UniProtKB - Q8WYL5 (SSH1_HUMAN)

BLAST

>sp|Q8WYL5|SSH1_HUMAN Protein phosphatase Slingshot homolog 1 OS=Homo sapiens OX=9606 GN=SSH1 PE=1 SV=2
MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQG
QRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESAWADRVRYMVVVYSSGRQDTE
ENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWS
ALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPAL
FVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKELKEFIDNEML
LILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRV
YDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAY
NYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFL
PETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREAL
LEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGR
WGQLPTQLDQNLLNSENLNNNSKRSCPNGMEDDAIFGILNKVKPSYKSCADCMYPTASGA
PEASRERCEDPNAPAICTQPAFLPHITSSPVAHLASRSRVPEKPASGPTEPPPFLPPAGS
RRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNSHCDKNPPSTEVVIKEESSPK
KDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSVPADPA
PPSRDGPASRLEASIPEESQDPAALHELGPLVMPSQAGSDEKSEAAPASLEGGSLKSPPP
FFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIET
RLRLAGLTVSSPLKRSHSLAKLGSLTFSTEDLSSEADPSTVADSQDTTLSESSFLHEPQG
TPRDPAATSKPSGKPAPENLKSPSWMSKS

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History
Entry version 150 (07 Nov 2018)
Sequence version 2 (22 Nov 2005)
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Protein

Protein phosphatase Slingshot homolog 1

Gene

SSH1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.10 Publications

Miscellaneous

Tyrosine phosphatase activity has not been demonstrated for this protein to date.

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.PROSITE-ProRule annotation

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	393	Phosphocysteine intermediateCurated		1

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11832213
phosphoprotein phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11832213
protein tyrosine/serine/threonine phosphatase activity Source: InterPro
protein tyrosine phosphatase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11832213
cell morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14645219
cellular response to ATP
Source: MGI
Inferred from direct assayⁱ
- 19000834
excitatory chemical synaptic transmission Source: Ensembl
positive regulation of AMPA glutamate receptor clustering Source: Ensembl
positive regulation of excitatory postsynaptic potential Source: Ensembl
positive regulation of neuron death Source: Ensembl
positive regulation of synaptic plasticity Source: Ensembl
positive regulation of vascular associated smooth muscle cell migration Source: Ensembl
protein dephosphorylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11832213
- 14645219
regulation of actin polymerization or depolymerization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of axonogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cellular protein metabolic process
Source: MGI
Inferred from direct assayⁱ
- 19000834
regulation of lamellipodium assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Hydrolase, Protein phosphatase

Molecular function

Actin-binding, Hydrolase, Protein phosphatase

Enzyme and pathway databases

SIGNORⁱ	Q8WYL5

SIGNORⁱ

Q8WYL5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein phosphatase Slingshot homolog 1 (EC:3.1.3.16, EC:3.1.3.48) Alternative name(s): SSH-like protein 1 Short name: SSH-1L Short name: hSSH-1L
Gene namesⁱ	Name:SSH1 Synonyms:KIAA1298, SSH1L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000084112.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30579 SSH1
MIMⁱ	606778 gene
neXtProtⁱ	NX_Q8WYL5

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	393	C → S: Abrogates phosphatase activity. 8 Publications	1
Mutagenesisⁱ	458	W → A: Impairs stimulation of phosphatase activity by actin but does not affect basal activity. 1 Publication	1
Mutagenesisⁱ	937	S → A: Reduces binding to YWHAB, YWHAG, YWHAQ and YWHAZ. Abolishes binding to YWHAB, YWHAG, YWHAQ and YWHAZ and increases association with F-actin; when associated with A-978. 1 Publication	1
Mutagenesisⁱ	978	S → A: Reduces binding to YWHAB, YWHAG, YWHAQ and YWHAZ. Abolishes binding to YWHAB, YWHAG, YWHAQ and YWHAZ and increases association with F-actin; when associated with A-937. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54434
Open Targets More...OpenTargetsⁱ	ENSG00000084112
PharmGKBⁱ	PA134941788

Polymorphism and mutation databases

BioMutaⁱ	SSH1
DMDMⁱ	82582267

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000094841	2 – 1049	Protein phosphatase Slingshot homolog 1Add BLAST		1048

