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Protein

Titin

Gene

TTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.1 Publication

Miscellaneous

In some isoforms, after the PEVK repeat region there is a long PEVK duplicated region. On account of this region, it has been very difficult to sequence the whole protein. The length of this region (ranging from 183 to 2174 residues), may be a key elastic element of titin.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Activity regulationi

Full activation of the protein kinase domain requires both phosphorylation of Tyr-32341, preventing it from blocking the catalytic aspartate residue, and binding of Ca/CALM to the C-terminal regulatory tail of the molecule which results in ATP binding to the kinase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32207ATPPROSITE-ProRule annotation1
Active sitei32298Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32184 – 32192ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-390522 Striated Muscle Contraction
SignaLinkiQ8WZ42
SIGNORiQ8WZ42

Protein family/group databases

MoonDBiQ8WZ42 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Titin (EC:2.7.11.1)
Alternative name(s):
Connectin
Rhabdomyosarcoma antigen MU-RMS-40.14
Gene namesi
Name:TTN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000155657.24
HGNCiHGNC:12403 TTN
MIMi188840 gene
neXtProtiNX_Q8WZ42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Hereditary myopathy with early respiratory failure (HMERF)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant, adult-onset myopathy with early respiratory muscle involvement.
See also OMIM:603689
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026634279R → W in HMERF; disrupts NBR1-binding. 1 PublicationCorresponds to variant dbSNP:rs138060032EnsemblClinVar.1
Cardiomyopathy, familial hypertrophic 9 (CMH9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:613765
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026687740R → L in CMH9. 1 PublicationCorresponds to variant dbSNP:rs28933405EnsemblClinVar.1
Cardiomyopathy, dilated 1G (CMD1G)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:604145
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02668554V → M in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs139517732EnsemblClinVar.1
Natural variantiVAR_026688743A → V in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs267607157EnsemblClinVar.1
Natural variantiVAR_026689976W → R in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs267607155EnsemblClinVar.1
Natural variantiVAR_0266903799S → Y in CMD1G. 1 Publication1
Natural variantiVAR_0266924465S → N in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs281864908Ensembl.1
Natural variantiVAR_02669332996R → Q in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs199642423Ensembl.1
Tardive tibial muscular dystrophy (TMD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant, late-onset distal myopathy. Muscle weakness and atrophy are usually confined to the anterior compartment of the lower leg, in particular the tibialis anterior muscle. Clinical symptoms usually occur at age 35-45 years or much later.
See also OMIM:600334
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02669434306I → N in TMD. 1 PublicationCorresponds to variant dbSNP:rs281864928Ensembl.1
Natural variantiVAR_02669534315L → P in TMD. 1 PublicationCorresponds to variant dbSNP:rs267607156Ensembl.1
Limb-girdle muscular dystrophy 2J (LGMD2J)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive degenerative myopathy characterized by progressive weakness of the pelvic and shoulder girdle muscles. Severe disability is observed within 20 years of onset.
See also OMIM:608807
Salih myopathy (SALMY)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, early-onset muscular disorder characterized by dilated cardiomyopathy, delayed motor development with generalized muscle weakness predominantly affecting proximal and distal lower limbs. Skeletal muscle biopsies show minicore-like lesions with mitochondrial depletion and sarcomere disorganization, centralized nuclei, and type 1 fiber predominance. Dystrophic changes become apparent in the second decade. Cardiac muscle biopsies show disruption of myocardial architecture, nuclear hypertrophy, and endomysial fibrosis. Sudden death may occurr due to cardiomyopathy.
See also OMIM:611705

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi32207K → A: Disrupts catalytic activity. 1 Publication1
Mutagenesisi32341Y → E: No phosphorylation on tyrosine. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNETi7273
GeneReviewsiTTN
MalaCardsiTTN
MIMi600334 phenotype
603689 phenotype
604145 phenotype
608807 phenotype
611705 phenotype
613765 phenotype
OpenTargetsiENSG00000155657
Orphaneti169186 Autosomal recessive centronuclear myopathy
140922 Autosomal recessive limb-girdle muscular dystrophy type 2J
466921 Childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome
324604 Classic multiminicore myopathy
289377 Early-onset myopathy with fatal cardiomyopathy
293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
154 Familial isolated dilated cardiomyopathy
178464 Hereditary proximal myopathy with early respiratory failure
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
609 Tibial muscular dystrophy
PharmGKBiPA37067

Polymorphism and mutation databases

BioMutaiTTN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393111 – 34350TitinAdd BLAST34350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei267PhosphothreonineBy similarity1
Disulfide bondi964 ↔ 1015PROSITE-ProRule annotation
Disulfide bondi1724 ↔ 1777PROSITE-ProRule annotation
Disulfide bondi2109 ↔ 2134PROSITE-ProRule annotation1 Publication
Disulfide bondi2196 ↔ 2246PROSITE-ProRule annotation
Disulfide bondi3259 ↔ 3311PROSITE-ProRule annotation
Disulfide bondi4404 ↔ 4455PROSITE-ProRule annotation
Disulfide bondi4499 ↔ 4550PROSITE-ProRule annotation
Disulfide bondi4592 ↔ 4643PROSITE-ProRule annotation
Disulfide bondi4686 ↔ 4737PROSITE-ProRule annotation
Disulfide bondi4779 ↔ 4830PROSITE-ProRule annotation
Disulfide bondi5061 ↔ 5112PROSITE-ProRule annotation
Disulfide bondi5248 ↔ 5299PROSITE-ProRule annotation
Disulfide bondi5623 ↔ 5674PROSITE-ProRule annotation
Disulfide bondi5810 ↔ 5861PROSITE-ProRule annotation
Disulfide bondi5903 ↔ 5954PROSITE-ProRule annotation
Disulfide bondi6185 ↔ 6236PROSITE-ProRule annotation
Disulfide bondi6372 ↔ 6423PROSITE-ProRule annotation
Disulfide bondi6465 ↔ 6516PROSITE-ProRule annotation
Disulfide bondi6748 ↔ 6799PROSITE-ProRule annotation
Modified residuei6920PhosphoserineBy similarity1
Disulfide bondi7027 ↔ 7078PROSITE-ProRule annotation
Disulfide bondi7123 ↔ 7174PROSITE-ProRule annotation
Disulfide bondi7219 ↔ 7270PROSITE-ProRule annotation
Disulfide bondi7313 ↔ 7364PROSITE-ProRule annotation
Disulfide bondi7406 ↔ 7457PROSITE-ProRule annotation
Disulfide bondi7689 ↔ 7740PROSITE-ProRule annotation
Disulfide bondi7968 ↔ 8019PROSITE-ProRule annotation
Disulfide bondi8064 ↔ 8115PROSITE-ProRule annotation
Disulfide bondi8160 ↔ 8211PROSITE-ProRule annotation
Disulfide bondi8254 ↔ 8305PROSITE-ProRule annotation
Disulfide bondi8347 ↔ 8398PROSITE-ProRule annotation
Disulfide bondi8630 ↔ 8681PROSITE-ProRule annotation
Disulfide bondi8909 ↔ 8960PROSITE-ProRule annotation
Disulfide bondi9005 ↔ 9056PROSITE-ProRule annotation
Disulfide bondi9101 ↔ 9152PROSITE-ProRule annotation
Modified residuei9122PhosphoserineBy similarity1
Disulfide bondi9294 ↔ 9345PROSITE-ProRule annotation
Disulfide bondi9693 ↔ 9743PROSITE-ProRule annotation
Modified residuei11503PhosphoserineBy similarity1
Modified residuei12007PhosphothreonineBy similarity1
Modified residuei12009PhosphoserineBy similarity1
Modified residuei12022PhosphoserineBy similarity1
Disulfide bondi12067 ↔ 12117PROSITE-ProRule annotation
Disulfide bondi12611 ↔ 12660PROSITE-ProRule annotation
Disulfide bondi12966 ↔ 13016PROSITE-ProRule annotation
Disulfide bondi13233 ↔ 13283PROSITE-ProRule annotation
Disulfide bondi13322 ↔ 13372PROSITE-ProRule annotation
Disulfide bondi13411 ↔ 13461PROSITE-ProRule annotation
Disulfide bondi13771 ↔ 13821PROSITE-ProRule annotation
Modified residuei30443PhosphothreonineBy similarity1
Disulfide bondi31481 ↔ 31532PROSITE-ProRule annotation
Modified residuei32341Phosphotyrosine1 Publication1
Disulfide bondi32516 ↔ 32568PROSITE-ProRule annotation
Modified residuei33245PhosphoserineBy similarity1
Modified residuei33247PhosphoserineBy similarity1
Modified residuei33602PhosphoserineBy similarity1
Modified residuei33614PhosphoserineBy similarity1
Disulfide bondi33664 ↔ 33718PROSITE-ProRule annotation

