UniProtKB - Q8WZ42 (TITIN_HUMAN)
Titin
TTN
Functioni
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
1 PublicationMiscellaneous
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 32207 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 32298 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 32184 – 32192 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- actin filament binding Source: BHF-UCL
- actinin binding Source: BHF-UCL
- ATP binding Source: UniProtKB-KW
- calcium ion binding Source: BHF-UCL
- calmodulin binding Source: BHF-UCL
- enzyme binding Source: UniProtKB
- identical protein binding Source: IntAct
- muscle alpha-actinin binding Source: BHF-UCL
- protease binding Source: UniProtKB
- protein kinase binding Source: BHF-UCL
- protein self-association Source: BHF-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: MGI
- structural constituent of muscle Source: BHF-UCL
- structural molecule activity conferring elasticity Source: BHF-UCL
- telethonin binding Source: BHF-UCL
GO - Biological processi
- cardiac muscle cell development Source: BHF-UCL
- cardiac muscle contraction Source: BHF-UCL
- cardiac muscle hypertrophy Source: BHF-UCL
- cardiac muscle tissue morphogenesis Source: BHF-UCL
- cardiac myofibril assembly Source: BHF-UCL
- detection of muscle stretch Source: MGI
- mitotic chromosome condensation Source: BHF-UCL
- muscle contraction Source: UniProtKB
- positive regulation of gene expression Source: CAFA
- positive regulation of protein secretion Source: CAFA
- protein kinase A signaling Source: CAFA
- regulation of catalytic activity Source: BHF-UCL
- regulation of protein kinase activity Source: BHF-UCL
- response to calcium ion Source: BHF-UCL
- sarcomere organization Source: BHF-UCL
- sarcomerogenesis Source: BHF-UCL
- skeletal muscle myosin thick filament assembly Source: BHF-UCL
- skeletal muscle thin filament assembly Source: BHF-UCL
- striated muscle contraction Source: UniProtKB
Keywordsi
Molecular function | Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q8WZ42 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-390522, Striated Muscle Contraction |
SignaLinki | Q8WZ42 |
SIGNORi | Q8WZ42 |
Protein family/group databases
MoonDBi | Q8WZ42, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Titin (EC:2.7.11.1)Alternative name(s): Connectin Rhabdomyosarcoma antigen MU-RMS-40.14 |
Gene namesi | Name:TTN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12403, TTN |
MIMi | 188840, gene |
neXtProti | NX_Q8WZ42 |
VEuPathDBi | HostDB:ENSG00000155657 |
Subcellular locationi
Cytoskeleton
- striated muscle thin filament Source: BHF-UCL
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- condensed nuclear chromosome Source: BHF-UCL
Other locations
- I band Source: BHF-UCL
- M band Source: BHF-UCL
- titin-telethonin complex Source: ComplexPortal
- Z disc Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Myopathy, myofibrillar, 9, with early respiratory failure (MFM9)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026634 | 279 | R → W in MFM9; disrupts NBR1-binding. 1 PublicationCorresponds to variant dbSNP:rs138060032EnsemblClinVar. | 1 |
Cardiomyopathy, familial hypertrophic 9 (CMH9)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026687 | 740 | R → L in CMH9. 1 PublicationCorresponds to variant dbSNP:rs28933405EnsemblClinVar. | 1 |
Cardiomyopathy, dilated 1G (CMD1G)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026685 | 54 | V → M in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs139517732EnsemblClinVar. | 1 | |
Natural variantiVAR_026688 | 743 | A → V in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs267607157EnsemblClinVar. | 1 | |
Natural variantiVAR_026689 | 976 | W → R in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs267607155EnsemblClinVar. | 1 | |