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	37	PhosphoserineCombined sources	1
Modified residueⁱ	57	PhosphoserineCombined sources	1
Modified residueⁱ	515	PhosphoserineBy similarity	1
Modified residueⁱ	576	PhosphoserineCombined sources	1
Modified residueⁱ	897	PhosphoserineCombined sources	1
Modified residueⁱ	978	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.4 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8WYL5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WYL5
PaxDbⁱ	Q8WYL5
PeptideAtlas More...PeptideAtlasⁱ	Q8WYL5
PRIDEⁱ	Q8WYL5
ProteomicsDBⁱ	75168 75169 [Q8WYL5-2] 75170 [Q8WYL5-3] 75171 [Q8WYL5-4] 75172 [Q8WYL5-5]

PTM databases

DEPODⁱ	Q8WYL5
GlyConnectⁱ	1667
iPTMnetⁱ	Q8WYL5
PhosphoSitePlusⁱ	Q8WYL5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000084112 Expressed in 233 organ(s), highest expression level in colon
CleanExⁱ	HS_SSH1
ExpressionAtlasⁱ	Q8WYL5 baseline and differential
Genevisibleⁱ	Q8WYL5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019845

HPAⁱ

HPA019845

Interactionⁱ

Subunit structureⁱ

Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CFL1	P23528	2	EBI-1222387,EBI-352733
CORO1B	Q9BR76	3	EBI-1222387,EBI-351152
LIMK1	P53667	6	EBI-1222387,EBI-444403
YWHAB	P31946	3	EBI-1222387,EBI-359815
YWHAQ	P27348	2	EBI-1222387,EBI-359854

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11832213

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119950, 37 interactors
IntActⁱ	Q8WYL5, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q8WYL5
STRINGⁱ	9606.ENSP00000315713

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WYL5
SMRⁱ	Q8WYL5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	308 – 448	Tyrosine-protein phosphataseAdd BLAST		141

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	897 – 1049	Interaction with YWHAG1 PublicationAdd BLAST		153

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1716 Eukaryota COG2453 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118902
HOGENOMⁱ	HOG000154427
HOVERGENⁱ	HBG094001
InParanoidⁱ	Q8WYL5
KEGG Orthology (KO) More...KOⁱ	K05766
OMAⁱ	CPEDFEH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0249
PhylomeDBⁱ	Q8WYL5
TreeFamⁱ	TF319444

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00127 DSPc, 1 hit
Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR014876 DEK_C IPR000340 Dual-sp_phosphatase_cat-dom IPR024950 DUSP IPR029021 Prot-tyrosine_phosphatase-like IPR027233 SSH1 IPR016130 Tyr_Pase_AS IPR000387 TYR_PHOSPHATASE_dom IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERⁱ	PTHR10159 PTHR10159, 1 hit PTHR10159:SF138 PTHR10159:SF138, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08766 DEK_C, 1 hit PF00782 DSPc, 1 hit
SMARTⁱ	View protein in SMART SM00195 DSPc, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8WYL5-1) [UniParc]FASTA Add to basket

Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVTLQRSP TPSAASSSAS NSELEAGSEE DRKLNLSLSE SFFMVKGAAL 
        60         70         80         90        100
FLQQGSSPQG QRSLQHPHKH AGDLPQHLQV MINLLRCEDR IKLAVRLESA 
       110        120        130        140        150
WADRVRYMVV VYSSGRQDTE ENILLGVDFS SKESKSCTIG MVLRLWSDTK 
       160        170        180        190        200
IHLDGDGGFS VSTAGRMHIF KPVSVQAMWS ALQVLHKACE VARRHNYFPG 
       210        220        230        240        250
GVALIWATYY ESCISSEQSC INEWNAMQDL ESTRPDSPAL FVDKPTEGER 
       260        270        280        290        300
TERLIKAKLR SIMMSQDLEN VTSKEIRNEL EKQMNCNLKE LKEFIDNEML 
       310        320        330        340        350
LILGQMDKPS LIFDHLYLGS EWNASNLEEL QGSGVDYILN VTREIDNFFP 
       360        370        380        390        400
GLFAYHNIRV YDEETTDLLA HWNEAYHFIN KAKRNHSKCL VHCKMGVSRS 
       410        420        430        440        450
ASTVIAYAMK EFGWPLEKAY NYVKQKRSIT RPNAGFMRQL SEYEGILDAS 
       460        470        480        490        500
KQRHNKLWRQ QTDSSLQQPV DDPAGPGDFL PETPDGTPES QLPFLDDAAQ 
       510        520        530        540        550
PGLGPPLPCC FRRLSDPLLP SPEDETGSLV HLEDPEREAL LEEAAPPAEV 
       560        570        580        590        600
HRPARQPQQG SGLCEKDVKK KLEFGSPKGR SGSLLQVEET EREEGLGAGR 
       610        620        630        640        650
WGQLPTQLDQ NLLNSENLNN NSKRSCPNGM EDDAIFGILN KVKPSYKSCA 
       660        670        680        690        700
DCMYPTASGA PEASRERCED PNAPAICTQP AFLPHITSSP VAHLASRSRV 
       710        720        730        740        750
PEKPASGPTE PPPFLPPAGS RRADTSGPGA GAALEPPASL LEPSRETPKV 
       760        770        780        790        800
LPKSLLLKNS HCDKNPPSTE VVIKEESSPK KDMKPAKDLR LLFSNESEKP 
       810        820        830        840        850
TTNSYLMQHQ ESIIQLQKAG LVRKHTKELE RLKSVPADPA PPSRDGPASR 
       860        870        880        890        900
LEASIPEESQ DPAALHELGP LVMPSQAGSD EKSEAAPASL EGGSLKSPPP 
       910        920        930        940        950
FFYRLDHTSS FSKDFLKTIC YTPTSSSMSS NLTRSSSSDS IHSVRGKPGL 
       960        970        980        990       1000
VKQRTQEIET RLRLAGLTVS SPLKRSHSLA KLGSLTFSTE DLSSEADPST 
      1010       1020       1030       1040 
VADSQDTTLS ESSFLHEPQG TPRDPAATSK PSGKPAPENL KSPSWMSKS

Length:1,049

Mass (Da):115,511

Last modified:November 22, 2005 - v2

Checksum:ⁱ0600B9690F0E6F9C

Isoform 2 (identifier: Q8WYL5-2) [UniParc]FASTA Add to basket

Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
632-692: DDAIFGILNK...LPHITSSPVA → VGRARPAGWH...LQGPEGSFTG
693-1049: Missing.

« Hide

        10         20         30         40         50
MALVTLQRSP TPSAASSSAS NSELEAGSEE DRKLNLSLSE SFFMVKGAAL 
        60         70         80         90        100
FLQQGSSPQG QRSLQHPHKH AGDLPQHLQV MINLLRCEDR IKLAVRLESA 
       110        120        130        140        150
WADRVRYMVV VYSSGRQDTE ENILLGVDFS SKESKSCTIG MVLRLWSDTK 
       160        170        180        190        200
IHLDGDGGFS VSTAGRMHIF KPVSVQAMWS ALQVLHKACE VARRHNYFPG 
       210        220        230        240        250
GVALIWATYY ESCISSEQSC INEWNAMQDL ESTRPDSPAL FVDKPTEGER 
       260        270        280        290        300
TERLIKAKLR SIMMSQDLEN VTSKEIRNEL EKQMNCNLKE LKEFIDNEML 
       310        320        330        340        350
LILGQMDKPS LIFDHLYLGS EWNASNLEEL QGSGVDYILN VTREIDNFFP 
       360        370        380        390        400
GLFAYHNIRV YDEETTDLLA HWNEAYHFIN KAKRNHSKCL VHCKMGVSRS 
       410        420        430        440        450
ASTVIAYAMK EFGWPLEKAY NYVKQKRSIT RPNAGFMRQL SEYEGILDAS 
       460        470        480        490        500
KQRHNKLWRQ QTDSSLQQPV DDPAGPGDFL PETPDGTPES QLPFLDDAAQ 
       510        520        530        540        550
PGLGPPLPCC FRRLSDPLLP SPEDETGSLV HLEDPEREAL LEEAAPPAEV 
       560        570        580        590        600
HRPARQPQQG SGLCEKDVKK KLEFGSPKGR SGSLLQVEET EREEGLGAGR 
       610        620        630        640        650
WGQLPTQLDQ NLLNSENLNN NSKRSCPNGM EVGRARPAGW HTPSLPSHSN 
       660        670        680        690 
WPTSASVVGT TGTRHHTQLI FFYCLLWAPS SHLQGPEGSF TG

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:692

Mass (Da):77,430

Checksum:ⁱ9DC1FF2FC8984384

Isoform 3 (identifier: Q8WYL5-3) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     74-93: LPQHLQVMINLLRCEDRIKL → MGGRHHLQRQVSESMSALFQ
     135-157: Missing.
     245-1049: Missing.