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ8WZ42
MaxQBiQ8WZ42
PaxDbiQ8WZ42
PeptideAtlasiQ8WZ42
PRIDEiQ8WZ42
ProteomicsDBi75209
75210 [Q8WZ42-10]
75211 [Q8WZ42-11]
75212 [Q8WZ42-2]
75213 [Q8WZ42-3]
75214 [Q8WZ42-4]
75215 [Q8WZ42-5]
75216 [Q8WZ42-6]
75217 [Q8WZ42-7]
75218 [Q8WZ42-8]
75219 [Q8WZ42-9]

PTM databases

CarbonylDBiQ8WZ42
iPTMnetiQ8WZ42
PhosphoSitePlusiQ8WZ42
SwissPalmiQ8WZ42

Expressioni

Tissue specificityi

Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000155657 Expressed in 160 organ(s), highest expression level in muscle tissue
ExpressionAtlasiQ8WZ42 baseline and differential
GenevisibleiQ8WZ42 HS

Organism-specific databases

HPAiCAB022682
HPA007042
HPA030048

Interactioni

Subunit structurei

Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts with actin, primarily via the PEVK domains and with MYPN (By similarity). Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains. Interacts with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142. Interacts with ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via immunoglobulin domain 79. Interacts with NBR1 through the protein kinase domain. Interacts with CALM/calmodulin. Isoform 6 interacts with OBSCN isoform 3. Interacts with CMYA5.By similarity13 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113124, 71 interactors
ComplexPortaliCPX-101 Titin-Telethonin complex
CORUMiQ8WZ42
DIPiDIP-33449N
IntActiQ8WZ42, 90 interactors
MINTiQ8WZ42
STRINGi9606.ENSP00000343764

Structurei

Secondary structure

134350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00072
ProteinModelPortaliQ8WZ42
SMRiQ8WZ42
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WZ42

