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Protein

Ras and Rab interactor 2

Gene

RIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras and Rab interactor 2
Alternative name(s):
Ras association domain family 4
Ras inhibitor JC265
Ras interaction/interference protein 2
Gene namesi
Name:RIN2
Synonyms:RASSF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000132669.12
HGNCiHGNC:18750 RIN2
MIMi610222 gene
neXtProtiNX_Q8WYP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

MACS syndrome (MACS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA complex disorder of elastic tissue characterized by sagging skin and occasionally by life-threatening visceral complications.
See also OMIM:613075

Organism-specific databases

DisGeNETi54453
MalaCardsiRIN2
MIMi613075 phenotype
OpenTargetsiENSG00000132669
Orphaneti217335 MACS syndrome
PharmGKBiPA38672

Polymorphism and mutation databases

BioMutaiRIN2
DMDMi28201876

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913201 – 895Ras and Rab interactor 2Add BLAST895

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei366PhosphoserineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei509PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WYP3
MaxQBiQ8WYP3
PaxDbiQ8WYP3
PeptideAtlasiQ8WYP3
PRIDEiQ8WYP3
ProteomicsDBi75179
75180 [Q8WYP3-2]

PTM databases

iPTMnetiQ8WYP3
PhosphoSitePlusiQ8WYP3

Expressioni

Tissue specificityi

Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood.1 Publication

Gene expression databases

BgeeiENSG00000132669 Expressed in 241 organ(s), highest expression level in tendon
CleanExiHS_RASSF4
HS_RIN2
ExpressionAtlasiQ8WYP3 baseline and differential
GenevisibleiQ8WYP3 HS

Organism-specific databases

HPAiHPA034641

Interactioni

Subunit structurei

Homotetramer; probably composed of anti-parallel linkage of two parallel dimers. Interacts with Ras. Interacts with RAB5B, with a much higher affinity for GTP-bound activated RAB5B. Does not interact with other members of the Rab family.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119960, 11 interactors
IntActiQ8WYP3, 3 interactors
MINTiQ8WYP3
STRINGi9606.ENSP00000255006

Structurei

3D structure databases

ProteinModelPortaliQ8WYP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 190SH2PROSITE-ProRule annotationAdd BLAST94
Domaini618 – 757VPS9PROSITE-ProRule annotationAdd BLAST140
Domaini787 – 878Ras-associatingPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi307 – 314Poly-Pro8

Sequence similaritiesi

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG2320 Eukaryota
ENOG410ZZW5 LUCA
GeneTreeiENSGT00530000063053
HOVERGENiHBG023719
InParanoidiQ8WYP3
OMAiRTPNANG
OrthoDBiEOG091G02V2
PhylomeDBiQ8WYP3
TreeFamiTF331067

