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UniProtKB - Q8WZ42 (TITIN_HUMAN)

Protein

Titin

Gene

TTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.1 Publication

Miscellaneous

In some isoforms, after the PEVK repeat region there is a long PEVK duplicated region. On account of this region, it has been very difficult to sequence the whole protein. The length of this region (ranging from 183 to 2174 residues), may be a key elastic element of titin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Full activation of the protein kinase domain requires both phosphorylation of Tyr-32341, preventing it from blocking the catalytic aspartate residue, and binding of Ca/CALM to the C-terminal regulatory tail of the molecule which results in ATP binding to the kinase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32207ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei32298Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi32184 – 32192ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-390522 Striated Muscle Contraction

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8WZ42

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8WZ42

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q8WZ42 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Titin (EC:2.7.11.1)
Alternative name(s):
Connectin
Rhabdomyosarcoma antigen MU-RMS-40.14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000155657.24

Human Gene Nomenclature Database

More...HGNCi		HGNC:12403 TTN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		188840 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WZ42

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hereditary myopathy with early respiratory failure (HMERF)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant, adult-onset myopathy with early respiratory muscle involvement.
See also OMIM:603689
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026634279R → W in HMERF; disrupts NBR1-binding. 1 PublicationCorresponds to variant dbSNP:rs138060032EnsemblClinVar.1
Cardiomyopathy, familial hypertrophic 9 (CMH9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:613765
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026687740R → L in CMH9. 1 PublicationCorresponds to variant dbSNP:rs28933405EnsemblClinVar.1
Cardiomyopathy, dilated 1G (CMD1G)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:604145
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02668554V → M in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs139517732EnsemblClinVar.1
Natural variantiVAR_026688743A → V in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs267607157EnsemblClinVar.1
Natural variantiVAR_026689976W → R in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs267607155EnsemblClinVar.1
Natural variantiVAR_0266903799S → Y in CMD1G. 1 Publication1
Natural variantiVAR_0266924465S → N in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs281864908Ensembl.1
Natural variantiVAR_02669332996R → Q in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs199642423Ensembl.1
Tardive tibial muscular dystrophy (TMD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant, late-onset distal myopathy. Muscle weakness and atrophy are usually confined to the anterior compartment of the lower leg, in particular the tibialis anterior muscle. Clinical symptoms usually occur at age 35-45 years or much later.
See also OMIM:600334
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02669434306I → N in TMD. 1 PublicationCorresponds to variant dbSNP:rs281864928Ensembl.1
Natural variantiVAR_02669534315L → P in TMD. 1 PublicationCorresponds to variant dbSNP:rs267607156Ensembl.1
Limb-girdle muscular dystrophy 2J (LGMD2J)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive degenerative myopathy characterized by progressive weakness of the pelvic and shoulder girdle muscles. Severe disability is observed within 20 years of onset.
See also OMIM:608807
Salih myopathy (SALMY)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, early-onset muscular disorder characterized by dilated cardiomyopathy, delayed motor development with generalized muscle weakness predominantly affecting proximal and distal lower limbs. Skeletal muscle biopsies show minicore-like lesions with mitochondrial depletion and sarcomere disorganization, centralized nuclei, and type 1 fiber predominance. Dystrophic changes become apparent in the second decade. Cardiac muscle biopsies show disruption of myocardial architecture, nuclear hypertrophy, and endomysial fibrosis. Sudden death may occurr due to cardiomyopathy.
See also OMIM:611705

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32207K → A: Disrupts catalytic activity. 1 Publication1
Mutagenesisi32341Y → E: No phosphorylation on tyrosine. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET

More...DisGeNETi		7273

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TTN

MalaCards human disease database

More...MalaCardsi		TTN
MIMi600334 phenotype
603689 phenotype
604145 phenotype
608807 phenotype
611705 phenotype
613765 phenotype

Open Targets

More...OpenTargetsi		ENSG00000155657

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169186 Autosomal recessive centronuclear myopathy
140922 Autosomal recessive limb-girdle muscular dystrophy type 2J
466921 Childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome
324604 Classic multiminicore myopathy
289377 Early-onset myopathy with fatal cardiomyopathy
293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
154 Familial isolated dilated cardiomyopathy
178464 Hereditary proximal myopathy with early respiratory failure
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
609 Tibial muscular dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37067