Natural variantiVAR_026690 | 3799 | S → Y in CMD1G. 1 Publication | 1 | |
Natural variantiVAR_026692 | 4465 | S → N in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs281864908Ensembl. | 1 | |
Natural variantiVAR_026693 | 32996 | R → Q in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs199642423Ensembl. | 1 |
Tardive tibial muscular dystrophy (TMD)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026694 | 34306 | I → N in TMD. 1 PublicationCorresponds to variant dbSNP:rs281864928Ensembl. | 1 | |
Natural variantiVAR_026695 | 34315 | L → P in TMD. 1 PublicationCorresponds to variant dbSNP:rs267607156Ensembl. | 1 |
Muscular dystrophy, limb-girdle, autosomal recessive 10 (LGMDR10)1 Publication
Salih myopathy (SALMY)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 32207 | K → A: Disrupts catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 32341 | Y → E: No phosphorylation on tyrosine. 1 Publication | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variant, Limb-girdle muscular dystrophy, Myofibrillar myopathyOrganism-specific databases
DisGeNETi | 7273 |
GeneReviewsi | TTN |
MalaCardsi | TTN |
MIMi | 600334, phenotype 603689, phenotype 604145, phenotype 608807, phenotype 611705, phenotype 613765, phenotype |
OpenTargetsi | ENSG00000155657 |
Orphaneti | 169186, Autosomal recessive centronuclear myopathy 466921, Childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome 324604, Classic multiminicore myopathy 289377, Early-onset myopathy with fatal cardiomyopathy 334, Familial atrial fibrillation 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 154, Familial isolated dilated cardiomyopathy 178464, Hereditary myopathy with early respiratory failure 155, NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy 609, Tibial muscular dystrophy 140922, Titin-related limb-girdle muscular dystrophy R10 |
PharmGKBi | PA37067 |
Miscellaneous databases
Pharosi | Q8WZ42, Tbio |
Genetic variation databases
BioMutai | TTN |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239311 | 1 – 34350 | TitinAdd BLAST | 34350 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 263 | PhosphoserineBy similarity | 1 | |
Modified residuei | 265 | PhosphoserineBy similarity | 1 | |
Modified residuei | 267 | PhosphothreonineBy similarity | 1 | |
Disulfide bondi | 964 ↔ 1015 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1724 ↔ 1777 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2109 ↔ 2134 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 2196 ↔ 2246 | PROSITE-ProRule annotation | ||
Disulfide bondi | 3259 ↔ 3311 | PROSITE-ProRule annotation | ||
Disulfide bondi | 4404 ↔ 4455 | PROSITE-ProRule annotation | ||
Disulfide bondi | 4499 ↔ 4550 | PROSITE-ProRule annotation | ||
Disulfide bondi | 4592 ↔ 4643 | PROSITE-ProRule annotation | ||
Disulfide bondi | 4686 ↔ 4737 | PROSITE-ProRule annotation | ||
Disulfide bondi | 4779 ↔ 4830 | PROSITE-ProRule annotation | ||
Disulfide bondi | 5061 ↔ 5112 | PROSITE-ProRule annotation | ||
Disulfide bondi | 5248 ↔ 5299 | PROSITE-ProRule annotation | ||
Disulfide bondi | 5623 ↔ 5674 | PROSITE-ProRule annotation | ||
Disulfide bondi | 5810 ↔ 5861 | PROSITE-ProRule annotation | ||
Disulfide bondi | 5903 ↔ 5954 | PROSITE-ProRule annotation | ||
Disulfide bondi | 6185 ↔ 6236 | PROSITE-ProRule annotation | ||
Disulfide bondi | 6372 ↔ 6423 | PROSITE-ProRule annotation | ||
Disulfide bondi | 6465 ↔ 6516 | PROSITE-ProRule annotation | ||
Disulfide bondi | 6748 ↔ 6799 | PROSITE-ProRule annotation | ||
Modified residuei | 6920 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 7027 ↔ 7078 | PROSITE-ProRule annotation | ||
Disulfide bondi | 7123 ↔ 7174 | PROSITE-ProRule annotation | ||
