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UniProtKB - Q8WZ42 (TITIN_HUMAN)

Protein

Titin

Gene

TTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.1 Publication

Miscellaneous

In some isoforms, after the PEVK repeat region there is a long PEVK duplicated region. On account of this region, it has been very difficult to sequence the whole protein. The length of this region (ranging from 183 to 2174 residues), may be a key elastic element of titin.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+

Activity regulationi

Full activation of the protein kinase domain requires both phosphorylation of Tyr-32341, preventing it from blocking the catalytic aspartate residue, and binding of Ca/CALM to the C-terminal regulatory tail of the molecule which results in ATP binding to the kinase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32207ATPPROSITE-ProRule annotation1
Active sitei32298Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32184 – 32192ATPPROSITE-ProRule annotation9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-390522 Striated Muscle Contraction
SignaLinkiQ8WZ42
SIGNORiQ8WZ42

Protein family/group databases

MoonDBiQ8WZ42 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Titin (EC:2.7.11.1)
Alternative name(s):
Connectin
Rhabdomyosarcoma antigen MU-RMS-40.14
Gene namesi
Name:TTN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000155657.24
HGNCiHGNC:12403 TTN
MIMi188840 gene
neXtProtiNX_Q8WZ42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Hereditary myopathy with early respiratory failure (HMERF)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant, adult-onset myopathy with early respiratory muscle involvement.
See also OMIM:603689
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026634279R → W in HMERF; disrupts NBR1-binding. 1 PublicationCorresponds to variant dbSNP:rs138060032EnsemblClinVar.1
Cardiomyopathy, familial hypertrophic 9 (CMH9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:613765
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026687740R → L in CMH9. 1 PublicationCorresponds to variant dbSNP:rs28933405EnsemblClinVar.1
Cardiomyopathy, dilated 1G (CMD1G)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:604145
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02668554V → M in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs139517732EnsemblClinVar.1
Natural variantiVAR_026688743A → V in CMD1G; affects interaction with TCAP/telethonin. 1 PublicationCorresponds to variant dbSNP:rs267607157EnsemblClinVar.1
Natural variantiVAR_026689976W → R in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs267607155EnsemblClinVar.1
Natural variantiVAR_0266903799S → Y in CMD1G. 1 Publication1
Natural variantiVAR_0266924465S → N in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs281864908Ensembl.1
Natural variantiVAR_02669332996R → Q in CMD1G. 1 PublicationCorresponds to variant dbSNP:rs199642423Ensembl.1
Tardive tibial muscular dystrophy (TMD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant, late-onset distal myopathy. Muscle weakness and atrophy are usually confined to the anterior compartment of the lower leg, in particular the tibialis anterior muscle. Clinical symptoms usually occur at age 35-45 years or much later.
See also OMIM:600334
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02669434306I → N in TMD. 1 PublicationCorresponds to variant dbSNP:rs281864928Ensembl.1
Natural variantiVAR_02669534315L → P in TMD. 1 PublicationCorresponds to variant dbSNP:rs267607156Ensembl.1
Limb-girdle muscular dystrophy 2J (LGMD2J)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive degenerative myopathy characterized by progressive weakness of the pelvic and shoulder girdle muscles. Severe disability is observed within 20 years of onset.
See also OMIM:608807
Salih myopathy (SALMY)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, early-onset muscular disorder characterized by dilated cardiomyopathy, delayed motor development with generalized muscle weakness predominantly affecting proximal and distal lower limbs. Skeletal muscle biopsies show minicore-like lesions with mitochondrial depletion and sarcomere disorganization, centralized nuclei, and type 1 fiber predominance. Dystrophic changes become apparent in the second decade. Cardiac muscle biopsies show disruption of myocardial architecture, nuclear hypertrophy, and endomysial fibrosis. Sudden death may occurr due to cardiomyopathy.
See also OMIM:611705

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi32207K → A: Disrupts catalytic activity. 1 Publication1
Mutagenesisi32341Y → E: No phosphorylation on tyrosine. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNETi7273
GeneReviewsiTTN
MalaCardsiTTN
MIMi600334 phenotype
603689 phenotype
604145 phenotype
608807 phenotype
611705 phenotype
613765 phenotype
OpenTargetsiENSG00000155657
Orphaneti169186 Autosomal recessive centronuclear myopathy
140922 Autosomal recessive limb-girdle muscular dystrophy type 2J
466921 Childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome
324604 Classic multiminicore myopathy
289377 Early-onset myopathy with fatal cardiomyopathy
293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
154 Familial isolated dilated cardiomyopathy
178464 Hereditary proximal myopathy with early respiratory failure
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
609 Tibial muscular dystrophy
PharmGKBiPA37067

Polymorphism and mutation databases

BioMutaiTTN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393111 – 34350TitinAdd BLAST34350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei267PhosphothreonineBy similarity1
Disulfide bondi964 ↔ 1015PROSITE-ProRule annotation
Disulfide bondi1724 ↔ 1777PROSITE-ProRule annotation
Disulfide bondi2109 ↔ 2134PROSITE-ProRule annotation1 Publication
Disulfide bondi2196 ↔ 2246PROSITE-ProRule annotation
Disulfide bondi3259 ↔ 3311PROSITE-ProRule annotation
Disulfide bondi4404 ↔ 4455PROSITE-ProRule annotation
Disulfide bondi4499 ↔ 4550PROSITE-ProRule annotation
Disulfide bondi4592 ↔ 4643PROSITE-ProRule annotation
Disulfide bondi4686 ↔ 4737PROSITE-ProRule annotation
Disulfide bondi4779 ↔ 4830PROSITE-ProRule annotation
Disulfide bondi5061 ↔ 5112PROSITE-ProRule annotation
Disulfide bondi5248 ↔ 5299PROSITE-ProRule annotation
Disulfide bondi5623 ↔ 5674PROSITE-ProRule annotation
Disulfide bondi5810 ↔ 5861PROSITE-ProRule annotation
Disulfide bondi5903 ↔ 5954PROSITE-ProRule annotation
Disulfide bondi6185 ↔ 6236PROSITE-ProRule annotation
Disulfide bondi6372 ↔ 6423PROSITE-ProRule annotation
Disulfide bondi6465 ↔ 6516PROSITE-ProRule annotation
Disulfide bondi6748 ↔ 6799PROSITE-ProRule annotation
Modified residuei6920PhosphoserineBy similarity1
Disulfide bondi7027 ↔ 7078PROSITE-ProRule annotation
Disulfide bondi7123 ↔ 7174PROSITE-ProRule annotation
Disulfide bondi7219 ↔ 7270PROSITE-ProRule annotation
Disulfide bondi7313 ↔ 7364PROSITE-ProRule annotation
Disulfide bondi7406 ↔ 7457PROSITE-ProRule annotation
Disulfide bondi7689 ↔ 7740PROSITE-ProRule annotation
Disulfide bondi7968 ↔ 8019PROSITE-ProRule annotation
Disulfide bondi8064 ↔ 8115PROSITE-ProRule annotation
Disulfide bondi8160 ↔ 8211PROSITE-ProRule annotation
Disulfide bondi8254 ↔ 8305PROSITE-ProRule annotation
Disulfide bondi8347 ↔ 8398PROSITE-ProRule annotation
Disulfide bondi8630 ↔ 8681PROSITE-ProRule annotation
Disulfide bondi8909 ↔ 8960PROSITE-ProRule annotation
Disulfide bondi9005 ↔ 9056PROSITE-ProRule annotation
Disulfide bondi9101 ↔ 9152PROSITE-ProRule annotation
Modified residuei9122PhosphoserineBy similarity1
Disulfide bondi9294 ↔ 9345PROSITE-ProRule annotation
Disulfide bondi9693 ↔ 9743PROSITE-ProRule annotation
Modified residuei11503PhosphoserineBy similarity1
Modified residuei12007PhosphothreonineBy similarity1
Modified residuei12009PhosphoserineBy similarity1
Modified residuei12022PhosphoserineBy similarity1
Disulfide bondi12067 ↔ 12117PROSITE-ProRule annotation
Disulfide bondi12611 ↔ 12660PROSITE-ProRule annotation
Disulfide bondi12966 ↔ 13016PROSITE-ProRule annotation
Disulfide bondi13233 ↔ 13283PROSITE-ProRule annotation
Disulfide bondi13322 ↔ 13372PROSITE-ProRule annotation
Disulfide bondi13411 ↔ 13461PROSITE-ProRule annotation
Disulfide bondi13771 ↔ 13821PROSITE-ProRule annotation
Modified residuei30443PhosphothreonineBy similarity1
Disulfide bondi31481 ↔ 31532PROSITE-ProRule annotation
Modified residuei32341Phosphotyrosine1 Publication1
Disulfide bondi32516 ↔ 32568PROSITE-ProRule annotation
Modified residuei33245PhosphoserineBy similarity1
Modified residuei33247PhosphoserineBy similarity1
Modified residuei33602PhosphoserineBy similarity1
Modified residuei33614PhosphoserineBy similarity1
Disulfide bondi33664 ↔ 33718PROSITE-ProRule annotation