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TTN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002393111 – 34350TitinAdd BLAST34350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei267PhosphothreonineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi964 ↔ 1015PROSITE-ProRule annotation
Disulfide bondi1724 ↔ 1777PROSITE-ProRule annotation
Disulfide bondi2109 ↔ 2134PROSITE-ProRule annotation1 Publication
Disulfide bondi2196 ↔ 2246PROSITE-ProRule annotation
Disulfide bondi3259 ↔ 3311PROSITE-ProRule annotation
Disulfide bondi4404 ↔ 4455PROSITE-ProRule annotation
Disulfide bondi4499 ↔ 4550PROSITE-ProRule annotation
Disulfide bondi4592 ↔ 4643PROSITE-ProRule annotation
Disulfide bondi4686 ↔ 4737PROSITE-ProRule annotation
Disulfide bondi4779 ↔ 4830PROSITE-ProRule annotation
Disulfide bondi5061 ↔ 5112PROSITE-ProRule annotation
Disulfide bondi5248 ↔ 5299PROSITE-ProRule annotation
Disulfide bondi5623 ↔ 5674PROSITE-ProRule annotation
Disulfide bondi5810 ↔ 5861PROSITE-ProRule annotation
Disulfide bondi5903 ↔ 5954PROSITE-ProRule annotation
Disulfide bondi6185 ↔ 6236PROSITE-ProRule annotation
Disulfide bondi6372 ↔ 6423PROSITE-ProRule annotation
Disulfide bondi6465 ↔ 6516PROSITE-ProRule annotation
Disulfide bondi6748 ↔ 6799PROSITE-ProRule annotation
Modified residuei6920PhosphoserineBy similarity1
Disulfide bondi7027 ↔ 7078PROSITE-ProRule annotation
Disulfide bondi7123 ↔ 7174PROSITE-ProRule annotation
Disulfide bondi7219 ↔ 7270PROSITE-ProRule annotation
Disulfide bondi7313 ↔ 7364PROSITE-ProRule annotation
Disulfide bondi7406 ↔ 7457PROSITE-ProRule annotation
Disulfide bondi7689 ↔ 7740PROSITE-ProRule annotation
Disulfide bondi7968 ↔ 8019PROSITE-ProRule annotation
Disulfide bondi8064 ↔ 8115PROSITE-ProRule annotation
Disulfide bondi8160 ↔ 8211PROSITE-ProRule annotation
Disulfide bondi8254 ↔ 8305PROSITE-ProRule annotation
Disulfide bondi8347 ↔ 8398PROSITE-ProRule annotation
Disulfide bondi8630 ↔ 8681PROSITE-ProRule annotation
Disulfide bondi8909 ↔ 8960PROSITE-ProRule annotation
Disulfide bondi9005 ↔ 9056PROSITE-ProRule annotation
Disulfide bondi9101 ↔ 9152PROSITE-ProRule annotation
Modified residuei9122PhosphoserineBy similarity1
Disulfide bondi9294 ↔ 9345PROSITE-ProRule annotation
Disulfide bondi9693 ↔ 9743PROSITE-ProRule annotation
Modified residuei11503PhosphoserineBy similarity1
Modified residuei12007PhosphothreonineBy similarity1
Modified residuei12009PhosphoserineBy similarity1
Modified residuei12022PhosphoserineBy similarity1
Disulfide bondi12067 ↔ 12117PROSITE-ProRule annotation
Disulfide bondi12611 ↔ 12660PROSITE-ProRule annotation
Disulfide bondi12966 ↔ 13016PROSITE-ProRule annotation
Disulfide bondi13233 ↔ 13283PROSITE-ProRule annotation
Disulfide bondi13322 ↔ 13372PROSITE-ProRule annotation
Disulfide bondi13411 ↔ 13461PROSITE-ProRule annotation
Disulfide bondi13771 ↔ 13821PROSITE-ProRule annotation
Modified residuei30443PhosphothreonineBy similarity1
Disulfide bondi31481 ↔ 31532PROSITE-ProRule annotation
Modified residuei32341Phosphotyrosine1 Publication1
Disulfide bondi32516 ↔ 32568PROSITE-ProRule annotation
Modified residuei33245PhosphoserineBy similarity1
Modified residuei33247PhosphoserineBy similarity1
Modified residuei33602PhosphoserineBy similarity1
Modified residuei33614PhosphoserineBy similarity1
Disulfide bondi33664 ↔ 33718PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WZ42

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WZ42

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WZ42

PeptideAtlas

More...PeptideAtlasi		Q8WZ42

PRoteomics IDEntifications database

More...PRIDEi		Q8WZ42

ProteomicsDB human proteome resource

More...ProteomicsDBi		75209
75210 [Q8WZ42-10]
75211 [Q8WZ42-11]
75212 [Q8WZ42-2]
75213 [Q8WZ42-3]
75214 [Q8WZ42-4]
75215 [Q8WZ42-5]
75216 [Q8WZ42-6]
75217 [Q8WZ42-7]
75218 [Q8WZ42-8]
75219 [Q8WZ42-9]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q8WZ42

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WZ42

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WZ42

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8WZ42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155657 Expressed in 160 organ(s), highest expression level in muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WZ42 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WZ42 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB022682
HPA007042
HPA030048

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts with actin, primarily via the PEVK domains and with MYPN (By similarity). Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains. Interacts with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142. Interacts with ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via immunoglobulin domain 79. Interacts with NBR1 through the protein kinase domain. Interacts with CALM/calmodulin. Isoform 6 interacts with OBSCN isoform 3. Interacts with CMYA5.By similarity13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113124, 70 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-101 Titin-Telethonin complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8WZ42

