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UniProtKB - Q8WYL5 (SSH1_HUMAN)

Entry version 166 (07 Oct 2020)
Sequence version 2 (22 Nov 2005)
Previous versions | rss
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Protein

Protein phosphatase Slingshot homolog 1

Gene

SSH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.10 Publications

Miscellaneous

Tyrosine phosphatase activity has not been demonstrated for this protein to date.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei393Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Hydrolase, Protein phosphatase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WYL5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8WYL5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase Slingshot homolog 1 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
SSH-like protein 1
Short name:
SSH-1L
Short name:
hSSH-1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSH1
Synonyms:KIAA1298, SSH1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000084112.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:30579, SSH1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606778, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WYL5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi393C → S: Abrogates phosphatase activity. 8 Publications1
Mutagenesisi458W → A: Impairs stimulation of phosphatase activity by actin but does not affect basal activity. 1 Publication1
Mutagenesisi937S → A: Reduces binding to YWHAB, YWHAG, YWHAQ and YWHAZ. Abolishes binding to YWHAB, YWHAG, YWHAQ and YWHAZ and increases association with F-actin; when associated with A-978. 1 Publication1
Mutagenesisi978S → A: Reduces binding to YWHAB, YWHAG, YWHAQ and YWHAZ. Abolishes binding to YWHAB, YWHAG, YWHAQ and YWHAZ and increases association with F-actin; when associated with A-937. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54434

Open Targets

More...OpenTargetsi		ENSG00000084112

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134941788

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WYL5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SSH1

Domain mapping of disease mutations (DMDM)

More...DMDMi		82582267

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000948412 – 1049Protein phosphatase Slingshot homolog 1Add BLAST1048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei515PhosphoserineBy similarity1
Modified residuei576PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1
Modified residuei978Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WYL5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WYL5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WYL5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WYL5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WYL5

PeptideAtlas

More...PeptideAtlasi		Q8WYL5

PRoteomics IDEntifications database

More...PRIDEi		Q8WYL5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75168 [Q8WYL5-1]
75169 [Q8WYL5-2]
75170 [Q8WYL5-3]
75171 [Q8WYL5-4]
75172 [Q8WYL5-5]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		SSH1

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WYL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WYL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000084112, Expressed in colon and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WYL5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WYL5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000084112, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with actin and this stimulates phosphatase activity.

Also interacts with LIMK1 and with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119950, 61 interactors

Protein interaction database and analysis system

More...IntActi		Q8WYL5, 21 interactors

Molecular INTeraction database

More...MINTi		Q8WYL5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315713

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WYL5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WYL5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini308 – 449Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni897 – 1049Interaction with YWHAG1 PublicationAdd BLAST153

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1716, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156133

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006650_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WYL5

KEGG Orthology (KO)

More...KOi		K05766

Identification of Orthologs from Complete Genome Data

More...OMAi		FLCRLDH

Database of Orthologous Groups

More...OrthoDBi		1576308at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WYL5

TreeFam database of animal gene trees

More...TreeFami		TF319444

Family and domain databases

Conserved Domains Database

More...CDDi		cd11652, SSH-N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014876, DEK_C
IPR000340, Dual-sp_phosphatase_cat-dom
IPR043587, Phosphatase_SSH-like
IPR029021, Prot-tyrosine_phosphatase-like
IPR043588, SSH-N
IPR027233, SSH1
IPR016130, Tyr_Pase_AS
IPR000387, TYR_PHOSPHATASE_dom
IPR020422, TYR_PHOSPHATASE_DUAL_dom

