98Add BLAST117
Domaini15731 – 15826Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST96
Domaini15832 – 15926Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST95
Domaini15929 – 16025Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST97
Domaini16029 – 16119Ig-like 99Add BLAST91
Domaini16126 – 16218Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST93
Domaini16224 – 16318Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST95
Domaini16322 – 16420Ig-like 100Add BLAST99
Domaini16427 – 16522Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST96
Domaini16528 – 16628Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST101
Domaini16634 – 16734Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST101
Domaini16727 – 16834Ig-like 101Add BLAST108
Domaini16841 – 16934Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST94
Domaini16941 – 17041Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST101
Domaini17044 – 17139Ig-like 102Add BLAST96
Domaini17147 – 17240Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST94
Domaini17246 – 17345Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST100
Domaini17348 – 17445Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST98
Domaini17449 – 17536Ig-like 103Add BLAST88
Domaini17545 – 17640Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST96
Domaini17646 – 17741Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST96
Domaini17745 – 17834Ig-like 104Add BLAST90
Domaini17842 – 17935Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST94
Domaini17941 – 18036Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST96
Domaini18042 – 18139Fibronectin type-III 31PROSITE-ProRule annotationAdd BLAST98
Domaini18143 – 18228Ig-like 105Add BLAST86
Domaini18239 – 18333Fibronectin type-III 32PROSITE-ProRule annotationAdd BLAST95
Domaini18339 – 18431Fibronectin type-III 33PROSITE-ProRule annotationAdd BLAST93
Domaini18435 – 18526Ig-like 106Add BLAST92
Domaini18533 – 18632Fibronectin type-III 34PROSITE-ProRule annotationAdd BLAST100
Domaini18633 – 18727Fibronectin type-III 35PROSITE-ProRule annotationAdd BLAST95
Domaini18733 – 18829Fibronectin type-III 36PROSITE-ProRule annotationAdd BLAST97
Domaini18833 – 18924Ig-like 107Add BLAST92
Domaini18931 – 19025Fibronectin type-III 37PROSITE-ProRule annotationAdd BLAST95
Domaini19030 – 19124Fibronectin type-III 38PROSITE-ProRule annotationAdd BLAST95
Domaini19128 – 19219Ig-like 108Add BLAST92
Domaini19226 – 19321Fibronectin type-III 39PROSITE-ProRule annotationAdd BLAST96
Domaini19325 – 19420Fibronectin type-III 40PROSITE-ProRule annotationAdd BLAST96
Domaini19426 – 19527Fibronectin type-III 41PROSITE-ProRule annotationAdd BLAST102
Domaini19531 – 19617Ig-like 109Add BLAST87
Domaini19628 – 19722Fibronectin type-III 42PROSITE-ProRule annotationAdd BLAST95
Domaini19728 – 19823Fibronectin type-III 43PROSITE-ProRule annotationAdd BLAST96
Domaini19826 – 19914Ig-like 110Add BLAST89
Domaini19921 – 20017Fibronectin type-III 44PROSITE-ProRule annotationAdd BLAST97
Domaini20018 – 20116Fibronectin type-III 45PROSITE-ProRule annotationAdd BLAST99
Domaini20119 – 20217Fibronectin type-III 46PROSITE-ProRule annotationAdd BLAST99