Family and domain databases

CDDicd10394 SH2_RIN2, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR035868 RIN2_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029071 Ubiquitin-like_domsf
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF54236 SSF54236, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50001 SH2, 1 hit
PS51205 VPS9, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAWTMGARG LDKRGSFFKL IDTIASEIGE LKQEMVRTDV NLENGLEPAE
60 70 80 90 100
THSMVRHKDG GYSEEEDVKT CARDSGYDSL SNRLSILDRL LHTHPIWLQL
110 120 130 140 150
SLSEEEAAEV LQAQPPGIFL VHKSTKMQKK VLSLRLPCEF GAPLKEFAIK
160 170 180 190 200
ESTYTFSLEG SGISFADLFR LIAFYCISRD VLPFTLKLPY AISTAKSEAQ
210 220 230 240 250
LEELAQMGLN FWSSPADSKP PNLPPPHRPL SSDGVCPASL RQLCLINGVH
260 270 280 290 300
SIKTRTPSEL ECSQTNGALC FINPLFLKVH SQDLSGGLKR PSTRTPNANG
310 320 330 340 350
TERTRSPPPR PPPPAINSLH TSPRLARTET QTSMPETVNH NKHGNVALPG
360 370 380 390 400
TKPTPIPPPR LKKQASFLEA EGGAKTLSGG RPGAGPELEL GTAGSPGGAP
410 420 430 440 450
PEAAPGDCTR APPPSSESRP PCHGGRQRLS DMSISTSSSD SLEFDRSMPL
460 470 480 490 500
FGYEADTNSS LEDYEGESDQ ETMAPPIKSK KKRSSSFVLP KLVKSQLQKV
510 520 530 540 550
SGVFSSFMTP EKRMVRRIAE LSRDKCTYFG CLVQDYVSFL QENKECHVSS
560 570 580 590 600
TDMLQTIRQF MTQVKNYLSQ SSELDPPIES LIPEDQIDVV LEKAMHKCIL
610 620 630 640 650
KPLKGHVEAM LKDFHMADGS WKQLKENLQL VRQRNPQELG VFAPTPDFVD
660 670 680 690 700
VEKIKVKFMT MQKMYSPEKK VMLLLRVCKL IYTVMENNSG RMYGADDFLP
710 720 730 740 750
VLTYVIAQCD MLELDTEIEY MMELLDPSLL HGEGGYYLTS AYGALSLIKN
760 770 780 790 800
FQEEQAARLL SSETRDTLRQ WHKRRTTNRT IPSVDDFQNY LRVAFQEVNS
810 820 830 840 850
GCTGKTLLVR PYITTEDVCQ ICAEKFKVGD PEEYSLFLFV DETWQQLAED
860 870 880 890
TYPQKIKAEL HSRPQPHIFH FVYKRIKNDP YGIIFQNGEE DLTTS
Length:895
Mass (Da):100,163
Last modified:March 1, 2002 - v1
Checksum:i0DECDBF8D2629EE4
GO
Isoform 2 (identifier: Q8WYP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLDSFSQESTLPFREARKRTSFQPVQVWRNFTASQTTESPACSGASLGEM

Note: No experimental confirmation available.
Show »
Length:944
Mass (Da):105,613
Checksum:iEB0C72971CE5BFB6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPJ1E7EPJ1_HUMAN
Ras and Rab interactor 2
RIN2
462Annotation score:

Sequence cautioni

The sequence CAB66858 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192I → V in AK094884 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024694197S → T1 PublicationCorresponds to variant dbSNP:rs3803981Ensembl.1
Natural variantiVAR_052945643A → T. Corresponds to variant dbSNP:rs199603EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0151451M → MLDSFSQESTLPFREARKRT SFQPVQVWRNFTASQTTESP ACSGASLGEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060339 mRNA Translation: BAB84317.1
AL049538 Genomic DNA No translation available.
AL132821 Genomic DNA No translation available.
AK094884 mRNA No translation available.
AL136924 mRNA Translation: CAB66858.1 Different initiation.
M37190 mRNA Translation: AAA36553.1
CCDSiCCDS56182.1 [Q8WYP3-2]
PIRiB38637
RefSeqiNP_001229510.1, NM_001242581.1 [Q8WYP3-2]
NP_061866.1, NM_018993.3 [Q8WYP3-1]
XP_005260788.1, XM_005260731.2 [Q8WYP3-1]
XP_006723637.1, XM_006723574.3 [Q8WYP3-1]
XP_006723638.1, XM_006723575.3 [Q8WYP3-1]
XP_006723640.1, XM_006723577.2 [Q8WYP3-1]
XP_011527559.1, XM_011529257.1 [Q8WYP3-1]
XP_011527560.1, XM_011529258.2 [Q8WYP3-1]
XP_016883376.1, XM_017027887.1 [Q8WYP3-2]
XP_016883377.1, XM_017027888.1 [Q8WYP3-2]
XP_016883379.1, XM_017027890.1 [Q8WYP3-1]
UniGeneiHs.472270
Hs.733605

