UniProtKB - Q8WYQ5 (DGCR8_HUMAN)
Microprocessor complex subunit DGCR8
DGCR8
Functioni
Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718).
The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994).
Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998).
Involved in the silencing of embryonic stem cell self-renewal (By similarity).
By similarity10 PublicationsCofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 352 | Iron (heme axial ligand)1 Publication | 1 |
GO - Molecular functioni
- double-stranded RNA binding Source: UniProtKB
- heme binding Source: BHF-UCL
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- primary miRNA binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- protein-RNA adaptor activity Source: BHF-UCL
GO - Biological processi
- primary miRNA processing Source: BHF-UCL
Keywordsi
Molecular function | RNA-binding |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WYQ5 |
Reactomei | R-HSA-203927, MicroRNA (miRNA) biogenesis R-HSA-8986944, Transcriptional Regulation by MECP2 |
SignaLinki | Q8WYQ5 |
SIGNORi | Q8WYQ5 |
Names & Taxonomyi
Protein namesi | Recommended name: Microprocessor complex subunit DGCR8Alternative name(s): DiGeorge syndrome critical region 8 |
Gene namesi | Name:DGCR8 Synonyms:C22orf12, DGCRK6 ORF Names:LP4941 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2847, DGCR8 |
MIMi | 609030, gene |
neXtProti | NX_Q8WYQ5 |
VEuPathDBi | HostDB:ENSG00000128191 |
Subcellular locationi
Nucleus
Note: Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994).
Cytosol
- cytosol Source: HPA
Nucleus
- microprocessor complex Source: BHF-UCL
- nuclear body Source: HPA
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- cytoplasm Source: LIFEdb
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 352 | C → A or H: Inhibits heme-binding and dimerization. 1 Publication | 1 | |
Mutagenesisi | 430 | C → A: Does not inhibit heme-binding and dimerization. 1 Publication | 1 | |
Mutagenesisi | 561 – 565 | KKLAK → AALAA: Strongly reduces pri-miRNA binding affinity. 1 Publication | 5 | |
Mutagenesisi | 568 – 569 | AA → KK: Reduces pri-miRNA binding affinity and pri-miRNA processing activity. Does not inhibit interaction with DROSHA. When associated with A-676 and S-677, strongly reduces binding affinity and pri-miRNA processing activity. 1 Publication | 2 | |
Mutagenesisi | 669 – 673 | KRVGK → AAVGA: Strongly reduces pri-miRNA binding affinity. 1 Publication | 5 | |
Mutagenesisi | 676 – 677 | AS → KK: Reduces pri-miRNA binding affinity and pri-miRNA processing activity. Slightly inhibits interaction with DROSHA. When associated with A-568 and A-568, strongly reduces binding affinity and pri-miRNA processing activity. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 54487 |
GeneReviewsi | DGCR8 |
MalaCardsi | DGCR8 |
OpenTargetsi | ENSG00000128191 |
PharmGKBi | PA27309 |
Miscellaneous databases
Pharosi | Q8WYQ5, Tbio |
Genetic variation databases
BioMutai | DGCR8 |
DMDMi | 23813990 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079878 | 1 – 773 | Microprocessor complex subunit DGCR8Add BLAST | 773 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | PhosphoserineCombined sources | 1 | |
Modified residuei | 92 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineCombined sources | 1 | |
Modified residuei | 271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 275 | PhosphoserineCombined sources | 1 | |
Modified residuei | 279 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 371 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 373 | PhosphoserineCombined sources | 1 | |
Modified residuei | 377 | PhosphoserineCombined sources | 1 | |
Cross-linki | 424 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 500 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 707 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8WYQ5 |
jPOSTi | Q8WYQ5 |
MassIVEi | Q8WYQ5 |
MaxQBi | Q8WYQ5 |
PaxDbi | Q8WYQ5 |
PeptideAtlasi | Q8WYQ5 |
PRIDEi | Q8WYQ5 |
ProteomicsDBi | 75188 [Q8WYQ5-1] 75189 [Q8WYQ5-2] 75190 [Q8WYQ5-3] |
PTM databases
GlyGeni | Q8WYQ5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8WYQ5 |
PhosphoSitePlusi | Q8WYQ5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000128191, Expressed in cerebellar hemisphere and 223 other tissues |
ExpressionAtlasi | Q8WYQ5, baseline and differential |
Genevisiblei | Q8WYQ5, HS |
Organism-specific databases
HPAi | ENSG00000128191, Low tissue specificity |
Interactioni
Subunit structurei
Monomer; in absence of heme. Homodimer; the association with heme promotes its dimerization (PubMed:17159994).
Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (PubMed:15589161, PubMed:15574589, PubMed:15531877, PubMed:16751099, PubMed:19135890, PubMed:26027739, PubMed:26748718). The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region) (PubMed:26027739, PubMed:26748718).
Interacts with ILF3, NCL and DROSHA (PubMed:17765891).
Interacts with CPSF3 and ISY1; this interaction is in an RNA dependent manner (By similarity).
Interacts with PUS10; interaction promotes pri-miRNAs processing (PubMed:31819270).
By similarity10 PublicationsBinary interactionsi
Q8WYQ5
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-528411,EBI-528411 |
DROSHA [Q9NRR4] | 13 | EBI-528411,EBI-528367 |
MEOX2 [P50222] | 3 | EBI-528411,EBI-748397 |
SRPK1 [Q96SB4] | 3 | EBI-528411,EBI-539478 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 119986, 231 interactors |
ComplexPortali | CPX-3080, Microprocessor complex |
CORUMi | Q8WYQ5 |
DIPi | DIP-29261N |
IntActi | Q8WYQ5, 118 interactors |
MINTi | Q8WYQ5 |
STRINGi | 9606.ENSP00000263209 |
Miscellaneous databases
RNActi | Q8WYQ5, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8WYQ5 |
BMRBi | Q8WYQ5 |
SASBDBi | Q8WYQ5 |
SMRi | Q8WYQ5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WYQ5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 301 – 334 | WWPROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 511 – 578 | DRBM 1PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 620 – 685 | DRBM 2PROSITE-ProRule annotationAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 342 | Necessary for interaction with NCL1 PublicationAdd BLAST | 342 | |
Regioni | 1 – 275 | Necessary for nuclear localization and retentionAdd BLAST | 275 | |
Regioni | 1 – 63 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 261 – 283 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 276 – 751 | Necessary for heme-binding and pri-miRNA processingAdd BLAST | 476 | |
Regioni | 360 – 414 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 701 – 773 | Interaction with DROSHA1 PublicationAdd BLAST | 73 | |
Regioni | 742 – 773 | DisorderedSequence analysisAdd BLAST | 32 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4334, Eukaryota |
GeneTreei | ENSGT00390000015977 |
HOGENOMi | CLU_017211_3_0_1 |
InParanoidi | Q8WYQ5 |
OMAi | QDYKADT |
OrthoDBi | 855874at2759 |
PhylomeDBi | Q8WYQ5 |
TreeFami | TF324256 |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
InterProi | View protein in InterPro IPR040375, DGCR8 IPR014720, dsRBD_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR13482, PTHR13482, 1 hit |
Pfami | View protein in Pfam PF00035, dsrm, 2 hits |
SMARTi | View protein in SMART SM00358, DSRM, 2 hits SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS50137, DS_RBD, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METDESPSPL PCGPAGEAVM ESRARPFQAL PREQSPPPPL QTSSGAEVMD
60 70 80 90 100
VGSGGDGQSE LPAEDPFNFY GASLLSKGSF SKGRLLIDPN CSGHSPRTAR
110 120 130 140 150
HAPAVRKFSP DLKLLKDVKI SVSFTESCRS KDRKVLYTGA ERDVRAECGL
160 170 180 190 200
LLSPVSGDVH ACPFGGSVGD GVGIGGESAD KKDEENELDQ EKRVEYAVLD
210 220 230 240 250
ELEDFTDNLE LDEEGAGGFT AKAIVQRDRV DEEALNFPYE DDFDNDVDAL
260 270 280 290 300
LEEGLCAPKK RRTEEKYGGD SDHPSDGETS VQPMMTKIKT VLKSRGRPPT
310 320 330 340 350
EPLPDGWIMT FHNSGVPVYL HRESRVVTWS RPYFLGTGSI RKHDPPLSSI
360 370 380 390 400
PCLHYKKMKD NEEREQSSDL TPSGDVSPVK PLSRSAELEF PLDEPDSMGA
410 420 430 440 450
DPGPPDEKDP LGAEAAPGAL GQVKAKVEVC KDESVDLEEF RSYLEKRFDF