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ8WZ42
MaxQBiQ8WZ42
PaxDbiQ8WZ42
PeptideAtlasiQ8WZ42
PRIDEiQ8WZ42
ProteomicsDBi75209
75210 [Q8WZ42-10]
75211 [Q8WZ42-11]
75212 [Q8WZ42-2]
75213 [Q8WZ42-3]
75214 [Q8WZ42-4]
75215 [Q8WZ42-5]
75216 [Q8WZ42-6]
75217 [Q8WZ42-7]
75218 [Q8WZ42-8]
75219 [Q8WZ42-9]

PTM databases

CarbonylDBiQ8WZ42
iPTMnetiQ8WZ42
PhosphoSitePlusiQ8WZ42
SwissPalmiQ8WZ42

Expressioni

Tissue specificityi

Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000155657 Expressed in 160 organ(s), highest expression level in muscle tissue
ExpressionAtlasiQ8WZ42 baseline and differential
GenevisibleiQ8WZ42 HS

Organism-specific databases

HPAiCAB022682
HPA007042
HPA030048

Interactioni

Subunit structurei

Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts with actin, primarily via the PEVK domains and with MYPN (By similarity). Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains. Interacts with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142. Interacts with ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via immunoglobulin domain 79. Interacts with NBR1 through the protein kinase domain. Interacts with CALM/calmodulin. Isoform 6 interacts with OBSCN isoform 3. Interacts with CMYA5.By similarity13 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi113124, 71 interactors
ComplexPortaliCPX-101 Titin-Telethonin complex
CORUMiQ8WZ42
DIPiDIP-33449N
IntActiQ8WZ42, 90 interactors
MINTiQ8WZ42
STRINGi9606.ENSP00000343764

Structurei

Secondary structure

134350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00072
ProteinModelPortaliQ8WZ42
SMRiQ8WZ42
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WZ42

