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Protein

Jun dimerization protein 2

Gene

JDP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ8WYK2

Names & Taxonomyi

Protein namesi
Recommended name:
Jun dimerization protein 2
Gene namesi
Name:JDP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000140044.12
HGNCiHGNC:17546 JDP2
MIMi608657 gene
neXtProtiNX_Q8WYK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi122953
OpenTargetsiENSG00000140044
PharmGKBiPA162392499

Chemistry databases

DrugBankiDB00852 Pseudoephedrine

Polymorphism and mutation databases

BioMutaiJDP2
DMDMi74751626

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003311301 – 163Jun dimerization protein 2Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei148Phosphothreonine; by MAPK8Combined sources1 Publication1

Post-translational modificationi

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.1 Publication
Polyubiquitinated; probably by IRF2BP1.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WYK2
MaxQBiQ8WYK2
PaxDbiQ8WYK2
PeptideAtlasiQ8WYK2
PRIDEiQ8WYK2
ProteomicsDBi75164

PTM databases

iPTMnetiQ8WYK2
PhosphoSitePlusiQ8WYK2

Expressioni

Gene expression databases

BgeeiENSG00000140044
CleanExiHS_JDP2
ExpressionAtlasiQ8WYK2 baseline and differential
GenevisibleiQ8WYK2 HS

Organism-specific databases

HPAiHPA059511

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer (By similarity). Interacts with IRF2BP1.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125807, 15 interactors
IntActiQ8WYK2, 16 interactors
MINTiQ8WYK2
STRINGi9606.ENSP00000267569

Structurei

3D structure databases

ProteinModelPortaliQ8WYK2
SMRiQ8WYK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 135bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 96Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni100 – 128Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110847
HOGENOMiHOG000034126
HOVERGENiHBG057870
InParanoidiQ8WYK2
KOiK09033
OMAiXESERLE
OrthoDBiEOG091G0M4N
PhylomeDBiQ8WYK2
TreeFamiTF326301

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029819 JDP2
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF10 PTHR23351:SF10, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WYK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPGQIPDPS VTTGSLPGLG PLTGLPSSAL TVEELKYADI RNLGAMIAPL
60 70 80 90 100
HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL
110 120 130 140 150
QRESERLELM NAELKTQIEE LKQERQQLIL MLNRHRPTCI VRTDSVKTPE
160
SEGNPLLEQL EKK
Length:163
Mass (Da):18,704
Last modified:March 1, 2002 - v1
Checksum:i29C576AF2C574BA8
GO
Isoform 2 (identifier: Q8WYK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVAGWPATPPAM

Note: Gene prediction based on EST data.
Show »
Length:174
Mass (Da):19,783
Checksum:i4E073AA3A46F0B7C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04273813T → A. Corresponds to variant dbSNP:rs3625Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471281M → MVAGWPATPPAM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077880 mRNA Translation: BAB83896.1
AF111167 Genomic DNA Translation: AAC98313.1
AC009363 Genomic DNA Translation: AAF21148.1
CH471061 Genomic DNA Translation: EAW81231.1
BC051303 mRNA Translation: AAH51303.1
CCDSiCCDS45139.1 [Q8WYK2-2]
CCDS9842.1 [Q8WYK2-1]
RefSeqiNP_001128519.1, NM_001135047.1 [Q8WYK2-1]
NP_001128520.1, NM_001135048.1 [Q8WYK2-1]
NP_001128521.1, NM_001135049.1 [Q8WYK2-2]
NP_569736.1, NM_130469.3 [Q8WYK2-1]
XP_005267389.1, XM_005267332.4 [Q8WYK2-1]
XP_016876461.1, XM_017020972.1 [Q8WYK2-2]
XP_016876462.1, XM_017020973.1 [Q8WYK2-1]
XP_016876463.1, XM_017020974.1 [Q8WYK2-1]
XP_016876464.1, XM_017020975.1 [Q8WYK2-1]
UniGeneiHs.196482

Genome annotation databases

EnsembliENST00000267569; ENSP00000267569; ENSG00000140044 [Q8WYK2-2]
ENST00000419727; ENSP00000415558; ENSG00000140044 [Q8WYK2-1]
ENST00000435893; ENSP00000399587; ENSG00000140044 [Q8WYK2-1]
ENST00000437176; ENSP00000409787; ENSG00000140044 [Q8WYK2-1]
GeneIDi122953
KEGGihsa:122953
UCSCiuc001xrq.4 human [Q8WYK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiJDP2_HUMAN
AccessioniPrimary (citable) accession number: Q8WYK2
Secondary accession number(s): J3KN58, O95430, Q9UIE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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