Disulfide bondi | 7219 ↔ 7270 | PROSITE-ProRule annotation | ||
Disulfide bondi | 7313 ↔ 7364 | PROSITE-ProRule annotation | ||
Disulfide bondi | 7406 ↔ 7457 | PROSITE-ProRule annotation | ||
Disulfide bondi | 7689 ↔ 7740 | PROSITE-ProRule annotation | ||
Disulfide bondi | 7968 ↔ 8019 | PROSITE-ProRule annotation | ||
Disulfide bondi | 8064 ↔ 8115 | PROSITE-ProRule annotation | ||
Disulfide bondi | 8160 ↔ 8211 | PROSITE-ProRule annotation | ||
Disulfide bondi | 8254 ↔ 8305 | PROSITE-ProRule annotation | ||
Disulfide bondi | 8347 ↔ 8398 | PROSITE-ProRule annotation | ||
Disulfide bondi | 8630 ↔ 8681 | PROSITE-ProRule annotation | ||
Disulfide bondi | 8909 ↔ 8960 | PROSITE-ProRule annotation | ||
Disulfide bondi | 9005 ↔ 9056 | PROSITE-ProRule annotation | ||
Disulfide bondi | 9101 ↔ 9152 | PROSITE-ProRule annotation | ||
Modified residuei | 9122 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 9294 ↔ 9345 | PROSITE-ProRule annotation | ||
Disulfide bondi | 9693 ↔ 9743 | PROSITE-ProRule annotation | ||
Modified residuei | 11503 | PhosphoserineBy similarity | 1 | |
Modified residuei | 12007 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 12009 | PhosphoserineBy similarity | 1 | |
Modified residuei | 12022 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 12067 ↔ 12117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 12611 ↔ 12660 | PROSITE-ProRule annotation | ||
Disulfide bondi | 12966 ↔ 13016 | PROSITE-ProRule annotation | ||
Disulfide bondi | 13233 ↔ 13283 | PROSITE-ProRule annotation | ||
Disulfide bondi | 13322 ↔ 13372 | PROSITE-ProRule annotation | ||
Disulfide bondi | 13411 ↔ 13461 | PROSITE-ProRule annotation | ||
Disulfide bondi | 13771 ↔ 13821 | PROSITE-ProRule annotation | ||
Modified residuei | 30443 | PhosphothreonineBy similarity | 1 | |
Disulfide bondi | 31481 ↔ 31532 | PROSITE-ProRule annotation | ||
Modified residuei | 32341 | Phosphotyrosine1 Publication | 1 | |
Disulfide bondi | 32516 ↔ 32568 | PROSITE-ProRule annotation | ||
Modified residuei | 33245 | PhosphoserineBy similarity | 1 | |
Modified residuei | 33247 | PhosphoserineBy similarity | 1 | |
Modified residuei | 33602 | PhosphoserineBy similarity | 1 | |
Modified residuei | 33614 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 33664 ↔ 33718 | PROSITE-ProRule annotation |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
EPDi | Q8WZ42 |
jPOSTi | Q8WZ42 |
MassIVEi | Q8WZ42 |
MaxQBi | Q8WZ42 |
PaxDbi | Q8WZ42 |
PeptideAtlasi | Q8WZ42 |
PRIDEi | Q8WZ42 |
ProteomicsDBi | 75209 [Q8WZ42-1] 75210 [Q8WZ42-10] 75211 [Q8WZ42-11] 75212 [Q8WZ42-2] 75213 [Q8WZ42-3] 75214 [Q8WZ42-4] 75215 [Q8WZ42-5] 75216 [Q8WZ42-6] 75217 [Q8WZ42-7] 75218 [Q8WZ42-8] 75219 [Q8WZ42-9] |
PTM databases
CarbonylDBi | Q8WZ42 |
GlyGeni | Q8WZ42, 11 sites, 2 O-linked glycans (11 sites) |
iPTMneti | Q8WZ42 |
MetOSitei | Q8WZ42 |
PhosphoSitePlusi | Q8WZ42 |
SwissPalmi | Q8WZ42 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000155657, Expressed in biceps brachii and 173 other tissues |
ExpressionAtlasi | Q8WZ42, baseline and differential |
Genevisiblei | Q8WZ42, HS |
Organism-specific databases
HPAi | ENSG00000155657, Group enriched (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Interacts with MYOM1, MYOM2, tropomyosin and myosin.
Interacts with actin, primarily via the PEVK domains and with MYPN (By similarity).
Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B.
Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains.
Interacts with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142.
Interacts with ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via immunoglobulin domain 79.
Interacts with NBR1 through the protein kinase domain.
Interacts with CALM/calmodulin.
Isoform 6 interacts with OBSCN isoform 3.
Interacts with CMYA5.
