Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine protease ATG4A

Gene

ATG4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.6 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-ethylmaleimide. Redox-regulated during autophagy since reducing conditions activate ATG4A whereas an oxidizing environment such as the presence of H2O2 inhibits its activity.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=33.9 µM for MAP1LC3B2 Publications
  2. KM=20.8 µM for GABARAP2 Publications
  3. KM=36.7 µM for GABARAPL12 Publications
  4. KM=15.7 µM for GABARAPL22 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei77NucleophileBy similarity1
    Active sitei279Sequence analysis1
    Active sitei281By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • cysteine-type endopeptidase activity Source: GO_Central
    • cysteine-type peptidase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease, Thiol protease
    Biological processAutophagy, Protein transport, Transport, Ubl conjugation pathway

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1632852 Macroautophagy

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    C54.002

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cysteine protease ATG4A (EC:3.4.22.-)
    Alternative name(s):
    AUT-like 2 cysteine endopeptidase
    Autophagin-2
    Autophagy-related cysteine endopeptidase 2
    Autophagy-related protein 4 homolog A
    Short name:
    hAPG4A
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ATG4A
    Synonyms:APG4A, AUTL2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000101844.17

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:16489 ATG4A

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    300663 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8WYN0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi81C → A: Reduces the redox sensitivity and retains activity in presence of H(2)O(2). 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    115201

    Open Targets

    More...
    OpenTargetsi
    ENSG00000101844

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA25184

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ATG4A

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    61211859

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002158381 – 398Cysteine protease ATG4AAdd BLAST398

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8WYN0

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8WYN0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8WYN0

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8WYN0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8WYN0

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    75173
    75174 [Q8WYN0-2]
    75175 [Q8WYN0-3]
    75176 [Q8WYN0-5]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8WYN0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8WYN0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000101844 Expressed in 213 organ(s), highest expression level in biceps brachii

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8WYN0 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8WYN0 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA036374
    HPA064759

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    125418, 15 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8WYN0, 9 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q8WYN0

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000361306

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1398
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q8WYN0

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8WYN0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q8WYN0

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase C54 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2674 Eukaryota
    ENOG410XPQ0 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00530000063000

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG050536

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8WYN0

    KEGG Orthology (KO)

    More...
    KOi
    K08342

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ACCPAWK

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0995

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8WYN0

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314847

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR033474 ATG4A
    IPR038765 Papain_like_cys_pep_sf
    IPR005078 Peptidase_C54

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR22624 PTHR22624, 1 hit
    PTHR22624:SF35 PTHR22624:SF35, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03416 Peptidase_C54, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF54001 SSF54001, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8WYN0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MESVLSKYED QITIFTDYLE EYPDTDELVW ILGKQHLLKT EKSKLLSDIS
    60 70 80 90 100
    ARLWFTYRRK FSPIGGTGPS SDAGWGCMLR CGQMMLAQAL ICRHLGRDWS
    110 120 130 140 150
    WEKQKEQPKE YQRILQCFLD RKDCCYSIHQ MAQMGVGEGK SIGEWFGPNT
    160 170 180 190 200
    VAQVLKKLAL FDEWNSLAVY VSMDNTVVIE DIKKMCRVLP LSADTAGDRP
    210 220 230 240 250
    PDSLTASNQS KGTSAYCSAW KPLLLIVPLR LGINQINPVY VDAFKECFKM
    260 270 280 290 300
    PQSLGALGGK PNNAYYFIGF LGDELIFLDP HTTQTFVDTE ENGTVNDQTF
    310 320 330 340 350
    HCLQSPQRMN ILNLDPSVAL GFFCKEEKDF DNWCSLVQKE ILKENLRMFE
    360 370 380 390
    LVQKHPSHWP PFVPPAKPEV TTTGAEFIDS TEQLEEFDLE EDFEILSV
    Length:398
    Mass (Da):45,378
    Last modified:March 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BE892E22E432151
    GO
    Isoform 2 (identifier: Q8WYN0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-272: Missing.

    Show »
    Length:336
    Mass (Da):38,601
    Checksum:i61D7819B73A0D8A9
    GO
    Isoform 3 (identifier: Q8WYN0-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-77: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:321
    Mass (Da):36,533
    Checksum:i5F6CAD07A44EC130
    GO
    Isoform 4 (identifier: Q8WYN0-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-64: Missing.

    Note: Gene prediction based on EST data.
    Show »
    Length:374
    Mass (Da):42,453
    Checksum:i4BB385D3C84939CB
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    G5E979G5E979_HUMAN
    Cysteine protease
    ATG4A hCG_21686
    231Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7BYM2H7BYM2_HUMAN
    Cysteine protease
    ATG4A
    312Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0A0MT61A0A0A0MT61_HUMAN
    Cysteine protease
    ATG4A
    202Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8W7J2F8W7J2_HUMAN
    Cysteine protease ATG4A
    ATG4A
    47Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49I → Y in AAH41862 (PubMed:15489334).Curated1
    Sequence conflicti218S → T in CAC69076 (Ref. 3) Curated1
    Sequence conflicti218S → T in CAC69077 (Ref. 3) Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0259021 – 77Missing in isoform 3. 1 PublicationAdd BLAST77
    Alternative sequenceiVSP_03049941 – 64Missing in isoform 4. CuratedAdd BLAST24
    Alternative sequenceiVSP_013025211 – 272Missing in isoform 2. 1 PublicationAdd BLAST62