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 96Ig-like 1Add BLAST91
Domaini104 – 192Ig-like 2Add BLAST89
Repeati417 – 462Z-repeat 1Add BLAST46
Repeati466 – 511Z-repeat 2Add BLAST46
Repeati512 – 554Z-repeat 3Add BLAST43
Repeati555 – 600Z-repeat 4Add BLAST46
Repeati601 – 646Z-repeat 5Add BLAST46
Repeati647 – 691Z-repeat 6Add BLAST45
Repeati692 – 740Z-repeat 7Add BLAST49
Domaini943 – 1031Ig-like 3Add BLAST89
Domaini1082 – 1172Ig-like 4Add BLAST91
Domaini1291 – 1382Ig-like 5Add BLAST92
Domaini1457 – 1546Ig-like 6Add BLAST90
Domaini1556 – 1646Ig-like 7Add BLAST91
Domaini1703 – 1793Ig-like 8Add BLAST91
Domaini1841 – 1928Ig-like 9Add BLAST88
Domaini2078 – 2167Ig-like 10Add BLAST90
Domaini2171 – 2262Ig-like 11Add BLAST92
Domaini2264 – 2354Ig-like 12Add BLAST91
Domaini2353 – 2443Ig-like 13Add BLAST91
Domaini2430 – 2529Ig-like 14Add BLAST100
Domaini2620 – 2703Ig-like 15Add BLAST84
Domaini2880 – 2965Ig-like 16Add BLAST86
Domaini2968 – 3050Ig-like 17Add BLAST83
Domaini3058 – 3141Ig-like 18Add BLAST84
Domaini3239 – 3327Ig-like 19Add BLAST89
Domaini3344 – 3432Ig-like 20Add BLAST89
Domaini3503 – 3586Ig-like 21Add BLAST84
Domaini3621 – 3712Ig-like 22Add BLAST92
Domaini4289 – 4376Ig-like 23Add BLAST88
Domaini4383 – 4471Ig-like 24Add BLAST89
Domaini4478 – 4566Ig-like 25Add BLAST89
Domaini4571 – 4659Ig-like 26Add BLAST89
Domaini4664 – 4753Ig-like 27Add BLAST90
Domaini4758 – 4846Ig-like 28Add BLAST89
Domaini4851 – 4936Ig-like 29Add BLAST86
Domaini4943 – 5032Ig-like 30Add BLAST90
Domaini5040 – 5128Ig-like 31Add BLAST89
Domaini5133 – 5221Ig-like 32Add BLAST89
Domaini5225 – 5314Ig-like 33Add BLAST90
Domaini5320 – 5408Ig-like 34Add BLAST89
Domaini5413 – 5501Ig-like 35Add BLAST89
Domaini5505 – 5594Ig-like 36Add BLAST90
Domaini5602 – 5690Ig-like 37Add BLAST89
Domaini5695 – 5783Ig-like 38Add BLAST89
Domaini5788 – 5877Ig-like 39Add BLAST90
Domaini5882 – 5970Ig-like 40Add BLAST89
Domaini5975 – 6063Ig-like 41Add BLAST89
Domaini6067 – 6156Ig-like 42Add BLAST90
Domaini6164 – 6252Ig-like 43Add BLAST89
Domaini6257 – 6347Ig-like 44Add BLAST91
Domaini6350 – 6440Ig-like 45Add BLAST91
Domaini6444 – 6534Ig-like 46Add BLAST91
Domaini6537 – 6626Ig-like 47Add BLAST90
Domaini6630 – 6721Ig-like 48Add BLAST92
Domaini6727 – 6815Ig-like 49Add BLAST89
Domaini6820 – 6908Ig-like 50Add BLAST89
Domaini6912 – 7001Ig-like 51Add BLAST90
Domaini7005 – 7093Ig-like 52Add BLAST89
Domaini7102 – 7190Ig-like 53Add BLAST89
Domaini7198 – 7286Ig-like 54Add BLAST89
Domaini7291 – 7380Ig-like 55Add BLAST90
Domaini7385 – 7473Ig-like 56Add BLAST89
Domaini7478 – 7567Ig-like 57Add BLAST90
Domaini7571 – 7662Ig-like 58Add BLAST92
Domaini7668 – 7756Ig-like 59Add BLAST89
Domaini7761 – 7849Ig-like 60Add BLAST89
Domaini7853 – 7942Ig-like 61Add BLAST90
Domaini7946 – 8035Ig-like 62Add BLAST90
Domaini8042 – 8133Ig-like 63Add BLAST92
Domaini8138 – 8229Ig-like 64Add BLAST92
Domaini8232 – 8321Ig-like 65Add BLAST90
Domaini8326 – 8414Ig-like 66Add BLAST89
Domaini8419 – 8508Ig-like 67Add BLAST90
Domaini8512 – 8603Ig-like 68Add BLAST92
Domaini8609 – 8697Ig-like 69Add BLAST89
Domaini8702 – 8790Ig-like 70Add BLAST89
Domaini8794 – 8883Ig-like 71Add BLAST90
Domaini8888 – 8976Ig-like 72Add BLAST89
Domaini8984 – 9074Ig-like 73Add BLAST91
Domaini9079 – 9168Ig-like 74Add BLAST90
Domaini9176 – 9265Ig-like 75Add BLAST90
Domaini9272 – 9361Ig-like 76Add BLAST90
Domaini9366 – 9470Ig-like 77Add BLAST105
Domaini9660 – 9755Ig-like 78Add BLAST96
Domaini9760 – 9851Ig-like 79Add BLAST92
Repeati10216 – 10242PEVK 1Add BLAST27
Repeati10244 – 10270PEVK 2Add BLAST27
Repeati10272 – 10298PEVK 3Add BLAST27
Repeati10300 – 10326PEVK 4Add BLAST27
Repeati10327 – 10353PEVK 5Add BLAST27
Repeati10355 – 10381PEVK 6Add BLAST27
Repeati10508 – 10534PEVK 7Add BLAST27
Repeati10536 – 10562PEVK 8Add BLAST27
Repeati10592 – 10618PEVK 9Add BLAST27
Repeati10878 – 10904PEVK 10Add BLAST27
Repeati10906 – 10930PEVK 11Add BLAST25
Repeati10932 – 10958PEVK 12Add BLAST27
Repeati10960 – 10986PEVK 13Add BLAST27
Repeati10987 – 11014PEVK 14Add BLAST28
Repeati11363 – 11396PEVK 15Add BLAST34
Repeati11397 – 11421PEVK 16Add BLAST25
Repeati11453 – 11479PEVK 17Add BLAST27
Repeati11481 – 11507PEVK 18Add BLAST27
Repeati11509 – 11535PEVK 19Add BLAST27
Repeati11537 – 11563PEVK 20Add BLAST27
Repeati11565 – 11591PEVK 21Add BLAST27
Repeati11657 – 11683PEVK 22Add BLAST27
Repeati11703 – 11729PEVK 23Add BLAST27
Repeati11745 – 11771PEVK 24Add BLAST27
Repeati11775 – 11801PEVK 25Add BLAST27
Repeati11836 – 11862PEVK 26Add BLAST27
Repeati11864 – 11890PEVK 27Add BLAST27
Repeati11893 – 11919PEVK 28Add BLAST27
Repeati11929 – 11955PEVK 29Add BLAST27
Repeati11966 – 11992PEVK 30Add BLAST27
Repeati11996 – 12022PEVK 31Add BLAST27
Domaini12041 – 12133Ig-like 80Add BLAST93
Domaini12138 – 12222Ig-like 81Add BLAST85
Domaini12233 – 12318Ig-like 82Add BLAST86
Domaini12499 – 12584Ig-like 83Add BLAST86
Domaini12590 – 12672Ig-like 84Add BLAST83
Domaini12766 – 12850Ig-like 85Add BLAST85
Domaini12945 – 13032Ig-like 86Add BLAST88
Domaini13120 – 13206Ig-like 87Add BLAST87
Domaini13210 – 13295Ig-like 88Add BLAST86
Domaini13299 – 13384Ig-like 89Add BLAST86
Domaini13388 – 13478Ig-like 90Add BLAST91
Domaini13479 – 13562Ig-like 91Add BLAST84
Domaini13565 – 13655Ig-like 92Add BLAST91
Domaini13659 – 13748Ig-like 93Add BLAST90
Domaini13749 – 13833Ig-like 94Add BLAST85
Domaini13927 – 14012Ig-like 95Add BLAST86
Domaini14019 – 14114Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini14120 – 14215Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini14221 – 14316Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini14417 – 14513Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini14517 – 14614Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST98
Domaini14615 – 14708Ig-like 96Add BLAST94
Domaini14713 – 14806Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini14812 – 14907Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini14913 – 15007Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini15010 – 15107Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini15113 – 15207Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST95
Domaini15214 – 15310Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini15314 – 15402Ig-like 97Add BLAST89
Domaini15409 – 15503Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST95
Domaini15509 – 15604Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST96
Domaini15608 – 15724Ig-like 98Add BLAST117