By similarity13 PublicationsBinary interactionsi
Q8WZ42
TTN - isoform 3 [Q8WZ42-3]
With | #Exp. | IntAct |
---|---|---|
TCAP [O15273] | 2 | EBI-15564183,EBI-954089 |
itself | 9 | EBI-15564183,EBI-15564183 |
GO - Molecular functioni
- actin filament binding Source: BHF-UCL
- actinin binding Source: BHF-UCL
- calmodulin binding Source: BHF-UCL
- enzyme binding Source: UniProtKB
- identical protein binding Source: IntAct
- muscle alpha-actinin binding Source: BHF-UCL
- protease binding Source: UniProtKB
- protein kinase binding Source: BHF-UCL
- protein self-association Source: BHF-UCL
- telethonin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 113124, 176 interactors |
ComplexPortali | CPX-101, Titin-Telethonin complex |
CORUMi | Q8WZ42 |
DIPi | DIP-33449N |
IntActi | Q8WZ42, 128 interactors |
MINTi | Q8WZ42 |
STRINGi | 9606.ENSP00000467141 |
Structurei
Secondary structure
3D structure databases
SASBDBi | Q8WZ42 |
SMRi | Q8WZ42 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WZ42 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 96 | Ig-like 1Add BLAST | 91 | |
Domaini | 104 – 192 | Ig-like 2Add BLAST | 89 | |
Repeati | 417 – 462 | Z-repeat 1Add BLAST | 46 | |
Repeati | 466 – 511 | Z-repeat 2Add BLAST | 46 | |
Repeati | 512 – 554 | Z-repeat 3Add BLAST | 43 | |
Repeati | 555 – 600 | Z-repeat 4Add BLAST | 46 | |
Repeati | 601 – 646 | Z-repeat 5Add BLAST | 46 | |
Repeati | 647 – 691 | Z-repeat 6Add BLAST | 45 | |
Repeati | 692 – 740 | Z-repeat 7Add BLAST | 49 | |
Domaini | 943 – 1031 | Ig-like 3Add BLAST | 89 | |
Domaini | 1082 – 1172 | Ig-like 4Add BLAST | 91 | |
Domaini | 1291 – 1382 | Ig-like 5Add BLAST | 92 | |
Domaini | 1457 – 1546 | Ig-like 6Add BLAST | 90 | |
Domaini | 1556 – 1646 | Ig-like 7Add BLAST | 91 | |
Domaini | 1703 – 1793 | Ig-like 8Add BLAST | 91 | |
Domaini | 1841 – 1928 | Ig-like 9Add BLAST | 88 | |
Domaini | 2078 – 2167 | Ig-like 10Add BLAST | 90 | |
Domaini | 2171 – 2262 | Ig-like 11Add BLAST | 92 | |
Domaini | 2264 – 2354 | Ig-like 12Add BLAST | 91 | |
Domaini | 2353 – 2443 | Ig-like 13Add BLAST | 91 | |
Domaini | 2430 – 2529 | Ig-like 14Add BLAST | 100 | |
Domaini | 2620 – 2703 | Ig-like 15Add BLAST | 84 | |
Domaini | 2880 – 2965 | Ig-like 16Add BLAST | 86 | |
Domaini | 2968 – 3050 | Ig-like 17Add BLAST | 83 | |
Domaini | 3058 – 3141 | Ig-like 18Add BLAST | 84 | |
Domaini | 3239 – 3327 | Ig-like 19Add BLAST | 89 | |
Domaini | 3344 – 3432 | Ig-like 20Add BLAST | 89 | |
Domaini | 3503 – 3586 | Ig-like 21Add BLAST | 84 | |
Domaini | 3621 – 3712 | Ig-like 22Add BLAST | 92 | |
Domaini | 4289 – 4376 | Ig-like 23Add BLAST | 88 | |
Domaini | 4383 – 4471 | Ig-like 24Add BLAST | 89 | |
Domaini | 4478 – 4566 | Ig-like 25Add BLAST | 89 | |
Domaini | 4571 – 4659 | Ig-like 26Add BLAST | 89 | |
Domaini | 4664 – 4753 | Ig-like 27Add BLAST | 90 | |
Domaini | 4758 – 4846 | Ig-like 28Add BLAST | 89 | |
Domaini | 4851 – 4936 | Ig-like 29Add BLAST | 86 | |
Domaini | 4943 – 5032 | Ig-like 30Add BLAST | 90 | |
Domaini | 5040 – 5128 | Ig-like 31Add BLAST | 89 | |
Domaini | 5133 – 5221 | Ig-like 32Add BLAST | 89 | |
Domaini | 5225 – 5314 | Ig-like 33Add BLAST | 90 | |
Domaini | 5320 – 5408 | Ig-like 34Add BLAST | 89 | |
Domaini | 5413 – 5501 | Ig-like 35Add BLAST | 89 | |
Domaini | 5505 – 5594 | Ig-like 36Add BLAST | 90 | |
Domaini | 5602 – 5690 | Ig-like 37Add BLAST | 89 | |
Domaini | 5695 – 5783 | Ig-like 38Add BLAST | 89 | |
Domaini | 5788 – 5877 | Ig-like 39Add BLAST | 90 | |
Domaini | 5882 – 5970 | Ig-like 40Add BLAST | 89 | |
Domaini | 5975 – 6063 | Ig-like 41Add BLAST | 89 | |
Domaini | 6067 – 6156 | Ig-like 42Add BLAST | 90 | |
Domaini | 6164 – 6252 | Ig-like 43Add BLAST | 89 | |
Domaini | 6257 – 6347 | Ig-like 44Add BLAST | 91 | |
Domaini | 6350 – 6440 | Ig-like 45Add BLAST | 91 | |
Domaini | 6444 – 6534 | Ig-like 46Add BLAST | 91 | |
Domaini | 6537 – 6626 | Ig-like 47Add BLAST | 90 | |
Domaini | 6630 – 6721 | Ig-like 48Add BLAST | 92 | |
Domaini | 6727 – 6815 | Ig-like 49Add BLAST | 89 | |