Database of interacting proteins

More...DIPi		DIP-33449N

Protein interaction database and analysis system

More...IntActi		Q8WZ42, 90 interactors

Molecular INTeraction database

More...MINTi		Q8WZ42

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343764

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

134350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

More...DisProti		DP00072

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8WZ42

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WZ42

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8WZ42

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 96Ig-like 1Add BLAST91
Domaini104 – 192Ig-like 2Add BLAST89
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati417 – 462Z-repeat 1Add BLAST46
Repeati466 – 511Z-repeat 2Add BLAST46
Repeati512 – 554Z-repeat 3Add BLAST43
Repeati555 – 600Z-repeat 4Add BLAST46
Repeati601 – 646Z-repeat 5Add BLAST46
Repeati647 – 691Z-repeat 6Add BLAST45
Repeati692 – 740Z-repeat 7Add BLAST49
Domaini943 – 1031Ig-like 3Add BLAST89
Domaini1082 – 1172Ig-like 4Add BLAST91
Domaini1291 – 1382Ig-like 5Add BLAST92
Domaini1457 – 1546Ig-like 6Add BLAST90
Domaini1556 – 1646Ig-like 7Add BLAST91
Domaini1703 – 1793Ig-like 8Add BLAST91
Domaini1841 – 1928Ig-like 9Add BLAST88
Domaini2078 – 2167Ig-like 10Add BLAST90
Domaini2171 – 2262Ig-like 11Add BLAST92
Domaini2264 – 2354Ig-like 12Add BLAST91
Domaini2353 – 2443Ig-like 13Add BLAST91
Domaini2430 – 2529Ig-like 14Add BLAST100
Domaini2620 – 2703Ig-like 15Add BLAST84
Domaini2880 – 2965Ig-like 16Add BLAST86
Domaini2968 – 3050Ig-like 17Add BLAST83
Domaini3058 – 3141Ig-like 18Add BLAST84
Domaini3239 – 3327Ig-like 19Add BLAST89
Domaini3344 – 3432Ig-like 20Add BLAST89
Domaini3503 – 3586Ig-like 21Add BLAST84
Domaini3621 – 3712Ig-like 22Add BLAST92
Domaini4289 – 4376Ig-like 23Add BLAST88
Domaini4383 – 4471Ig-like 24Add BLAST89
Domaini4478 – 4566Ig-like 25Add BLAST89
Domaini4571 – 4659Ig-like 26Add BLAST89
Domaini4664 – 4753Ig-like 27Add BLAST90
Domaini4758 – 4846Ig-like 28Add BLAST89
Domaini4851 – 4936Ig-like 29Add BLAST86
Domaini4943 – 5032Ig-like 30Add BLAST90
Domaini5040 – 5128Ig-like 31Add BLAST89
Domaini5133 – 5221Ig-like 32Add BLAST89
Domaini5225 – 5314Ig-like 33Add BLAST90
Domaini5320 – 5408Ig-like 34Add BLAST89
Domaini5413 – 5501Ig-like 35Add BLAST89
Domaini5505 – 5594Ig-like 36Add BLAST90
Domaini5602 – 5690Ig-like 37Add BLAST89
Domaini5695 – 5783Ig-like 38Add BLAST89
Domaini5788 – 5877Ig-like 39Add BLAST90
Domaini5882 – 5970Ig-like 40Add BLAST89
Domaini5975 – 6063Ig-like 41Add BLAST89
Domaini6067 – 6156Ig-like 42Add BLAST90
Domaini6164 – 6252Ig-like 43Add BLAST89
Domaini6257 – 6347Ig-like 44Add BLAST91
Domaini6350 – 6440Ig-like 45Add BLAST91
Domaini6444 – 6534Ig-like 46Add BLAST91
Domaini6537 – 6626Ig-like 47Add BLAST90
Domaini6630 – 6721Ig-like 48Add BLAST92
Domaini6727 – 6815Ig-like 49Add BLAST89
Domaini6820 – 6908Ig-like 50Add BLAST89
Domaini6912 – 7001Ig-like 51Add BLAST90
Domaini7005 – 7093Ig-like 52Add BLAST89
Domaini7102 – 7190Ig-like 53Add BLAST89
Domaini7198 – 7286Ig-like 54Add BLAST89
Domaini7291 – 7380Ig-like 55Add BLAST90
Domaini7385 – 7473Ig-like 56Add BLAST89
Domaini7478 – 7567Ig-like 57Add BLAST90
Domaini7571 – 7662Ig-like 58Add BLAST92
Domaini7668 – 7756Ig-like 59Add BLAST89
Domaini7761 – 7849Ig-like 60Add BLAST89
Domaini7853 – 7942Ig-like 61Add BLAST90
Domaini7946 – 8035Ig-like 62Add BLAST90
Domaini8042 – 8133Ig-like 63Add BLAST92
Domaini8138 – 8229Ig-like 64Add BLAST92
Domaini8232 – 8321Ig-like 65Add BLAST90
Domaini8326 – 8414Ig-like 66Add BLAST89
Domaini8419 – 8508Ig-like 67Add BLAST90
Domaini8512 – 8603Ig-like 68Add BLAST92
Domaini8609 – 8697Ig-like 69Add BLAST89
Domaini8702 – 8790Ig-like 70Add BLAST89
Domaini8794 – 8883Ig-like 71Add BLAST90
Domaini8888 – 8976Ig-like 72Add BLAST89
Domaini8984 – 9074Ig-like 73Add BLAST91
Domaini9079 – 9168Ig-like 74Add BLAST90
Domaini9176 – 9265Ig-like 75Add BLAST90
Domaini9272 – 9361Ig-like 76Add BLAST90
