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Entry version 152 (22 Apr 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Jun dimerization protein 2

Gene

JDP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8WYK2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Jun dimerization protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JDP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17546 JDP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608657 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WYK2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
122953

Open Targets

More...
OpenTargetsi
ENSG00000140044

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162392499

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WYK2 Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00852 Pseudoephedrine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
JDP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751626

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003311301 – 163Jun dimerization protein 2Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei148Phosphothreonine; by MAPK8Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.1 Publication
Polyubiquitinated; probably by IRF2BP1.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WYK2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8WYK2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8WYK2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WYK2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WYK2

PeptideAtlas

More...
PeptideAtlasi
Q8WYK2

PRoteomics IDEntifications database

More...
PRIDEi
Q8WYK2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75164 [Q8WYK2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WYK2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WYK2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140044 Expressed in layer of synovial tissue and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WYK2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WYK2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000140044 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer (By similarity).

Interacts with IRF2BP1.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125807, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WYK2, 15 interactors

Molecular INTeraction database

More...
MINTi
Q8WYK2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000267569

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WYK2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WYK2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 135bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni74 – 96Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni100 – 128Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1414 Eukaryota
ENOG4111CH5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155693

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_088612_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WYK2

KEGG Orthology (KO)

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KOi
K09033

Identification of Orthologs from Complete Genome Data

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OMAi
QEFGTML

Database of Orthologous Groups

More...
OrthoDBi
1457971at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WYK2

TreeFam database of animal gene trees

More...
TreeFami
TF326301

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029819 JDP2

The PANTHER Classification System

More...
PANTHERi
PTHR23351 PTHR23351, 1 hit
PTHR23351:SF10 PTHR23351:SF10, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00170 bZIP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00042 LEUZIPPRFOS

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338 BRLZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMPGQIPDPS VTTGSLPGLG PLTGLPSSAL TVEELKYADI RNLGAMIAPL
60 70 80 90 100
HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL
110 120 130 140 150
QRESERLELM NAELKTQIEE LKQERQQLIL MLNRHRPTCI VRTDSVKTPE
160
SEGNPLLEQL EKK
Length:163
Mass (Da):18,704
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29C576AF2C574BA8
GO
Isoform 2 (identifier: Q8WYK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVAGWPATPPAM

Show »
Length:174
Mass (Da):19,783
Checksum:i4E073AA3A46F0B7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKE4H0YKE4_HUMAN
Jun dimerization protein 2
JDP2
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04273813T → A. Corresponds to variant dbSNP:rs3625Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0471281M → MVAGWPATPPAM in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB077880 mRNA Translation: BAB83896.1
AF111167 Genomic DNA Translation: AAC98313.1
AC009363 Genomic DNA Translation: AAF21148.1
CH471061 Genomic DNA Translation: EAW81231.1
BC051303 mRNA Translation: AAH51303.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45139.1 [Q8WYK2-2]
CCDS9842.1 [Q8WYK2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001128519.1, NM_001135047.1 [Q8WYK2-1]
NP_001128520.1, NM_001135048.1 [Q8WYK2-1]
NP_001128521.1, NM_001135049.1 [Q8WYK2-2]
NP_569736.1, NM_130469.3 [Q8WYK2-1]
XP_005267389.1, XM_005267332.4 [Q8WYK2-1]
XP_016876461.1, XM_017020972.1 [Q8WYK2-2]
XP_016876462.1, XM_017020973.1 [Q8WYK2-1]
XP_016876463.1, XM_017020974.1 [Q8WYK2-1]
XP_016876464.1, XM_017020975.1 [Q8WYK2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267569; ENSP00000267569; ENSG00000140044 [Q8WYK2-2]
ENST00000419727; ENSP00000415558; ENSG00000140044 [Q8WYK2-1]
ENST00000435893; ENSP00000399587; ENSG00000140044 [Q8WYK2-1]
ENST00000437176; ENSP00000409787; ENSG00000140044 [Q8WYK2-1]
ENST00000651602; ENSP00000498745; ENSG00000140044 [Q8WYK2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
122953

