UniProtKB - Q8WYP3 (RIN2_HUMAN)
Protein
Ras and Rab interactor 2
Gene
RIN2
Organism
Homo sapiens (Human)
Status
Functioni
Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.1 Publication
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- GTPase regulator activity Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: UniProtKB
GO - Biological processi
- endocytosis Source: UniProtKB-KW
- positive regulation of endothelial cell-matrix adhesion via fibronectin Source: CACAO
- positive regulation of endothelial cell migration Source: CACAO
- positive regulation of vasculogenesis Source: CACAO
- small GTPase mediated signal transduction Source: UniProtKB
Keywordsi
Molecular function | GTPase activation |
Biological process | Endocytosis |
Enzyme and pathway databases
PathwayCommonsi | Q8WYP3 |
Reactomei | R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Ras and Rab interactor 2Alternative name(s): Ras association domain family 4 Ras inhibitor JC265 Ras interaction/interference protein 2 |
Gene namesi | Name:RIN2 Synonyms:RASSF4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18750, RIN2 |
MIMi | 610222, gene |
neXtProti | NX_Q8WYP3 |
VEuPathDBi | HostDB:ENSG00000132669.12 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
MACS syndrome (MACS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA complex disorder of elastic tissue characterized by sagging skin and occasionally by life-threatening visceral complications.
Related information in OMIMOrganism-specific databases
DisGeNETi | 54453 |
MalaCardsi | RIN2 |
MIMi | 613075, phenotype |
OpenTargetsi | ENSG00000132669 |
Orphaneti | 217335, RIN2 syndrome |
PharmGKBi | PA38672 |
Miscellaneous databases
Pharosi | Q8WYP3, Tbio |
Genetic variation databases
BioMutai | RIN2 |
DMDMi | 28201876 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191320 | 1 – 895 | Ras and Rab interactor 2Add BLAST | 895 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 501 | PhosphoserineBy similarity | 1 | |
Modified residuei | 509 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8WYP3 |
jPOSTi | Q8WYP3 |
MassIVEi | Q8WYP3 |
MaxQBi | Q8WYP3 |
PaxDbi | Q8WYP3 |
PeptideAtlasi | Q8WYP3 |
PRIDEi | Q8WYP3 |
ProteomicsDBi | 75179 [Q8WYP3-1] 75180 [Q8WYP3-2] |
PTM databases
iPTMneti | Q8WYP3 |
PhosphoSitePlusi | Q8WYP3 |
Expressioni
Tissue specificityi
Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood.1 Publication
Gene expression databases
Bgeei | ENSG00000132669, Expressed in tendon and 250 other tissues |
ExpressionAtlasi | Q8WYP3, baseline and differential |
Genevisiblei | Q8WYP3, HS |
Organism-specific databases
HPAi | ENSG00000132669, Low tissue specificity |
Interactioni
Subunit structurei
Homotetramer; probably composed of anti-parallel linkage of two parallel dimers.
Interacts with Ras.
Interacts with RAB5B, with a much higher affinity for GTP-bound activated RAB5B. Does not interact with other members of the Rab family.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 119960, 14 interactors |
IntActi | Q8WYP3, 3 interactors |
MINTi | Q8WYP3 |
STRINGi | 9606.ENSP00000255006 |
Miscellaneous databases
RNActi | Q8WYP3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 97 – 190 | SH2PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 618 – 757 | VPS9PROSITE-ProRule annotationAdd BLAST | 140 | |
Domaini | 787 – 878 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 307 – 314 | Poly-Pro | 8 |
Sequence similaritiesi
Belongs to the RIN (Ras interaction/interference) family.Curated
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG2320, Eukaryota |
GeneTreei | ENSGT00940000154866 |
HOGENOMi | CLU_011829_1_0_1 |
InParanoidi | Q8WYP3 |