« Hide

        10         20         30         40         50
MGGRHHLQRQ VSESMSALFQ AVRLESAWAD RVRYMVVVYS SGRQDTEENI 
        60         70         80         90        100
LLGVDFSSKE SGFSVSTAGR MHIFKPVSVQ AMWSALQVLH KACEVARRHN 
       110        120        130        140 
YFPGGVALIW ATYYESCISS EQSCINEWNA MQDLESTRPD SPALFVDK

Note: Due to intron retention. No experimental confirmation available.

Show »

Length:148

Mass (Da):16,695

Checksum:ⁱ3EF171D933E3424D

Isoform 4 (identifier: Q8WYL5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-312: Missing.
313-334: FDHLYLGSEWNASNLEELQGSG → MRCYLSWDRWTSPPLSSIIFIS

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        10         20         30         40         50
MRCYLSWDRW TSPPLSSIIF ISVDYILNVT REIDNFFPGL FAYHNIRVYD 
        60         70         80         90        100
EETTDLLAHW NEAYHFINKA KRNHSKCLVH CKMGVSRSAS TVIAYAMKEF 
       110        120        130        140        150
GWPLEKAYNY VKQKRSITRP NAGFMRQLSE YEGILDASKQ RHNKLWRQQT 
       160        170        180        190        200
DSSLQQPVDD PAGPGDFLPE TPDGTPESQL PFLDDAAQPG LGPPLPCCFR 
       210        220        230        240        250
RLSDPLLPSP EDETGSLVHL EDPEREALLE EAAPPAEVHR PARQPQQGSG 
       260        270        280        290        300
LCEKDVKKKL EFGSPKGRSG SLLQVEETER EEGLGAGRWG QLPTQLDQNL 
       310        320        330        340        350
LNSENLNNNS KRSCPNGMED DAIFGILNKV KPSYKSCADC MYPTASGAPE 
       360        370        380        390        400
ASRERCEDPN APAICTQPAF LPHITSSPVA HLASRSRVPE KPASGPTEPP 
       410        420        430        440        450
PFLPPAGSRR ADTSGPGAGA ALEPPASLLE PSRETPKVLP KSLLLKNSHC 
       460        470        480        490        500
DKNPPSTEVV IKEESSPKKD MKPAKDLRLL FSNESEKPTT NSYLMQHQES 
       510        520        530        540        550
IIQLQKAGLV RKHTKELERL KSVPADPAPP SRDGPASRLE ASIPEESQDP 
       560        570        580        590        600
AALHELGPLV MPSQAGSDEK SEAAPASLEG GSLKSPPPFF YRLDHTSSFS 
       610        620        630        640        650
KDFLKTICYT PTSSSMSSNL TRSSSSDSIH SVRGKPGLVK QRTQEIETRL 
       660        670        680        690        700
RLAGLTVSSP LKRSHSLAKL GSLTFSTEDL SSEADPSTVA DSQDTTLSES 
       710        720        730 
SFLHEPQGTP RDPAATSKPS GKPAPENLKS PSWMSKS

Show »

Length:737

Mass (Da):80,684

Checksum:ⁱE3825E2328B088D2

Isoform 5 (identifier: Q8WYL5-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MALVTLQRSP...SEEDRKLNLS → MARARRAVVG...CCPEVSSSNY
     632-692: DDAIFGILNK...LPHITSSPVA → VGRARPAGWH...LQGPEGSFTG
     693-1049: Missing.