Domaini9366 – 9470Ig-like 77Add BLAST105
Domaini9660 – 9755Ig-like 78Add BLAST96
Domaini9760 – 9851Ig-like 79Add BLAST92
Repeati10216 – 10242PEVK 1Add BLAST27
Repeati10244 – 10270PEVK 2Add BLAST27
Repeati10272 – 10298PEVK 3Add BLAST27
Repeati10300 – 10326PEVK 4Add BLAST27
Repeati10327 – 10353PEVK 5Add BLAST27
Repeati10355 – 10381PEVK 6Add BLAST27
Repeati10508 – 10534PEVK 7Add BLAST27
Repeati10536 – 10562PEVK 8Add BLAST27
Repeati10592 – 10618PEVK 9Add BLAST27
Repeati10878 – 10904PEVK 10Add BLAST27
Repeati10906 – 10930PEVK 11Add BLAST25
Repeati10932 – 10958PEVK 12Add BLAST27
Repeati10960 – 10986PEVK 13Add BLAST27
Repeati10987 – 11014PEVK 14Add BLAST28
Repeati11363 – 11396PEVK 15Add BLAST34
Repeati11397 – 11421PEVK 16Add BLAST25
Repeati11453 – 11479PEVK 17Add BLAST27
Repeati11481 – 11507PEVK 18Add BLAST27
Repeati11509 – 11535PEVK 19Add BLAST27
Repeati11537 – 11563PEVK 20Add BLAST27
Repeati11565 – 11591PEVK 21Add BLAST27
Repeati11657 – 11683PEVK 22Add BLAST27
Repeati11703 – 11729PEVK 23Add BLAST27
Repeati11745 – 11771PEVK 24Add BLAST27
Repeati11775 – 11801PEVK 25Add BLAST27
Repeati11836 – 11862PEVK 26Add BLAST27
Repeati11864 – 11890PEVK 27Add BLAST27
Repeati11893 – 11919PEVK 28Add BLAST27
Repeati11929 – 11955PEVK 29Add BLAST27
Repeati11966 – 11992PEVK 30Add BLAST27
Repeati11996 – 12022PEVK 31Add BLAST27
Domaini12041 – 12133Ig-like 80Add BLAST93
Domaini12138 – 12222Ig-like 81Add BLAST85
Domaini12233 – 12318Ig-like 82Add BLAST86
Domaini12499 – 12584Ig-like 83Add BLAST86
Domaini12590 – 12672Ig-like 84Add BLAST83
Domaini12766 – 12850Ig-like 85Add BLAST85
Domaini12945 – 13032Ig-like 86Add BLAST88
Domaini13120 – 13206Ig-like 87Add BLAST87
Domaini13210 – 13295Ig-like 88Add BLAST86
Domaini13299 – 13384Ig-like 89Add BLAST86
Domaini13388 – 13478Ig-like 90Add BLAST91
Domaini13479 – 13562Ig-like 91Add BLAST84
Domaini13565 – 13655Ig-like 92Add BLAST91
Domaini13659 – 13748Ig-like 93Add BLAST90
Domaini13749 – 13833Ig-like 94Add BLAST85
Domaini13927 – 14012Ig-like 95Add BLAST86
Domaini14019 – 14114Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini14120 – 14215Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini14221 – 14316Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini14417 – 14513Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini14517 – 14614Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST98
Domaini14615 – 14708Ig-like 96Add BLAST94
Domaini14713 – 14806Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini14812 – 14907Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini14913 – 15007Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini15010 – 15107Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini15113 – 15207Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST95
Domaini15214 – 15310Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini15314 – 15402Ig-like 97Add BLAST89
Domaini15409 – 15503Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST95
Domaini15509 – 15604Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST96
Domaini15608 – 15724Ig-like 98Add BLAST117
Domaini15731 – 15826Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST96
Domaini15832 – 15926Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST95
Domaini15929 – 16025Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST97
Domaini16029 – 16119Ig-like 99Add BLAST91
Domaini16126 – 16218Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST93
Domaini16224 – 16318Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST95
Domaini16322 – 16420Ig-like 100Add BLAST99
Domaini16427 – 16522Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST96
Domaini16528 – 16628Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST101
Domaini16634 – 16734Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST101
Domaini16727 – 16834Ig-like 101Add BLAST108
Domaini16841 – 16934Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST94
Domaini16941 – 17041Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST101
Domaini17044 – 17139Ig-like 102Add BLAST96