Domaini | 6820 – 6908 | Ig-like 50Add BLAST | 89 | |
Domaini | 6912 – 7001 | Ig-like 51Add BLAST | 90 | |
Domaini | 7005 – 7093 | Ig-like 52Add BLAST | 89 | |
Domaini | 7102 – 7190 | Ig-like 53Add BLAST | 89 | |
Domaini | 7198 – 7286 | Ig-like 54Add BLAST | 89 | |
Domaini | 7291 – 7380 | Ig-like 55Add BLAST | 90 | |
Domaini | 7385 – 7473 | Ig-like 56Add BLAST | 89 | |
Domaini | 7478 – 7567 | Ig-like 57Add BLAST | 90 | |
Domaini | 7571 – 7662 | Ig-like 58Add BLAST | 92 | |
Domaini | 7668 – 7756 | Ig-like 59Add BLAST | 89 | |
Domaini | 7761 – 7849 | Ig-like 60Add BLAST | 89 | |
Domaini | 7853 – 7942 | Ig-like 61Add BLAST | 90 | |
Domaini | 7946 – 8035 | Ig-like 62Add BLAST | 90 | |
Domaini | 8042 – 8133 | Ig-like 63Add BLAST | 92 | |
Domaini | 8138 – 8229 | Ig-like 64Add BLAST | 92 | |
Domaini | 8232 – 8321 | Ig-like 65Add BLAST | 90 | |
Domaini | 8326 – 8414 | Ig-like 66Add BLAST | 89 | |
Domaini | 8419 – 8508 | Ig-like 67Add BLAST | 90 | |
Domaini | 8512 – 8603 | Ig-like 68Add BLAST | 92 | |
Domaini | 8609 – 8697 | Ig-like 69Add BLAST | 89 | |
Domaini | 8702 – 8790 | Ig-like 70Add BLAST | 89 | |
Domaini | 8794 – 8883 | Ig-like 71Add BLAST | 90 | |
Domaini | 8888 – 8976 | Ig-like 72Add BLAST | 89 | |
Domaini | 8984 – 9074 | Ig-like 73Add BLAST | 91 | |
Domaini | 9079 – 9168 | Ig-like 74Add BLAST | 90 | |
Domaini | 9176 – 9265 | Ig-like 75Add BLAST | 90 | |
Domaini | 9272 – 9361 | Ig-like 76Add BLAST | 90 | |
Domaini | 9366 – 9470 | Ig-like 77Add BLAST | 105 | |
Domaini | 9660 – 9755 | Ig-like 78Add BLAST | 96 | |
Domaini | 9760 – 9851 | Ig-like 79Add BLAST | 92 | |
Repeati | 10216 – 10242 | PEVK 1Add BLAST | 27 | |
Repeati | 10244 – 10270 | PEVK 2Add BLAST | 27 | |
Repeati | 10272 – 10298 | PEVK 3Add BLAST | 27 | |
Repeati | 10300 – 10326 | PEVK 4Add BLAST | 27 | |
Repeati | 10327 – 10353 | PEVK 5Add BLAST | 27 | |
Repeati | 10355 – 10381 | PEVK 6Add BLAST | 27 | |
Repeati | 10508 – 10534 | PEVK 7Add BLAST | 27 | |
Repeati | 10536 – 10562 | PEVK 8Add BLAST | 27 | |
Repeati | 10592 – 10618 | PEVK 9Add BLAST | 27 | |
Repeati | 10878 – 10904 | PEVK 10Add BLAST | 27 | |
Repeati | 10906 – 10930 | PEVK 11Add BLAST | 25 | |
Repeati | 10932 – 10958 | PEVK 12Add BLAST | 27 | |
Repeati | 10960 – 10986 | PEVK 13Add BLAST | 27 | |
Repeati | 10987 – 11014 | PEVK 14Add BLAST | 28 | |
Repeati | 11363 – 11396 | PEVK 15Add BLAST | 34 | |
Repeati | 11397 – 11421 | PEVK 16Add BLAST | 25 | |
Repeati | 11453 – 11479 | PEVK 17Add BLAST | 27 | |
Repeati | 11481 – 11507 | PEVK 18Add BLAST | 27 | |
Repeati | 11509 – 11535 | PEVK 19Add BLAST | 27 | |
Repeati | 11537 – 11563 | PEVK 20Add BLAST | 27 | |
Repeati | 11565 – 11591 | PEVK 21Add BLAST | 27 | |
Repeati | 11657 – 11683 | PEVK 22Add BLAST | 27 | |
Repeati | 11703 – 11729 | PEVK 23Add BLAST | 27 | |
Repeati | 11745 – 11771 | PEVK 24Add BLAST | 27 | |
Repeati | 11775 – 11801 | PEVK 25Add BLAST | 27 | |
Repeati | 11836 – 11862 | PEVK 26Add BLAST | 27 | |
Repeati | 11864 – 11890 | PEVK 27Add BLAST | 27 | |
Repeati | 11893 – 11919 | PEVK 28Add BLAST | 27 | |
Repeati | 11929 – 11955 | PEVK 29Add BLAST | 27 | |
Repeati | 11966 – 11992 | PEVK 30Add BLAST | 27 | |
Repeati | 11996 – 12022 | PEVK 31Add BLAST | 27 | |
Domaini | 12041 – 12133 | Ig-like 80Add BLAST | 93 | |
Domaini | 12138 – 12222 | Ig-like 81Add BLAST | 85 | |
Domaini | 12233 – 12318 | Ig-like 82Add BLAST | 86 | |
Domaini | 12499 – 12584 | Ig-like 83Add BLAST | 86 | |
Domaini | 12590 – 12672 | Ig-like 84Add BLAST | 83 | |
Domaini | 12766 – 12850 | Ig-like 85Add BLAST | 85 | |
Domaini | 12945 – 13032 | Ig-like 86Add BLAST | 88 | |
Domaini | 13120 – 13206 | Ig-like 87Add BLAST | 87 | |
Domaini | 13210 – 13295 | Ig-like 88Add BLAST | 86 | |
Domaini | 13299 – 13384 | Ig-like 89Add BLAST | 86 | |
Domaini | 13388 – 13478 | Ig-like 90Add BLAST | 91 | |
Domaini | 13479 – 13562 | Ig-like 91Add BLAST | 84 | |
Domaini | 13565 – 13655 | Ig-like 92Add BLAST | 91 | |
Domaini | 13659 – 13748 | Ig-like 93Add BLAST | 90 | |
Domaini | 13749 – 13833 | Ig-like 94Add BLAST | 85 | |