The PANTHER Classification System

More...PANTHERi		PTHR45864, PTHR45864, 1 hit
PTHR45864:SF5, PTHR45864:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08766, DEK_C, 1 hit
PF00782, DSPc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00195, DSPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYL5-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVTLQRSP TPSAASSSAS NSELEAGSEE DRKLNLSLSE SFFMVKGAAL 
        60         70         80         90        100
FLQQGSSPQG QRSLQHPHKH AGDLPQHLQV MINLLRCEDR IKLAVRLESA 
       110        120        130        140        150
WADRVRYMVV VYSSGRQDTE ENILLGVDFS SKESKSCTIG MVLRLWSDTK 
       160        170        180        190        200
IHLDGDGGFS VSTAGRMHIF KPVSVQAMWS ALQVLHKACE VARRHNYFPG 
       210        220        230        240        250
GVALIWATYY ESCISSEQSC INEWNAMQDL ESTRPDSPAL FVDKPTEGER 
       260        270        280        290        300
TERLIKAKLR SIMMSQDLEN VTSKEIRNEL EKQMNCNLKE LKEFIDNEML 
       310        320        330        340        350
LILGQMDKPS LIFDHLYLGS EWNASNLEEL QGSGVDYILN VTREIDNFFP 
       360        370        380        390        400
GLFAYHNIRV YDEETTDLLA HWNEAYHFIN KAKRNHSKCL VHCKMGVSRS 
       410        420        430        440        450
ASTVIAYAMK EFGWPLEKAY NYVKQKRSIT RPNAGFMRQL SEYEGILDAS 
       460        470        480        490        500
KQRHNKLWRQ QTDSSLQQPV DDPAGPGDFL PETPDGTPES QLPFLDDAAQ 
       510        520        530        540        550
PGLGPPLPCC FRRLSDPLLP SPEDETGSLV HLEDPEREAL LEEAAPPAEV 
       560        570        580        590        600
HRPARQPQQG SGLCEKDVKK KLEFGSPKGR SGSLLQVEET EREEGLGAGR 
       610        620        630        640        650
WGQLPTQLDQ NLLNSENLNN NSKRSCPNGM EDDAIFGILN KVKPSYKSCA 
       660        670        680        690        700
DCMYPTASGA PEASRERCED PNAPAICTQP AFLPHITSSP VAHLASRSRV 
       710        720        730        740        750
PEKPASGPTE PPPFLPPAGS RRADTSGPGA GAALEPPASL LEPSRETPKV 
       760        770        780        790        800
LPKSLLLKNS HCDKNPPSTE VVIKEESSPK KDMKPAKDLR LLFSNESEKP 
       810        820        830        840        850
TTNSYLMQHQ ESIIQLQKAG LVRKHTKELE RLKSVPADPA PPSRDGPASR 
       860        870        880        890        900
LEASIPEESQ DPAALHELGP LVMPSQAGSD EKSEAAPASL EGGSLKSPPP 
       910        920        930        940        950
FFYRLDHTSS FSKDFLKTIC YTPTSSSMSS NLTRSSSSDS IHSVRGKPGL 
       960        970        980        990       1000
VKQRTQEIET RLRLAGLTVS SPLKRSHSLA KLGSLTFSTE DLSSEADPST 
      1010       1020       1030       1040 
VADSQDTTLS ESSFLHEPQG TPRDPAATSK PSGKPAPENL KSPSWMSKS
Length:1,049
Mass (Da):115,511
Last modified:November 22, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0600B9690F0E6F9C
GO
Isoform 2 (identifier: Q8WYL5-2) [UniParc]FASTAAdd to basket
Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     632-692: DDAIFGILNK...LPHITSSPVA → VGRARPAGWH...LQGPEGSFTG
     693-1049: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:692
Mass (Da):77,430
Checksum:i9DC1FF2FC8984384
GO
Isoform 3 (identifier: Q8WYL5-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     74-93: LPQHLQVMINLLRCEDRIKL → MGGRHHLQRQVSESMSALFQ
     135-157: Missing.
     245-1049: Missing.

Note: Due to intron retention.Curated
Show »
Length:148
Mass (Da):16,695
Checksum:i3EF171D933E3424D
GO
Isoform 4 (identifier: Q8WYL5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     313-334: FDHLYLGSEWNASNLEELQGSG → MRCYLSWDRWTSPPLSSIIFIS

Show »
Length:737
Mass (Da):80,684
Checksum:iE3825E2328B088D2
GO
Isoform 5 (identifier: Q8WYL5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MALVTLQRSP...SEEDRKLNLS → MARARRAVVG...CCPEVSSSNY
     632-692: DDAIFGILNK...LPHITSSPVA → VGRARPAGWH...LQGPEGSFTG
     693-1049: Missing.

Show »
Length:703
Mass (Da):78,978
Checksum:i3ACFAB4B97CBDF7A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YHR3H0YHR3_HUMAN
Protein phosphatase Slingshot homol...
SSH1
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1D9F8W1D9_HUMAN
Protein phosphatase Slingshot homol...
SSH1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS18F8VS18_HUMAN
Protein phosphatase Slingshot homol...
SSH1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92536 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → V in AAH62341 (PubMed:15489334).Curated1
Sequence conflicti230L → P in BAB84116 (PubMed:11832213).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0163111 – 312Missing in isoform 4. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_0163121 – 73Missing in isoform 3. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0163131 – 37MALVT…KLNLS → MARARRAVVGSVRDVSTAAT NLFYFTDFCIFLQPTHCFCC PEVSSSNY in isoform 5. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_01631474 – 93LPQHL…DRIKL → MGGRHHLQRQVSESMSALFQ in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_016315135 – 157Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_016316245 – 1049Missing in isoform 3. 1 PublicationAdd BLAST805
Alternative sequenceiVSP_016317313 – 334FDHLY…LQGSG → MRCYLSWDRWTSPPLSSIIF IS in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_016318632 – 692DDAIF…SSPVA → VGRARPAGWHTPSLPSHSNW PTSASVVGTTGTRHHTQLIF FYCLLWAPSSHLQGPEGSFT G in isoform 2 and isoform 5. 2 PublicationsAdd BLAST61
Alternative sequenceiVSP_016319693 – 1049Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST357