Domaini15731 – 15826Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST96
Domaini15832 – 15926Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST95
Domaini15929 – 16025Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST97
Domaini16029 – 16119Ig-like 99Add BLAST91
Domaini16126 – 16218Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST93
Domaini16224 – 16318Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST95
Domaini16322 – 16420Ig-like 100Add BLAST99
Domaini16427 – 16522Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST96
Domaini16528 – 16628Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST101
Domaini16634 – 16734Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST101
Domaini16727 – 16834Ig-like 101Add BLAST108
Domaini16841 – 16934Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST94
Domaini16941 – 17041Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST101
Domaini17044 – 17139Ig-like 102Add BLAST96
Domaini17147 – 17240Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST94
Domaini17246 – 17345Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST100
Domaini17348 – 17445Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST98
Domaini17449 – 17536Ig-like 103Add BLAST88
Domaini17545 – 17640Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST96
Domaini17646 – 17741Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST96
Domaini17745 – 17834Ig-like 104Add BLAST90
Domaini17842 – 17935Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST94
Domaini17941 – 18036Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST96
Domaini18042 – 18139Fibronectin type-III 31PROSITE-ProRule annotationAdd BLAST98
Domaini18143 – 18228Ig-like 105Add BLAST86
Domaini18239 – 18333Fibronectin type-III 32PROSITE-ProRule annotationAdd BLAST95
Domaini18339 – 18431Fibronectin type-III 33PROSITE-ProRule annotationAdd BLAST93
Domaini18435 – 18526Ig-like 106Add BLAST92
Domaini18533 – 18632Fibronectin type-III 34PROSITE-ProRule annotationAdd BLAST100
Domaini18633 – 18727Fibronectin type-III 35PROSITE-ProRule annotationAdd BLAST95
Domaini18733 – 18829Fibronectin type-III 36PROSITE-ProRule annotationAdd BLAST97
Domaini18833 – 18924Ig-like 107Add BLAST92
Domaini18931 – 19025Fibronectin type-III 37PROSITE-ProRule annotationAdd BLAST95
Domaini19030 – 19124Fibronectin type-III 38PROSITE-ProRule annotationAdd BLAST95
Domaini19128 – 19219Ig-like 108Add BLAST92
Domaini19226 – 19321Fibronectin type-III 39PROSITE-ProRule annotationAdd BLAST96
Domaini19325 – 19420Fibronectin type-III 40PROSITE-ProRule annotationAdd BLAST96
Domaini19426 – 19527Fibronectin type-III 41PROSITE-ProRule annotationAdd BLAST102
Domaini19531 – 19617Ig-like 109Add BLAST87
Domaini19628 – 19722Fibronectin type-III 42PROSITE-ProRule annotationAdd BLAST95
Domaini19728 – 19823Fibronectin type-III 43PROSITE-ProRule annotationAdd BLAST96
Domaini19826 – 19914Ig-like 110Add BLAST89
Domaini19921 – 20017Fibronectin type-III 44PROSITE-ProRule annotationAdd BLAST97
Domaini20018 – 20116Fibronectin type-III 45PROSITE-ProRule annotationAdd BLAST99
Domaini20119 – 20217Fibronectin type-III 46PROSITE-ProRule annotationAdd BLAST99
Domaini20220 – 20311Ig-like 111Add BLAST92
Domaini20318 – 20411Fibronectin type-III 47PROSITE-ProRule annotationAdd BLAST94
Domaini20417 – 20512Fibronectin type-III 48PROSITE-ProRule annotationAdd BLAST96
Domaini20518 – 20613Fibronectin type-III 49PROSITE-ProRule annotationAdd BLAST96
Domaini20716 – 20813Fibronectin type-III 50PROSITE-ProRule annotationAdd BLAST98
Domaini20814 – 20908Fibronectin type-III 51PROSITE-ProRule annotationAdd BLAST95
Domaini20893 – 20996Ig-like 112Add BLAST104
Domaini21006 – 21101Fibronectin type-III 52PROSITE-ProRule annotationAdd BLAST96
Domaini21105 – 21200Fibronectin type-III 53PROSITE-ProRule annotationAdd BLAST96
Domaini21203 – 21299Fibronectin type-III 54PROSITE-ProRule annotationAdd BLAST97
Domaini21303 – 21395Ig-like 113Add BLAST93
Domaini21402 – 21495Fibronectin type-III 55PROSITE-ProRule annotationAdd BLAST94
Domaini21501 – 21596Fibronectin type-III 56PROSITE-ProRule annotationAdd BLAST96
Domaini21602 – 21697Fibronectin type-III 57PROSITE-ProRule annotationAdd BLAST96
Domaini21701 – 21793Ig-like 114Add BLAST93
Domaini21797 – 21891Fibronectin type-III 58PROSITE-ProRule annotationAdd BLAST95
Domaini21894 – 21986Fibronectin type-III 59PROSITE-ProRule annotationAdd BLAST93
Domaini21990 – 22083Ig-like 115Add BLAST94
Domaini22088 – 22182Fibronectin type-III 60PROSITE-ProRule annotationAdd BLAST95
Domaini22188 – 22283Fibronectin type-III 61PROSITE-ProRule annotationAdd BLAST96
Domaini22286 – 22382Fibronectin type-III 62PROSITE-ProRule annotationAdd BLAST97
Domaini22386 – 22477Ig-like 116Add BLAST92
Domaini22484 – 22578Fibronectin type-III 63PROSITE-ProRule annotationAdd BLAST95
Domaini22584 – 22679Fibronectin type-III 64PROSITE-ProRule annotationAdd BLAST96
Domaini22685 – 22781Fibronectin type-III 65PROSITE-ProRule annotationAdd BLAST97
Domaini22785 – 22874Ig-like 117Add BLAST90
Domaini22881 – 22976Fibronectin type-III 66PROSITE-ProRule annotationAdd BLAST96
Domaini22978 – 23071Fibronectin type-III 67PROSITE-ProRule annotationAdd BLAST94
Domaini23075 – 23163Ig-like 118Add BLAST89
Domaini23170 – 23264Fibronectin type-III 68PROSITE-ProRule annotationAdd BLAST95
Domaini23270 – 23364Fibronectin type-III 69PROSITE-ProRule annotationAdd BLAST95
Domaini23368 – 23463Fibronectin type-III 70PROSITE-ProRule annotationAdd BLAST96
Domaini23468 – 23555Ig-like 119Add BLAST88
Domaini23566 – 23660Fibronectin type-III 71PROSITE-ProRule annotationAdd BLAST95
Domaini23666 – 23761Fibronectin type-III 72PROSITE-ProRule annotationAdd BLAST96
Domaini23767 – 23863Fibronectin type-III 73PROSITE-ProRule annotationAdd BLAST97
Domaini23867 – 23954Ig-like 120Add BLAST88
Domaini23963 – 24057Fibronectin type-III 74PROSITE-ProRule annotationAdd BLAST95
Domaini24060 – 24153Fibronectin type-III 75PROSITE-ProRule annotationAdd BLAST94
Domaini24157 – 24241Ig-like 121Add BLAST85
Domaini24252 – 24346Fibronectin type-III 76PROSITE-ProRule annotationAdd BLAST95
Domaini24352 – 24446Fibronectin type-III 77PROSITE-ProRule annotationAdd BLAST95
Domaini24450 – 24546Fibronectin type-III 78PROSITE-ProRule annotationAdd BLAST97
Domaini24550 – 24641Ig-like 122Add BLAST92
Domaini24648 – 24742Fibronectin type-III 79PROSITE-ProRule annotationAdd BLAST95
Domaini24748 – 24843Fibronectin type-III 80PROSITE-ProRule annotationAdd BLAST96
Domaini24849 – 24945Fibronectin type-III 81PROSITE-ProRule annotationAdd BLAST97