Domaini | 13927 – 14012 | Ig-like 95Add BLAST | 86 | |
Domaini | 14019 – 14114 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 14120 – 14215 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 14221 – 14316 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 14417 – 14513 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 14517 – 14614 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 14615 – 14708 | Ig-like 96Add BLAST | 94 | |
Domaini | 14713 – 14806 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 14812 – 14907 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 14913 – 15007 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 15010 – 15107 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 15113 – 15207 | Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 15214 – 15310 | Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 15314 – 15402 | Ig-like 97Add BLAST | 89 | |
Domaini | 15409 – 15503 | Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 15509 – 15604 | Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 15608 – 15724 | Ig-like 98Add BLAST | 117 | |
Domaini | 15731 – 15826 | Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 15832 – 15926 | Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 15929 – 16025 | Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 16029 – 16119 | Ig-like 99Add BLAST | 91 | |
Domaini | 16126 – 16218 | Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 16224 – 16318 | Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 16322 – 16420 | Ig-like 100Add BLAST | 99 | |
Domaini | 16427 – 16522 | Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 16528 – 16628 | Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 16634 – 16734 | Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 16727 – 16834 | Ig-like 101Add BLAST | 108 | |
Domaini | 16841 – 16934 | Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 16941 – 17041 | Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 17044 – 17139 | Ig-like 102Add BLAST | 96 | |
Domaini | 17147 – 17240 | Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 17246 – 17345 | Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 17348 – 17445 | Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 17449 – 17536 | Ig-like 103Add BLAST | 88 | |
Domaini | 17545 – 17640 | Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 17646 – 17741 | Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 17745 – 17834 | Ig-like 104Add BLAST | 90 | |
Domaini | 17842 – 17935 | Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 17941 – 18036 | Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 18042 – 18139 | Fibronectin type-III 31PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 18143 – 18228 | Ig-like 105Add BLAST | 86 | |
Domaini | 18239 – 18333 | Fibronectin type-III 32PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 18339 – 18431 | Fibronectin type-III 33PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 18435 – 18526 | Ig-like 106Add BLAST | 92 | |
Domaini | 18533 – 18632 | Fibronectin type-III 34PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 18633 – 18727 | Fibronectin type-III 35PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 18733 – 18829 | Fibronectin type-III 36PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 18833 – 18924 | Ig-like 107Add BLAST | 92 | |
Domaini | 18931 – 19025 | Fibronectin type-III 37PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 19030 – 19124 | Fibronectin type-III 38PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 19128 – 19219 | Ig-like 108Add BLAST | 92 | |
Domaini | 19226 – 19321 | Fibronectin type-III 39PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 19325 – 19420 | Fibronectin type-III 40PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 19426 – 19527 | Fibronectin type-III 41PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 19531 – 19617 | Ig-like 109Add BLAST | 87 | |