Domaini17147 – 17240Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST94
Domaini17246 – 17345Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST100
Domaini17348 – 17445Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST98
Domaini17449 – 17536Ig-like 103Add BLAST88
Domaini17545 – 17640Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST96
Domaini17646 – 17741Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST96
Domaini17745 – 17834Ig-like 104Add BLAST90
Domaini17842 – 17935Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST94
Domaini17941 – 18036Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST96
Domaini18042 – 18139Fibronectin type-III 31PROSITE-ProRule annotationAdd BLAST98
Domaini18143 – 18228Ig-like 105Add BLAST86
Domaini18239 – 18333Fibronectin type-III 32PROSITE-ProRule annotationAdd BLAST95
Domaini18339 – 18431Fibronectin type-III 33PROSITE-ProRule annotationAdd BLAST93
Domaini18435 – 18526Ig-like 106Add BLAST92
Domaini18533 – 18632Fibronectin type-III 34PROSITE-ProRule annotationAdd BLAST100
Domaini18633 – 18727Fibronectin type-III 35PROSITE-ProRule annotationAdd BLAST95
Domaini18733 – 18829Fibronectin type-III 36PROSITE-ProRule annotationAdd BLAST97
Domaini18833 – 18924Ig-like 107Add BLAST92
Domaini18931 – 19025Fibronectin type-III 37PROSITE-ProRule annotationAdd BLAST95
Domaini19030 – 19124Fibronectin type-III 38PROSITE-ProRule annotationAdd BLAST95
Domaini19128 – 19219Ig-like 108Add BLAST92
Domaini19226 – 19321Fibronectin type-III 39PROSITE-ProRule annotationAdd BLAST96
Domaini19325 – 19420Fibronectin type-III 40PROSITE-ProRule annotationAdd BLAST96
Domaini19426 – 19527Fibronectin type-III 41PROSITE-ProRule annotationAdd BLAST102
Domaini19531 – 19617Ig-like 109Add BLAST87
Domaini19628 – 19722Fibronectin type-III 42PROSITE-ProRule annotationAdd BLAST95
Domaini19728 – 19823Fibronectin type-III 43PROSITE-ProRule annotationAdd BLAST96
Domaini19826 – 19914Ig-like 110Add BLAST89
Domaini19921 – 20017Fibronectin type-III 44PROSITE-ProRule annotationAdd BLAST97
Domaini20018 – 20116Fibronectin type-III 45PROSITE-ProRule annotationAdd BLAST99
Domaini20119 – 20217Fibronectin type-III 46PROSITE-ProRule annotationAdd BLAST99
Domaini20220 – 20311Ig-like 111Add BLAST92
Domaini20318 – 20411Fibronectin type-III 47PROSITE-ProRule annotationAdd BLAST94
Domaini20417 – 20512Fibronectin type-III 48PROSITE-ProRule annotationAdd BLAST96
Domaini20518 – 20613Fibronectin type-III 49PROSITE-ProRule annotationAdd BLAST96
Domaini20716 – 20813Fibronectin type-III 50PROSITE-ProRule annotationAdd BLAST98
Domaini20814 – 20908Fibronectin type-III 51PROSITE-ProRule annotationAdd BLAST95
Domaini20893 – 20996Ig-like 112Add BLAST104
Domaini21006 – 21101Fibronectin type-III 52PROSITE-ProRule annotationAdd BLAST96
Domaini21105 – 21200Fibronectin type-III 53PROSITE-ProRule annotationAdd BLAST96
Domaini21203 – 21299Fibronectin type-III 54PROSITE-ProRule annotationAdd BLAST97
Domaini21303 – 21395Ig-like 113Add BLAST93
Domaini21402 – 21495Fibronectin type-III 55PROSITE-ProRule annotationAdd BLAST94
Domaini21501 – 21596Fibronectin type-III 56PROSITE-ProRule annotationAdd BLAST96
Domaini21602 – 21697Fibronectin type-III 57PROSITE-ProRule annotationAdd BLAST96
Domaini21701 – 21793Ig-like 114Add BLAST93
Domaini21797 – 21891Fibronectin type-III 58PROSITE-ProRule annotationAdd BLAST95
Domaini21894 – 21986Fibronectin type-III 59PROSITE-ProRule annotationAdd BLAST93
Domaini21990 – 22083Ig-like 115Add BLAST94
Domaini22088 – 22182Fibronectin type-III 60PROSITE-ProRule annotationAdd BLAST95
Domaini22188 – 22283Fibronectin type-III 61PROSITE-ProRule annotationAdd BLAST96
Domaini22286 – 22382Fibronectin type-III 62PROSITE-ProRule annotationAdd BLAST97
Domaini22386 – 22477Ig-like 116Add BLAST92
Domaini22484 – 22578Fibronectin type-III 63PROSITE-ProRule annotationAdd BLAST95
Domaini22584 – 22679Fibronectin type-III 64PROSITE-ProRule annotationAdd BLAST96
Domaini22685 – 22781Fibronectin type-III 65PROSITE-ProRule annotationAdd BLAST97