Domaini24949 – 25038Ig-like 123Add BLAST90
Domaini25045 – 25139Fibronectin type-III 82PROSITE-ProRule annotationAdd BLAST95
Domaini25142 – 25235Fibronectin type-III 83PROSITE-ProRule annotationAdd BLAST94
Domaini25239 – 25325Ig-like 124Add BLAST87
Domaini25335 – 25428Fibronectin type-III 84PROSITE-ProRule annotationAdd BLAST94
Domaini25434 – 25529Fibronectin type-III 85PROSITE-ProRule annotationAdd BLAST96
Domaini25532 – 25627Fibronectin type-III 86PROSITE-ProRule annotationAdd BLAST96
Domaini25632 – 25722Ig-like 125Add BLAST91
Domaini25731 – 25825Fibronectin type-III 87PROSITE-ProRule annotationAdd BLAST95
Domaini25831 – 25926Fibronectin type-III 88PROSITE-ProRule annotationAdd BLAST96
Domaini25932 – 26028Fibronectin type-III 89PROSITE-ProRule annotationAdd BLAST97
Domaini26032 – 26121Ig-like 126Add BLAST90
Domaini26128 – 26222Fibronectin type-III 90PROSITE-ProRule annotationAdd BLAST95
Domaini26225 – 26318Fibronectin type-III 91PROSITE-ProRule annotationAdd BLAST94
Domaini26322 – 26410Ig-like 127Add BLAST89
Domaini26417 – 26510Fibronectin type-III 92PROSITE-ProRule annotationAdd BLAST94
Domaini26516 – 26611Fibronectin type-III 93PROSITE-ProRule annotationAdd BLAST96
Domaini26614 – 26710Fibronectin type-III 94PROSITE-ProRule annotationAdd BLAST97
Domaini26714 – 26801Ig-like 128Add BLAST88
Domaini26812 – 26906Fibronectin type-III 95PROSITE-ProRule annotationAdd BLAST95
Domaini26912 – 27007Fibronectin type-III 96PROSITE-ProRule annotationAdd BLAST96
Domaini27013 – 27107Fibronectin type-III 97PROSITE-ProRule annotationAdd BLAST95
Domaini27101 – 27196Ig-like 129Add BLAST96
Domaini27205 – 27296Fibronectin type-III 98PROSITE-ProRule annotationAdd BLAST92
Domaini27302 – 27392Fibronectin type-III 99PROSITE-ProRule annotationAdd BLAST91
Domaini27499 – 27593Fibronectin type-III 100PROSITE-ProRule annotationAdd BLAST95
Domaini27599 – 27694Fibronectin type-III 101PROSITE-ProRule annotationAdd BLAST96
Domaini27697 – 27793Fibronectin type-III 102PROSITE-ProRule annotationAdd BLAST97
Domaini27797 – 27888Ig-like 130Add BLAST92
Domaini27895 – 27989Fibronectin type-III 103PROSITE-ProRule annotationAdd BLAST95
Domaini27995 – 28090Fibronectin type-III 104PROSITE-ProRule annotationAdd BLAST96
Domaini28096 – 28192Fibronectin type-III 105PROSITE-ProRule annotationAdd BLAST97
Domaini28196 – 28286Ig-like 131Add BLAST91
Domaini28295 – 28389Fibronectin type-III 106PROSITE-ProRule annotationAdd BLAST95
Domaini28392 – 28484Fibronectin type-III 107PROSITE-ProRule annotationAdd BLAST93
Domaini28488 – 28577Ig-like 132Add BLAST90
Domaini28583 – 28680Fibronectin type-III 108PROSITE-ProRule annotationAdd BLAST98
Domaini28686 – 28781Fibronectin type-III 109PROSITE-ProRule annotationAdd BLAST96
Domaini28784 – 28879Fibronectin type-III 110PROSITE-ProRule annotationAdd BLAST96
Domaini28882 – 28974Ig-like 133Add BLAST93
Domaini28979 – 29071Fibronectin type-III 111PROSITE-ProRule annotationAdd BLAST93
Domaini29081 – 29177Fibronectin type-III 112PROSITE-ProRule annotationAdd BLAST97
Domaini29180 – 29278Fibronectin type-III 113PROSITE-ProRule annotationAdd BLAST99
Domaini29282 – 29367Ig-like 134Add BLAST86
Domaini29378 – 29473Fibronectin type-III 114PROSITE-ProRule annotationAdd BLAST96
Domaini29475 – 29568Fibronectin type-III 115PROSITE-ProRule annotationAdd BLAST94
Domaini29568 – 29663Ig-like 135Add BLAST96
Domaini29670 – 29764Fibronectin type-III 116PROSITE-ProRule annotationAdd BLAST95
Domaini29770 – 29865Fibronectin type-III 117PROSITE-ProRule annotationAdd BLAST96
Domaini29868 – 29967Fibronectin type-III 118PROSITE-ProRule annotationAdd BLAST100
Domaini29971 – 30059Ig-like 136Add BLAST89
Domaini30070 – 30163Fibronectin type-III 119PROSITE-ProRule annotationAdd BLAST94
Domaini30169 – 30265Fibronectin type-III 120PROSITE-ProRule annotationAdd BLAST97
Domaini30271 – 30367Fibronectin type-III 121PROSITE-ProRule annotationAdd BLAST97
Domaini30371 – 30460Ig-like 137Add BLAST90
Domaini30467 – 30561Fibronectin type-III 122PROSITE-ProRule annotationAdd BLAST95
Domaini30564 – 30658Fibronectin type-III 123PROSITE-ProRule annotationAdd BLAST95
Domaini30663 – 30754Ig-like 138Add BLAST92
Domaini30761 – 30855Fibronectin type-III 124PROSITE-ProRule annotationAdd BLAST95
Domaini30861 – 30956Fibronectin type-III 125PROSITE-ProRule annotationAdd BLAST96
Domaini30962 – 31058Fibronectin type-III 126PROSITE-ProRule annotationAdd BLAST97
Domaini31061 – 31150Ig-like 139Add BLAST90
Domaini31158 – 31254Fibronectin type-III 127PROSITE-ProRule annotationAdd BLAST97
Domaini31258 – 31354Fibronectin type-III 128PROSITE-ProRule annotationAdd BLAST97
Domaini31360 – 31455Fibronectin type-III 129PROSITE-ProRule annotationAdd BLAST96
Domaini31460 – 31548Ig-like 140Add BLAST89
Domaini31653 – 31748Fibronectin type-III 130PROSITE-ProRule annotationAdd BLAST96
Domaini31754 – 31849Fibronectin type-III 131PROSITE-ProRule annotationAdd BLAST96
Domaini31855 – 31945Ig-like 141Add BLAST91
Domaini31955 – 32046Ig-like 142Add BLAST92
Domaini32051 – 32144Fibronectin type-III 132PROSITE-ProRule annotationAdd BLAST94
Domaini32178 – 32432Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini32496 – 32584Ig-like 143Add BLAST89
Domaini32617 – 32710Ig-like 144Add BLAST94
Domaini32722 – 32811Ig-like 145Add BLAST90
Domaini33301 – 33391Ig-like 146Add BLAST91
Domaini33488 – 33576Ig-like 147Add BLAST89
Domaini33645 – 33732Ig-like 148Add BLAST88
Domaini33779 – 33867Ig-like 149Add BLAST89
Domaini33963 – 34052Ig-like 150Add BLAST90
Domaini34061 – 34149Ig-like 151Add BLAST89
Domaini34256 – 34344Ig-like 152Add BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni253 – 341ZIS1Add BLAST89
Regioni1410 – 1440ZIS5Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili529 – 561Sequence analysisAdd BLAST33
Coiled coili2025 – 2052Sequence analysisAdd BLAST28
Coiled coili3462 – 3487Sequence analysisAdd BLAST26
Coiled coili9534 – 9577Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi391 – 436Ala-richAdd BLAST46
Compositional biasi453 – 456Poly-Thr4
Compositional biasi9500 – 9503Poly-Glu4
Compositional biasi9861 – 9952Pro-richAdd BLAST92
Compositional biasi9974 – 11917Glu-richAdd BLAST1944
Compositional biasi9974 – 10089Glu-richAdd BLAST116
Compositional biasi10102 – 10105Poly-Pro4
Compositional biasi10211 – 12032Pro-richAdd BLAST1822
Compositional biasi33188 – 33193Poly-Ser6
Compositional biasi33197 – 33200Poly-Arg4
Compositional biasi34102 – 34244Ser-richAdd BLAST143