Domaini20220 – 20311Ig-like 111Add BLAST92
Domaini20318 – 20411Fibronectin type-III 47PROSITE-ProRule annotationAdd BLAST94
Domaini20417 – 20512Fibronectin type-III 48PROSITE-ProRule annotationAdd BLAST96
Domaini20518 – 20613Fibronectin type-III 49PROSITE-ProRule annotationAdd BLAST96
Domaini20716 – 20813Fibronectin type-III 50PROSITE-ProRule annotationAdd BLAST98
Domaini20814 – 20908Fibronectin type-III 51PROSITE-ProRule annotationAdd BLAST95
Domaini20893 – 20996Ig-like 112Add BLAST104
Domaini21006 – 21101Fibronectin type-III 52PROSITE-ProRule annotationAdd BLAST96
Domaini21105 – 21200Fibronectin type-III 53PROSITE-ProRule annotationAdd BLAST96
Domaini21203 – 21299Fibronectin type-III 54PROSITE-ProRule annotationAdd BLAST97
Domaini21303 – 21395Ig-like 113Add BLAST93
Domaini21402 – 21495Fibronectin type-III 55PROSITE-ProRule annotationAdd BLAST94
Domaini21501 – 21596Fibronectin type-III 56PROSITE-ProRule annotationAdd BLAST96
Domaini21602 – 21697Fibronectin type-III 57PROSITE-ProRule annotationAdd BLAST96
Domaini21701 – 21793Ig-like 114Add BLAST93
Domaini21797 – 21891Fibronectin type-III 58PROSITE-ProRule annotationAdd BLAST95
Domaini21894 – 21986Fibronectin type-III 59PROSITE-ProRule annotationAdd BLAST93
Domaini21990 – 22083Ig-like 115Add BLAST94
Domaini22088 – 22182Fibronectin type-III 60PROSITE-ProRule annotationAdd BLAST95
Domaini22188 – 22283Fibronectin type-III 61PROSITE-ProRule annotationAdd BLAST96
Domaini22286 – 22382Fibronectin type-III 62PROSITE-ProRule annotationAdd BLAST97
Domaini22386 – 22477Ig-like 116Add BLAST92
Domaini22484 – 22578Fibronectin type-III 63PROSITE-ProRule annotationAdd BLAST95
Domaini22584 – 22679Fibronectin type-III 64PROSITE-ProRule annotationAdd BLAST96
Domaini22685 – 22781Fibronectin type-III 65PROSITE-ProRule annotationAdd BLAST97
Domaini22785 – 22874Ig-like 117Add BLAST90
Domaini22881 – 22976Fibronectin type-III 66PROSITE-ProRule annotationAdd BLAST96
Domaini22978 – 23071Fibronectin type-III 67PROSITE-ProRule annotationAdd BLAST94
Domaini23075 – 23163Ig-like 118Add BLAST89
Domaini23170 – 23264Fibronectin type-III 68PROSITE-ProRule annotationAdd BLAST95
Domaini23270 – 23364Fibronectin type-III 69PROSITE-ProRule annotationAdd BLAST95
Domaini23368 – 23463Fibronectin type-III 70PROSITE-ProRule annotationAdd BLAST96
Domaini23468 – 23555Ig-like 119Add BLAST88
Domaini23566 – 23660Fibronectin type-III 71PROSITE-ProRule annotationAdd BLAST95
Domaini23666 – 23761Fibronectin type-III 72PROSITE-ProRule annotationAdd BLAST96
Domaini23767 – 23863Fibronectin type-III 73PROSITE-ProRule annotationAdd BLAST97
Domaini23867 – 23954Ig-like 120Add BLAST88
Domaini23963 – 24057Fibronectin type-III 74PROSITE-ProRule annotationAdd BLAST95
Domaini24060 – 24153Fibronectin type-III 75PROSITE-ProRule annotationAdd BLAST94
Domaini24157 – 24241Ig-like 121Add BLAST85
Domaini24252 – 24346Fibronectin type-III 76PROSITE-ProRule annotationAdd BLAST95
Domaini24352 – 24446Fibronectin type-III 77PROSITE-ProRule annotationAdd BLAST95
Domaini24450 – 24546Fibronectin type-III 78PROSITE-ProRule annotationAdd BLAST97
Domaini24550 – 24641Ig-like 122Add BLAST92
Domaini24648 – 24742Fibronectin type-III 79PROSITE-ProRule annotationAdd BLAST95
