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Entry version 147 (03 Jul 2019)
Sequence version 3 (22 Sep 2009)
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Protein

Protein ELYS

Gene

AHCTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1971 – 1983A.T hookBy similarityAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ELYS
Alternative name(s):
Embryonic large molecule derived from yolk sac
Protein MEL-28
Putative AT-hook-containing transcription factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AHCTF1
Synonyms:ELYS, TMBS62
ORF Names:MSTP108
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24618 AHCTF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610853 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8WYP5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000153207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142672631

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AHCTF1

Domain mapping of disease mutations (DMDM)

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DMDMi
259016354

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002463191 – 2266Protein ELYSAdd BLAST2266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei509PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Modified residuei1080PhosphoserineBy similarity1
Modified residuei1138PhosphoserineBy similarity1
Modified residuei1142PhosphoserineCombined sources1
Modified residuei1150PhosphoserineCombined sources1
Modified residuei1153PhosphoserineCombined sources1
Modified residuei1155PhosphoserineCombined sources1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1175PhosphothreonineCombined sources1
Modified residuei1214PhosphoserineCombined sources1
Modified residuei1218PhosphoserineCombined sources1
Modified residuei1222PhosphoserineCombined sources1
Modified residuei1232PhosphoserineCombined sources1
Modified residuei1250PhosphoserineCombined sources1
Modified residuei1257PhosphothreonineCombined sources1
Modified residuei1283PhosphoserineCombined sources1
Modified residuei1297PhosphoserineCombined sources1
Modified residuei1369PhosphothreonineCombined sources1
Modified residuei1371PhosphoserineBy similarity1
Modified residuei1513PhosphoserineCombined sources1
Modified residuei1517PhosphothreonineCombined sources1
Modified residuei1533PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1729PhosphoserineCombined sources1
Modified residuei1806PhosphoserineCombined sources1
Modified residuei1808PhosphothreonineCombined sources1
Modified residuei1878PhosphoserineCombined sources1
Modified residuei1884PhosphoserineCombined sources1
Modified residuei1898PhosphoserineCombined sources1
Modified residuei1944PhosphoserineCombined sources1
Modified residuei1946PhosphoserineCombined sources1
Modified residuei1996PhosphoserineCombined sources1
Modified residuei2043PhosphoserineCombined sources1
Modified residuei2044PhosphoserineCombined sources1
Modified residuei2060PhosphoserineCombined sources1
Modified residuei2089PhosphoserineCombined sources1
Modified residuei2120PhosphoserineCombined sources1
Modified residuei2123PhosphoserineCombined sources1
Modified residuei2154PhosphoserineCombined sources1
Modified residuei2212PhosphoserineCombined sources1
Modified residuei2222PhosphoserineCombined sources1
Modified residuei2226PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WYP5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8WYP5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8WYP5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WYP5

PeptideAtlas

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PeptideAtlasi
Q8WYP5

PRoteomics IDEntifications database

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PRIDEi
Q8WYP5

ProteomicsDB human proteome resource

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ProteomicsDBi
75181
75182 [Q8WYP5-2]
75183 [Q8WYP5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8WYP5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8WYP5

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q8WYP5

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
Q8WYP5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000153207 Expressed in 227 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WYP5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WYP5 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA031658

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the Nup107-160 subcomplex of the NPC.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117414, 31 interactors

Protein interaction database and analysis system

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IntActi
Q8WYP5, 35 interactors

Molecular INTeraction database

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MINTi
Q8WYP5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355465

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WYP5

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 981Necessary for cytoplasmic localizationBy similarityAdd BLAST981
Regioni1 – 494Seven-bladed beta propeller repeatsBy similarityAdd BLAST494
Regioni591 – 1092Important for nuclear localization1 PublicationAdd BLAST502
Regioni1019 – 2266DisorderedBy similarityAdd BLAST1248
Regioni1149 – 2266Necessary for nuclear localizationBy similarityAdd BLAST1118
Regioni1446 – 1698Mediates transcriptional activityBy similarityAdd BLAST253
Regioni1842 – 2266Important for nuclear localization and chromatin binding1 PublicationAdd BLAST425

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus forms a highly conserved seven-bladed beta propeller decorated with long loops and mediates anchorage to the Nup107-160 subcomplex of the nuclear pore, synergistically with the central alpha domain. The disordered C-terminus is responsible for the interactions with chromatin (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ELYS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG0H Eukaryota
ENOG410XQV6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018900

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WYP5

Identification of Orthologs from Complete Genome Data

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OMAi
IEQQFCD

Database of Orthologous Groups

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OrthoDBi
1040332at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8WYP5