Domaini22785 – 22874Ig-like 117Add BLAST90
Domaini22881 – 22976Fibronectin type-III 66PROSITE-ProRule annotationAdd BLAST96
Domaini22978 – 23071Fibronectin type-III 67PROSITE-ProRule annotationAdd BLAST94
Domaini23075 – 23163Ig-like 118Add BLAST89
Domaini23170 – 23264Fibronectin type-III 68PROSITE-ProRule annotationAdd BLAST95
Domaini23270 – 23364Fibronectin type-III 69PROSITE-ProRule annotationAdd BLAST95
Domaini23368 – 23463Fibronectin type-III 70PROSITE-ProRule annotationAdd BLAST96
Domaini23468 – 23555Ig-like 119Add BLAST88
Domaini23566 – 23660Fibronectin type-III 71PROSITE-ProRule annotationAdd BLAST95
Domaini23666 – 23761Fibronectin type-III 72PROSITE-ProRule annotationAdd BLAST96
Domaini23767 – 23863Fibronectin type-III 73PROSITE-ProRule annotationAdd BLAST97
Domaini23867 – 23954Ig-like 120Add BLAST88
Domaini23963 – 24057Fibronectin type-III 74PROSITE-ProRule annotationAdd BLAST95
Domaini24060 – 24153Fibronectin type-III 75PROSITE-ProRule annotationAdd BLAST94
Domaini24157 – 24241Ig-like 121Add BLAST85
Domaini24252 – 24346Fibronectin type-III 76PROSITE-ProRule annotationAdd BLAST95
Domaini24352 – 24446Fibronectin type-III 77PROSITE-ProRule annotationAdd BLAST95
Domaini24450 – 24546Fibronectin type-III 78PROSITE-ProRule annotationAdd BLAST97
Domaini24550 – 24641Ig-like 122Add BLAST92
Domaini24648 – 24742Fibronectin type-III 79PROSITE-ProRule annotationAdd BLAST95
Domaini24748 – 24843Fibronectin type-III 80PROSITE-ProRule annotationAdd BLAST96
Domaini24849 – 24945Fibronectin type-III 81PROSITE-ProRule annotationAdd BLAST97
Domaini24949 – 25038Ig-like 123Add BLAST90
Domaini25045 – 25139Fibronectin type-III 82PROSITE-ProRule annotationAdd BLAST95
Domaini25142 – 25235Fibronectin type-III 83PROSITE-ProRule annotationAdd BLAST94
Domaini25239 – 25325Ig-like 124Add BLAST87
Domaini25335 – 25428Fibronectin type-III 84PROSITE-ProRule annotationAdd BLAST94
Domaini25434 – 25529Fibronectin type-III 85PROSITE-ProRule annotationAdd BLAST96
Domaini25532 – 25627Fibronectin type-III 86PROSITE-ProRule annotationAdd BLAST96
Domaini25632 – 25722Ig-like 125Add BLAST91
Domaini25731 – 25825Fibronectin type-III 87PROSITE-ProRule annotationAdd BLAST95
Domaini25831 – 25926Fibronectin type-III 88PROSITE-ProRule annotationAdd BLAST96
Domaini25932 – 26028Fibronectin type-III 89PROSITE-ProRule annotationAdd BLAST97
Domaini26032 – 26121Ig-like 126Add BLAST90
Domaini26128 – 26222Fibronectin type-III 90PROSITE-ProRule annotationAdd BLAST95
Domaini26225 – 26318Fibronectin type-III 91PROSITE-ProRule annotationAdd BLAST94
Domaini26322 – 26410Ig-like 127Add BLAST89
Domaini26417 – 26510Fibronectin type-III 92PROSITE-ProRule annotationAdd BLAST94
Domaini26516 – 26611Fibronectin type-III 93PROSITE-ProRule annotationAdd BLAST96
Domaini26614 – 26710Fibronectin type-III 94PROSITE-ProRule annotationAdd BLAST97
Domaini26714 – 26801Ig-like 128Add BLAST88
Domaini26812 – 26906Fibronectin type-III 95PROSITE-ProRule annotationAdd BLAST95
Domaini26912 – 27007Fibronectin type-III 96PROSITE-ProRule annotationAdd BLAST96
Domaini27013 – 27107Fibronectin type-III 97PROSITE-ProRule annotationAdd BLAST95
Domaini27101 – 27196Ig-like 129Add BLAST96
Domaini27205 – 27296Fibronectin type-III 98PROSITE-ProRule annotationAdd BLAST92
Domaini27302 – 27392Fibronectin type-III 99PROSITE-ProRule annotationAdd BLAST91
Domaini27499 – 27593Fibronectin type-III 100PROSITE-ProRule annotationAdd BLAST95
Domaini27599 – 27694Fibronectin type-III 101PROSITE-ProRule annotationAdd BLAST96
Domaini27697 – 27793Fibronectin type-III 102PROSITE-ProRule annotationAdd BLAST97
Domaini27797 – 27888Ig-like 130Add BLAST92
Domaini27895 – 27989Fibronectin type-III 103PROSITE-ProRule annotationAdd BLAST95
Domaini27995 – 28090Fibronectin type-III 104PROSITE-ProRule annotationAdd BLAST96
Domaini28096 – 28192Fibronectin type-III 105PROSITE-ProRule annotationAdd BLAST97
Domaini28196 – 28286Ig-like 131Add BLAST91
Domaini28295 – 28389Fibronectin type-III 106PROSITE-ProRule annotationAdd BLAST95