Domaini

ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site.
The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere.

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00860000133679
HOGENOMiHOG000203078
HOVERGENiHBG080472
InParanoidiQ8WZ42
KOiK12567
OMAiAEKMSPN
TreeFamiTF316477

Family and domain databases

CDDicd00063 FN3, 132 hits
Gene3Di2.60.40.10, 194 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR004168 PPAK_motif
IPR000719 Prot_kinase_dom
IPR015129 Titin_Z_rpt
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 132 hits
PF07679 I-set, 162 hits
PF00069 Pkinase, 1 hit
PF02818 PPAK, 8 hits
PF09042 Titin_Z, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 132 hits
SM00409 IG, 167 hits
SM00408 IGc2, 148 hits
SM00406 IGv, 23 hits
SUPFAMiSSF48726 SSF48726, 167 hits
SSF49265 SSF49265, 74 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 132 hits
PS50835 IG_LIKE, 140 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (13+)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms may be produced, ranging from 27000 to 33000 residues in different striated muscle tissues, the size of the full-length protein may be up to 38138 residues.

This entry has 13 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WZ42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST 
        60         70         80         90        100
LPGVQISFSD GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE 
       110        120        130        140        150
TAPPNFVQRL QSMTVRQGSQ VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF 
       160        170        180        190        200
QISQEGDLYS LLIAEAYPED SGTYSVNATN SVGRATSTAE LLVQGEEEVP 
       210        220        230        240        250
AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV IDGAAGQQLP 
       260        270        280        290        300
HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT 
       310        320        330        340        350
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY 
       360        370        380        390        400
VASSSEAEMR ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA 
       410        420        430        440        450
SASYAAEAVA TGAKEVKQDA DKSAAVATVV AAVDMARVRE PVISAVEQTA 
       460        470        480        490        500
QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV VAADKAKEQE LKSRTKEVIT 
       510        520        530        540        550
TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS EEITKKQKQV 
       560        570        580        590        600
TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK 
       610        620        630        640        650
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE 
       660        670        680        690        700
AEKTALSTIA VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE 
       710        720        730        740        750
AVATVVAAVD QARVREPREP GHLEESYAQQ TTLEYGYKER ISAAKVAEPP 
       760        770        780        790        800
QRPASEPHVV PKAVKPRVIQ APSETHIKTT DQKGMHISSQ IKKTTDLTTE 
       810        820        830        840        850
RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA TLQKELSATS 
       860        870        880        890        900
SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK 
       910        920        930        940        950
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK 
       960        970        980        990       1000
NVTVIEGESV TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL 
      1010       1020       1030       1040       1050
MIREAFAEDS GRFTCSAVNE AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT 
      1060       1070       1080       1090       1100
TEEKRFVESR DVVMTDTSLT EEQAGPGEPA APYFITKPVV QKLVEGGSVV 
      1110       1120       1130       1140       1150
FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK LVISMTFADD 
      1160       1170       1180       1190       1200
AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP 
      1210       1220       1230       1240       1250
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF 
      1260       1270       1280       1290       1300
EERLIKEIEY RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY 
      1310       1320       1330       1340       1350
RILEGMGVTF HCKMSGYPLP KIAWYKDGKR IKHGERYQMD FLQDGRASLR 
      1360       1370       1380       1390       1400
IPVVLPEDEG IYTAFASNIK GNAICSGKLY VEPAAPLGAP TYIPTLEPVS 
      1410       1420       1430       1440       1450
RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG RRLEETDESQ 
      1460       1470       1480       1490       1500
LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND 
      1510       1520       1530       1540       1550
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV 
      1560       1570       1580       1590       1600
EHQVKPMFVE KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK 
      1610       1620       1630       1640       1650
YPKIRIEGTK GEAALKIDST VSQDSAWYTA TAINKAGRDT TRCKVNVEVE 
      1660       1670       1680       1690       1700
FAEPEPERKL IIPRGTYRAK EIAAPELEPL HLRYGQEQWE EGDLYDKEKQ 
      1710       1720       1730       1740       1750
QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH DGKPLEAANR 
      1760       1770       1780       1790       1800
LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL 
      1810       1820       1830       1840       1850
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV 
      1860       1870       1880       1890       1900
RVLEGETARF RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV 
      1910       1920       1930       1940       1950
DCKSYDTGEV KVTAENPEGV IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH 
      1960       1970       1980       1990       2000
VHEPGKLQFE VQKVDRPVDT TETKEVVKLK RAERITHEKV PEESEELRSK 
      2010       2020       2030       2040       2050
FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH WTKELTEEEK 
      2060       2070       2080       2090       2100
KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR 
      2110       2120       2130       2140       2150
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM 
      2160       2170       2180       2190       2200
VKAINIAGET SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE 
      2210       2220       2230       2240       2250
PFVKVKWYKD GMEVHEGDKY RMHSDRKVHF LSILTIDTSD AEDYSCVLVE 
      2260       2270       2280       2290       2300
DENVKTTAKL IVEGAVVEFV KELQDIEVPE SYSGELECIV SPENIEGKWY 
      2310       2320       2330       2340       2350
HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI DGKKTTCKLK 
      2360       2370       2380       2390       2400
MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR 
      2410       2420       2430       2440       2450
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP 
      2460       2470       2480       2490       2500
LKDVNVIEGT KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ 
      2510       2520       2530       2540       2550
RLVINRTHAS DEGPYKLIVG RVETNCNLSV EKIKIIRGLR DLTCTETQNV 
      2560       2570       2580       2590       2600
VFEVELSHSG IDVLWNFKDK EIKPSSKYKI EAHGKIYKLT VLNMMKDDEG 
      2610       2620       2630       2640       2650
KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE CEVANPDSKG 
      2660       2670       2680       2690       2700
EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA 
      2710       2720       2730       2740       2750
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN 
      2760       2770       2780       2790       2800
EKYAISVKGT IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK 
      2810       2820       2830       2840       2850
PKDVTALENA TVAFEVSVSH DTVPVKWFHK SVEIKPSDKH RLVSERKVHK 
      2860       2870       2880       2890       2900
LMLQNISPSD AGEYTAVVGQ LECKAKLFVE TLHITKTMKN IEVPETKTAS 
      2910       2920       2930       2940       2950
FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII MNTSTEDSAE 
      2960       2970       2980       2990       3000
YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK 
      3010       3020       3030       3040       3050
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT 
      3060       3070       3080       3090       3100
LYVEARHIEF RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT 
      3110       3120       3130       3140       3150
DRIKIQKEKY VHRLLIPSTR MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR 
      3160       3170       3180       3190       3200
SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY KDGIEINFQV QERHKYVVER 
      3210       3220       3230       3240       3250
RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ VLQELQPVTV 
      3260       3270       3280       3290       3300
QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE 
      3310       3320       3330       3340       3350