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 96Ig-like 1Add BLAST91
Domaini104 – 192Ig-like 2Add BLAST89
Repeati417 – 462Z-repeat 1Add BLAST46
Repeati466 – 511Z-repeat 2Add BLAST46
Repeati512 – 554Z-repeat 3Add BLAST43
Repeati555 – 600Z-repeat 4Add BLAST46
Repeati601 – 646Z-repeat 5Add BLAST46
Repeati647 – 691Z-repeat 6Add BLAST45
Repeati692 – 740Z-repeat 7Add BLAST49
Domaini943 – 1031Ig-like 3Add BLAST89
Domaini1082 – 1172Ig-like 4Add BLAST91
Domaini1291 – 1382Ig-like 5Add BLAST92
Domaini1457 – 1546Ig-like 6Add BLAST90
Domaini1556 – 1646Ig-like 7Add BLAST91
Domaini1703 – 1793Ig-like 8Add BLAST91
Domaini1841 – 1928Ig-like 9Add BLAST88
Domaini2078 – 2167Ig-like 10Add BLAST90
Domaini2171 – 2262Ig-like 11Add BLAST92
Domaini2264 – 2354Ig-like 12Add BLAST91
Domaini2353 – 2443Ig-like 13Add BLAST91
Domaini2430 – 2529Ig-like 14Add BLAST100
Domaini2620 – 2703Ig-like 15Add BLAST84
Domaini2880 – 2965Ig-like 16Add BLAST86
Domaini2968 – 3050Ig-like 17Add BLAST83
Domaini3058 – 3141Ig-like 18Add BLAST84
Domaini3239 – 3327Ig-like 19Add BLAST89
Domaini3344 – 3432Ig-like 20Add BLAST89
Domaini3503 – 3586Ig-like 21Add BLAST84
Domaini3621 – 3712Ig-like 22Add BLAST92
Domaini4289 – 4376Ig-like 23Add BLAST88
Domaini4383 – 4471Ig-like 24Add BLAST89
Domaini4478 – 4566Ig-like 25Add BLAST89
Domaini4571 – 4659Ig-like 26Add BLAST89
Domaini4664 – 4753Ig-like 27Add BLAST90
Domaini4758 – 4846Ig-like 28Add BLAST89
Domaini4851 – 4936Ig-like 29Add BLAST86
Domaini4943 – 5032Ig-like 30Add BLAST90
Domaini5040 – 5128Ig-like 31Add BLAST89
Domaini5133 – 5221Ig-like 32Add BLAST89
Domaini5225 – 5314Ig-like 33Add BLAST90
Domaini5320 – 5408Ig-like 34Add BLAST89
Domaini5413 – 5501Ig-like 35Add BLAST89
Domaini5505 – 5594Ig-like 36Add BLAST90
Domaini5602 – 5690Ig-like 37Add BLAST89
Domaini5695 – 5783Ig-like 38Add BLAST89
Domaini5788 – 5877Ig-like 39Add BLAST90
Domaini5882 – 5970Ig-like 40Add BLAST89
Domaini5975 – 6063Ig-like 41Add BLAST89
Domaini6067 – 6156Ig-like 42Add BLAST90
Domaini6164 – 6252Ig-like 43Add BLAST89
Domaini6257 – 6347Ig-like 44Add BLAST91
Domaini6350 – 6440Ig-like 45Add BLAST91
Domaini6444 – 6534Ig-like 46Add BLAST91
Domaini6537 – 6626Ig-like 47Add BLAST90
Domaini6630 – 6721Ig-like 48Add BLAST92
Domaini6727 – 6815Ig-like 49Add BLAST89
Domaini6820 – 6908Ig-like 50Add BLAST89
Domaini6912 – 7001Ig-like 51Add BLAST90
Domaini7005 – 7093Ig-like 52Add BLAST89
Domaini7102 – 7190Ig-like 53Add BLAST89
Domaini7198 – 7286Ig-like 54Add BLAST89
Domaini7291 – 7380Ig-like 55Add BLAST90
Domaini7385 – 7473Ig-like 56Add BLAST89
Domaini7478 – 7567Ig-like 57Add BLAST90
Domaini7571 – 7662Ig-like 58Add BLAST92
Domaini7668 – 7756Ig-like 59Add BLAST89
Domaini7761 – 7849Ig-like 60Add BLAST89
Domaini7853 – 7942Ig-like 61Add BLAST90
Domaini7946 – 8035Ig-like 62Add BLAST90
Domaini8042 – 8133Ig-like 63Add BLAST92
Domaini8138 – 8229Ig-like 64Add BLAST92
Domaini8232 – 8321Ig-like 65Add BLAST90
Domaini8326 – 8414Ig-like 66Add BLAST89
Domaini8419 – 8508Ig-like 67Add BLAST90
Domaini8512 – 8603Ig-like 68Add BLAST92
Domaini8609 – 8697Ig-like 69Add BLAST89
Domaini8702 – 8790Ig-like 70Add BLAST89
Domaini8794 – 8883Ig-like 71Add BLAST90
Domaini8888 – 8976Ig-like 72Add BLAST89
Domaini8984 – 9074Ig-like 73Add BLAST91
Domaini9079 – 9168Ig-like 74Add BLAST90
Domaini9176 – 9265Ig-like 75Add BLAST90
Domaini9272 – 9361Ig-like 76Add BLAST90
Domaini9366 – 9470Ig-like 77Add BLAST105
Domaini9660 – 9755Ig-like 78Add BLAST96
Domaini9760 – 9851Ig-like 79Add BLAST92
Repeati10216 – 10242PEVK 1Add BLAST27
Repeati10244 – 10270PEVK 2Add BLAST27
Repeati10272 – 10298PEVK 3Add BLAST27
Repeati10300 – 10326PEVK 4Add BLAST27
Repeati10327 – 10353PEVK 5Add BLAST27
Repeati10355 – 10381PEVK 6Add BLAST27
Repeati10508 – 10534PEVK 7Add BLAST27
Repeati10536 – 10562PEVK 8Add BLAST27
Repeati10592 – 10618PEVK 9Add BLAST27
Repeati10878 – 10904PEVK 10Add BLAST27
Repeati10906 – 10930PEVK 11Add BLAST25
Repeati10932 – 10958PEVK 12Add BLAST27
Repeati10960 – 10986PEVK 13Add BLAST27
Repeati10987 – 11014PEVK 14Add BLAST28
Repeati11363 – 11396PEVK 15Add BLAST34
Repeati11397 – 11421PEVK 16Add BLAST25
Repeati11453 – 11479PEVK 17Add BLAST27
Repeati11481 – 11507PEVK 18Add BLAST27
Repeati11509 – 11535PEVK 19Add BLAST27
Repeati11537 – 11563PEVK 20Add BLAST27
Repeati11565 – 11591PEVK 21Add BLAST27
Repeati11657 – 11683PEVK 22Add BLAST27
Repeati11703 – 11729PEVK 23Add BLAST27
Repeati11745 – 11771PEVK 24Add BLAST27
Repeati11775 – 11801PEVK 25Add BLAST27
Repeati11836 – 11862PEVK 26Add BLAST27
Repeati11864 – 11890PEVK 27Add BLAST27
Repeati11893 – 11919PEVK 28Add BLAST27
Repeati11929 – 11955PEVK 29Add BLAST27
Repeati11966 – 11992PEVK 30Add BLAST27
Repeati11996 – 12022PEVK 31Add BLAST27
Domaini12041 – 12133Ig-like 80Add BLAST93
Domaini12138 – 12222Ig-like 81Add BLAST85
Domaini12233 – 12318Ig-like 82Add BLAST86
Domaini12499 – 12584Ig-like 83Add BLAST86
Domaini12590 – 12672Ig-like 84Add BLAST83
Domaini12766 – 12850Ig-like 85Add BLAST85
Domaini12945 – 13032Ig-like 86Add BLAST88
Domaini13120 – 13206Ig-like 87Add BLAST87
Domaini13210 – 13295Ig-like 88Add BLAST86
Domaini13299 – 13384Ig-like 89Add BLAST86
Domaini13388 – 13478Ig-like 90Add BLAST91
Domaini13479 – 13562Ig-like 91Add BLAST84
Domaini13565 – 13655Ig-like 92Add BLAST91
Domaini13659 – 13748Ig-like 93Add BLAST90
Domaini13749 – 13833Ig-like 94Add BLAST85
Domaini13927 – 14012Ig-like 95Add BLAST86
Domaini14019 – 14114Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini14120 – 14215Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini14221 – 14316Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini14417 – 14513Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini14517 – 14614Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST98
Domaini14615 – 14708Ig-like 96Add BLAST94
Domaini14713 – 14806Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini14812 – 14907Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini14913 – 15007Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini15010 – 15107Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini15113 – 15207Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST95
Domaini15214 – 15310Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini15314 – 15402Ig-like 97Add BLAST89
Domaini15409 – 15503Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST95
Domaini15509 – 15604Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST96
Domaini15608 – 15724Ig-like 98Add BLAST117