« Hide

        10         20         30         40         50
MARARRAVVG SVRDVSTAAT NLFYFTDFCI FLQPTHCFCC PEVSSSNYLS 
        60         70         80         90        100
ESFFMVKGAA LFLQQGSSPQ GQRSLQHPHK HAGDLPQHLQ VMINLLRCED 
       110        120        130        140        150
RIKLAVRLES AWADRVRYMV VVYSSGRQDT EENILLGVDF SSKESKSCTI 
       160        170        180        190        200
GMVLRLWSDT KIHLDGDGGF SVSTAGRMHI FKPVSVQAMW SALQVLHKAC 
       210        220        230        240        250
EVARRHNYFP GGVALIWATY YESCISSEQS CINEWNAMQD LESTRPDSPA 
       260        270        280        290        300
LFVDKPTEGE RTERLIKAKL RSIMMSQDLE NVTSKEIRNE LEKQMNCNLK 
       310        320        330        340        350
ELKEFIDNEM LLILGQMDKP SLIFDHLYLG SEWNASNLEE LQGSGVDYIL 
       360        370        380        390        400
NVTREIDNFF PGLFAYHNIR VYDEETTDLL AHWNEAYHFI NKAKRNHSKC 
       410        420        430        440        450
LVHCKMGVSR SASTVIAYAM KEFGWPLEKA YNYVKQKRSI TRPNAGFMRQ 
       460        470        480        490        500
LSEYEGILDA SKQRHNKLWR QQTDSSLQQP VDDPAGPGDF LPETPDGTPE 
       510        520        530        540        550
SQLPFLDDAA QPGLGPPLPC CFRRLSDPLL PSPEDETGSL VHLEDPEREA 
       560        570        580        590        600
LLEEAAPPAE VHRPARQPQQ GSGLCEKDVK KKLEFGSPKG RSGSLLQVEE 
       610        620        630        640        650
TEREEGLGAG RWGQLPTQLD QNLLNSENLN NNSKRSCPNG MEVGRARPAG 
       660        670        680        690        700
WHTPSLPSHS NWPTSASVVG TTGTRHHTQL IFFYCLLWAP SSHLQGPEGS 

FTG

Note: No experimental confirmation available.

Show »

Length:703

Mass (Da):78,978

Checksum:ⁱ3ACFAB4B97CBDF7A

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W1D9	F8W1D9_HUMAN	Protein phosphatase Slingshot homol... Protein phosphatase Slingshot homolog 1	SSH1	154	Annotation score:
H0YHR3	H0YHR3_HUMAN	Protein phosphatase Slingshot homol... Protein phosphatase Slingshot homolog 1	SSH1	95	Annotation score:
F8VS18	F8VS18_HUMAN	Protein phosphatase Slingshot homol... Protein phosphatase Slingshot homolog 1	SSH1	37	Annotation score:

Sequence cautionⁱ

The sequence BAA92536 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	2	A → V in AAH62341 (PubMed:15489334).Curated		1
Sequence conflictⁱ	230	L → P in BAB84116 (PubMed:11832213).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_016311	1 – 312	Missing in isoform 4. 1 PublicationAdd BLAST	312
Alternative sequenceⁱVSP_016312	1 – 73	Missing in isoform 3. 1 PublicationAdd BLAST	73
Alternative sequenceⁱVSP_016313	1 – 37	MALVT…KLNLS → MARARRAVVGSVRDVSTAAT NLFYFTDFCIFLQPTHCFCC PEVSSSNY in isoform 5. 1 PublicationAdd BLAST	37
Alternative sequenceⁱVSP_016314	74 – 93	LPQHL…DRIKL → MGGRHHLQRQVSESMSALFQ in isoform 3. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_016315	135 – 157	Missing in isoform 3. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_016316	245 – 1049	Missing in isoform 3. 1 PublicationAdd BLAST	805
Alternative sequenceⁱVSP_016317	313 – 334	FDHLY…LQGSG → MRCYLSWDRWTSPPLSSIIF IS in isoform 4. 1 PublicationAdd BLAST	22
Alternative sequenceⁱVSP_016318	632 – 692	DDAIF…SSPVA → VGRARPAGWHTPSLPSHSNW PTSASVVGTTGTRHHTQLIF FYCLLWAPSSHLQGPEGSFT G in isoform 2 and isoform 5. 2 PublicationsAdd BLAST	61
Alternative sequenceⁱVSP_016319	693 – 1049	Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST	357