Domaini28392 – 28484Fibronectin type-III 107PROSITE-ProRule annotationAdd BLAST93
Domaini28488 – 28577Ig-like 132Add BLAST90
Domaini28583 – 28680Fibronectin type-III 108PROSITE-ProRule annotationAdd BLAST98
Domaini28686 – 28781Fibronectin type-III 109PROSITE-ProRule annotationAdd BLAST96
Domaini28784 – 28879Fibronectin type-III 110PROSITE-ProRule annotationAdd BLAST96
Domaini28882 – 28974Ig-like 133Add BLAST93
Domaini28979 – 29071Fibronectin type-III 111PROSITE-ProRule annotationAdd BLAST93
Domaini29081 – 29177Fibronectin type-III 112PROSITE-ProRule annotationAdd BLAST97
Domaini29180 – 29278Fibronectin type-III 113PROSITE-ProRule annotationAdd BLAST99
Domaini29282 – 29367Ig-like 134Add BLAST86
Domaini29378 – 29473Fibronectin type-III 114PROSITE-ProRule annotationAdd BLAST96
Domaini29475 – 29568Fibronectin type-III 115PROSITE-ProRule annotationAdd BLAST94
Domaini29568 – 29663Ig-like 135Add BLAST96
Domaini29670 – 29764Fibronectin type-III 116PROSITE-ProRule annotationAdd BLAST95
Domaini29770 – 29865Fibronectin type-III 117PROSITE-ProRule annotationAdd BLAST96
Domaini29868 – 29967Fibronectin type-III 118PROSITE-ProRule annotationAdd BLAST100
Domaini29971 – 30059Ig-like 136Add BLAST89
Domaini30070 – 30163Fibronectin type-III 119PROSITE-ProRule annotationAdd BLAST94
Domaini30169 – 30265Fibronectin type-III 120PROSITE-ProRule annotationAdd BLAST97
Domaini30271 – 30367Fibronectin type-III 121PROSITE-ProRule annotationAdd BLAST97
Domaini30371 – 30460Ig-like 137Add BLAST90
Domaini30467 – 30561Fibronectin type-III 122PROSITE-ProRule annotationAdd BLAST95
Domaini30564 – 30658Fibronectin type-III 123PROSITE-ProRule annotationAdd BLAST95
Domaini30663 – 30754Ig-like 138Add BLAST92
Domaini30761 – 30855Fibronectin type-III 124PROSITE-ProRule annotationAdd BLAST95
Domaini30861 – 30956Fibronectin type-III 125PROSITE-ProRule annotationAdd BLAST96
Domaini30962 – 31058Fibronectin type-III 126PROSITE-ProRule annotationAdd BLAST97
Domaini31061 – 31150Ig-like 139Add BLAST90
Domaini31158 – 31254Fibronectin type-III 127PROSITE-ProRule annotationAdd BLAST97
Domaini31258 – 31354Fibronectin type-III 128PROSITE-ProRule annotationAdd BLAST97
Domaini31360 – 31455Fibronectin type-III 129PROSITE-ProRule annotationAdd BLAST96
Domaini31460 – 31548Ig-like 140Add BLAST89
Domaini31653 – 31748Fibronectin type-III 130PROSITE-ProRule annotationAdd BLAST96
Domaini31754 – 31849Fibronectin type-III 131PROSITE-ProRule annotationAdd BLAST96
Domaini31855 – 31945Ig-like 141Add BLAST91
Domaini31955 – 32046Ig-like 142Add BLAST92
Domaini32051 – 32144Fibronectin type-III 132PROSITE-ProRule annotationAdd BLAST94
Domaini32178 – 32432Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini32496 – 32584Ig-like 143Add BLAST89
Domaini32617 – 32710Ig-like 144Add BLAST94
Domaini32722 – 32811Ig-like 145Add BLAST90
Domaini33301 – 33391Ig-like 146Add BLAST91
Domaini33488 – 33576Ig-like 147Add BLAST89
Domaini33645 – 33732Ig-like 148Add BLAST88
Domaini33779 – 33867Ig-like 149Add BLAST89
Domaini33963 – 34052Ig-like 150Add BLAST90
Domaini34061 – 34149Ig-like 151Add BLAST89
Domaini34256 – 34344Ig-like 152Add BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni253 – 341ZIS1Add BLAST89
Regioni1410 – 1440ZIS5Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili529 – 561Sequence analysisAdd BLAST33
Coiled coili2025 – 2052Sequence analysisAdd BLAST28
Coiled coili3462 – 3487Sequence analysisAdd BLAST26
Coiled coili9534 – 9577Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi391 – 436Ala-richAdd BLAST46
Compositional biasi453 – 456Poly-Thr4
Compositional biasi9500 – 9503Poly-Glu4
Compositional biasi9861 – 9952Pro-richAdd BLAST92
Compositional biasi9974 – 11917Glu-richAdd BLAST1944
Compositional biasi9974 – 10089Glu-richAdd BLAST116
Compositional biasi10102 – 10105Poly-Pro4
Compositional biasi10211 – 12032Pro-richAdd BLAST1822
Compositional biasi33188 – 33193Poly-Ser6
Compositional biasi33197 – 33200Poly-Arg4
Compositional biasi34102 – 34244Ser-richAdd BLAST143