TreeFam database of animal gene trees

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TreeFami
TF350425

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032040 ELYS-bb
IPR025151 ELYS_dom
IPR011047 Quinoprotein_ADH-like_supfam

Pfam protein domain database

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Pfami
View protein in Pfam
PF13934 ELYS, 1 hit
PF16687 ELYS-bb, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998 SSF50998, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRDLRAQVTS GLLPFPEVTL QALGEDEITL ESVLRGKFAA GKNGLACLAC
60 70 80 90 100
GPQLEVVNSI TGERLSAYRF SGVNEQPPVV LAVKEFSWQK RTGLLIGLEE
110 120 130 140 150
TEGSVLCLYD LGISKVVKAV VLPGRVTAIE PIINHGGASA STQHLHPSLR
160 170 180 190 200
WLFGVAAVVT DVGQILLVDL CLDDLSCNQN EVEASDLEVL TGIPAEVPHI
210 220 230 240 250
RESVMRQGRH LCFQLVSPTG TAVSTLSYIS RTNQLAVGFS DGYLALWNMK
260 270 280 290 300
SMKREYYIQL ESGQVPVYAV TFQEPENDPR NCCYLWAVQS TQDSEGDVLS
310 320 330 340 350
LHLLQLAFGN RKCLASGQIL YEGLEYCEER YTLDLTGGMF PLRGQTSNTK
360 370 380 390 400
LLGCQSIEKF RSHGDREEGV NEALSPDTSV SVFTWQVNIY GQGKPSVYLG
410 420 430 440 450
LFDINRWYHA QMPDSLRSGE YLHNCSYFAL WSLESVVSRT SPHGILDILV
460 470 480 490 500
HERSLNRGVP PSYPPPEQFF NPSTYNFDAT CLLNSGVVHL TCTGFQKETL
510 520 530 540 550
TFLKKSGPSL NELIPDGYNR CLVAGLLSPR FVDVQPSSLS QEEQLEAILS
560 570 580 590 600
AAIQTSSLGL LTGYIRRWIT EEQPNSATNL RFVLEWTWNK VVLTKEEFDR
610 620 630 640 650
LCVPLFDGSC HFMDPQTIQS IQQCYLLLSN LNIVLSCFAS EAREITERGL
660 670 680 690 700
IDLSNKFVVS HLICQYAQVV LWFSHSGLLP EGIDDSVQLS RLCYNYPVIQ
710 720 730 740 750
NYYTSRRQKF ERLSRGKWNP DCLMIDGLVS QLGERIEKLW KRDEGGTGKY
760 770 780 790 800
PPASLHAVLD MYLLDGVTEA AKHSITIYLL LDIMYSFPNK TDTPIESFPT
810 820 830 840 850
VFAISWGQVK LIQGFWLIDH NDYESGLDLL FHPATAKPLS WQHSKIIQAF
860 870 880 890 900
MSQGEHRQAL RYIQTMKPTV SSGNDVILHL TVLLFNRCMV EAWNFLRQHC
910 920 930 940 950
NRLNIEELLK HMYEVCQEMG LMEDLLKLPF TDTEQECLVK FLQSSASVQN
960 970 980 990 1000
HEFLLVHHLQ RANYVPALKL NQTLKINVMN DRDPRLRERS LARNSILDQY
1010 1020 1030 1040 1050
GKILPRVHRK LAIERAKPYH LSTSSVFRLV SRPKPLSAVP KQVVTGTVLT
1060 1070 1080 1090 1100
RSVFINNVLS KIGEVWASKE PINSTTPFNS SKIEEPSPIV YSLPAPELPE
1110 1120 1130 1140 1150
AFFGTPISKA SQKISRLLDL VVQPVPRPSQ CSEFIQQSSM KSPLYLVSRS
1160 1170 1180 1190 1200
LPSSSQLKGS PQAISRASEL HLLETPLVVK KAKSLAMSVT TSGFSEFTPQ
1210 1220 1230 1240 1250
SILRSTLRST PLASPSPSPG RSPQRLKETR ISFVEEDVHP KWIPGAADDS
1260 1270 1280 1290 1300
KLEVFTTPKK CAVPVETEWL KSKDRTTSFF LNSPEKEHQE MDEGSQSLEK
1310 1320 1330 1340 1350
LDVSKGNSSV SITSDETTLE YQDAPSPEDL EETVFTASKP KSSSTALTTN
1360 1370 1380 1390 1400
VTEQTEKDGD KDVFASEVTP SDLQKQMGNL EDAETKDLLV AAEAFSELNH
1410 1420 1430 1440 1450
LSPVQGTEAS LCAPSVYEGK IFTQKSKVPV LDEGLTSVET YTPAIRANDN
1460 1470 1480 1490 1500
KSMADVLGDG GNSSLTISEG PIVSERRLNQ EVALNLKEDH EVEVGVLKES
1510 1520 1530 1540 1550
VDLPEEKLPI SDSPPDTQEI HVIEQEKLEA QDSGEEARNL SFNELYPSGT
1560 1570 1580 1590 1600
LKLQYNFDTI DQQFCDLADN KDTAECDIAE VDGELFVAQS NFTLILEGEE
1610 1620 1630 1640 1650
GEVEPGDFAS SDVLPKAANT ATEEKLVCSG ENDNHGQIAN LPSAVTSDQK
1660 1670 1680 1690 1700
SQKVDTLPYV PEPIKVAIAE NLLDVIKDTR SKEITSDTME QSIHETIPLV
1710 1720 1730 1740 1750
SQNIMCPTKL VKSAFKTAQE TSTMTMNVSQ VDDVVSSKTR TRGQRIQNVN
1760 1770 1780 1790 1800
VKSAQQEASA DVATPKMPGQ SVRKKTRKAK EISEASENIY SDVRGLSQNQ
1810 1820 1830 1840 1850
QIPQNSVTPR RGRRKKEVNQ DILENTSSVE QELQITTGRE SKRLKSSQLL
1860 1870 1880 1890 1900
EPAVEETTKK EVKVSSVTKR TPRRIKRSVE NQESVEIIND LKVSTVTSPS
1910 1920 1930 1940 1950
RMIRKLRSTN LDASENTGNK QDDKSSDKQL RIKHVRRVRG REVSPSDVRE
1960 1970 1980 1990 2000
DSNLESSQLT VQAEFDMSAI PRKRGRPRKI NPSEDVGSKA VKEERSPKKK
2010 2020 2030 2040 2050
EAPSIRRRST RNTPAKSENV DVGKPALGKS ILVPNEELSM VMSSKKKLTK
2060 2070 2080 2090 2100
KTESQSQKRS LHSVSEERTD EMTHKETNEQ EERLLATASF TKSSRSSRTR
2110 2120 2130 2140 2150
SSKAILLPDL SEPNNEPLFS PASEVPRKAK AKKIEVPAQL KELVSDLSSQ
2160 2170 2180 2190 2200
FVISPPALRS RQKNTSNKNK LEDELKDDAQ SVETLGKPKA KRIRTSKTKQ
2210 2220 2230 2240 2250
ASKNTEKESA WSPPPIEIRL ISPLASPADG VKSKPRKTTE VTGTGLGRNR
2260
KKLSSYPKQI LRRKML
Length:2,266
Mass (Da):252,498
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i465452FD42ACCFAE
GO
Isoform 2 (identifier: Q8WYP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDSLAGLSPREAAGVLSLSCVGVCSTCAWAWPHGSM