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB072355 mRNA Translation: BAB84114.1
AB072356 mRNA Translation: BAB84115.1
AB072357 mRNA Translation: BAB84116.1
AB037719 mRNA Translation: BAA92536.1 Different initiation.
AK095421 mRNA Translation: BAC04546.1
BC062341 mRNA Translation: AAH62341.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53825.1 [Q8WYL5-5]
CCDS55882.1 [Q8WYL5-2]
CCDS9121.1 [Q8WYL5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001154802.1, NM_001161330.1 [Q8WYL5-2]
NP_001154803.1, NM_001161331.1 [Q8WYL5-5]
NP_061857.3, NM_018984.3 [Q8WYL5-1]
XP_016874982.1, XM_017019493.1 [Q8WYL5-4]
XP_016874983.1, XM_017019494.1 [Q8WYL5-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000326470; ENSP00000326107; ENSG00000084112 [Q8WYL5-5]
ENST00000326495; ENSP00000315713; ENSG00000084112 [Q8WYL5-1]
ENST00000551165; ENSP00000448824; ENSG00000084112 [Q8WYL5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54434

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54434

UCSC genome browser

More...UCSCi		uc001tnm.4, human [Q8WYL5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072355 mRNA Translation: BAB84114.1
AB072356 mRNA Translation: BAB84115.1
AB072357 mRNA Translation: BAB84116.1
AB037719 mRNA Translation: BAA92536.1 Different initiation.
AK095421 mRNA Translation: BAC04546.1
BC062341 mRNA Translation: AAH62341.1
CCDSiCCDS53825.1 [Q8WYL5-5]
CCDS55882.1 [Q8WYL5-2]
CCDS9121.1 [Q8WYL5-1]
RefSeqiNP_001154802.1, NM_001161330.1 [Q8WYL5-2]
NP_001154803.1, NM_001161331.1 [Q8WYL5-5]
NP_061857.3, NM_018984.3 [Q8WYL5-1]
XP_016874982.1, XM_017019493.1 [Q8WYL5-4]
XP_016874983.1, XM_017019494.1 [Q8WYL5-4]

3D structure databases

SMRiQ8WYL5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119950, 61 interactors
IntActiQ8WYL5, 21 interactors
MINTiQ8WYL5
STRINGi9606.ENSP00000315713

PTM databases

DEPODiSSH1
iPTMnetiQ8WYL5
PhosphoSitePlusiQ8WYL5

Polymorphism and mutation databases

BioMutaiSSH1
DMDMi82582267

Proteomic databases

EPDiQ8WYL5
jPOSTiQ8WYL5
MassIVEiQ8WYL5
MaxQBiQ8WYL5
PaxDbiQ8WYL5
PeptideAtlasiQ8WYL5
PRIDEiQ8WYL5
ProteomicsDBi75168 [Q8WYL5-1]
75169 [Q8WYL5-2]
75170 [Q8WYL5-3]
75171 [Q8WYL5-4]
75172 [Q8WYL5-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18311, 187 antibodies

The DNASU plasmid repository

More...DNASUi		54434

Genome annotation databases

EnsembliENST00000326470; ENSP00000326107; ENSG00000084112 [Q8WYL5-5]
ENST00000326495; ENSP00000315713; ENSG00000084112 [Q8WYL5-1]
ENST00000551165; ENSP00000448824; ENSG00000084112 [Q8WYL5-2]
GeneIDi54434
KEGGihsa:54434
UCSCiuc001tnm.4, human [Q8WYL5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54434
DisGeNETi54434
EuPathDBiHostDB:ENSG00000084112.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		SSH1
HGNCiHGNC:30579, SSH1
HPAiENSG00000084112, Low tissue specificity
MIMi606778, gene
neXtProtiNX_Q8WYL5
OpenTargetsiENSG00000084112
PharmGKBiPA134941788

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1716, Eukaryota
GeneTreeiENSGT00940000156133
HOGENOMiCLU_006650_1_0_1
InParanoidiQ8WYL5
KOiK05766
OMAiFLCRLDH
OrthoDBi1576308at2759
PhylomeDBiQ8WYL5
TreeFamiTF319444

Enzyme and pathway databases

PathwayCommonsiQ8WYL5
SIGNORiQ8WYL5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54434, 8 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SSH1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SSH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54434
PharosiQ8WYL5, Tbio

Protein Ontology

More...PROi		PR:Q8WYL5
RNActiQ8WYL5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000084112, Expressed in colon and 243 other tissues
ExpressionAtlasiQ8WYL5, baseline and differential
GenevisibleiQ8WYL5, HS

Family and domain databases

CDDicd11652, SSH-N, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR014876, DEK_C
IPR000340, Dual-sp_phosphatase_cat-dom
IPR043587, Phosphatase_SSH-like
IPR029021, Prot-tyrosine_phosphatase-like
IPR043588, SSH-N
IPR027233, SSH1
IPR016130, Tyr_Pase_AS
IPR000387, TYR_PHOSPHATASE_dom
IPR020422, TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR45864, PTHR45864, 1 hit
PTHR45864:SF5, PTHR45864:SF5, 1 hit
PfamiView protein in Pfam
PF08766, DEK_C, 1 hit
PF00782, DSPc, 1 hit
SMARTiView protein in SMART
SM00195, DSPc, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSH1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYL5
Secondary accession number(s): Q6P6C0
, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 7, 2020
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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