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP 
      3360       3370       3380       3390       3400
LQDTVTSEGQ PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ 
      3410       3420       3430       3440       3450
LEIAEAYPED EGTYTFVASN AVGQVSSTAN LSLEAPESIL HERIEQEIEM 
      3460       3470       3480       3490       3500
EMKEFSSSFL SAEEEGLHSA ELQLSKINET LELLSESPVY PTKFDSEKEG 
      3510       3520       3530       3540       3550
TGPIFIKEVS NADISMGDVA TLSVTVIGIP KPKIQWFFNG VLLTPSADYK 
      3560       3570       3580       3590       3600
FVFDGDDHSL IILFTKLEDE GEYTCMASND YGKTICSAYL KINSKGEGHK 
      3610       3620       3630       3640       3650
DTETESAVAK SLEKLGGPCP PHFLKELKPI RCAQGLPAIF EYTVVGEPAP 
      3660       3670       3680       3690       3700
TVTWFKENKQ LCTSVYYTII HNPNGSGTFI VNDPQREDSG LYICKAENML 
      3710       3720       3730       3740       3750
GESTCAAELL VLLEDTDMTD TPCKAKSTPE APEDFPQTPL KGPAVEALDS 
      3760       3770       3780       3790       3800
EQEIATFVKD TILKAALITE ENQQLSYEHI AKANELSSQL PLGAQELQSI 
      3810       3820       3830       3840       3850
LEQDKLTPES TREFLCINGS IHFQPLKEPS PNLQLQIVQS QKTFSKEGIL 
      3860       3870       3880       3890       3900
MPEEPETQAV LSDTEKIFPS AMSIEQINSL TVEPLKTLLA EPEGNYPQSS 
      3910       3920       3930       3940       3950
IEPPMHSYLT SVAEEVLSPK EKTVSDTNRE QRVTLQKQEA QSALILSQSL 
      3960       3970       3980       3990       4000
AEGHVESLQS PDVMISQVNY EPLVPSEHSC TEGGKILIES ANPLENAGQD 
      4010       4020       4030       4040       4050
SAVRIEEGKS LRFPLALEEK QVLLKEEHSD NVVMPPDQII ESKREPVAIK 
      4060       4070       4080       4090       4100
KVQEVQGRDL LSKESLLSGI PEEQRLNLKI QICRALQAAV ASEQPGLFSE 
      4110       4120       4130       4140       4150
WLRNIEKVEV EAVNITQEPR HIMCMYLVTS AKSVTEEVTI IIEDVDPQMA 
      4160       4170       4180       4190       4200
NLKMELRDAL CAIIYEEIDI LTAEGPRIQQ GAKTSLQEEM DSFSGSQKVE 
      4210       4220       4230       4240       4250
PITEPEVESK YLISTEEVSY FNVQSRVKYL DATPVTKGVA SAVVSDEKQD 
      4260       4270       4280       4290       4300
ESLKPSEEKE ESSSESGTEE VATVKIQEAE GGLIKEDGPM IHTPLVDTVS 
      4310       4320       4330       4340       4350
EEGDIVHLTT SITNAKEVNW YFENKLVPSD EKFKCLQDQN TYTLVIDKVN 
      4360       4370       4380       4390       4400
TEDHQGEYVC EALNDSGKTA TSAKLTVVKR AAPVIKRKIE PLEVALGHLA 
      4410       4420       4430       4440       4450
KFTCEIQSAP NVRFQWFKAG REIYESDKCS IRSSKYISSL EILRTQVVDC 
      4460       4470       4480       4490       4500
GEYTCKASNE YGSVSCTATL TVTEAYPPTF LSRPKSLTTF VGKAAKFICT 
      4510       4520       4530       4540       4550
VTGTPVIETI WQKDGAALSP SPNWRISDAE NKHILELSNL TIQDRGVYSC 
      4560       4570       4580       4590       4600
KASNKFGADI CQAELIIIDK PHFIKELEPV QSAINKKVHL ECQVDEDRKV 
      4610       4620       4630       4640       4650
TVTWSKDGQK LPPGKDYKIC FEDKIATLEI PLAKLKDSGT YVCTASNEAG 
      4660       4670       4680       4690       4700
SSSCSATVTV REPPSFVKKV DPSYLMLPGE SARLHCKLKG SPVIQVTWFK 
      4710       4720       4730       4740       4750
NNKELSESNT VRMYFVNSEA ILDITDVKVE DSGSYSCEAV NDVGSDSCST 
      4760       4770       4780       4790       4800
EIVIKEPPSF IKTLEPADIV RGTNALLQCE VSGTGPFEIS WFKDKKQIRS 
      4810       4820       4830       4840       4850
SKKYRLFSQK SLVCLEIFSF NSADVGEYEC VVANEVGKCG CMATHLLKEP 
      4860       4870       4880       4890       4900
PTFVKKVDDL IALGGQTVTL QAAVRGSEPI SVTWMKGQEV IREDGKIKMS 
      4910       4920       4930       4940       4950
FSNGVAVLII PDVQISFGGK YTCLAENEAG SQTSVGELIV KEPAKIIERA 
      4960       4970       4980       4990       5000
ELIQVTAGDP ATLEYTVAGT PELKPKWYKD GRPLVASKKY RISFKNNVAQ 
      5010       5020       5030       5040       5050
LKFYSAELHD SGQYTFEISN EVGSSSCETT FTVLDRDIAP FFTKPLRNVD 
      5060       5070       5080       5090       5100
SVVNGTCRLD CKIAGSLPMR VSWFKDGKEI AASDRYRIAF VEGTASLEII 
      5110       5120       5130       5140       5150
RVDMNDAGNF TCRATNSVGS KDSSGALIVQ EPPSFVTKPG SKDVLPGSAV 
      5160       5170       5180       5190       5200
CLKSTFQGST PLTIRWFKGN KELVSGGSCY ITKEALESSL ELYLVKTSDS 
      5210       5220       5230       5240       5250
GTYTCKVSNV AGGVECSANL FVKEPATFVE KLEPSQLLKK GDATQLACKV 
      5260       5270       5280       5290       5300
TGTPPIKITW FANDREIKES SKHRMSFVES TAVLRLTDVG IEDSGEYMCE 
      5310       5320       5330       5340       5350
AQNEAGSDHC SSIVIVKESP YFTKEFKPIE VLKEYDVMLL AEVAGTPPFE 
      5360       5370       5380       5390       5400
ITWFKDNTIL RSGRKYKTFI QDHLVSLQIL KFVAADAGEY QCRVTNEVGS 
      5410       5420       5430       5440       5450
SICSARVTLR EPPSFIKKIE STSSLRGGTA AFQATLKGSL PITVTWLKDS 
      5460       5470       5480       5490       5500
DEITEDDNIR MTFENNVASL YLSGIEVKHD GKYVCQAKND AGIQRCSALL 
      5510       5520       5530       5540       5550
SVKEPATITE EAVSIDVTQG DPATLQVKFS GTKEITAKWF KDGQELTLGS 
      5560       5570       5580       5590       5600
KYKISVTDTV SILKIISTEK KDSGEYTFEV QNDVGRSSCK ARINVLDLII 
      5610       5620       5630       5640       5650
PPSFTKKLKK MDSIKGSFID LECIVAGSHP ISIQWFKDDQ EISASEKYKF 
      5660       5670       5680       5690       5700
SFHDNTAFLE ISQLEGTDSG TYTCSATNKA GHNQCSGHLT VKEPPYFVEK 
      5710       5720       5730       5740       5750
PQSQDVNPNT RVQLKALVGG TAPMTIKWFK DNKELHSGAA RSVWKDDTST 
      5760       5770       5780       5790       5800
SLELFAAKAT DSGTYICQLS NDVGTATSKA TLFVKEPPQF IKKPSPVLVL 
      5810       5820       5830       5840       5850
RNGQSTTFEC QITGTPKIRV SWYLDGNEIT AIQKHGISFI DGLATFQISG 
      5860       5870       5880       5890       5900
ARVENSGTYV CEARNDAGTA SCSIELKVKE PPTFIRELKP VEVVKYSDVE 
      5910       5920       5930       5940       5950
LECEVTGTPP FEVTWLKNNR EIRSSKKYTL TDRVSVFNLH ITKCDPSDTG 
      5960       5970       5980       5990       6000
EYQCIVSNEG GSCSCSTRVA LKEPPSFIKK IENTTTVLKS SATFQSTVAG 
      6010       6020       6030       6040       6050
SPPISITWLK DDQILDEDDN VYISFVDSVA TLQIRSVDNG HSGRYTCQAK 
      6060       6070       6080       6090       6100
NESGVERCYA FLLVQEPAQI VEKAKSVDVT EKDPMTLECV VAGTPELKVK 
      6110       6120       6130       6140       6150
WLKDGKQIVP SRYFSMSFEN NVASFRIQSV MKQDSGQYTF KVENDFGSSS 
      6160       6170       6180       6190       6200
CDAYLRVLDQ NIPPSFTKKL TKMDKVLGSS IHMECKVSGS LPISAQWFKD 
      6210       6220       6230       6240       6250
GKEISTSAKY RLVCHERSVS LEVNNLELED TANYTCKVSN VAGDDACSGI 
      6260       6270       6280       6290       6300
LTVKEPPSFL VKPGRQQAIP DSTVEFKAIL KGTPPFKIKW FKDDVELVSG 
      6310       6320       6330       6340       6350
PKCFIGLEGS TSFLNLYSVD ASKTGQYTCH VTNDVGSDSC TTMLLVTEPP 
      6360       6370       6380       6390       6400
KFVKKLEASK IVKAGDSSRL ECKIAGSPEI RVVWFRNEHE LPASDKYRMT 
      6410       6420       6430       6440       6450
FIDSVAVIQM NNLSTEDSGD FICEAQNPAG STSCSTKVIV KEPPVFSSFP 
      6460       6470       6480       6490       6500
PIVETLKNAE VSLECELSGT PPFEVVWYKD KRQLRSSKKY KIASKNFHTS 
      6510       6520       6530       6540       6550
IHILNVDTSD IGEYHCKAQN EVGSDTCVCT VKLKEPPRFV SKLNSLTVVA 
      6560       6570       6580       6590       6600
GEPAELQASI EGAQPIFVQW LKEKEEVIRE SENIRITFVE NVATLQFAKA 
      6610       6620       6630       6640       6650
EPANAGKYIC QIKNDGGMRE NMATLMVLEP AVIVEKAGPM TVTVGETCTL 
      6660       6670       6680       6690       6700
ECKVAGTPEL SVEWYKDGKL LTSSQKHKFS FYNKISSLRI LSVERQDAGT 
      6710       6720       6730       6740       6750
YTFQVQNNVG KSSCTAVVDV SDRAVPPSFT RRLKNTGGVL GASCILECKV 
      6760       6770       6780       6790       6800
AGSSPISVAW FHEKTKIVSG AKYQTTFSDN VCTLQLNSLD SSDMGNYTCV 
      6810       6820       6830       6840       6850
AANVAGSDEC RAVLTVQEPP SFVKEPEPLE VLPGKNVTFT SVIRGTPPFK 
      6860       6870       6880       6890       6900
VNWFRGAREL VKGDRCNIYF EDTVAELELF NIDISQSGEY TCVVSNNAGQ 
      6910       6920       6930       6940       6950
ASCTTRLFVK EPAAFLKRLS DHSVEPGKSI ILESTYTGTL PISVTWKKDG 
      6960       6970       6980       6990       7000
FNITTSEKCN IVTTEKTCIL EILNSTKRDA GQYSCEIENE AGRDVCGALV 
      7010       7020       7030       7040       7050
STLEPPYFVT ELEPLEAAVG DSVSLQCQVA GTPEITVSWY KGDTKLRPTP 
      7060       7070       7080       7090       7100
EYRTYFTNNV ATLVFNKVNI NDSGEYTCKA ENSIGTASSK TVFRIQERQL 
      7110       7120       7130       7140       7150
PPSFARQLKD IEQTVGLPVT LTCRLNGSAP IQVCWYRDGV LLRDDENLQT 
      7160       7170       7180       7190       7200
SFVDNVATLK ILQTDLSHSG QYSCSASNPL GTASSSARLT AREPKKSPFF 
      7210       7220       7230       7240       7250
DIKPVSIDVI AGESADFECH VTGAQPMRIT WSKDNKEIRP GGNYTITCVG 
      7260       7270       7280       7290       7300
NTPHLRILKV GKGDSGQYTC QATNDVGKDM CSAQLSVKEP PKFVKKLEAS 
      7310       7320       7330       7340       7350
KVAKQGESIQ LECKISGSPE IKVSWFRNDS ELHESWKYNM SFINSVALLT 