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site.
The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0613 Eukaryota
ENOG410XQFD LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154034

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000203078

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG080472

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WZ42

KEGG Orthology (KO)

More...KOi		K12567

Identification of Orthologs from Complete Genome Data

More...OMAi		AEKMSPN

TreeFam database of animal gene trees

More...TreeFami		TF316477

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 132 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 194 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR004168 PPAK_motif
IPR000719 Prot_kinase_dom
IPR015129 Titin_Z_rpt
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 132 hits
PF07679 I-set, 162 hits
PF00069 Pkinase, 1 hit
PF02818 PPAK, 7 hits
PF09042 Titin_Z, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060 FN3, 132 hits
SM00409 IG, 167 hits
SM00408 IGc2, 148 hits
SM00406 IGv, 23 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 167 hits
SSF49265 SSF49265, 74 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 132 hits
PS50835 IG_LIKE, 140 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 13 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms may be produced, ranging from 27000 to 33000 residues in different striated muscle tissues, the size of the full-length protein may be up to 38138 residues.

This entry has 13 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WZ42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST 
        60         70         80         90        100
LPGVQISFSD GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE 
       110        120        130        140        150
TAPPNFVQRL QSMTVRQGSQ VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF 
       160        170        180        190        200
QISQEGDLYS LLIAEAYPED SGTYSVNATN SVGRATSTAE LLVQGEEEVP 
       210        220        230        240        250
AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV IDGAAGQQLP 
       260        270        280        290        300
HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT 
       310        320        330        340        350
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY 
       360        370        380        390        400
VASSSEAEMR ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA 
       410        420        430        440        450
SASYAAEAVA TGAKEVKQDA DKSAAVATVV AAVDMARVRE PVISAVEQTA 
       460        470        480        490        500
QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV VAADKAKEQE LKSRTKEVIT 
       510        520        530        540        550
TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS EEITKKQKQV 
       560        570        580        590        600
TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK 
       610        620        630        640        650
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE 
       660        670        680        690        700
AEKTALSTIA VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE 
       710        720        730        740        750
AVATVVAAVD QARVREPREP GHLEESYAQQ TTLEYGYKER ISAAKVAEPP 
       760        770        780        790        800
QRPASEPHVV PKAVKPRVIQ APSETHIKTT DQKGMHISSQ IKKTTDLTTE 
       810        820        830        840        850
RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA TLQKELSATS 
       860        870        880        890        900
SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK 
       910        920        930        940        950
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK 
       960        970        980        990       1000
NVTVIEGESV TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL 
      1010       1020       1030       1040       1050
MIREAFAEDS GRFTCSAVNE AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT 
      1060       1070       1080       1090       1100
TEEKRFVESR DVVMTDTSLT EEQAGPGEPA APYFITKPVV QKLVEGGSVV 
      1110       1120       1130       1140       1150
FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK LVISMTFADD 
      1160       1170       1180       1190       1200
AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP 
      1210       1220       1230       1240       1250
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF 
      1260       1270       1280       1290       1300
EERLIKEIEY RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY 
      1310       1320       1330       1340       1350
RILEGMGVTF HCKMSGYPLP KIAWYKDGKR IKHGERYQMD FLQDGRASLR 
      1360       1370       1380       1390       1400
IPVVLPEDEG IYTAFASNIK GNAICSGKLY VEPAAPLGAP TYIPTLEPVS 
      1410       1420       1430       1440       1450
RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG RRLEETDESQ 
      1460       1470       1480       1490       1500
LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND 
      1510       1520       1530       1540       1550
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV 
      1560       1570       1580       1590       1600
EHQVKPMFVE KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK 
      1610       1620       1630       1640       1650
YPKIRIEGTK GEAALKIDST VSQDSAWYTA TAINKAGRDT TRCKVNVEVE 
      1660       1670       1680       1690       1700
FAEPEPERKL IIPRGTYRAK EIAAPELEPL HLRYGQEQWE EGDLYDKEKQ 
      1710       1720       1730       1740       1750
QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH DGKPLEAANR 
      1760       1770       1780       1790       1800
LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL 
      1810       1820       1830       1840       1850
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV 
      1860       1870       1880       1890       1900
RVLEGETARF RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV 
      1910       1920       1930       1940       1950
DCKSYDTGEV KVTAENPEGV IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH 
      1960       1970       1980       1990       2000
VHEPGKLQFE VQKVDRPVDT TETKEVVKLK RAERITHEKV PEESEELRSK 
      2010       2020       2030       2040       2050
FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH WTKELTEEEK 
      2060       2070       2080       2090       2100
KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR 
      2110       2120       2130       2140       2150
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM 
      2160       2170       2180       2190       2200
VKAINIAGET SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE 
      2210       2220       2230       2240       2250
PFVKVKWYKD GMEVHEGDKY RMHSDRKVHF LSILTIDTSD AEDYSCVLVE 
      2260       2270       2280       2290       2300
DENVKTTAKL IVEGAVVEFV KELQDIEVPE SYSGELECIV SPENIEGKWY 
      2310       2320       2330       2340       2350
HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI DGKKTTCKLK 
      2360       2370       2380       2390       2400
MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR <