Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8WYP3 (RIN2_HUMAN)

Entry version 157 (07 Apr 2021)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Ras and Rab interactor 2

Gene

RIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processEndocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WYP3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras and Rab interactor 2
Alternative name(s):
Ras association domain family 4
Ras inhibitor JC265
Ras interaction/interference protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIN2
Synonyms:RASSF4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18750, RIN2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610222, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WYP3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132669.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

MACS syndrome (MACS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA complex disorder of elastic tissue characterized by sagging skin and occasionally by life-threatening visceral complications.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		54453

MalaCards human disease database

More...MalaCardsi		RIN2
MIMi613075, phenotype

Open Targets

More...OpenTargetsi		ENSG00000132669

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		217335, RIN2 syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38672

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WYP3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RIN2

Domain mapping of disease mutations (DMDM)

More...DMDMi		28201876

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913201 – 895Ras and Rab interactor 2Add BLAST895

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei366PhosphoserineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei509PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WYP3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WYP3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WYP3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WYP3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WYP3

PeptideAtlas

More...PeptideAtlasi		Q8WYP3

PRoteomics IDEntifications database

More...PRIDEi		Q8WYP3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75179 [Q8WYP3-1]
75180 [Q8WYP3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WYP3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WYP3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132669, Expressed in tendon and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WYP3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WYP3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132669, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; probably composed of anti-parallel linkage of two parallel dimers.

Interacts with Ras.

Interacts with RAB5B, with a much higher affinity for GTP-bound activated RAB5B. Does not interact with other members of the Rab family.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119960, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q8WYP3, 3 interactors

Molecular INTeraction database

More...MINTi		Q8WYP3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000255006

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WYP3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WYP3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 190SH2PROSITE-ProRule annotationAdd BLAST94
Domaini618 – 757VPS9PROSITE-ProRule annotationAdd BLAST140
Domaini787 – 878Ras-associatingPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi307 – 314Poly-Pro8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIN (Ras interaction/interference) family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2320, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154866

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011829_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WYP3

Identification of Orthologs from Complete Genome Data

More...OMAi		WRNFTAS

Database of Orthologous Groups

More...OrthoDBi		1311692at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WYP3

TreeFam database of animal gene trees

More...TreeFami		TF331067

Family and domain databases

Conserved Domains Database

More...CDDi		cd10394, SH2_RIN2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1050.80, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000159, RA_dom
IPR035868, RIN2_SH2
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR029071, Ubiquitin-like_domsf
IPR003123, VPS9
IPR037191, VPS9_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00788, RA, 1 hit
PF02204, VPS9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00314, RA, 1 hit
SM00167, VPS9, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109993, SSF109993, 1 hit
SSF54236, SSF54236, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50200, RA, 1 hit
PS50001, SH2, 1 hit
PS51205, VPS9, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAWTMGARG LDKRGSFFKL IDTIASEIGE LKQEMVRTDV NLENGLEPAE 
        60         70         80         90        100
THSMVRHKDG GYSEEEDVKT CARDSGYDSL SNRLSILDRL LHTHPIWLQL 
       110        120        130        140        150
SLSEEEAAEV LQAQPPGIFL VHKSTKMQKK VLSLRLPCEF GAPLKEFAIK 
       160        170        180        190        200
ESTYTFSLEG SGISFADLFR LIAFYCISRD VLPFTLKLPY AISTAKSEAQ 
       210        220        230        240        250
LEELAQMGLN FWSSPADSKP PNLPPPHRPL SSDGVCPASL RQLCLINGVH 
       260        270        280        290        300
SIKTRTPSEL ECSQTNGALC FINPLFLKVH SQDLSGGLKR PSTRTPNANG 
       310        320        330        340        350
TERTRSPPPR PPPPAINSLH TSPRLARTET QTSMPETVNH NKHGNVALPG 
       360        370        380        390        400
TKPTPIPPPR LKKQASFLEA EGGAKTLSGG RPGAGPELEL GTAGSPGGAP 
       410        420        430        440        450
PEAAPGDCTR APPPSSESRP PCHGGRQRLS DMSISTSSSD SLEFDRSMPL 
       460        470        480        490        500
FGYEADTNSS LEDYEGESDQ ETMAPPIKSK KKRSSSFVLP KLVKSQLQKV 
       510        520        530        540        550
SGVFSSFMTP EKRMVRRIAE LSRDKCTYFG CLVQDYVSFL QENKECHVSS 
       560        570        580        590        600
TDMLQTIRQF MTQVKNYLSQ SSELDPPIES LIPEDQIDVV LEKAMHKCIL 
       610        620        630        640        650
KPLKGHVEAM LKDFHMADGS WKQLKENLQL VRQRNPQELG VFAPTPDFVD 
       660        670        680        690        700
VEKIKVKFMT MQKMYSPEKK VMLLLRVCKL IYTVMENNSG RMYGADDFLP 
       710        720        730        740        750
VLTYVIAQCD MLELDTEIEY MMELLDPSLL HGEGGYYLTS AYGALSLIKN 
       760        770        780        790        800
FQEEQAARLL SSETRDTLRQ WHKRRTTNRT IPSVDDFQNY LRVAFQEVNS 
       810        820        830        840        850
GCTGKTLLVR PYITTEDVCQ ICAEKFKVGD PEEYSLFLFV DETWQQLAED 
       860        870        880        890 
TYPQKIKAEL HSRPQPHIFH FVYKRIKNDP YGIIFQNGEE DLTTS
Length:895
Mass (Da):100,163
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DECDBF8D2629EE4
GO
Isoform 2 (identifier: Q8WYP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLDSFSQESTLPFREARKRTSFQPVQVWRNFTASQTTESPACSGASLGEM