Show »
Length:2,301
Mass (Da):256,000
Checksum:i71D2E4A758E09BD3
GO
Isoform 3 (identifier: Q8WYP5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAAERRCGSM

Show »
Length:2,275
Mass (Da):253,460
Checksum:i5C8BB4E793190599
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4S1H7C4S1_HUMAN
Protein ELYS
AHCTF1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN65622 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAQ13621 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB78516 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti168V → I in BAB78516 (PubMed:11952839).Curated1
Sequence conflicti207Q → E in BAB78516 (PubMed:11952839).Curated1
Sequence conflicti237V → A in BAB78516 (PubMed:11952839).Curated1
Sequence conflicti279P → R in BAB78516 (PubMed:11952839).Curated1
Sequence conflicti403D → G in AAN65622 (Ref. 2) Curated1
Sequence conflicti646T → A in BAB78516 (PubMed:11952839).Curated1
Sequence conflicti743D → G in AAN65622 (Ref. 2) Curated1
Sequence conflicti753A → G in AAN65622 (Ref. 2) Curated1
Sequence conflicti1134F → S in AAN65622 (Ref. 2) Curated1
Sequence conflicti1207L → P in BAB78516 (PubMed:11952839).Curated1
Sequence conflicti1270L → P in BAB78516 (PubMed:11952839).Curated1
Sequence conflicti1737S → F in CAB45737 (PubMed:17974005).Curated1
Sequence conflicti1797S → F in BAB78516 (PubMed:11952839).Curated1
Sequence conflicti1830E → G in AAN65622 (Ref. 2) Curated1
Sequence conflicti2128K → E in AAN65622 (Ref. 2) Curated1
Sequence conflicti2187K → E in AAH12307 (PubMed:15489334).Curated1
Sequence conflicti2213P → L in BAB78516 (PubMed:11952839).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027037874N → S. Corresponds to variant dbSNP:rs2642990Ensembl.1
Natural variantiVAR_0270382185L → V. Corresponds to variant dbSNP:rs12410563Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0198441M → MDSLAGLSPREAAGVLSLSC VGVCSTCAWAWPHGSM in isoform 2. 1 Publication1
Alternative sequenceiVSP_0426911M → MAAERRCGSM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB059277 mRNA Translation: BAB78516.1 Different initiation.
AY157619 mRNA Translation: AAN65622.1 Frameshift.
AC113174 Genomic DNA No translation available.
AL080144 mRNA Translation: CAB45737.1
AF173978 mRNA Translation: AAQ13621.1 Different initiation.
BC012307 mRNA Translation: AAH12307.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1629.2 [Q8WYP5-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T12528