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:122953

UCSC genome browser

More...
UCSCi
uc001xrq.4 human [Q8WYK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077880 mRNA Translation: BAB83896.1
AF111167 Genomic DNA Translation: AAC98313.1
AC009363 Genomic DNA Translation: AAF21148.1
CH471061 Genomic DNA Translation: EAW81231.1
BC051303 mRNA Translation: AAH51303.1
CCDSiCCDS45139.1 [Q8WYK2-2]
CCDS9842.1 [Q8WYK2-1]
RefSeqiNP_001128519.1, NM_001135047.1 [Q8WYK2-1]
NP_001128520.1, NM_001135048.1 [Q8WYK2-1]
NP_001128521.1, NM_001135049.1 [Q8WYK2-2]
NP_569736.1, NM_130469.3 [Q8WYK2-1]
XP_005267389.1, XM_005267332.4 [Q8WYK2-1]
XP_016876461.1, XM_017020972.1 [Q8WYK2-2]
XP_016876462.1, XM_017020973.1 [Q8WYK2-1]
XP_016876463.1, XM_017020974.1 [Q8WYK2-1]
XP_016876464.1, XM_017020975.1 [Q8WYK2-1]

3D structure databases

SMRiQ8WYK2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125807, 16 interactors
IntActiQ8WYK2, 15 interactors
MINTiQ8WYK2
STRINGi9606.ENSP00000267569

Chemistry databases

DrugBankiDB00852 Pseudoephedrine

PTM databases

iPTMnetiQ8WYK2
PhosphoSitePlusiQ8WYK2

Polymorphism and mutation databases

BioMutaiJDP2
DMDMi74751626

Proteomic databases

EPDiQ8WYK2
jPOSTiQ8WYK2
MassIVEiQ8WYK2
MaxQBiQ8WYK2
PaxDbiQ8WYK2
PeptideAtlasiQ8WYK2
PRIDEiQ8WYK2
ProteomicsDBi75164 [Q8WYK2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25829 109 antibodies

Genome annotation databases

EnsembliENST00000267569; ENSP00000267569; ENSG00000140044 [Q8WYK2-2]
ENST00000419727; ENSP00000415558; ENSG00000140044 [Q8WYK2-1]
ENST00000435893; ENSP00000399587; ENSG00000140044 [Q8WYK2-1]
ENST00000437176; ENSP00000409787; ENSG00000140044 [Q8WYK2-1]
ENST00000651602; ENSP00000498745; ENSG00000140044 [Q8WYK2-1]
GeneIDi122953
KEGGihsa:122953
UCSCiuc001xrq.4 human [Q8WYK2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
122953
DisGeNETi122953

GeneCards: human genes, protein and diseases

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GeneCardsi
JDP2
HGNCiHGNC:17546 JDP2
HPAiENSG00000140044 Low tissue specificity
MIMi608657 gene
neXtProtiNX_Q8WYK2
OpenTargetsiENSG00000140044
PharmGKBiPA162392499

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00940000155693
HOGENOMiCLU_088612_0_1_1
InParanoidiQ8WYK2
KOiK09033
OMAiQEFGTML
OrthoDBi1457971at2759
PhylomeDBiQ8WYK2
TreeFamiTF326301

Enzyme and pathway databases

SIGNORiQ8WYK2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
JDP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
JDP2_(gene)
Jun_dimerization_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
122953
PharosiQ8WYK2 Tbio

Protein Ontology

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PROi
PR:Q8WYK2
RNActiQ8WYK2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000140044 Expressed in layer of synovial tissue and 197 other tissues
ExpressionAtlasiQ8WYK2 baseline and differential
GenevisibleiQ8WYK2 HS

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029819 JDP2
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF10 PTHR23351:SF10, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJDP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYK2
Secondary accession number(s): J3KN58, O95430, Q9UIE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2002
Last modified: April 22, 2020
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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