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Entry version 125 (05 Jun 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Phosphoinositide 3-kinase regulatory subunit 5

Gene

PIK3R5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Greatly activated by G gamma proteins.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS13887-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide 3-kinase regulatory subunit 5
Short name:
PI3-kinase regulatory subunit 5
Alternative name(s):
PI3-kinase p101 subunit
Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
Short name:
PtdIns-3-kinase regulatory subunit
Protein FOAP-2
PtdIns-3-kinase p101
p101-PI3K
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIK3R5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30035 PIK3R5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611317 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WYR1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ataxia-oculomotor apraxia 3 (AOA3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067052629P → S in AOA3. 1 PublicationCorresponds to variant dbSNP:rs61761068EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
23533

MalaCards human disease database

More...
MalaCardsi
PIK3R5
MIMi615217 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000141506

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
64753 Spinocerebellar ataxia with axonal neuropathy type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134890823

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3430881

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIK3R5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74716480

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000584211 – 880Phosphoinositide 3-kinase regulatory subunit 5Add BLAST880

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei458PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WYR1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WYR1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WYR1

PeptideAtlas

More...
PeptideAtlasi
Q8WYR1

PRoteomics IDEntifications database

More...
PRIDEi
Q8WYR1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75194
75195 [Q8WYR1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WYR1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WYR1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141506 Expressed in 134 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WYR1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WYR1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044505
HPA052247
HPA052412

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117079, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WYR1, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000392812

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8WYR1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WYR1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 101HeterodimerizationBy similarityAdd BLAST77
Regioni653 – 753Interaction with beta-gamma G protein dimersBy similarityAdd BLAST101

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The heterodimerization region allows the binding to the catalytic subunit.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IES2 Eukaryota
ENOG410Y2ZG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063753

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WYR1

KEGG Orthology (KO)

More...
KOi
K21290

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGMDSGY

Database of Orthologous Groups

More...
OrthoDBi
220934at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WYR1

TreeFam database of animal gene trees

More...
TreeFami
TF102035

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019522 PIK3R5/6

The PANTHER Classification System

More...
PANTHERi
PTHR15593 PTHR15593, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10486 PI3K_1B_p101, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPGATTCTE DRIQHALERC LHGLSLSRRS TSWSAGLCLN CWSLQELVSR
60 70 80 90 100
DPGHFLILLE QILQKTREVQ EKGTYDLLTP LALLFYSTVL CTPHFPPDSD
110 120 130 140 150
LLLKAASTYH RFLTWPVPYC SICQELLTFI DAELKAPGIS YQRLVRAEQG
160 170 180 190 200
LPIRSHRSST VTVLLLNPVE VQAEFLAVAN KLSTPGHSPH SAYTTLLLHA
210 220 230 240 250
FQATFGAHCD VPGLHCRLQA KTLAELEDIF TETAEAQELA SGIGDAAEAR
260 270 280 290 300
RWLRTKLQAV GEKAGFPGVL DTAKPGKLHT IPIPVARCYT YSWSQDSFDI
310 320 330 340 350
LQEILLKEQE LLQPGILGDD EEEEEEEEEV EEDLETDGHC AERDSLLSTS
360 370 380 390 400
SLASHDSTLS LASSQASGPA LSRHLLTSFV SGLSDGMDSG YVEDSEESSS
410 420 430 440 450
EWPWRRGSQE RRGHRRPGQK FIRIYKLFKS TSQLVLRRDS RSLEGSSDTA
460 470 480 490 500
LPLRRAGSLC SPLDEPVSPP SRAQRSRSLP QPKLGTQLPS WLLAPASRPQ
510 520 530 540 550
RRRPFLSGDE DPKASTLRVV VFGSDRISGK VARAYSNLRR LENNRPLLTR
560 570 580 590 600
FFKLQFFYVP VKRSHGTSPG ACPPPRSQTP SPPTDSPRHA SPGELGTTPW
610 620 630 640 650
EESTNDISHY LGMLDPWYER NVLGLMHLPP EVLCQQSLKA EAQALEGSPT
660 670 680 690 700
QLPILADMLL YYCRFAARPV LLQVYQTELT FITGEKTTEI FIHSLELGHS
710 720 730 740 750
AATRAIKASG PGSKRLGIDG DREAVPLTLQ IIYSKGAISG RSRWSNLEKV
760 770 780 790 800
CTSVNLNKAC RKQEELDSSM EALTLNLTEV VKRQNSKSKK GFNQISTSQI
810 820 830 840 850
KVDKVQIIGS NSCPFAVCLD QDERKILQSV VRCEVSPCYK PEKSDLSSPP
860 870 880
QTPPDLPAQA APDLCSLLCL PIMTFSGALP
Length:880
Mass (Da):97,348
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70E356773B148A8A
GO
Isoform 2 (identifier: Q8WYR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.

Note: No experimental confirmation available.
Show »
Length:494
Mass (Da):54,878
Checksum:iC8962DD01304C8C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KSW1J3KSW1_HUMAN
Phosphoinositide 3-kinase regulator...
PIK3R5
879Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT66J3KT66_HUMAN
Phosphoinositide 3-kinase regulator...
PIK3R5
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R3K3X6R3K3_HUMAN
Phosphoinositide 3-kinase regulator...
PIK3R5
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRE9J3KRE9_HUMAN
Phosphoinositide 3-kinase regulator...
PIK3R5
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15H → L in AAW63122 (Ref. 6) Curated1
Sequence conflicti29R → C in AAW63122 (Ref. 6) Curated1
Sequence conflicti47L → Q in AAW63122 (Ref. 6) Curated1
Sequence conflicti95F → L in AAW63122 (Ref. 6) Curated1
Sequence conflicti171V → E in AAW63122 (Ref. 6) Curated1
Sequence conflicti220 – 297AKTLA…WSQDS → TLQNQGSSIPSPSLSPGATP TAGARTALTSCRKSCSRNRS CSSQGSWEMMKRRKRRRRRW RRTWKLMGTVPREIPCSP in AAW63122 (Ref. 6) CuratedAdd BLAST78
Sequence conflicti299 – 368DILQE…SQASG → GNIEGDPGPRRPDSAGLASL QTSCRKSCSRNRSYSSQGSW EMMKRRERRRRRWRRTWKLT GTVPREIPCS in AAW63121 (Ref. 6) CuratedAdd BLAST70
Sequence conflicti674V → L in AAD33397 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03622728R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs371789171Ensembl.1
Natural variantiVAR_067052629P → S in AOA3. 1 PublicationCorresponds to variant dbSNP:rs61761068EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0163881 – 386Missing in isoform 2. 1 PublicationAdd BLAST386

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB028925 mRNA Translation: BAB82464.1
AF128881 mRNA Translation: AAD33397.1
EU332864 Genomic DNA Translation: ABY87553.1
CH471108 Genomic DNA Translation: EAW90035.1
CH471108 Genomic DNA Translation: EAW90036.1
BC028212 mRNA Translation: AAH28212.1
AY725851 mRNA Translation: AAW63121.1
AY725852 mRNA Translation: AAW63122.1
AY725853 mRNA Translation: AAW63123.1
AY725854 mRNA Translation: AAW63124.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11147.1 [Q8WYR1-1]
CCDS73986.1 [Q8WYR1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001136105.1, NM_001142633.2 [Q8WYR1-1]
NP_001238780.1, NM_001251851.1 [Q8WYR1-2]
NP_001238781.1, NM_001251852.1 [Q8WYR1-2]
NP_001238782.1, NM_001251853.1 [Q8WYR1-2]
NP_001238784.1, NM_001251855.1 [Q8WYR1-2]
NP_055123.2, NM_014308.3 [Q8WYR1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000447110; ENSP00000392812; ENSG00000141506 [Q8WYR1-1]
ENST00000581552; ENSP00000462433; ENSG00000141506 [Q8WYR1-1]
ENST00000611902; ENSP00000477795; ENSG00000141506 [Q8WYR1-2]
ENST00000616147; ENSP00000484211; ENSG00000141506 [Q8WYR1-2]
ENST00000623421; ENSP00000485280; ENSG00000141506 [Q8WYR1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23533

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23533

UCSC genome browser

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UCSCi
uc002glt.4 human [Q8WYR1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028925 mRNA Translation: BAB82464.1
AF128881 mRNA Translation: AAD33397.1
EU332864 Genomic DNA Translation: ABY87553.1
CH471108 Genomic DNA Translation: EAW90035.1
CH471108 Genomic DNA Translation: EAW90036.1
BC028212 mRNA Translation: AAH28212.1
AY725851 mRNA Translation: AAW63121.1
AY725852 mRNA Translation: AAW63122.1
AY725853 mRNA Translation: AAW63123.1
AY725854 mRNA Translation: AAW63124.1
CCDSiCCDS11147.1 [Q8WYR1-1]
CCDS73986.1 [Q8WYR1-2]
RefSeqiNP_001136105.1, NM_001142633.2 [Q8WYR1-1]
NP_001238780.1, NM_001251851.1 [Q8WYR1-2]
NP_001238781.1, NM_001251852.1 [Q8WYR1-2]
NP_001238782.1, NM_001251853.1 [Q8WYR1-2]
NP_001238784.1, NM_001251855.1 [Q8WYR1-2]
NP_055123.2, NM_014308.3 [Q8WYR1-1]

3D structure databases

SMRiQ8WYR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117079, 7 interactors
IntActiQ8WYR1, 7 interactors
STRINGi9606.ENSP00000392812

Chemistry databases

BindingDBiQ8WYR1
ChEMBLiCHEMBL3430881

PTM databases

iPTMnetiQ8WYR1
PhosphoSitePlusiQ8WYR1

Polymorphism and mutation databases

BioMutaiPIK3R5
DMDMi74716480

Proteomic databases

jPOSTiQ8WYR1
MaxQBiQ8WYR1
PaxDbiQ8WYR1
PeptideAtlasiQ8WYR1
PRIDEiQ8WYR1
ProteomicsDBi75194
75195 [Q8WYR1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000447110; ENSP00000392812; ENSG00000141506 [Q8WYR1-1]
ENST00000581552; ENSP00000462433; ENSG00000141506 [Q8WYR1-1]
ENST00000611902; ENSP00000477795; ENSG00000141506 [Q8WYR1-2]
ENST00000616147; ENSP00000484211; ENSG00000141506 [Q8WYR1-2]
ENST00000623421; ENSP00000485280; ENSG00000141506 [Q8WYR1-2]
GeneIDi23533
KEGGihsa:23533
UCSCiuc002glt.4 human [Q8WYR1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23533
DisGeNETi23533

GeneCards: human genes, protein and diseases

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GeneCardsi
PIK3R5

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0027111
HGNCiHGNC:30035 PIK3R5
HPAiHPA044505
HPA052247
HPA052412
MalaCardsiPIK3R5
MIMi611317 gene
615217 phenotype
neXtProtiNX_Q8WYR1
OpenTargetsiENSG00000141506
Orphaneti64753 Spinocerebellar ataxia with axonal neuropathy type 2
PharmGKBiPA134890823

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IES2 Eukaryota
ENOG410Y2ZG LUCA
GeneTreeiENSGT00530000063753
InParanoidiQ8WYR1
KOiK21290
OMAiDGMDSGY
OrthoDBi220934at2759
PhylomeDBiQ8WYR1
TreeFamiTF102035

Enzyme and pathway databases

BioCyciMetaCyc:HS13887-MONOMER
ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PIK3R5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PIK3R5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23533

Protein Ontology

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PROi
PR:Q8WYR1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141506 Expressed in 134 organ(s), highest expression level in blood
ExpressionAtlasiQ8WYR1 baseline and differential
GenevisibleiQ8WYR1 HS

Family and domain databases

InterProiView protein in InterPro
IPR019522 PIK3R5/6
PANTHERiPTHR15593 PTHR15593, 1 hit
PfamiView protein in Pfam
PF10486 PI3K_1B_p101, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI3R5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYR1
Secondary accession number(s): B0LPH4
, D3DTS3, Q5G936, Q5G938, Q5G939, Q8IZ23, Q9Y2Y2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2002
Last modified: June 5, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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