Domaini | 19628 – 19722 | Fibronectin type-III 42PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 19728 – 19823 | Fibronectin type-III 43PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 19826 – 19914 | Ig-like 110Add BLAST | 89 | |
Domaini | 19921 – 20017 | Fibronectin type-III 44PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 20018 – 20116 | Fibronectin type-III 45PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 20119 – 20217 | Fibronectin type-III 46PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 20220 – 20311 | Ig-like 111Add BLAST | 92 | |
Domaini | 20318 – 20411 | Fibronectin type-III 47PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 20417 – 20512 | Fibronectin type-III 48PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 20518 – 20613 | Fibronectin type-III 49PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 20716 – 20813 | Fibronectin type-III 50PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 20814 – 20908 | Fibronectin type-III 51PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 20893 – 20996 | Ig-like 112Add BLAST | 104 | |
Domaini | 21006 – 21101 | Fibronectin type-III 52PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 21105 – 21200 | Fibronectin type-III 53PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 21203 – 21299 | Fibronectin type-III 54PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 21303 – 21395 | Ig-like 113Add BLAST | 93 | |
Domaini | 21402 – 21495 | Fibronectin type-III 55PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 21501 – 21596 | Fibronectin type-III 56PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 21602 – 21697 | Fibronectin type-III 57PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 21701 – 21793 | Ig-like 114Add BLAST | 93 | |
Domaini | 21797 – 21891 | Fibronectin type-III 58PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 21894 – 21986 | Fibronectin type-III 59PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 21990 – 22083 | Ig-like 115Add BLAST | 94 | |
Domaini | 22088 – 22182 | Fibronectin type-III 60PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 22188 – 22283 | Fibronectin type-III 61PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 22286 – 22382 | Fibronectin type-III 62PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 22386 – 22477 | Ig-like 116Add BLAST | 92 | |
Domaini | 22484 – 22578 | Fibronectin type-III 63PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 22584 – 22679 | Fibronectin type-III 64PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 22685 – 22781 | Fibronectin type-III 65PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 22785 – 22874 | Ig-like 117Add BLAST | 90 | |
Domaini | 22881 – 22976 | Fibronectin type-III 66PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 22978 – 23071 | Fibronectin type-III 67PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 23075 – 23163 | Ig-like 118Add BLAST | 89 | |
Domaini | 23170 – 23264 | Fibronectin type-III 68PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 23270 – 23364 | Fibronectin type-III 69PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 23368 – 23463 | Fibronectin type-III 70PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 23468 – 23555 | Ig-like 119Add BLAST | 88 | |
Domaini | 23566 – 23660 | Fibronectin type-III 71PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 23666 – 23761 | Fibronectin type-III 72PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 23767 – 23863 | Fibronectin type-III 73PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 23867 – 23954 | Ig-like 120Add BLAST | 88 | |
Domaini | 23963 – 24057 | Fibronectin type-III 74PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 24060 – 24153 | Fibronectin type-III 75PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 24157 – 24241 | Ig-like 121Add BLAST | 85 | |