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB072355 mRNA Translation: BAB84114.1 AB072356 mRNA Translation: BAB84115.1 AB072357 mRNA Translation: BAB84116.1 AB037719 mRNA Translation: BAA92536.1 Different initiation. AK095421 mRNA Translation: BAC04546.1 BC062341 mRNA Translation: AAH62341.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53825.1 [Q8WYL5-5] CCDS55882.1 [Q8WYL5-2] CCDS9121.1 [Q8WYL5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001154802.1, NM_001161330.1 [Q8WYL5-2] NP_001154803.1, NM_001161331.1 [Q8WYL5-5] NP_061857.3, NM_018984.3 [Q8WYL5-1] XP_016874982.1, XM_017019493.1 [Q8WYL5-4] XP_016874983.1, XM_017019494.1 [Q8WYL5-4]
UniGeneⁱ	Hs.199763

Genome annotation databases

Ensemblⁱ	ENST00000326470; ENSP00000326107; ENSG00000084112 [Q8WYL5-5] ENST00000326495; ENSP00000315713; ENSG00000084112 [Q8WYL5-1] ENST00000551165; ENSP00000448824; ENSG00000084112 [Q8WYL5-2]
GeneIDⁱ	54434
KEGGⁱ	hsa:54434
UCSC genome browser More...UCSCⁱ	uc001tnm.4 human [Q8WYL5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WYL5	Uncharacterized protein		CERAT		1122	UniRef90_Q8WYL5
Uncharacterized protein		MACNE		1122
Uncharacterized protein		AOTNA		1119
Uncharacterized protein		MACFA		1071
Uncharacterized protein		PANTR		1062
+94
Q8WYL5-2	Isoform 5 of Protein phosphatase Slingshot homolog 1		HUMAN		703	UniRef90_Q8WYL5-5
SSH1 isoform 4		PANTR		704
Uncharacterized protein		MACFA		704
SSH1 isoform 4		PONAB		704
Uncharacterized protein		NOMLE		704
+19
Q8WYL5-4	Uncharacterized protein (Fragment)		MACMU		672	UniRef90_Q8WYL5-4
Q8WYL5-5	SSH1 isoform 4		PANTR		704	UniRef90_Q8WYL5-5
Uncharacterized protein		MACFA		704
SSH1 isoform 4		PONAB		704
Uncharacterized protein		NOMLE		704
Slingshot protein phosphatase 1		SAIBB		704
+19

Protein	Similar proteins		Species	Score	Length	Source
Q8WYL5	Protein phosphatase Slingshot homolog 1		MOUSE		1042	UniRef50_Q8WYL5
Uncharacterized protein		MACNE		1122
Uncharacterized protein		CERAT		1122
Uncharacterized protein		AOTNA		1119
Uncharacterized protein		MACFA		1071
+334
Q8WYL5-2	Isoform 5 of Protein phosphatase Slingshot homolog 1		HUMAN		703	UniRef50_Q8WYL5-5
Uncharacterized protein		Cebus capucinus imitator		704
SSH1 isoform 4		PONAB		704
Uncharacterized protein		MANLE		704
Slingshot protein phosphatase 1		SAIBB		704
+26
Q8WYL5-3	SSH1 (Fragment)		blackstripe livebearer		126	UniRef50_Q8WYL5-3
UPI00064D6A04		JACJA		142
Q8WYL5-4	Uncharacterized protein (Fragment)		MACMU		672	UniRef50_Q8WYL5-4
protein phosphatase Slingshot homolog 1-like		LEPWE		750
Q8WYL5-5	Uncharacterized protein		Cebus capucinus imitator		704	UniRef50_Q8WYL5-5
SSH1 isoform 4		PONAB		704
Uncharacterized protein		MANLE		704
Slingshot protein phosphatase 1		SAIBB		704
Slingshot protein phosphatase 1		CALJA		704
+26

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB072355 mRNA Translation: BAB84114.1 AB072356 mRNA Translation: BAB84115.1 AB072357 mRNA Translation: BAB84116.1 AB037719 mRNA Translation: BAA92536.1 Different initiation. AK095421 mRNA Translation: BAC04546.1 BC062341 mRNA Translation: AAH62341.1
CCDSⁱ	CCDS53825.1 [Q8WYL5-5] CCDS55882.1 [Q8WYL5-2] CCDS9121.1 [Q8WYL5-1]
RefSeqⁱ	NP_001154802.1, NM_001161330.1 [Q8WYL5-2] NP_001154803.1, NM_001161331.1 [Q8WYL5-5] NP_061857.3, NM_018984.3 [Q8WYL5-1] XP_016874982.1, XM_017019493.1 [Q8WYL5-4] XP_016874983.1, XM_017019494.1 [Q8WYL5-4]
UniGeneⁱ	Hs.199763