Domaini15731 – 15826Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST96
Domaini15832 – 15926Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST95
Domaini15929 – 16025Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST97
Domaini16029 – 16119Ig-like 99Add BLAST91
Domaini16126 – 16218Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST93
Domaini16224 – 16318Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST95
Domaini16322 – 16420Ig-like 100Add BLAST99
Domaini16427 – 16522Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST96
Domaini16528 – 16628Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST101
Domaini16634 – 16734Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST101
Domaini16727 – 16834Ig-like 101Add BLAST108
Domaini16841 – 16934Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST94
Domaini16941 – 17041Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST101
Domaini17044 – 17139Ig-like 102Add BLAST96
Domaini17147 – 17240Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST94
Domaini17246 – 17345Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST100
Domaini17348 – 17445Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST98
Domaini17449 – 17536Ig-like 103Add BLAST88
Domaini17545 – 17640Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST96
Domaini17646 – 17741Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST96
Domaini17745 – 17834Ig-like 104Add BLAST90
Domaini17842 – 17935Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST94
Domaini17941 – 18036Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST96
Domaini18042 – 18139Fibronectin type-III 31PROSITE-ProRule annotationAdd BLAST98
Domaini18143 – 18228Ig-like 105Add BLAST86
Domaini18239 – 18333Fibronectin type-III 32PROSITE-ProRule annotationAdd BLAST95
Domaini18339 – 18431Fibronectin type-III 33PROSITE-ProRule annotationAdd BLAST93
Domaini18435 – 18526Ig-like 106Add BLAST92
Domaini18533 – 18632Fibronectin type-III 34PROSITE-ProRule annotationAdd BLAST100
Domaini18633 – 18727Fibronectin type-III 35PROSITE-ProRule annotationAdd BLAST95
Domaini18733 – 18829Fibronectin type-III 36PROSITE-ProRule annotationAdd BLAST97
Domaini18833 – 18924Ig-like 107Add BLAST92
Domaini18931 – 19025Fibronectin type-III 37PROSITE-ProRule annotationAdd BLAST95
Domaini19030 – 19124Fibronectin type-III 38PROSITE-ProRule annotationAdd BLAST95
Domaini19128 – 19219Ig-like 108Add BLAST92
Domaini19226 – 19321Fibronectin type-III 39PROSITE-ProRule annotationAdd BLAST96
Domaini19325 – 19420Fibronectin type-III 40PROSITE-ProRule annotationAdd BLAST96
Domaini19426 – 19527Fibronectin type-III 41PROSITE-ProRule annotationAdd BLAST102
Domaini19531 – 19617Ig-like 109Add BLAST87
Domaini19628 – 19722Fibronectin type-III 42PROSITE-ProRule annotationAdd BLAST95
Domaini19728 – 19823Fibronectin type-III 43PROSITE-ProRule annotationAdd BLAST96
Domaini19826 – 19914Ig-like 110Add BLAST89
Domaini19921 – 20017Fibronectin type-III 44PROSITE-ProRule annotationAdd BLAST97
Domaini20018 – 20116Fibronectin type-III 45PROSITE-ProRule annotationAdd BLAST99
Domaini20119 – 20217Fibronectin type-III 46PROSITE-ProRule annotationAdd BLAST99
Domaini20220 – 20311Ig-like 111Add BLAST92
Domaini20318 – 20411Fibronectin type-III 47PROSITE-ProRule annotationAdd BLAST94
Domaini20417 – 20512Fibronectin type-III 48PROSITE-ProRule annotationAdd BLAST96
Domaini20518 – 20613Fibronectin type-III 49PROSITE-ProRule annotationAdd BLAST96
Domaini20716 – 20813Fibronectin type-III 50PROSITE-ProRule annotationAdd BLAST98
Domaini20814 – 20908Fibronectin type-III 51PROSITE-ProRule annotationAdd BLAST95
Domaini20893 – 20996Ig-like 112Add BLAST104
Domaini21006 – 21101Fibronectin type-III 52PROSITE-ProRule annotationAdd BLAST96
Domaini21105 – 21200Fibronectin type-III 53PROSITE-ProRule annotationAdd BLAST96
Domaini21203 – 21299Fibronectin type-III 54PROSITE-ProRule annotationAdd BLAST97
Domaini21303 – 21395Ig-like 113Add BLAST93
Domaini21402 – 21495Fibronectin type-III 55PROSITE-ProRule annotationAdd BLAST94
Domaini21501 – 21596Fibronectin type-III 56PROSITE-ProRule annotationAdd BLAST96
Domaini21602 – 21697Fibronectin type-III 57PROSITE-ProRule annotationAdd BLAST96
Domaini21701 – 21793Ig-like 114Add BLAST93
Domaini21797 – 21891Fibronectin type-III 58PROSITE-ProRule annotationAdd BLAST95
Domaini21894 – 21986Fibronectin type-III 59PROSITE-ProRule annotationAdd BLAST93
Domaini21990 – 22083Ig-like 115Add BLAST94
Domaini22088 – 22182Fibronectin type-III 60PROSITE-ProRule annotationAdd BLAST95
Domaini22188 – 22283Fibronectin type-III 61PROSITE-ProRule annotationAdd BLAST96
Domaini22286 – 22382Fibronectin type-III 62PROSITE-ProRule annotationAdd BLAST97
Domaini22386 – 22477Ig-like 116Add BLAST92
Domaini22484 – 22578Fibronectin type-III 63PROSITE-ProRule annotationAdd BLAST95
Domaini22584 – 22679Fibronectin type-III 64PROSITE-ProRule annotationAdd BLAST96
Domaini22685 – 22781Fibronectin type-III 65PROSITE-ProRule annotationAdd BLAST97
Domaini22785 – 22874Ig-like 117Add BLAST90
Domaini22881 – 22976Fibronectin type-III 66PROSITE-ProRule annotationAdd BLAST96
Domaini22978 – 23071Fibronectin type-III 67PROSITE-ProRule annotationAdd BLAST94
Domaini23075 – 23163Ig-like 118Add BLAST89
Domaini23170 – 23264Fibronectin type-III 68PROSITE-ProRule annotationAdd BLAST95
Domaini23270 – 23364Fibronectin type-III 69PROSITE-ProRule annotationAdd BLAST95
Domaini23368 – 23463Fibronectin type-III 70PROSITE-ProRule annotationAdd BLAST96
Domaini23468 – 23555Ig-like 119Add BLAST88
Domaini23566 – 23660Fibronectin type-III 71PROSITE-ProRule annotationAdd BLAST95
Domaini23666 – 23761Fibronectin type-III 72PROSITE-ProRule annotationAdd BLAST96
Domaini23767 – 23863Fibronectin type-III 73PROSITE-ProRule annotationAdd BLAST97
Domaini23867 – 23954Ig-like 120Add BLAST88
Domaini23963 – 24057Fibronectin type-III 74PROSITE-ProRule annotationAdd BLAST95
Domaini24060 – 24153Fibronectin type-III 75PROSITE-ProRule annotationAdd BLAST94
Domaini24157 – 24241Ig-like 121Add BLAST85
Domaini24252 – 24346Fibronectin type-III 76PROSITE-ProRule annotationAdd BLAST95
Domaini24352 – 24446Fibronectin type-III 77PROSITE-ProRule annotationAdd BLAST95
Domaini24450 – 24546Fibronectin type-III 78PROSITE-ProRule annotationAdd BLAST97
Domaini24550 – 24641Ig-like 122Add BLAST92
Domaini24648 – 24742Fibronectin type-III 79PROSITE-ProRule annotationAdd BLAST95
Domaini24748 – 24843Fibronectin type-III 80PROSITE-ProRule annotationAdd BLAST96
Domaini24849 – 24945Fibronectin type-III 81PROSITE-ProRule annotationAdd BLAST97