OMAi | WRNFTAS |
OrthoDBi | 1311692at2759 |
PhylomeDBi | Q8WYP3 |
TreeFami | TF331067 |
Family and domain databases
CDDi | cd10394, SH2_RIN2, 1 hit |
Gene3Di | 1.20.1050.80, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000159, RA_dom IPR035868, RIN2_SH2 IPR000980, SH2 IPR036860, SH2_dom_sf IPR029071, Ubiquitin-like_domsf IPR003123, VPS9 IPR037191, VPS9_dom_sf |
Pfami | View protein in Pfam PF00788, RA, 1 hit PF02204, VPS9, 1 hit |
SMARTi | View protein in SMART SM00314, RA, 1 hit SM00167, VPS9, 1 hit |
SUPFAMi | SSF109993, SSF109993, 1 hit SSF54236, SSF54236, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50200, RA, 1 hit PS50001, SH2, 1 hit PS51205, VPS9, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WYP3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTAWTMGARG LDKRGSFFKL IDTIASEIGE LKQEMVRTDV NLENGLEPAE
60 70 80 90 100
THSMVRHKDG GYSEEEDVKT CARDSGYDSL SNRLSILDRL LHTHPIWLQL
110 120 130 140 150
SLSEEEAAEV LQAQPPGIFL VHKSTKMQKK VLSLRLPCEF GAPLKEFAIK
160 170 180 190 200
ESTYTFSLEG SGISFADLFR LIAFYCISRD VLPFTLKLPY AISTAKSEAQ
210 220 230 240 250
LEELAQMGLN FWSSPADSKP PNLPPPHRPL SSDGVCPASL RQLCLINGVH
260 270 280 290 300
SIKTRTPSEL ECSQTNGALC FINPLFLKVH SQDLSGGLKR PSTRTPNANG
310 320 330 340 350
TERTRSPPPR PPPPAINSLH TSPRLARTET QTSMPETVNH NKHGNVALPG
360 370 380 390 400
TKPTPIPPPR LKKQASFLEA EGGAKTLSGG RPGAGPELEL GTAGSPGGAP
410 420 430 440 450
PEAAPGDCTR APPPSSESRP PCHGGRQRLS DMSISTSSSD SLEFDRSMPL
460 470 480 490 500
FGYEADTNSS LEDYEGESDQ ETMAPPIKSK KKRSSSFVLP KLVKSQLQKV
510 520 530 540 550
SGVFSSFMTP EKRMVRRIAE LSRDKCTYFG CLVQDYVSFL QENKECHVSS
560 570 580 590 600
TDMLQTIRQF MTQVKNYLSQ SSELDPPIES LIPEDQIDVV LEKAMHKCIL
610 620 630 640 650
KPLKGHVEAM LKDFHMADGS WKQLKENLQL VRQRNPQELG VFAPTPDFVD
660 670 680 690 700
VEKIKVKFMT MQKMYSPEKK VMLLLRVCKL IYTVMENNSG RMYGADDFLP
710 720 730 740 750
VLTYVIAQCD MLELDTEIEY MMELLDPSLL HGEGGYYLTS AYGALSLIKN
760 770 780 790 800
FQEEQAARLL SSETRDTLRQ WHKRRTTNRT IPSVDDFQNY LRVAFQEVNS
810 820 830 840 850
GCTGKTLLVR PYITTEDVCQ ICAEKFKVGD PEEYSLFLFV DETWQQLAED
860 870 880 890
TYPQKIKAEL HSRPQPHIFH FVYKRIKNDP YGIIFQNGEE DLTTS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE7EPJ1 | E7EPJ1_HUMAN | Ras and Rab interactor 2 | RIN2 | 462 | Annotation score: |
Sequence cautioni
The sequence CAB66858 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 192 | I → V in AK094884 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024694 | 197 | S → T1 PublicationCorresponds to variant dbSNP:rs3803981EnsemblClinVar. | 1 | |
Natural variantiVAR_052945 | 643 | A → T. Corresponds to variant dbSNP:rs199603EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015145 | 1 | M → MLDSFSQESTLPFREARKRT SFQPVQVWRNFTASQTTESP ACSGASLGEM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB060339 mRNA Translation: BAB84317.1 AL049538 Genomic DNA No translation available. AL132821 Genomic DNA No translation available. AK094884 mRNA No translation available. AL136924 mRNA Translation: CAB66858.1 Different initiation. M37190 mRNA Translation: AAA36553.1 |
CCDSi | CCDS56182.1 [Q8WYP3-2] |
PIRi | B38637 |
RefSeqi | NP_001229510.1, NM_001242581.1 [Q8WYP3-2] NP_061866.1, NM_018993.3 [Q8WYP3-1] XP_005260788.1, XM_005260731.2 [Q8WYP3-1] XP_006723637.1, XM_006723574.3 [Q8WYP3-1] XP_006723638.1, XM_006723575.3 XP_006723640.1, XM_006723577.2 [Q8WYP3-1] XP_011527559.1, XM_011529257.1 [Q8WYP3-1] XP_011527560.1, XM_011529258.2 [Q8WYP3-1] XP_016883376.1, XM_017027887.1 [Q8WYP3-2] XP_016883377.1, XM_017027888.1 [Q8WYP3-2] XP_016883379.1, XM_017027890.1 [Q8WYP3-1] |
Genome annotation databases
Ensembli | ENST00000255006; ENSP00000255006; ENSG00000132669 [Q8WYP3-2] ENST00000648440; ENSP00000498085; ENSG00000132669 [Q8WYP3-1] |