Domaini24748 – 24843Fibronectin type-III 80PROSITE-ProRule annotationAdd BLAST96
Domaini24849 – 24945Fibronectin type-III 81PROSITE-ProRule annotationAdd BLAST97
Domaini24949 – 25038Ig-like 123Add BLAST90
Domaini25045 – 25139Fibronectin type-III 82PROSITE-ProRule annotationAdd BLAST95
Domaini25142 – 25235Fibronectin type-III 83PROSITE-ProRule annotationAdd BLAST94
Domaini25239 – 25325Ig-like 124Add BLAST87
Domaini25335 – 25428Fibronectin type-III 84PROSITE-ProRule annotationAdd BLAST94
Domaini25434 – 25529Fibronectin type-III 85PROSITE-ProRule annotationAdd BLAST96
Domaini25532 – 25627Fibronectin type-III 86PROSITE-ProRule annotationAdd BLAST96
Domaini25632 – 25722Ig-like 125Add BLAST91
Domaini25731 – 25825Fibronectin type-III 87PROSITE-ProRule annotationAdd BLAST95
Domaini25831 – 25926Fibronectin type-III 88PROSITE-ProRule annotationAdd BLAST96
Domaini25932 – 26028Fibronectin type-III 89PROSITE-ProRule annotationAdd BLAST97
Domaini26032 – 26121Ig-like 126Add BLAST90
Domaini26128 – 26222Fibronectin type-III 90PROSITE-ProRule annotationAdd BLAST95
Domaini26225 – 26318Fibronectin type-III 91PROSITE-ProRule annotationAdd BLAST94
Domaini26322 – 26410Ig-like 127Add BLAST89
Domaini26417 – 26510Fibronectin type-III 92PROSITE-ProRule annotationAdd BLAST94
Domaini26516 – 26611Fibronectin type-III 93PROSITE-ProRule annotationAdd BLAST96
Domaini26614 – 26710Fibronectin type-III 94PROSITE-ProRule annotationAdd BLAST97
Domaini26714 – 26801Ig-like 128Add BLAST88
Domaini26812 – 26906Fibronectin type-III 95PROSITE-ProRule annotationAdd BLAST95
Domaini26912 – 27007Fibronectin type-III 96PROSITE-ProRule annotationAdd BLAST96
Domaini27013 – 27107Fibronectin type-III 97PROSITE-ProRule annotationAdd BLAST95
Domaini27101 – 27196Ig-like 129Add BLAST96
Domaini27205 – 27296Fibronectin type-III 98PROSITE-ProRule annotationAdd BLAST92
Domaini27302 – 27392Fibronectin type-III 99PROSITE-ProRule annotationAdd BLAST91
Domaini27499 – 27593Fibronectin type-III 100PROSITE-ProRule annotationAdd BLAST95
Domaini27599 – 27694Fibronectin type-III 101PROSITE-ProRule annotationAdd BLAST96
Domaini27697 – 27793Fibronectin type-III 102PROSITE-ProRule annotationAdd BLAST97
Domaini27797 – 27888Ig-like 130Add BLAST92
Domaini27895 – 27989Fibronectin type-III 103PROSITE-ProRule annotationAdd BLAST95
Domaini27995 – 28090Fibronectin type-III 104PROSITE-ProRule annotationAdd BLAST96
Domaini28096 – 28192Fibronectin type-III 105PROSITE-ProRule annotationAdd BLAST97
Domaini28196 – 28286Ig-like 131Add BLAST91
Domaini28295 – 28389Fibronectin type-III 106PROSITE-ProRule annotationAdd BLAST95
Domaini28392 – 28484Fibronectin type-III 107PROSITE-ProRule annotationAdd BLAST93
Domaini28488 – 28577Ig-like 132Add BLAST90
Domaini28583 – 28680Fibronectin type-III 108PROSITE-ProRule annotationAdd BLAST98
Domaini28686 – 28781Fibronectin type-III 109PROSITE-ProRule annotationAdd BLAST96
Domaini28784 – 28879Fibronectin type-III 110PROSITE-ProRule annotationAdd BLAST96
Domaini28882 – 28974Ig-like 133Add BLAST93
Domaini28979 – 29071Fibronectin type-III 111PROSITE-ProRule annotationAdd BLAST93
Domaini29081 – 29177Fibronectin type-III 112PROSITE-ProRule annotationAdd