Domaini24949 – 25038Ig-like 123Add BLAST90
Domaini25045 – 25139Fibronectin type-III 82PROSITE-ProRule annotationAdd BLAST95
Domaini25142 – 25235Fibronectin type-III 83PROSITE-ProRule annotationAdd BLAST94
Domaini25239 – 25325Ig-like 124Add BLAST87
Domaini25335 – 25428Fibronectin type-III 84PROSITE-ProRule annotationAdd BLAST94
Domaini25434 – 25529Fibronectin type-III 85PROSITE-ProRule annotationAdd BLAST96
Domaini25532 – 25627Fibronectin type-III 86PROSITE-ProRule annotationAdd BLAST96
Domaini25632 – 25722Ig-like 125Add BLAST91
Domaini25731 – 25825Fibronectin type-III 87PROSITE-ProRule annotationAdd BLAST95
Domaini25831 – 25926Fibronectin type-III 88PROSITE-ProRule annotationAdd BLAST96
Domaini25932 – 26028Fibronectin type-III 89PROSITE-ProRule annotationAdd BLAST97
Domaini26032 – 26121Ig-like 126Add BLAST90
Domaini26128 – 26222Fibronectin type-III 90PROSITE-ProRule annotationAdd BLAST95
Domaini26225 – 26318Fibronectin type-III 91PROSITE-ProRule annotationAdd BLAST94
Domaini26322 – 26410Ig-like 127Add BLAST89
Domaini26417 – 26510Fibronectin type-III 92PROSITE-ProRule annotationAdd BLAST94
Domaini26516 – 26611Fibronectin type-III 93PROSITE-ProRule annotationAdd BLAST96
Domaini26614 – 26710Fibronectin type-III 94PROSITE-ProRule annotationAdd BLAST97
Domaini26714 – 26801Ig-like 128Add BLAST88
Domaini26812 – 26906Fibronectin type-III 95PROSITE-ProRule annotationAdd BLAST95
Domaini26912 – 27007Fibronectin type-III 96PROSITE-ProRule annotationAdd BLAST96
Domaini27013 – 27107Fibronectin type-III 97PROSITE-ProRule annotationAdd BLAST95
Domaini27101 – 27196Ig-like 129Add BLAST96
Domaini27205 – 27296Fibronectin type-III 98PROSITE-ProRule annotationAdd BLAST92
Domaini27302 – 27392Fibronectin type-III 99PROSITE-ProRule annotationAdd BLAST91
Domaini27499 – 27593Fibronectin type-III 100PROSITE-ProRule annotationAdd BLAST95
Domaini27599 – 27694Fibronectin type-III 101PROSITE-ProRule annotationAdd BLAST96
Domaini27697 – 27793Fibronectin type-III 102PROSITE-ProRule annotationAdd BLAST97
Domaini27797 – 27888Ig-like 130Add BLAST92
Domaini27895 – 27989Fibronectin type-III 103PROSITE-ProRule annotationAdd BLAST95
Domaini27995 – 28090Fibronectin type-III 104PROSITE-ProRule annotationAdd BLAST96
Domaini28096 – 28192Fibronectin type-III 105PROSITE-ProRule annotationAdd BLAST97
Domaini28196 – 28286Ig-like 131Add BLAST91
Domaini28295 – 28389Fibronectin type-III 106PROSITE-ProRule annotationAdd BLAST95
Domaini28392 – 28484Fibronectin type-III 107PROSITE-ProRule annotationAdd BLAST93
Domaini28488 – 28577Ig-like 132Add BLAST90
Domaini28583 – 28680Fibronectin type-III 108PROSITE-ProRule annotationAdd BLAST98
Domaini28686 – 28781Fibronectin type-III 109PROSITE-ProRule annotationAdd BLAST96
Domaini28784 – 28879Fibronectin type-III 110PROSITE-ProRule annotationAdd BLAST96
Domaini28882 – 28974Ig-like 133Add BLAST93
Domaini28979 – 29071Fibronectin type-III 111PROSITE-ProRule annotationAdd BLAST93
Domaini29081 – 29177Fibronectin type-III 112PROSITE-ProRule annotationAdd BLAST97
Domaini29180 – 29278Fibronectin type-III 113PROSITE-ProRule annotationAdd BLAST99
Domaini29282 – 29367Ig-like 134Add BLAST86
Domaini29378 – 29473Fibronectin type-III 114PROSITE-ProRule annotationAdd BLAST96
Domaini29475 – 29568Fibronectin type-III 115PROSITE-ProRule annotationAdd BLAST94
Domaini29568 – 29663Ig-like 135Add BLAST96
Domaini29670 – 29764Fibronectin type-III 116PROSITE-ProRule annotationAdd BLAST95
Domaini29770 – 29865Fibronectin type-III 117PROSITE-ProRule annotationAdd BLAST96
Domaini29868 – 29967Fibronectin type-III 118PROSITE-ProRule annotationAdd BLAST100
Domaini29971 – 30059Ig-like 136Add BLAST89
Domaini30070 – 30163Fibronectin type-III 119PROSITE-ProRule annotationAdd BLAST94
Domaini30169 – 30265Fibronectin type-III 120PROSITE-ProRule annotationAdd BLAST97
Domaini30271 – 30367Fibronectin type-III 121PROSITE-ProRule annotationAdd BLAST97
Domaini30371 – 30460Ig-like 137Add BLAST90
Domaini30467 – 30561Fibronectin type-III 122PROSITE-ProRule annotationAdd BLAST95
Domaini30564 – 30658Fibronectin type-III 123PROSITE-ProRule annotationAdd BLAST95
Domaini30663 – 30754Ig-like 138Add BLAST92
Domaini30761 – 30855Fibronectin type-III 124PROSITE-ProRule annotationAdd BLAST95
Domaini30861 – 30956Fibronectin type-III 125PROSITE-ProRule annotationAdd BLAST96
Domaini30962 – 31058Fibronectin type-III 126PROSITE-ProRule annotationAdd BLAST97
Domaini31061 – 31150Ig-like 139Add BLAST90
Domaini31158 – 31254Fibronectin type-III 127PROSITE-ProRule annotationAdd BLAST97
Domaini31258 – 31354Fibronectin type-III 128PROSITE-ProRule annotationAdd BLAST97
Domaini31360 – 31455Fibronectin type-III 129PROSITE-ProRule annotationAdd BLAST96
Domaini31460 – 31548Ig-like 140Add BLAST89
Domaini31653 – 31748Fibronectin type-III 130PROSITE-ProRule annotationAdd BLAST96
Domaini31754 – 31849Fibronectin type-III 131PROSITE-ProRule annotationAdd BLAST96
Domaini31855 – 31945Ig-like 141Add BLAST91
Domaini31955 – 32046Ig-like 142Add BLAST92
Domaini32051 – 32144Fibronectin type-III 132PROSITE-ProRule annotationAdd BLAST94
Domaini32178 – 32432Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini32496 – 32584Ig-like 143Add BLAST89
Domaini32617 – 32710Ig-like 144Add BLAST94
Domaini32722 – 32811Ig-like 145Add BLAST90
Domaini33301 – 33391Ig-like 146Add BLAST91
Domaini33488 – 33576Ig-like 147Add BLAST89
Domaini33645 – 33732Ig-like 148Add BLAST88
Domaini33779 – 33867Ig-like 149Add BLAST89
Domaini33963 – 34052Ig-like 150Add BLAST90
Domaini34061 – 34149Ig-like 151Add BLAST89
Domaini34256 – 34344Ig-like 152Add BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni253 – 341ZIS1Add BLAST89
Regioni1410 – 1440ZIS5Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili529 – 561Sequence analysisAdd BLAST33
Coiled coili2025 – 2052Sequence analysisAdd BLAST28
Coiled coili3462 – 3487Sequence analysisAdd BLAST26
Coiled coili9534 – 9577Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi391 – 436Ala-richAdd BLAST46
Compositional biasi453 – 456Poly-Thr4
Compositional biasi9500 – 9503Poly-Glu4
Compositional biasi9861 – 9952Pro-richAdd BLAST92
Compositional biasi9974 – 11917Glu-richAdd BLAST1944
Compositional biasi9974 – 10089Glu-richAdd BLAST116
Compositional biasi10102 – 10105Poly-Pro4
Compositional biasi10211 – 12032Pro-richAdd BLAST1822
Compositional biasi33188 – 33193Poly-Ser6
Compositional biasi33197 – 33200Poly-Arg4
Compositional biasi34102 – 34244Ser-richAdd BLAST143