Genome annotation databases

EnsembliENST00000255006; ENSP00000255006; ENSG00000132669 [Q8WYP3-2]
GeneIDi54453
KEGGihsa:54453
UCSCiuc002wro.3 human [Q8WYP3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060339 mRNA Translation: BAB84317.1
AL049538 Genomic DNA No translation available.
AL132821 Genomic DNA No translation available.
AK094884 mRNA No translation available.
AL136924 mRNA Translation: CAB66858.1 Different initiation.
M37190 mRNA Translation: AAA36553.1
CCDSiCCDS56182.1 [Q8WYP3-2]
PIRiB38637
RefSeqiNP_001229510.1, NM_001242581.1 [Q8WYP3-2]
NP_061866.1, NM_018993.3 [Q8WYP3-1]
XP_005260788.1, XM_005260731.2 [Q8WYP3-1]
XP_006723637.1, XM_006723574.3 [Q8WYP3-1]
XP_006723638.1, XM_006723575.3 [Q8WYP3-1]
XP_006723640.1, XM_006723577.2 [Q8WYP3-1]
XP_011527559.1, XM_011529257.1 [Q8WYP3-1]
XP_011527560.1, XM_011529258.2 [Q8WYP3-1]
XP_016883376.1, XM_017027887.1 [Q8WYP3-2]
XP_016883377.1, XM_017027888.1 [Q8WYP3-2]
XP_016883379.1, XM_017027890.1 [Q8WYP3-1]
UniGeneiHs.472270
Hs.733605

3D structure databases

ProteinModelPortaliQ8WYP3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119960, 11 interactors
IntActiQ8WYP3, 3 interactors
MINTiQ8WYP3
STRINGi9606.ENSP00000255006

PTM databases

iPTMnetiQ8WYP3
PhosphoSitePlusiQ8WYP3

Polymorphism and mutation databases

BioMutaiRIN2
DMDMi28201876

Proteomic databases

EPDiQ8WYP3
MaxQBiQ8WYP3
PaxDbiQ8WYP3
PeptideAtlasiQ8WYP3
PRIDEiQ8WYP3
ProteomicsDBi75179
75180 [Q8WYP3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255006; ENSP00000255006; ENSG00000132669 [Q8WYP3-2]
GeneIDi54453
KEGGihsa:54453
UCSCiuc002wro.3 human [Q8WYP3-1]

Organism-specific databases

CTDi54453
DisGeNETi54453
EuPathDBiHostDB:ENSG00000132669.12
GeneCardsiRIN2
HGNCiHGNC:18750 RIN2
HPAiHPA034641
MalaCardsiRIN2
MIMi610222 gene
613075 phenotype
neXtProtiNX_Q8WYP3
OpenTargetsiENSG00000132669
Orphaneti217335 MACS syndrome
PharmGKBiPA38672
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2320 Eukaryota
ENOG410ZZW5 LUCA
GeneTreeiENSGT00530000063053
HOVERGENiHBG023719
InParanoidiQ8WYP3
OMAiRTPNANG
OrthoDBiEOG091G02V2
PhylomeDBiQ8WYP3
TreeFamiTF331067

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiRIN2 human
GenomeRNAii54453
PROiPR:Q8WYP3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132669 Expressed in 241 organ(s), highest expression level in tendon
CleanExiHS_RASSF4
HS_RIN2
ExpressionAtlasiQ8WYP3 baseline and differential
GenevisibleiQ8WYP3 HS

Family and domain databases

CDDicd10394 SH2_RIN2, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR035868 RIN2_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029071 Ubiquitin-like_domsf
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF54236 SSF54236, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50001 SH2, 1 hit
PS51205 VPS9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRIN2_HUMAN
AccessioniPrimary (citable) accession number: Q8WYP3
Secondary accession number(s): Q00425
, Q5TFT8, Q9BQL3, Q9H071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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