Domaini | 24252 – 24346 | Fibronectin type-III 76PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 24352 – 24446 | Fibronectin type-III 77PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 24450 – 24546 | Fibronectin type-III 78PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 24550 – 24641 | Ig-like 122Add BLAST | 92 | |
Domaini | 24648 – 24742 | Fibronectin type-III 79PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 24748 – 24843 | Fibronectin type-III 80PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 24849 – 24945 | Fibronectin type-III 81PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 24949 – 25038 | Ig-like 123Add BLAST | 90 | |
Domaini | 25045 – 25139 | Fibronectin type-III 82PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 25142 – 25235 | Fibronectin type-III 83PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 25239 – 25325 | Ig-like 124Add BLAST | 87 | |
Domaini | 25335 – 25428 | Fibronectin type-III 84PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 25434 – 25529 | Fibronectin type-III 85PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 25532 – 25627 | Fibronectin type-III 86PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 25632 – 25722 | Ig-like 125Add BLAST | 91 | |
Domaini | 25731 – 25825 | Fibronectin type-III 87PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 25831 – 25926 | Fibronectin type-III 88PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 25932 – 26028 | Fibronectin type-III 89PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 26032 – 26121 | Ig-like 126Add BLAST | 90 | |
Domaini | 26128 – 26222 | Fibronectin type-III 90PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 26225 – 26318 | Fibronectin type-III 91PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 26322 – 26410 | Ig-like 127Add BLAST | 89 | |
Domaini | 26417 – 26510 | Fibronectin type-III 92PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 26516 – 26611 | Fibronectin type-III 93PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 26614 – 26710 | Fibronectin type-III 94PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 26714 – 26801 | Ig-like 128Add BLAST | 88 | |
Domaini | 26812 – 26906 | Fibronectin type-III 95PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 26912 – 27007 | Fibronectin type-III 96PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 27013 – 27107 | Fibronectin type-III 97PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 27101 – 27196 | Ig-like 129Add BLAST | 96 | |
Domaini | 27205 – 27296 | Fibronectin type-III 98PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 27302 – 27392 | Fibronectin type-III 99PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 27499 – 27593 | Fibronectin type-III 100PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 27599 – 27694 | Fibronectin type-III 101PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 27697 – 27793 | Fibronectin type-III 102PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 27797 – 27888 | Ig-like 130Add BLAST | 92 | |
Domaini | 27895 – 27989 | Fibronectin type-III 103PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 27995 – 28090 | Fibronectin type-III 104PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 28096 – 28192 | Fibronectin type-III 105PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 28196 – 28286 | Ig-like 131Add BLAST | 91 | |
Domaini | 28295 – 28389 | Fibronectin type-III 106PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 28392 – 28484 | Fibronectin type-III 107PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 28488 – 28577 | Ig-like 132Add BLAST | 90 | |
Domaini | 28583 – 28680 | Fibronectin type-III 108PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 28686 – 28781 | Fibronectin type-III 109PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 28784 – 28879 | Fibronectin type-III 110PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 28882 – 28974 | Ig-like 133Add BLAST | 93 | |
Domaini | 28979 – 29071 | Fibronectin type-III 111PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 29081 – 29177 | Fibronectin type-III 112PROSITE-ProRule annotationAdd |