Domaini

ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site.
The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00860000133679
HOGENOMiHOG000203078
HOVERGENiHBG080472
InParanoidiQ8WZ42
KOiK12567
OMAiAEKMSPN
TreeFamiTF316477

Family and domain databases

CDDicd00063 FN3, 132 hits
Gene3Di2.60.40.10, 194 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR004168 PPAK_motif
IPR000719 Prot_kinase_dom
IPR015129 Titin_Z_rpt
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 132 hits
PF07679 I-set, 162 hits
PF00069 Pkinase, 1 hit
PF02818 PPAK, 8 hits
PF09042 Titin_Z, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 132 hits
SM00409 IG, 167 hits
SM00408 IGc2, 148 hits
SM00406 IGv, 23 hits
SUPFAMiSSF48726 SSF48726, 167 hits
SSF49265 SSF49265, 74 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 132 hits
PS50835 IG_LIKE, 140 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (13+)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms may be produced, ranging from 27000 to 33000 residues in different striated muscle tissues, the size of the full-length protein may be up to 38138 residues.

This entry has 13 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WZ42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST
60 70 80 90 100
LPGVQISFSD GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE
110 120 130 140 150
TAPPNFVQRL QSMTVRQGSQ VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF
160 170 180 190 200
QISQEGDLYS LLIAEAYPED SGTYSVNATN SVGRATSTAE LLVQGEEEVP
210 220 230 240 250
AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV IDGAAGQQLP
260 270 280 290 300
HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
310 320 330 340 350
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY
360 370 380 390 400
VASSSEAEMR ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA
410 420 430 440 450
SASYAAEAVA TGAKEVKQDA DKSAAVATVV AAVDMARVRE PVISAVEQTA
460 470 480 490 500
QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV VAADKAKEQE LKSRTKEVIT
510 520 530 540 550
TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS EEITKKQKQV
560 570 580 590 600
TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
610 620 630 640 650
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE
660 670 680 690 700
AEKTALSTIA VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE
710 720 730 740 750
AVATVVAAVD QARVREPREP GHLEESYAQQ TTLEYGYKER ISAAKVAEPP
760 770 780 790 800
QRPASEPHVV PKAVKPRVIQ APSETHIKTT DQKGMHISSQ IKKTTDLTTE
810 820 830 840 850
RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA TLQKELSATS
860 870 880 890 900
SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
910 920 930 940 950
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK
960 970 980 990 1000
NVTVIEGESV TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL
1010 1020 1030 1040 1050
MIREAFAEDS GRFTCSAVNE AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT
1060 1070 1080 1090 1100
TEEKRFVESR DVVMTDTSLT EEQAGPGEPA APYFITKPVV QKLVEGGSVV
1110 1120 1130 1140 1150
FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK LVISMTFADD
1160 1170 1180 1190 1200
AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
1210 1220 1230 1240 1250
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF
1260 1270 1280 1290 1300
EERLIKEIEY RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY
1310 1320 1330 1340 1350
RILEGMGVTF HCKMSGYPLP KIAWYKDGKR IKHGERYQMD FLQDGRASLR
1360 1370 1380 1390 1400
IPVVLPEDEG IYTAFASNIK GNAICSGKLY VEPAAPLGAP TYIPTLEPVS
1410 1420 1430 1440 1450
RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG RRLEETDESQ
1460 1470 1480 1490 1500
LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
1510 1520 1530 1540 1550
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV
1560 1570 1580 1590 1600
EHQVKPMFVE KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK
1610 1620 1630 1640 1650
YPKIRIEGTK GEAALKIDST VSQDSAWYTA TAINKAGRDT TRCKVNVEVE
1660 1670 1680 1690 1700
FAEPEPERKL IIPRGTYRAK EIAAPELEPL HLRYGQEQWE EGDLYDKEKQ
1710 1720 1730 1740 1750
QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH DGKPLEAANR
1760 1770 1780 1790 1800
LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
1810 1820 1830 1840 1850
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV
1860 1870 1880 1890 1900
RVLEGETARF RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV
1910 1920 1930 1940 1950
DCKSYDTGEV KVTAENPEGV IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH
1960 1970 1980 1990 2000
VHEPGKLQFE VQKVDRPVDT TETKEVVKLK RAERITHEKV PEESEELRSK
2010 2020 2030 2040 2050
FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH WTKELTEEEK
2060 2070 2080 2090 2100
KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
2110 2120 2130 2140 2150
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM
2160 2170 2180 2190 2200
VKAINIAGET SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE
2210 2220 2230 2240 2250
PFVKVKWYKD GMEVHEGDKY RMHSDRKVHF LSILTIDTSD AEDYSCVLVE
2260 2270 2280 2290 2300
DENVKTTAKL IVEGAVVEFV KELQDIEVPE SYSGELECIV SPENIEGKWY
2310 2320 2330 2340 2350
HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI DGKKTTCKLK
2360 2370 2380 2390 2400
MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
2410 2420 2430 2440 2450
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP
2460 2470 2480 2490 2500
LKDVNVIEGT KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ
2510 2520 2530 2540 2550
RLVINRTHAS DEGPYKLIVG RVETNCNLSV EKIKIIRGLR DLTCTETQNV
2560 2570 2580 2590 2600
VFEVELSHSG IDVLWNFKDK EIKPSSKYKI EAHGKIYKLT VLNMMKDDEG
2610 2620 2630 2640 2650
KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE CEVANPDSKG
2660 2670 2680 2690 2700
EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
2710 2720 2730 2740 2750
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN
2760 2770 2780 2790 2800
EKYAISVKGT IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK
2810 2820 2830 2840 2850
PKDVTALENA TVAFEVSVSH DTVPVKWFHK SVEIKPSDKH RLVSERKVHK
2860 2870 2880 2890 2900
LMLQNISPSD AGEYTAVVGQ LECKAKLFVE TLHITKTMKN IEVPETKTAS
2910 2920 2930 2940 2950
FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII MNTSTEDSAE
2960 2970 2980 2990 3000
YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
3010 3020 3030 3040 3050
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT
3060 3070 3080 3090 3100
LYVEARHIEF RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT
3110 3120 3130 3140 3150
DRIKIQKEKY VHRLLIPSTR MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR
3160 3170 3180 3190 3200
SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY KDGIEINFQV QERHKYVVER
3210 3220 3230 3240 3250
RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ VLQELQPVTV
3260 3270 3280 3290 3300
QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
3310 3320 3330 3340 3350
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP
3360 3370 3380 3390 3400
LQDTVTSEGQ PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ
3410 3420 3430 3440 3450
LEIAEAYPED EGTYTFVASN AVGQVSSTAN LSLEAPESIL HERIEQEIEM
3460 3470 3480 3490 3500
EMKEFSSSFL SAEEEGLHSA ELQLSKINET LELLSESPVY PTKFDSEKEG
3510 3520 3530 3540 3550
TGPIFIKEVS NADISMGDVA TLSVTVIGIP KPKIQWFFNG VLLTPSADYK
3560 3570 3580 3590 3600
FVFDGDDHSL IILFTKLEDE GEYTCMASND YGKTICSAYL KINSKGEGHK
3610 3620 3630 3640 3650
DTETESAVAK SLEKLGGPCP PHFLKELKPI RCAQGLPAIF EYTVVGEPAP
3660 3670 3680 3690 3700
TVTWFKENKQ LCTSVYYTII HNPNGSGTFI VNDPQREDSG LYICKAENML
3710 3720 3730 3740 3750
GESTCAAELL VLLEDTDMTD TPCKAKSTPE APEDFPQTPL KGPAVEALDS
3760 3770 3780 3790 3800
EQEIATFVKD TILKAALITE ENQQLSYEHI AKANELSSQL PLGAQELQSI
3810 3820 3830 3840 3850
LEQDKLTPES TREFLCINGS IHFQPLKEPS PNLQLQIVQS QKTFSKEGIL
3860 3870 3880 3890 3900
MPEEPETQAV LSDTEKIFPS AMSIEQINSL TVEPLKTLLA EPEGNYPQSS
3910 3920 3930 3940 3950
IEPPMHSYLT SVAEEVLSPK EKTVSDTNRE QRVTLQKQEA QSALILSQSL
3960 3970 3980 3990 4000
AEGHVESLQS PDVMISQVNY EPLVPSEHSC TEGGKILIES ANPLENAGQD
4010 4020 4030 4040 4050
SAVRIEEGKS LRFPLALEEK QVLLKEEHSD NVVMPPDQII ESKREPVAIK
4060 4070 4080 4090 4100
KVQEVQGRDL LSKESLLSGI PEEQRLNLKI QICRALQAAV ASEQPGLFSE
4110 4120 4130 4140 4150
WLRNIEKVEV EAVNITQEPR HIMCMYLVTS AKSVTEEVTI IIEDVDPQMA
4160 4170 4180 4190 4200
NLKMELRDAL CAIIYEEIDI LTAEGPRIQQ GAKTSLQEEM DSFSGSQKVE
4210 4220 4230 4240 4250
PITEPEVESK YLISTEEVSY FNVQSRVKYL DATPVTKGVA SAVVSDEKQD
4260 4270 4280 4290 4300
ESLKPSEEKE ESSSESGTEE VATVKIQEAE GGLIKEDGPM IHTPLVDTVS
4310 4320 4330 4340 4350
EEGDIVHLTT SITNAKEVNW YFENKLVPSD EKFKCLQDQN TYTLVIDKVN
4360 4370 4380 4390 4400
TEDHQGEYVC EALNDSGKTA TSAKLTVVKR AAPVIKRKIE PLEVALGHLA
4410 4420 4430 4440 4450
KFTCEIQSAP NVRFQWFKAG REIYESDKCS IRSSKYISSL EILRTQVVDC
4460 4470 4480 4490 4500
GEYTCKASNE YGSVSCTATL TVTEAYPPTF LSRPKSLTTF VGKAAKFICT
4510 4520 4530 4540 4550
VTGTPVIETI WQKDGAALSP SPNWRISDAE NKHILELSNL TIQDRGVYSC
4560 4570 4580 4590 4600
KASNKFGADI CQAELIIIDK PHFIKELEPV QSAINKKVHL ECQVDEDRKV
4610 4620 4630 4640 4650
TVTWSKDGQK LPPGKDYKIC FEDKIATLEI PLAKLKDSGT YVCTASNEAG
4660 4670 4680 4690 4700
SSSCSATVTV REPPSFVKKV DPSYLMLPGE SARLHCKLKG SPVIQVTWFK
4710 4720 4730 4740 4750
NNKELSESNT VRMYFVNSEA ILDITDVKVE DSGSYSCEAV NDVGSDSCST
4760 4770 4780 4790 4800
EIVIKEPPSF IKTLEPADIV RGTNALLQCE VSGTGPFEIS WFKDKKQIRS
4810 4820 4830 4840 4850
SKKYRLFSQK SLVCLEIFSF NSADVGEYEC VVANEVGKCG CMATHLLKEP
4860 4870 4880 4890 4900
PTFVKKVDDL IALGGQTVTL QAAVRGSEPI SVTWMKGQEV IREDGKIKMS
4910 4920 4930 4940 4950
FSNGVAVLII PDVQISFGGK YTCLAENEAG SQTSVGELIV KEPAKIIERA
4960 4970 4980 4990 5000
ELIQVTAGDP ATLEYTVAGT PELKPKWYKD GRPLVASKKY RISFKNNVAQ
5010 5020 5030 5040 5050
LKFYSAELHD SGQYTFEISN EVGSSSCETT FTVLDRDIAP FFTKPLRNVD
5060 5070 5080 5090 5100
SVVNGTCRLD CKIAGSLPMR VSWFKDGKEI AASDRYRIAF VEGTASLEII
5110 5120 5130 5140 5150
RVDMNDAGNF TCRATNSVGS KDSSGALIVQ EPPSFVTKPG SKDVLPGSAV
5160 5170 5180 5190 5200
CLKSTFQGST PLTIRWFKGN KELVSGGSCY ITKEALESSL ELYLVKTSDS
5210 5220 5230 5240 5250
GTYTCKVSNV AGGVECSANL FVKEPATFVE KLEPSQLLKK GDATQLACKV
5260 5270 5280 5290 5300
TGTPPIKITW FANDREIKES SKHRMSFVES TAVLRLTDVG IEDSGEYMCE
5310 5320 5330 5340 5350
AQNEAGSDHC SSIVIVKESP YFTKEFKPIE VLKEYDVMLL AEVAGTPPFE
5360 5370 5380 5390 5400
ITWFKDNTIL RSGRKYKTFI QDHLVSLQIL KFVAADAGEY QCRVTNEVGS
5410 5420 5430 5440 5450
SICSARVTLR EPPSFIKKIE STSSLRGGTA AFQATLKGSL PITVTWLKDS
5460 5470 5480 5490 5500
DEITEDDNIR MTFENNVASL YLSGIEVKHD GKYVCQAKND AGIQRCSALL
5510 5520 5530 5540 5550
SVKEPATITE EAVSIDVTQG DPATLQVKFS GTKEITAKWF KDGQELTLGS
5560 5570 5580 5590 5600
KYKISVTDTV SILKIISTEK KDSGEYTFEV QNDVGRSSCK ARINVLDLII
5610 5620 5630 5640 5650
PPSFTKKLKK MDSIKGSFID LECIVAGSHP ISIQWFKDDQ EISASEKYKF
5660 5670 5680 5690 5700
SFHDNTAFLE ISQLEGTDSG TYTCSATNKA GHNQCSGHLT VKEPPYFVEK
5710 5720 5730 5740 5750
PQSQDVNPNT RVQLKALVGG TAPMTIKWFK DNKELHSGAA RSVWKDDTST
5760 5770 5780 5790 5800
SLELFAAKAT DSGTYICQLS NDVGTATSKA TLFVKEPPQF IKKPSPVLVL
5810 5820 5830 5840 5850
RNGQSTTFEC QITGTPKIRV SWYLDGNEIT AIQKHGISFI DGLATFQISG
5860 5870 5880 5890 5900
ARVENSGTYV CEARNDAGTA SCSIELKVKE PPTFIRELKP VEVVKYSDVE
5910 5920 5930 5940 5950
LECEVTGTPP FEVTWLKNNR EIRSSKKYTL TDRVSVFNLH ITKCDPSDTG
5960 5970 5980 5990 6000
EYQCIVSNEG GSCSCSTRVA LKEPPSFIKK IENTTTVLKS SATFQSTVAG
6010 6020 6030 6040 6050
SPPISITWLK DDQILDEDDN VYISFVDSVA TLQIRSVDNG HSGRYTCQAK
6060 6070 6080 6090 6100
NESGVERCYA FLLVQEPAQI VEKAKSVDVT EKDPMTLECV VAGTPELKVK
6110 6120 6130 6140 6150
WLKDGKQIVP SRYFSMSFEN NVASFRIQSV MKQDSGQYTF KVENDFGSSS
6160 6170 6180 6190 6200
CDAYLRVLDQ NIPPSFTKKL TKMDKVLGSS IHMECKVSGS LPISAQWFKD
6210 6220 6230 6240 6250
GKEISTSAKY RLVCHERSVS LEVNNLELED TANYTCKVSN VAGDDACSGI
6260 6270 6280 6290 6300
LTVKEPPSFL VKPGRQQAIP DSTVEFKAIL KGTPPFKIKW FKDDVELVSG
6310 6320 6330 6340 6350
PKCFIGLEGS TSFLNLYSVD ASKTGQYTCH VTNDVGSDSC TTMLLVTEPP
6360 6370 6380 6390 6400
KFVKKLEASK IVKAGDSSRL ECKIAGSPEI RVVWFRNEHE LPASDKYRMT
6410 6420 6430 6440 6450
FIDSVAVIQM NNLSTEDSGD FICEAQNPAG STSCSTKVIV KEPPVFSSFP
6460 6470 6480 6490 6500
PIVETLKNAE VSLECELSGT PPFEVVWYKD KRQLRSSKKY KIASKNFHTS
6510 6520 6530 6540 6550
IHILNVDTSD IGEYHCKAQN EVGSDTCVCT VKLKEPPRFV SKLNSLTVVA
6560 6570 6580 6590 6600
GEPAELQASI EGAQPIFVQW LKEKEEVIRE SENIRITFVE NVATLQFAKA
6610 6620 6630 6640 6650
EPANAGKYIC QIKNDGGMRE NMATLMVLEP AVIVEKAGPM TVTVGETCTL
6660 6670 6680 6690 6700
ECKVAGTPEL SVEWYKDGKL LTSSQKHKFS FYNKISSLRI LSVERQDAGT
6710 6720 6730 6740 6750
YTFQVQNNVG KSSCTAVVDV SDRAVPPSFT RRLKNTGGVL GASCILECKV
6760 6770 6780 6790 6800
AGSSPISVAW FHEKTKIVSG AKYQTTFSDN VCTLQLNSLD SSDMGNYTCV
6810 6820 6830 6840 6850
AANVAGSDEC RAVLTVQEPP SFVKEPEPLE VLPGKNVTFT SVIRGTPPFK
6860 6870 6880 6890 6900
VNWFRGAREL VKGDRCNIYF EDTVAELELF NIDISQSGEY TCVVSNNAGQ
6910 6920 6930 6940 6950
ASCTTRLFVK EPAAFLKRLS DHSVEPGKSI ILESTYTGTL PISVTWKKDG
6960 6970 6980 6990 7000
FNITTSEKCN IVTTEKTCIL EILNSTKRDA GQYSCEIENE AGRDVCGALV
7010 7020 7030 7040 7050
STLEPPYFVT ELEPLEAAVG DSVSLQCQVA GTPEITVSWY KGDTKLRPTP
7060 7070 7080 7090 7100
EYRTYFTNNV ATLVFNKVNI NDSGEYTCKA ENSIGTASSK TVFRIQERQL
7110 7120 7130 7140 7150
PPSFARQLKD IEQTVGLPVT LTCRLNGSAP IQVCWYRDGV LLRDDENLQT
7160 7170 7180 7190 7200
SFVDNVATLK ILQTDLSHSG QYSCSASNPL GTASSSARLT AREPKKSPFF
7210 7220 7230 7240 7250
DIKPVSIDVI AGESADFECH VTGAQPMRIT WSKDNKEIRP GGNYTITCVG
7260 7270 7280 7290 7300
NTPHLRILKV GKGDSGQYTC QATNDVGKDM CSAQLSVKEP PKFVKKLEAS
7310 7320 7330 7340 7350
KVAKQGESIQ LECKISGSPE IKVSWFRNDS ELHESWKYNM SFINSVALLT