NCBI Reference Sequences

More...
RefSeqi
NP_001310271.1, NM_001323342.1 [Q8WYP5-1]
NP_056261.4, NM_015446.4 [Q8WYP5-3]
XP_006711821.1, XM_006711758.1 [Q8WYP5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326225; ENSP00000355465; ENSG00000153207 [Q8WYP5-3]
ENST00000366508; ENSP00000355464; ENSG00000153207 [Q8WYP5-2]
ENST00000648844; ENSP00000497061; ENSG00000153207 [Q8WYP5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25909

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25909

UCSC genome browser

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UCSCi
uc001ibv.3 human [Q8WYP5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059277 mRNA Translation: BAB78516.1 Different initiation.
AY157619 mRNA Translation: AAN65622.1 Frameshift.
AC113174 Genomic DNA No translation available.
AL080144 mRNA Translation: CAB45737.1
AF173978 mRNA Translation: AAQ13621.1 Different initiation.
BC012307 mRNA Translation: AAH12307.1
CCDSiCCDS1629.2 [Q8WYP5-3]
PIRiT12528
RefSeqiNP_001310271.1, NM_001323342.1 [Q8WYP5-1]
NP_056261.4, NM_015446.4 [Q8WYP5-3]
XP_006711821.1, XM_006711758.1 [Q8WYP5-2]

3D structure databases

SMRiQ8WYP5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117414, 31 interactors
IntActiQ8WYP5, 35 interactors
MINTiQ8WYP5
STRINGi9606.ENSP00000355465

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ8WYP5
PhosphoSitePlusiQ8WYP5
SwissPalmiQ8WYP5

Polymorphism and mutation databases

BioMutaiAHCTF1
DMDMi259016354

Proteomic databases

EPDiQ8WYP5
jPOSTiQ8WYP5
MaxQBiQ8WYP5
PaxDbiQ8WYP5
PeptideAtlasiQ8WYP5
PRIDEiQ8WYP5
ProteomicsDBi75181
75182 [Q8WYP5-2]
75183 [Q8WYP5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326225; ENSP00000355465; ENSG00000153207 [Q8WYP5-3]
ENST00000366508; ENSP00000355464; ENSG00000153207 [Q8WYP5-2]
ENST00000648844; ENSP00000497061; ENSG00000153207 [Q8WYP5-1]
GeneIDi25909
KEGGihsa:25909
UCSCiuc001ibv.3 human [Q8WYP5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25909

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AHCTF1
HGNCiHGNC:24618 AHCTF1
HPAiHPA031658
MIMi610853 gene
neXtProtiNX_Q8WYP5
OpenTargetsiENSG00000153207
PharmGKBiPA142672631

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG0H Eukaryota
ENOG410XQV6 LUCA
GeneTreeiENSGT00390000018900
InParanoidiQ8WYP5
OMAiIEQQFCD
OrthoDBi1040332at2759
PhylomeDBiQ8WYP5
TreeFamiTF350425

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AHCTF1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AHCTF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25909
PMAP-CutDBiQ8WYP5

Protein Ontology

More...
PROi
PR:Q8WYP5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153207 Expressed in 227 organ(s), highest expression level in testis
ExpressionAtlasiQ8WYP5 baseline and differential
GenevisibleiQ8WYP5 HS

Family and domain databases

InterProiView protein in InterPro
IPR032040 ELYS-bb
IPR025151 ELYS_dom
IPR011047 Quinoprotein_ADH-like_supfam
PfamiView protein in Pfam
PF13934 ELYS, 1 hit
PF16687 ELYS-bb, 1 hit
SUPFAMiSSF50998 SSF50998, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELYS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYP5
Secondary accession number(s): A6NGM0
, A8MSG9, A8MZ86, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: September 22, 2009
Last modified: July 3, 2019
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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