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ504651 mRNA Translation: CAD43218.1
    AB066214 mRNA Translation: BAB83889.1
    AJ320508 mRNA Translation: CAC69076.1
    AJ320509 mRNA Translation: CAC69077.1
    AK314429 mRNA Translation: BAG37044.1
    AL031177 Genomic DNA No translation available.
    CH471120 Genomic DNA Translation: EAX02689.1
    CH471120 Genomic DNA Translation: EAX02691.1
    CH471120 Genomic DNA Translation: EAX02693.1
    BC041862 mRNA Translation: AAH41862.1
    BC061696 mRNA Translation: AAH61696.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS14538.1 [Q8WYN0-1]
    CCDS14539.1 [Q8WYN0-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001308216.1, NM_001321287.1 [Q8WYN0-3]
    NP_001308217.1, NM_001321288.1 [Q8WYN0-3]
    NP_001308218.1, NM_001321289.1
    NP_443168.2, NM_052936.4 [Q8WYN0-1]
    NP_840054.1, NM_178270.3 [Q8WYN0-2]
    NP_840055.1, NM_178271.2 [Q8WYN0-3]
    XP_011529144.1, XM_011530842.1 [Q8WYN0-3]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.8763

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000345734; ENSP00000298131; ENSG00000101844 [Q8WYN0-2]
    ENST00000372232; ENSP00000361306; ENSG00000101844 [Q8WYN0-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    115201

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:115201

    UCSC genome browser

    More...
    UCSCi
    uc004enr.4 human [Q8WYN0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ504651 mRNA Translation: CAD43218.1
    AB066214 mRNA Translation: BAB83889.1
    AJ320508 mRNA Translation: CAC69076.1
    AJ320509 mRNA Translation: CAC69077.1
    AK314429 mRNA Translation: BAG37044.1
    AL031177 Genomic DNA No translation available.
    CH471120 Genomic DNA Translation: EAX02689.1
    CH471120 Genomic DNA Translation: EAX02691.1
    CH471120 Genomic DNA Translation: EAX02693.1
    BC041862 mRNA Translation: AAH41862.1
    BC061696 mRNA Translation: AAH61696.1
    CCDSiCCDS14538.1 [Q8WYN0-1]
    CCDS14539.1 [Q8WYN0-2]
    RefSeqiNP_001308216.1, NM_001321287.1 [Q8WYN0-3]
    NP_001308217.1, NM_001321288.1 [Q8WYN0-3]
    NP_001308218.1, NM_001321289.1
    NP_443168.2, NM_052936.4 [Q8WYN0-1]
    NP_840054.1, NM_178270.3 [Q8WYN0-2]
    NP_840055.1, NM_178271.2 [Q8WYN0-3]
    XP_011529144.1, XM_011530842.1 [Q8WYN0-3]
    UniGeneiHs.8763

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2FUYmodel-A1-398[»]
    2P82X-ray2.10A/B/C/D23-359[»]
    ProteinModelPortaliQ8WYN0
    SMRiQ8WYN0
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi125418, 15 interactors
    IntActiQ8WYN0, 9 interactors
    MINTiQ8WYN0
    STRINGi9606.ENSP00000361306

    Protein family/group databases

    MEROPSiC54.002

    PTM databases

    iPTMnetiQ8WYN0
    PhosphoSitePlusiQ8WYN0

    Polymorphism and mutation databases

    BioMutaiATG4A
    DMDMi61211859

    Proteomic databases

    EPDiQ8WYN0
    MaxQBiQ8WYN0
    PaxDbiQ8WYN0
    PeptideAtlasiQ8WYN0
    PRIDEiQ8WYN0
    ProteomicsDBi75173
    75174 [Q8WYN0-2]
    75175 [Q8WYN0-3]
    75176 [Q8WYN0-5]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    115201
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000345734; ENSP00000298131; ENSG00000101844 [Q8WYN0-2]
    ENST00000372232; ENSP00000361306; ENSG00000101844 [Q8WYN0-1]
    GeneIDi115201
    KEGGihsa:115201
    UCSCiuc004enr.4 human [Q8WYN0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    115201
    DisGeNETi115201
    EuPathDBiHostDB:ENSG00000101844.17

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ATG4A
    HGNCiHGNC:16489 ATG4A
    HPAiHPA036374
    HPA064759
    MIMi300663 gene
    neXtProtiNX_Q8WYN0
    OpenTargetsiENSG00000101844
    PharmGKBiPA25184

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2674 Eukaryota
    ENOG410XPQ0 LUCA
    GeneTreeiENSGT00530000063000
    HOVERGENiHBG050536
    InParanoidiQ8WYN0
    KOiK08342
    OMAiACCPAWK
    OrthoDBiEOG091G0995
    PhylomeDBiQ8WYN0
    TreeFamiTF314847

    Enzyme and pathway databases

    ReactomeiR-HSA-1632852 Macroautophagy

    Miscellaneous databases

    EvolutionaryTraceiQ8WYN0

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ATG4A

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    115201

    Protein Ontology

    More...
    PROi
    PR:Q8WYN0

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000101844 Expressed in 213 organ(s), highest expression level in biceps brachii
    ExpressionAtlasiQ8WYN0 baseline and differential
    GenevisibleiQ8WYN0 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR033474 ATG4A
    IPR038765 Papain_like_cys_pep_sf
    IPR005078 Peptidase_C54
    PANTHERiPTHR22624 PTHR22624, 1 hit
    PTHR22624:SF35 PTHR22624:SF35, 1 hit
    PfamiView protein in Pfam
    PF03416 Peptidase_C54, 1 hit
    SUPFAMiSSF54001 SSF54001, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG4A_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYN0
    Secondary accession number(s): A6NCH2
    , B2RAZ7, D3DUY0, O95534, Q5JYY9, Q5JYZ0, Q86VE5, Q96KQ0, Q96KQ1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 1, 2002
    Last modified: November 7, 2018
    This is version 134 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again