      7360       7370       7380       7390       7400
INEASAEDSG DYICEAHNGV GDASCSTALT VKAPPVFTQK PSPVGALKGS 
      7410       7420       7430       7440       7450
DVILQCEISG TPPFEVVWVK DRKQVRNSKK FKITSKHFDT SLHILNLEAS 
      7460       7470       7480       7490       7500
DVGEYHCKAT NEVGSDTCSC SVKFKEPPRF VKKLSDTSTL IGDAVELRAI 
      7510       7520       7530       7540       7550
VEGFQPISVV WLKDRGEVIR ESENTRISFI DNIATLQLGS PEASNSGKYI 
      7560       7570       7580       7590       7600
CQIKNDAGMR ECSAVLTVLE PARIIEKPEP MTVTTGNPFA LECVVTGTPE 
      7610       7620       7630       7640       7650
LSAKWFKDGR ELSADSKHHI TFINKVASLK IPCAEMSDKG LYSFEVKNSV 
      7660       7670       7680       7690       7700
GKSNCTVSVH VSDRIVPPSF IRKLKDVNAI LGASVVLECR VSGSAPISVG 
      7710       7720       7730       7740       7750
WFQDGNEIVS GPKCQSSFSE NVCTLNLSLL EPSDTGIYTC VAANVAGSDE 
      7760       7770       7780       7790       7800
CSAVLTVQEP PSFEQTPDSV EVLPGMSLTF TSVIRGTPPF KVKWFKGSRE 
      7810       7820       7830       7840       7850
LVPGESCNIS LEDFVTELEL FEVQPLESGD YSCLVTNDAG SASCTTHLFV 
      7860       7870       7880       7890       7900
KEPATFVKRL ADFSVETGSP IVLEATYTGT PPISVSWIKD EYLISQSERC 
      7910       7920       7930       7940       7950
SITMTEKSTI LEILESTIED YAQYSCLIEN EAGQDICEAL VSVLEPPYFI 
      7960       7970       7980       7990       8000
EPLEHVEAVI GEPATLQCKV DGTPEIRISW YKEHTKLRSA PAYKMQFKNN 
      8010       8020       8030       8040       8050
VASLVINKVD HSDVGEYSCK ADNSVGAVAS SAVLVIKARK LPPFFARKLK 
      8060       8070       8080       8090       8100
DVHETLGFPV AFECRINGSE PLQVSWYKDG VLLKDDANLQ TSFVHNVATL 
      8110       8120       8130       8140       8150
QILQTDQSHI GQYNCSASNP LGTASSSAKL ILSEHEVPPF FDLKPVSVDL 
      8160       8170       8180       8190       8200
ALGESGTFKC HVTGTAPIKI TWAKDNREIR PGGNYKMTLV ENTATLTVLK 
      8210       8220       8230       8240       8250
VGKGDAGQYT CYASNIAGKD SCSAQLGVQE PPRFIKKLEP SRIVKQDEFT 
      8260       8270       8280       8290       8300
RYECKIGGSP EIKVLWYKDE TEIQESSKFR MSFVDSVAVL EMHNLSVEDS 
      8310       8320       8330       8340       8350
GDYTCEAHNA AGSASSSTSL KVKEPPIFRK KPHPIETLKG ADVHLECELQ 
      8360       8370       8380       8390       8400
GTPPFHVSWY KDKRELRSGK KYKIMSENFL TSIHILNVDA ADIGEYQCKA 
      8410       8420       8430       8440       8450
TNDVGSDTCV GSIALKAPPR FVKKLSDIST VVGKEVQLQT TIEGAEPISV 
      8460       8470       8480       8490       8500
VWFKDKGEIV RESDNIWISY SENIATLQFS RVEPANAGKY TCQIKNDAGM 
      8510       8520       8530       8540       8550
QECFATLSVL EPATIVEKPE SIKVTTGDTC TLECTVAGTP ELSTKWFKDG 
      8560       8570       8580       8590       8600
KELTSDNKYK ISFFNKVSGL KIINVAPSDS GVYSFEVQNP VGKDSCTASL 
      8610       8620       8630       8640       8650
QVSDRTVPPS FTRKLKETNG LSGSSVVMEC KVYGSPPISV SWFHEGNEIS 
      8660       8670       8680       8690       8700
SGRKYQTTLT DNTCALTVNM LEESDSGDYT CIATNMAGSD ECSAPLTVRE 
      8710       8720       8730       8740       8750
PPSFVQKPDP MDVLTGTNVT FTSIVKGTPP FSVSWFKGSS ELVPGDRCNV 
      8760       8770       8780       8790       8800
SLEDSVAELE LFDVDTSQSG EYTCIVSNEA GKASCTTHLY IKAPAKFVKR 
      8810       8820       8830       8840       8850
LNDYSIEKGK PLILEGTFTG TPPISVTWKK NGINVTPSQR CNITTTEKSA 
      8860       8870       8880       8890       8900
ILEIPSSTVE DAGQYNCYIE NASGKDSCSA QILILEPPYF VKQLEPVKVS 
      8910       8920       8930       8940       8950
VGDSASLQCQ LAGTPEIGVS WYKGDTKLRP TTTYKMHFRN NVATLVFNQV 
      8960       8970       8980       8990       9000
DINDSGEYIC KAENSVGEVS ASTFLTVQEQ KLPPSFSRQL RDVQETVGLP 
      9010       9020       9030       9040       9050
VVFDCAISGS EPISVSWYKD GKPLKDSPNV QTSFLDNTAT LNIFKTDRSL 
      9060       9070       9080       9090       9100
AGQYSCTATN PIGSASSSAR LILTEGKNPP FFDIRLAPVD AVVGESADFE 
      9110       9120       9130       9140       9150
CHVTGTQPIK VSWAKDSREI RSGGKYQISY LENSAHLTVL KVDKGDSGQY 
      9160       9170       9180       9190       9200
TCYAVNEVGK DSCTAQLNIK ERLIPPSFTK RLSETVEETE GNSFKLEGRV 
      9210       9220       9230       9240       9250
AGSQPITVAW YKNNIEIQPT SNCEITFKNN TLVLQVRKAG MNDAGLYTCK 
      9260       9270       9280       9290       9300
VSNDAGSALC TSSIVIKEPK KPPVFDQHLT PVTVSEGEYV QLSCHVQGSE 
      9310       9320       9330       9340       9350
PIRIQWLKAG REIKPSDRCS FSFASGTAVL ELRDVAKADS GDYVCKASNV 
      9360       9370       9380       9390       9400
AGSDTTKSKV TIKDKPAVAP ATKKAAVDGR LFFVSEPQSI RVVEKTTATF 
      9410       9420       9430       9440       9450
IAKVGGDPIP NVKWTKGKWR QLNQGGRVFI HQKGDEAKLE IRDTTKTDSG 
      9460       9470       9480       9490       9500
LYRCVAFNEH GEIESNVNLQ VDERKKQEKI EGDLRAMLKK TPILKKGAGE 
      9510       9520       9530       9540       9550
EEEIDIMELL KNVDPKEYEK YARMYGITDF RGLLQAFELL KQSQEEETHR 
      9560       9570       9580       9590       9600
LEIEEIERSE RDEKEFEELV SFIQQRLSQT EPVTLIKDIE NQTVLKDNDA 
      9610       9620       9630       9640       9650
VFEIDIKINY PEIKLSWYKG TEKLEPSDKF EISIDGDRHT LRVKNCQLKD 
      9660       9670       9680       9690       9700
QGNYRLVCGP HIASAKLTVI EPAWERHLQD VTLKEGQTCT MTCQFSVPNV 
      9710       9720       9730       9740       9750
KSEWFRNGRI LKPQGRHKTE VEHKVHKLTI ADVRAEDQGQ YTCKYEDLET 
      9760       9770       9780       9790       9800
SAELRIEAEP IQFTKRIQNI VVSEHQSATF ECEVSFDDAI VTWYKGPTEL 
      9810       9820       9830       9840       9850
TESQKYNFRN DGRCHYMTIH NVTPDDEGVY SVIARLEPRG EARSTAELYL 
      9860       9870       9880       9890       9900
TTKEIKLELK PPDIPDSRVP IPTMPIRAVP PEEIPPVVAP PIPLLLPTPE 
      9910       9920       9930       9940       9950
EKKPPPKRIE VTKKAVKKDA KKVVAKPKEM TPREEIVKKP PPPTTLIPAK 
      9960       9970       9980       9990      10000
APEIIDVSSK AEEVKIMTIT RKKEVQKEKE AVYEKKQAVH KEKRVFIESF 
     10010      10020      10030      10040      10050
EEPYDELEVE PYTEPFEQPY YEEPDEDYEE IKVEAKKEVH EEWEEDFEEG 
     10060      10070      10080      10090      10100
QEYYEREEGY DEGEEEWEEA YQEREVIQVQ KEVYEESHER KVPAKVPEKK 
     10110      10120      10130      10140      10150
APPPPKVIKK PVIEKIEKTS RRMEEEKVQV TKVPEVSKKI VPQKPSRTPV 
     10160      10170      10180      10190      10200
QEEVIEVKVP AVHTKKMVIS EEKMFFASHT EEEVSVTVPE VQKEIVTEEK 
     10210      10220      10230      10240      10250
IHVAISKRVE PPPKVPELPE KPAPEEVAPV PIPKKVEPPA PKVPEVPKKP 
     10260      10270      10280      10290      10300
VPEEKKPVPV PKKEPAAPPK VPEVPKKPVP EEKIPVPVAK KKEAPPAKVP 
     10310      10320      10330      10340      10350
EVQKGVVTEE KITIVTQREE SPPPAVPEIP KKKVPEERKP VPRKEEEVPP 
     10360      10370      10380      10390      10400
PPKVPALPKK PVPEEKVAVP VPVAKKAPPP RAEVSKKTVV EEKRFVAEEK 
     10410      10420      10430      10440      10450
LSFAVPQRVE VTRHEVSAEE EWSYSEEEEG VSISVYREEE REEEEEAEVT 
     10460      10470      10480      10490      10500
EYEVMEEPEE YVVEEKLHII SKRVEAEPAE VTERQEKKIV LKPKIPAKIE 
     10510      10520      10530      10540      10550
EPPPAKVPEA PKKIVPEKKV PAPVPKKEKV PPPKVPEEPK KPVPEKKVPP 
     10560      10570      10580      10590      10600
KVIKMEEPLP AKVTERHMQI TQEEKVLVAV TKKEAPPKAR VPEEPKRAVP 
     10610      10620      10630      10640      10650
EEKVLKLKPK REEEPPAKVT EFRKRVVKEE KVSIEAPKRE PQPIKEVTIM 
     10660      10670      10680      10690      10700
EEKERAYTLE EEAVSVQREE EYEEYEEYDY KEFEEYEPTE EYDQYEEYEE 
     10710      10720      10730      10740      10750
REYERYEEHE EYITEPEKPI PVKPVPEEPV PTKPKAPPAK VLKKAVPEEK 
     10760      10770      10780      10790      10800
VPVPIPKKLK PPPPKVPEEP KKVFEEKIRI SITKREKEQV TEPAAKVPMK 
     10810      10820      10830      10840      10850
PKRVVAEEKV PVPRKEVAPP VRVPEVPKEL EPEEVAFEEE VVTHVEEYLV 
     10860      10870      10880      10890      10900
EEEEEYIHEE EEFITEEEVV PVIPVKVPEV PRKPVPEEKK PVPVPKKKEA 
     10910      10920      10930      10940      10950
PPAKVPEVPK KPEEKVPVLI PKKEKPPPAK VPEVPKKPVP EEKVPVPVPK 
     10960      10970      10980      10990      11000
KVEAPPAKVP EVPKKPVPEK KVPVPAPKKV EAPPAKVPEV PKKLIPEEKK 
     11010      11020      11030      11040      11050
PTPVPKKVEA PPPKVPKKRE PVPVPVALPQ EEEVLFEEEI VPEEEVLPEE 
     11060      11070      11080      11090      11100
EEVLPEEEEV LPEEEEVLPE EEEIPPEEEE VPPEEEYVPE EEEFVPEEEV 
     11110      11120      11130      11140      11150
LPEVKPKVPV PAPVPEIKKK VTEKKVVIPK KEEAPPAKVP EVPKKVEEKR 
     11160      11170      11180      11190      11200
IILPKEEEVL PVEVTEEPEE EPISEEEIPE EPPSIEEVEE VAPPRVPEVI 
     11210      11220      11230      11240      11250
KKAVPEAPTP VPKKVEAPPA KVSKKIPEEK VPVPVQKKEA PPAKVPEVPK 
     11260      11270      11280      11290      11300
KVPEKKVLVP KKEAVPPAKG RTVLEEKVSV AFRQEVVVKE RLELEVVEAE 
     11310      11320      11330      11340      11350
VEEIPEEEEF HEVEEYFEEG EFHEVEEFIK LEQHRVEEEH RVEKVHRVIE 
     11360      11370      11380      11390      11400
VFEAEEVEVF EKPKAPPKGP EISEKIIPPK KPPTKVVPRK EPPAKVPEVP 
     11410      11420