Show »
Length:944
Mass (Da):105,613
Checksum:iEB0C72971CE5BFB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPJ1E7EPJ1_HUMAN
Ras and Rab interactor 2
RIN2
462Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB66858 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192I → V in AK094884 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024694197S → T1 PublicationCorresponds to variant dbSNP:rs3803981EnsemblClinVar.1
Natural variantiVAR_052945643A → T. Corresponds to variant dbSNP:rs199603EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0151451M → MLDSFSQESTLPFREARKRT SFQPVQVWRNFTASQTTESP ACSGASLGEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB060339 mRNA Translation: BAB84317.1
AL049538 Genomic DNA No translation available.
AL132821 Genomic DNA No translation available.
AK094884 mRNA No translation available.
AL136924 mRNA Translation: CAB66858.1 Different initiation.
M37190 mRNA Translation: AAA36553.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56182.1 [Q8WYP3-2]

Protein sequence database of the Protein Information Resource

More...PIRi		B38637

NCBI Reference Sequences

More...RefSeqi		NP_001229510.1, NM_001242581.1 [Q8WYP3-2]
NP_061866.1, NM_018993.3 [Q8WYP3-1]
XP_005260788.1, XM_005260731.2 [Q8WYP3-1]
XP_006723637.1, XM_006723574.3 [Q8WYP3-1]
XP_006723638.1, XM_006723575.3
XP_006723640.1, XM_006723577.2 [Q8WYP3-1]
XP_011527559.1, XM_011529257.1 [Q8WYP3-1]
XP_011527560.1, XM_011529258.2 [Q8WYP3-1]
XP_016883376.1, XM_017027887.1 [Q8WYP3-2]
XP_016883377.1, XM_017027888.1 [Q8WYP3-2]
XP_016883379.1, XM_017027890.1 [Q8WYP3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000255006; ENSP00000255006; ENSG00000132669 [Q8WYP3-2]
ENST00000648440; ENSP00000498085; ENSG00000132669 [Q8WYP3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54453

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54453

UCSC genome browser

More...UCSCi		uc002wro.3, human [Q8WYP3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060339 mRNA Translation: BAB84317.1
AL049538 Genomic DNA No translation available.
AL132821 Genomic DNA No translation available.
AK094884 mRNA No translation available.
AL136924 mRNA Translation: CAB66858.1 Different initiation.
M37190 mRNA Translation: AAA36553.1
CCDSiCCDS56182.1 [Q8WYP3-2]
PIRiB38637
RefSeqiNP_001229510.1, NM_001242581.1 [Q8WYP3-2]
NP_061866.1, NM_018993.3 [Q8WYP3-1]
XP_005260788.1, XM_005260731.2 [Q8WYP3-1]
XP_006723637.1, XM_006723574.3 [Q8WYP3-1]
XP_006723638.1, XM_006723575.3
XP_006723640.1, XM_006723577.2 [Q8WYP3-1]
XP_011527559.1, XM_011529257.1 [Q8WYP3-1]
XP_011527560.1, XM_011529258.2 [Q8WYP3-1]
XP_016883376.1, XM_017027887.1 [Q8WYP3-2]
XP_016883377.1, XM_017027888.1 [Q8WYP3-2]
XP_016883379.1, XM_017027890.1 [Q8WYP3-1]

3D structure databases

SMRiQ8WYP3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119960, 14 interactors
IntActiQ8WYP3, 3 interactors
MINTiQ8WYP3
STRINGi9606.ENSP00000255006

PTM databases

iPTMnetiQ8WYP3
PhosphoSitePlusiQ8WYP3

Genetic variation databases

BioMutaiRIN2
DMDMi28201876

Proteomic databases

EPDiQ8WYP3
jPOSTiQ8WYP3
MassIVEiQ8WYP3
MaxQBiQ8WYP3
PaxDbiQ8WYP3
PeptideAtlasiQ8WYP3
PRIDEiQ8WYP3
ProteomicsDBi75179 [Q8WYP3-1]
75180 [Q8WYP3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24653, 81 antibodies

Genome annotation databases

EnsembliENST00000255006; ENSP00000255006; ENSG00000132669 [Q8WYP3-2]
ENST00000648440; ENSP00000498085; ENSG00000132669 [Q8WYP3-1]
GeneIDi54453
KEGGihsa:54453
UCSCiuc002wro.3, human [Q8WYP3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54453
DisGeNETi54453

GeneCards: human genes, protein and diseases

More...GeneCardsi		RIN2
HGNCiHGNC:18750, RIN2
HPAiENSG00000132669, Low tissue specificity
MalaCardsiRIN2
MIMi610222, gene
613075, phenotype
neXtProtiNX_Q8WYP3
OpenTargetsiENSG00000132669
Orphaneti217335, RIN2 syndrome
PharmGKBiPA38672
VEuPathDBiHostDB:ENSG00000132669.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2320, Eukaryota
GeneTreeiENSGT00940000154866
HOGENOMiCLU_011829_1_0_1
InParanoidiQ8WYP3
OMAiWRNFTAS
OrthoDBi1311692at2759
PhylomeDBiQ8WYP3
TreeFamiTF331067

Enzyme and pathway databases

PathwayCommonsiQ8WYP3
ReactomeiR-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54453, 7 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RIN2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54453
PharosiQ8WYP3, Tbio

Protein Ontology

More...PROi		PR:Q8WYP3
RNActiQ8WYP3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132669, Expressed in tendon and 250 other tissues
ExpressionAtlasiQ8WYP3, baseline and differential
GenevisibleiQ8WYP3, HS

Family and domain databases

CDDicd10394, SH2_RIN2, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159, RA_dom
IPR035868, RIN2_SH2
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR029071, Ubiquitin-like_domsf
IPR003123, VPS9
IPR037191, VPS9_dom_sf
PfamiView protein in Pfam
PF00788, RA, 1 hit
PF02204, VPS9, 1 hit
SMARTiView protein in SMART
SM00314, RA, 1 hit
SM00167, VPS9, 1 hit
SUPFAMiSSF109993, SSF109993, 1 hit
SSF54236, SSF54236, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200, RA, 1 hit
PS50001, SH2, 1 hit
PS51205, VPS9, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYP3
Secondary accession number(s): Q00425
, Q5TFT8, Q9BQL3, Q9H071
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2002
Last modified: April 7, 2021
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again