GeneIDi | 54453 |
KEGGi | hsa:54453 |
UCSCi | uc002wro.3, human [Q8WYP3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB060339 mRNA Translation: BAB84317.1 AL049538 Genomic DNA No translation available. AL132821 Genomic DNA No translation available. AK094884 mRNA No translation available. AL136924 mRNA Translation: CAB66858.1 Different initiation. M37190 mRNA Translation: AAA36553.1 |
CCDSi | CCDS56182.1 [Q8WYP3-2] |
PIRi | B38637 |
RefSeqi | NP_001229510.1, NM_001242581.1 [Q8WYP3-2] NP_061866.1, NM_018993.3 [Q8WYP3-1] XP_005260788.1, XM_005260731.2 [Q8WYP3-1] XP_006723637.1, XM_006723574.3 [Q8WYP3-1] XP_006723638.1, XM_006723575.3 XP_006723640.1, XM_006723577.2 [Q8WYP3-1] XP_011527559.1, XM_011529257.1 [Q8WYP3-1] XP_011527560.1, XM_011529258.2 [Q8WYP3-1] XP_016883376.1, XM_017027887.1 [Q8WYP3-2] XP_016883377.1, XM_017027888.1 [Q8WYP3-2] XP_016883379.1, XM_017027890.1 [Q8WYP3-1] |
3D structure databases
SMRi | Q8WYP3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119960, 14 interactors |
IntActi | Q8WYP3, 3 interactors |
MINTi | Q8WYP3 |
STRINGi | 9606.ENSP00000255006 |
PTM databases
iPTMneti | Q8WYP3 |
PhosphoSitePlusi | Q8WYP3 |
Genetic variation databases
BioMutai | RIN2 |
DMDMi | 28201876 |
Proteomic databases
EPDi | Q8WYP3 |
jPOSTi | Q8WYP3 |
MassIVEi | Q8WYP3 |
MaxQBi | Q8WYP3 |
PaxDbi | Q8WYP3 |
PeptideAtlasi | Q8WYP3 |
PRIDEi | Q8WYP3 |
ProteomicsDBi | 75179 [Q8WYP3-1] 75180 [Q8WYP3-2] |
Protocols and materials databases
Antibodypediai | 24653, 81 antibodies |
Genome annotation databases
Ensembli | ENST00000255006; ENSP00000255006; ENSG00000132669 [Q8WYP3-2] ENST00000648440; ENSP00000498085; ENSG00000132669 [Q8WYP3-1] |
GeneIDi | 54453 |
KEGGi | hsa:54453 |
UCSCi | uc002wro.3, human [Q8WYP3-1] |
Organism-specific databases
CTDi | 54453 |
DisGeNETi | 54453 |
GeneCardsi | RIN2 |
HGNCi | HGNC:18750, RIN2 |
HPAi | ENSG00000132669, Low tissue specificity |
MalaCardsi | RIN2 |
MIMi | 610222, gene 613075, phenotype |
neXtProti | NX_Q8WYP3 |
OpenTargetsi | ENSG00000132669 |
Orphaneti | 217335, RIN2 syndrome |
PharmGKBi | PA38672 |
VEuPathDBi | HostDB:ENSG00000132669.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2320, Eukaryota |
GeneTreei | ENSGT00940000154866 |
HOGENOMi | CLU_011829_1_0_1 |
InParanoidi | Q8WYP3 |
OMAi | WRNFTAS |
OrthoDBi | 1311692at2759 |
PhylomeDBi | Q8WYP3 |
TreeFami | TF331067 |
Enzyme and pathway databases
PathwayCommonsi | Q8WYP3 |
Reactomei | R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 54453, 7 hits in 989 CRISPR screens |
ChiTaRSi | RIN2, human |
GenomeRNAii | 54453 |
Pharosi | Q8WYP3, Tbio |
PROi | PR:Q8WYP3 |
RNActi | Q8WYP3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132669, Expressed in tendon and 250 other tissues |
ExpressionAtlasi | Q8WYP3, baseline and differential |
Genevisiblei | Q8WYP3, HS |
Family and domain databases
CDDi | cd10394, SH2_RIN2, 1 hit |
Gene3Di | 1.20.1050.80, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000159, RA_dom IPR035868, RIN2_SH2 IPR000980, SH2 IPR036860, SH2_dom_sf IPR029071, Ubiquitin-like_domsf IPR003123, VPS9 IPR037191, VPS9_dom_sf |
Pfami | View protein in Pfam PF00788, RA, 1 hit PF02204, VPS9, 1 hit |
SMARTi | View protein in SMART SM00314, RA, 1 hit SM00167, VPS9, 1 hit |
SUPFAMi | SSF109993, SSF109993, 1 hit SSF54236, SSF54236, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50200, RA, 1 hit PS50001, SH2, 1 hit PS51205, VPS9, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RIN2_HUMAN | |
Accessioni | Q8WYP3Primary (citable) accession number: Q8WYP3 Secondary accession number(s): Q00425 Q9H071 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families