3D structure databases

ProteinModelPortalⁱ	Q8WYL5
SMRⁱ	Q8WYL5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119950, 37 interactors
IntActⁱ	Q8WYL5, 13 interactors
MINTⁱ	Q8WYL5
STRINGⁱ	9606.ENSP00000315713

PTM databases

DEPODⁱ	Q8WYL5
GlyConnectⁱ	1667
iPTMnetⁱ	Q8WYL5
PhosphoSitePlusⁱ	Q8WYL5

Polymorphism and mutation databases

BioMutaⁱ	SSH1
DMDMⁱ	82582267

Proteomic databases

EPDⁱ	Q8WYL5
MaxQBⁱ	Q8WYL5
PaxDbⁱ	Q8WYL5
PeptideAtlasⁱ	Q8WYL5
PRIDEⁱ	Q8WYL5
ProteomicsDBⁱ	75168 75169 [Q8WYL5-2] 75170 [Q8WYL5-3] 75171 [Q8WYL5-4] 75172 [Q8WYL5-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54434
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000326470; ENSP00000326107; ENSG00000084112 [Q8WYL5-5] ENST00000326495; ENSP00000315713; ENSG00000084112 [Q8WYL5-1] ENST00000551165; ENSP00000448824; ENSG00000084112 [Q8WYL5-2]
GeneIDⁱ	54434
KEGGⁱ	hsa:54434
UCSCⁱ	uc001tnm.4 human [Q8WYL5-1]

Organism-specific databases

CTDⁱ	54434
DisGeNETⁱ	54434
EuPathDBⁱ	HostDB:ENSG00000084112.14
GeneCardsⁱ	SSH1
HGNCⁱ	HGNC:30579 SSH1
HPAⁱ	HPA019845
MIMⁱ	606778 gene
neXtProtⁱ	NX_Q8WYL5
OpenTargetsⁱ	ENSG00000084112
PharmGKBⁱ	PA134941788
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1716 Eukaryota COG2453 LUCA
GeneTreeⁱ	ENSGT00760000118902
HOGENOMⁱ	HOG000154427
HOVERGENⁱ	HBG094001
InParanoidⁱ	Q8WYL5
KOⁱ	K05766
OMAⁱ	CPEDFEH
OrthoDBⁱ	EOG091G0249
PhylomeDBⁱ	Q8WYL5
TreeFamⁱ	TF319444

Enzyme and pathway databases

SIGNORⁱ	Q8WYL5

SIGNORⁱ

Q8WYL5

Miscellaneous databases

ChiTaRSⁱ	SSH1 human
GeneWikiⁱ	SSH1
GenomeRNAiⁱ	54434
Protein Ontology More...PROⁱ	PR:Q8WYL5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000084112 Expressed in 233 organ(s), highest expression level in colon
CleanExⁱ	HS_SSH1
ExpressionAtlasⁱ	Q8WYL5 baseline and differential
Genevisibleⁱ	Q8WYL5 HS

Family and domain databases

CDDⁱ	cd00127 DSPc, 1 hit
Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR014876 DEK_C IPR000340 Dual-sp_phosphatase_cat-dom IPR024950 DUSP IPR029021 Prot-tyrosine_phosphatase-like IPR027233 SSH1 IPR016130 Tyr_Pase_AS IPR000387 TYR_PHOSPHATASE_dom IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERⁱ	PTHR10159 PTHR10159, 1 hit PTHR10159:SF138 PTHR10159:SF138, 1 hit
Pfamⁱ	View protein in Pfam PF08766 DEK_C, 1 hit PF00782 DSPc, 1 hit
SMARTⁱ	View protein in SMART SM00195 DSPc, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SSH1_HUMAN
Accessionⁱ	Q8WYL5Primary (citable) accession number: Q8WYL5 Secondary accession number(s): Q6P6C0 , Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
	Last sequence update:	November 22, 2005
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q8WYL5 (SSH1_HUMAN)

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Protein phosphatase Slingshot homolog 1

SSH1

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