7360 7370 7380 7390 7400
INEASAEDSG DYICEAHNGV GDASCSTALT VKAPPVFTQK PSPVGALKGS
7410 7420 7430 7440 7450
DVILQCEISG TPPFEVVWVK DRKQVRNSKK FKITSKHFDT SLHILNLEAS
7460 7470 7480 7490 7500
DVGEYHCKAT NEVGSDTCSC SVKFKEPPRF VKKLSDTSTL IGDAVELRAI
7510 7520 7530 7540 7550
VEGFQPISVV WLKDRGEVIR ESENTRISFI DNIATLQLGS PEASNSGKYI
7560 7570 7580 7590 7600
CQIKNDAGMR ECSAVLTVLE PARIIEKPEP MTVTTGNPFA LECVVTGTPE
7610 7620 7630 7640 7650
LSAKWFKDGR ELSADSKHHI TFINKVASLK IPCAEMSDKG LYSFEVKNSV
7660 7670 7680 7690 7700
GKSNCTVSVH VSDRIVPPSF IRKLKDVNAI LGASVVLECR VSGSAPISVG
7710 7720 7730 7740 7750
WFQDGNEIVS GPKCQSSFSE NVCTLNLSLL EPSDTGIYTC VAANVAGSDE
7760 7770 7780 7790 7800
CSAVLTVQEP PSFEQTPDSV EVLPGMSLTF TSVIRGTPPF KVKWFKGSRE
7810 7820 7830 7840 7850
LVPGESCNIS LEDFVTELEL FEVQPLESGD YSCLVTNDAG SASCTTHLFV
7860 7870 7880 7890 7900
KEPATFVKRL ADFSVETGSP IVLEATYTGT PPISVSWIKD EYLISQSERC
7910 7920 7930 7940 7950
SITMTEKSTI LEILESTIED YAQYSCLIEN EAGQDICEAL VSVLEPPYFI
7960 7970 7980 7990 8000
EPLEHVEAVI GEPATLQCKV DGTPEIRISW YKEHTKLRSA PAYKMQFKNN
8010 8020 8030 8040 8050
VASLVINKVD HSDVGEYSCK ADNSVGAVAS SAVLVIKARK LPPFFARKLK
8060 8070 8080 8090 8100
DVHETLGFPV AFECRINGSE PLQVSWYKDG VLLKDDANLQ TSFVHNVATL
8110 8120 8130 8140 8150
QILQTDQSHI GQYNCSASNP LGTASSSAKL ILSEHEVPPF FDLKPVSVDL
8160 8170 8180 8190 8200
ALGESGTFKC HVTGTAPIKI TWAKDNREIR PGGNYKMTLV ENTATLTVLK
8210 8220 8230 8240 8250
VGKGDAGQYT CYASNIAGKD SCSAQLGVQE PPRFIKKLEP SRIVKQDEFT
8260 8270 8280 8290 8300
RYECKIGGSP EIKVLWYKDE TEIQESSKFR MSFVDSVAVL EMHNLSVEDS
8310 8320 8330 8340 8350
GDYTCEAHNA AGSASSSTSL KVKEPPIFRK KPHPIETLKG ADVHLECELQ
8360 8370 8380 8390 8400
GTPPFHVSWY KDKRELRSGK KYKIMSENFL TSIHILNVDA ADIGEYQCKA
8410 8420 8430 8440 8450
TNDVGSDTCV GSIALKAPPR FVKKLSDIST VVGKEVQLQT TIEGAEPISV
8460 8470 8480 8490 8500
VWFKDKGEIV RESDNIWISY SENIATLQFS RVEPANAGKY TCQIKNDAGM
8510 8520 8530 8540 8550
QECFATLSVL EPATIVEKPE SIKVTTGDTC TLECTVAGTP ELSTKWFKDG
8560 8570 8580 8590 8600
KELTSDNKYK ISFFNKVSGL KIINVAPSDS GVYSFEVQNP VGKDSCTASL
8610 8620 8630 8640 8650
QVSDRTVPPS FTRKLKETNG LSGSSVVMEC KVYGSPPISV SWFHEGNEIS
8660 8670 8680 8690 8700
SGRKYQTTLT DNTCALTVNM LEESDSGDYT CIATNMAGSD ECSAPLTVRE
8710 8720 8730 8740 8750
PPSFVQKPDP MDVLTGTNVT FTSIVKGTPP FSVSWFKGSS ELVPGDRCNV
8760 8770 8780 8790 8800
SLEDSVAELE LFDVDTSQSG EYTCIVSNEA GKASCTTHLY IKAPAKFVKR
8810 8820 8830 8840 8850
LNDYSIEKGK PLILEGTFTG TPPISVTWKK NGINVTPSQR CNITTTEKSA
8860 8870 8880 8890 8900
ILEIPSSTVE DAGQYNCYIE NASGKDSCSA QILILEPPYF VKQLEPVKVS
8910 8920 8930 8940 8950
VGDSASLQCQ LAGTPEIGVS WYKGDTKLRP TTTYKMHFRN NVATLVFNQV
8960 8970 8980 8990 9000
DINDSGEYIC KAENSVGEVS ASTFLTVQEQ KLPPSFSRQL RDVQETVGLP
9010 9020 9030 9040 9050
VVFDCAISGS EPISVSWYKD GKPLKDSPNV QTSFLDNTAT LNIFKTDRSL
9060 9070 9080 9090 9100
AGQYSCTATN PIGSASSSAR LILTEGKNPP FFDIRLAPVD AVVGESADFE
9110 9120 9130 9140 9150
CHVTGTQPIK VSWAKDSREI RSGGKYQISY LENSAHLTVL KVDKGDSGQY
9160 9170 9180 9190 9200
TCYAVNEVGK DSCTAQLNIK ERLIPPSFTK RLSETVEETE GNSFKLEGRV
9210 9220 9230 9240 9250
AGSQPITVAW YKNNIEIQPT SNCEITFKNN TLVLQVRKAG MNDAGLYTCK
9260 9270 9280 9290 9300
VSNDAGSALC TSSIVIKEPK KPPVFDQHLT PVTVSEGEYV QLSCHVQGSE
9310 9320 9330 9340 9350
PIRIQWLKAG REIKPSDRCS FSFASGTAVL ELRDVAKADS GDYVCKASNV
9360 9370 9380 9390 9400
AGSDTTKSKV TIKDKPAVAP ATKKAAVDGR LFFVSEPQSI RVVEKTTATF
9410 9420 9430 9440 9450
IAKVGGDPIP NVKWTKGKWR QLNQGGRVFI HQKGDEAKLE IRDTTKTDSG
9460 9470 9480 9490 9500
LYRCVAFNEH GEIESNVNLQ VDERKKQEKI EGDLRAMLKK TPILKKGAGE
9510 9520 9530 9540 9550
EEEIDIMELL KNVDPKEYEK YARMYGITDF RGLLQAFELL KQSQEEETHR
9560 9570 9580 9590 9600
LEIEEIERSE RDEKEFEELV SFIQQRLSQT EPVTLIKDIE NQTVLKDNDA
9610 9620 9630 9640 9650
VFEIDIKINY PEIKLSWYKG TEKLEPSDKF EISIDGDRHT LRVKNCQLKD
9660 9670 9680 9690 9700
QGNYRLVCGP HIASAKLTVI EPAWERHLQD VTLKEGQTCT MTCQFSVPNV
9710 9720 9730 9740 9750
KSEWFRNGRI LKPQGRHKTE VEHKVHKLTI ADVRAEDQGQ YTCKYEDLET
9760 9770 9780 9790 9800
SAELRIEAEP IQFTKRIQNI VVSEHQSATF ECEVSFDDAI VTWYKGPTEL
9810 9820 9830 9840 9850
TESQKYNFRN DGRCHYMTIH NVTPDDEGVY SVIARLEPRG EARSTAELYL
9860 9870 9880 9890 9900
TTKEIKLELK PPDIPDSRVP IPTMPIRAVP PEEIPPVVAP PIPLLLPTPE
9910 9920 9930 9940 9950
EKKPPPKRIE VTKKAVKKDA KKVVAKPKEM TPREEIVKKP PPPTTLIPAK
9960 9970 9980 9990 10000
APEIIDVSSK AEEVKIMTIT RKKEVQKEKE AVYEKKQAVH KEKRVFIESF
10010 10020 10030 10040 10050
EEPYDELEVE PYTEPFEQPY YEEPDEDYEE IKVEAKKEVH EEWEEDFEEG
10060 10070 10080 10090 10100
QEYYEREEGY DEGEEEWEEA YQEREVIQVQ KEVYEESHER KVPAKVPEKK
10110 10120 10130 10140 10150
APPPPKVIKK PVIEKIEKTS RRMEEEKVQV TKVPEVSKKI VPQKPSRTPV
10160 10170 10180 10190 10200
QEEVIEVKVP AVHTKKMVIS EEKMFFASHT EEEVSVTVPE VQKEIVTEEK
10210 10220 10230 10240 10250
IHVAISKRVE PPPKVPELPE KPAPEEVAPV PIPKKVEPPA PKVPEVPKKP
10260 10270 10280 10290 10300
VPEEKKPVPV PKKEPAAPPK VPEVPKKPVP EEKIPVPVAK KKEAPPAKVP
10310 10320 10330 10340 10350
EVQKGVVTEE KITIVTQREE SPPPAVPEIP KKKVPEERKP VPRKEEEVPP
10360 10370 10380 10390 10400
PPKVPALPKK PVPEEKVAVP VPVAKKAPPP RAEVSKKTVV EEKRFVAEEK
10410 10420 10430 10440 10450
LSFAVPQRVE VTRHEVSAEE EWSYSEEEEG VSISVYREEE REEEEEAEVT
10460 10470 10480 10490 10500
EYEVMEEPEE YVVEEKLHII SKRVEAEPAE VTERQEKKIV LKPKIPAKIE
10510 10520 10530 10540 10550
EPPPAKVPEA PKKIVPEKKV PAPVPKKEKV PPPKVPEEPK KPVPEKKVPP
10560 10570 10580 10590 10600
KVIKMEEPLP AKVTERHMQI TQEEKVLVAV TKKEAPPKAR VPEEPKRAVP
10610 10620 10630 10640 10650
EEKVLKLKPK REEEPPAKVT EFRKRVVKEE KVSIEAPKRE PQPIKEVTIM
10660 10670 10680 10690 10700
EEKERAYTLE EEAVSVQREE EYEEYEEYDY KEFEEYEPTE EYDQYEEYEE
10710 10720 10730 10740 10750
REYERYEEHE EYITEPEKPI PVKPVPEEPV PTKPKAPPAK VLKKAVPEEK
10760 10770 10780 10790 10800
VPVPIPKKLK PPPPKVPEEP KKVFEEKIRI SITKREKEQV TEPAAKVPMK
10810 10820 10830 10840 10850
PKRVVAEEKV PVPRKEVAPP VRVPEVPKEL EPEEVAFEEE VVTHVEEYLV
10860 10870 10880 10890 10900
EEEEEYIHEE EEFITEEEVV PVIPVKVPEV PRKPVPEEKK PVPVPKKKEA
10910 10920 10930 10940 10950
PPAKVPEVPK KPEEKVPVLI PKKEKPPPAK VPEVPKKPVP EEKVPVPVPK
10960 10970 10980 10990 11000
KVEAPPAKVP EVPKKPVPEK KVPVPAPKKV EAPPAKVPEV PKKLIPEEKK
11010 11020 11030 11040 11050
PTPVPKKVEA PPPKVPKKRE PVPVPVALPQ EEEVLFEEEI VPEEEVLPEE
11060 11070 11080 11090 11100
EEVLPEEEEV LPEEEEVLPE EEEIPPEEEE VPPEEEYVPE EEEFVPEEEV
11110 11120 11130 11140 11150
LPEVKPKVPV PAPVPEIKKK VTEKKVVIPK KEEAPPAKVP EVPKKVEEKR
11160 11170 11180 11190 11200
IILPKEEEVL PVEVTEEPEE EPISEEEIPE EPPSIEEVEE VAPPRVPEVI
11210 11220 11230 11240 11250
KKAVPEAPTP VPKKVEAPPA KVSKKIPEEK VPVPVQKKEA PPAKVPEVPK
11260 11270 11280 11290 11300
KVPEKKVLVP KKEAVPPAKG RTVLEEKVSV AFRQEVVVKE RLELEVVEAE
11310 11320 11330 11340 11350
VEEIPEEEEF HEVEEYFEEG EFHEVEEFIK LEQHRVEEEH RVEKVHRVIE
11360 11370 11380 11390 11400
VFEAEEVEVF EKPKAPPKGP EISEKIIPPK KPPTKVVPRK EPPAKVPEVP
11410 11420