460 470 480 490 500
EQVTVKKFRT WAERRQFNRE MKRKQAESER PILPANQKLI TLSVQDAPTK
510 520 530 540 550
KEFVINPNGK SEVCILHEYM QRVLKVRPVY NFFECENPSE PFGASVTIDG
560 570 580 590 600
VTYGSGTASS KKLAKNKAAR ATLEILIPDF VKQTSEEKPK DSEELEYFNH
610 620 630 640 650
ISIEDSRVYE LTSKAGLLSP YQILHECLKR NHGMGDTSIK FEVVPGKNQK
660 670 680 690 700
SEYVMACGKH TVRGWCKNKR VGKQLASQKI LQLLHPHVKN WGSLLRMYGR
710 720 730 740 750
ESSKMVKQET SDKSVIELQQ YAKKNKPNLH ILSKLQEEMK RLAEEREETR
760 770
KKPKMSIVAS AQPGGEPLCT VDV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JSD5 | C9JSD5_HUMAN | Microprocessor complex subunit DGCR... | DGCR8 | 125 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 – 247 | DDFDNDV → VCWQPLL in AAF82263 (Ref. 6) Curated | 7 | |
Sequence conflicti | 274 | P → L in BAB15165 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 343 | H → Y in BAB15165 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 706 | V → A in BAB15165 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050952 | 174 | I → V. Corresponds to variant dbSNP:rs35987994Ensembl. | 1 | |
Natural variantiVAR_050953 | 725 | N → D. Corresponds to variant dbSNP:rs11546015Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003847 | 303 – 304 | LP → VL in isoform 2. 2 Publications | 2 | |
Alternative sequenceiVSP_003848 | 305 – 773 | Missing in isoform 2. 2 PublicationsAdd BLAST | 469 | |
Alternative sequenceiVSP_012707 | 536 – 568 | Missing in isoform 3. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB050770 Genomic DNA Translation: BAB83032.1 CR456356 mRNA Translation: CAG30242.1 AK025539 mRNA Translation: BAB15165.1 Different initiation. AK025780 mRNA Translation: BAB15238.1 Different initiation. AK313357 mRNA Translation: BAG36158.1 AC006547 Genomic DNA No translation available. BC009323 mRNA Translation: AAH09323.2 BC009984 mRNA Translation: AAH09984.1 BC078147 mRNA Translation: AAH78147.1 AF165527 mRNA Translation: AAF82263.1 BX649187 mRNA Translation: CAE46205.2 AY189282 mRNA Translation: AAO86726.1 Different initiation. |
CCDSi | CCDS13773.1 [Q8WYQ5-1] CCDS54501.1 [Q8WYQ5-3] |
RefSeqi | NP_001177255.1, NM_001190326.1 [Q8WYQ5-3] NP_073557.3, NM_022720.6 [Q8WYQ5-1] |
Genome annotation databases
Ensembli | ENST00000351989.8; ENSP00000263209.3; ENSG00000128191.16 ENST00000383024.6; ENSP00000372488.2; ENSG00000128191.16 [Q8WYQ5-3] ENST00000407755.1; ENSP00000384726.1; ENSG00000128191.16 [Q8WYQ5-3] |
GeneIDi | 54487 |
KEGGi | hsa:54487 |
MANE-Selecti | ENST00000351989.8; ENSP00000263209.3; NM_022720.7; NP_073557.3 |
UCSCi | uc002zri.4, human [Q8WYQ5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB050770 Genomic DNA Translation: BAB83032.1 CR456356 mRNA Translation: CAG30242.1 AK025539 mRNA Translation: BAB15165.1 Different initiation. AK025780 mRNA Translation: BAB15238.1 Different initiation. AK313357 mRNA Translation: BAG36158.1 AC006547 Genomic DNA No translation available. BC009323 mRNA Translation: AAH09323.2 BC009984 mRNA Translation: AAH09984.1 BC078147 mRNA Translation: AAH78147.1 AF165527 mRNA Translation: AAF82263.1 BX649187 mRNA Translation: CAE46205.2 AY189282 mRNA Translation: AAO86726.1 Different initiation. |
CCDSi | CCDS13773.1 [Q8WYQ5-1] CCDS54501.1 [Q8WYQ5-3] |
RefSeqi | NP_001177255.1, NM_001190326.1 [Q8WYQ5-3] NP_073557.3, NM_022720.6 [Q8WYQ5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X47 | NMR | - | A | 502-586 | [»] | |
2YT4 | X-ray | 2.60 | A | 493-720 | [»] | |
3LE4 | X-ray | 1.70 | A | 275-353 | [»] | |
5B16 | X-ray | 3.20 | B/C | 728-750 | [»] | |
6LXD | electron microscopy | 3.90 | B/C | 1-773 | [»] | |
6LXE | electron microscopy | 4.20 | B/C | 1-773 | [»] | |
6V5B | electron microscopy | 3.70 | B/C | 223-751 | [»] | |
6V5C | electron microscopy | 4.40 | B/C | 223-751 | [»] | |
7CNC | X-ray | 1.60 | B | 96-126 | [»] | |
AlphaFoldDBi | Q8WYQ5 | |||||
BMRBi | Q8WYQ5 | |||||
SASBDBi | Q8WYQ5 | |||||
SMRi | Q8WYQ5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119986, 231 interactors |
ComplexPortali | CPX-3080, Microprocessor complex |
CORUMi | Q8WYQ5 |
DIPi | DIP-29261N |
IntActi | Q8WYQ5, 118 interactors |
MINTi | Q8WYQ5 |
STRINGi | 9606.ENSP00000263209 |
PTM databases
GlyGeni | Q8WYQ5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8WYQ5 |
PhosphoSitePlusi | Q8WYQ5 |
Genetic variation databases
BioMutai | DGCR8 |
DMDMi | 23813990 |
Proteomic databases
EPDi | Q8WYQ5 |
jPOSTi | Q8WYQ5 |
MassIVEi | Q8WYQ5 |
MaxQBi | Q8WYQ5 |
PaxDbi | Q8WYQ5 |
PeptideAtlasi | Q8WYQ5 |
PRIDEi | Q8WYQ5 |
ProteomicsDBi | 75188 [Q8WYQ5-1] 75189 [Q8WYQ5-2] 75190 [Q8WYQ5-3] |
Protocols and materials databases
Antibodypediai | 7887, 317 antibodies from 35 providers |
DNASUi | 54487 |
Genome annotation databases
Ensembli | ENST00000351989.8; ENSP00000263209.3; ENSG00000128191.16 ENST00000383024.6; ENSP00000372488.2; ENSG00000128191.16 [Q8WYQ5-3] ENST00000407755.1; ENSP00000384726.1; ENSG00000128191.16 [Q8WYQ5-3] |
GeneIDi | 54487 |
KEGGi | hsa:54487 |
MANE-Selecti | ENST00000351989.8; ENSP00000263209.3; NM_022720.7; NP_073557.3 |
UCSCi | uc002zri.4, human [Q8WYQ5-1] |
Organism-specific databases
CTDi | 54487 |
DisGeNETi | 54487 |
GeneCardsi | DGCR8 |
GeneReviewsi | DGCR8 |
HGNCi | HGNC:2847, DGCR8 |
HPAi | ENSG00000128191, Low tissue specificity |
MalaCardsi | DGCR8 |
MIMi | 609030, gene |
neXtProti | NX_Q8WYQ5 |
OpenTargetsi | ENSG00000128191 |
PharmGKBi | PA27309 |
VEuPathDBi | HostDB:ENSG00000128191 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4334, Eukaryota |
GeneTreei | ENSGT00390000015977 |
HOGENOMi | CLU_017211_3_0_1 |
InParanoidi | Q8WYQ5 |
OMAi | QDYKADT |
OrthoDBi | 855874at2759 |
PhylomeDBi | Q8WYQ5 |
TreeFami | TF324256 |
Enzyme and pathway databases
PathwayCommonsi | Q8WYQ5 |
Reactomei | R-HSA-203927, MicroRNA (miRNA) biogenesis R-HSA-8986944, Transcriptional Regulation by MECP2 |
SignaLinki | Q8WYQ5 |
SIGNORi | Q8WYQ5 |
Miscellaneous databases
BioGRID-ORCSi | 54487, 362 hits in 1093 CRISPR screens |
ChiTaRSi | DGCR8, human |
EvolutionaryTracei | Q8WYQ5 |
GeneWikii | DGCR8_(gene) |
GenomeRNAii | 54487 |
Pharosi | Q8WYQ5, Tbio |
PROi | PR:Q8WYQ5 |
RNActi | Q8WYQ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128191, Expressed in cerebellar hemisphere and 223 other tissues |
ExpressionAtlasi | Q8WYQ5, baseline and differential |
Genevisiblei | Q8WYQ5, HS |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
InterProi | View protein in InterPro IPR040375, DGCR8 IPR014720, dsRBD_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR13482, PTHR13482, 1 hit |
Pfami | View protein in Pfam PF00035, dsrm, 2 hits |
SMARTi | View protein in SMART SM00358, DSRM, 2 hits SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS50137, DS_RBD, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DGCR8_HUMAN | |
Accessioni | Q8WYQ5Primary (citable) accession number: Q8WYQ5 Secondary accession number(s): B2R8G1 Q9NRW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references