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Entry version 150 (16 Oct 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Acetyl-coenzyme A thioesterase

Gene

ACOT12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16951743). Acyl-coenzyme A thioesterase 12/ACOT12 preferentially hydrolyzes acetyl-CoA (PubMed:16951743).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by ADP. Active in the presence of ATP (PubMed:16951743). Cold labile, it dissociates into inactive monomers at low temperature (By similarity).By similarity1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 7000 s(-1) for the hydrolysis of acetyl-CoA.1 Publication
  1. KM=150 µM for acetyl-CoA1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

    This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei144Coenzyme A1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Serine esterase
    Biological processFatty acid metabolism, Lipid metabolism

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.1.2.1 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00199

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    4.C.3.1.2 the acyl-coa thioesterase (acot) family

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001187

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Acetyl-coenzyme A thioesteraseCurated (EC:3.1.2.11 Publication)
    Alternative name(s):
    Acyl-CoA thioester hydrolase 12
    Acyl-coenzyme A thioesterase 12
    Short name:
    Acyl-CoA thioesterase 12
    Cytoplasmic acetyl-CoA hydrolase 1
    Short name:
    CACH-1
    Short name:
    hCACH-1
    START domain-containing protein 15
    Short name:
    StARD15
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ACOT12
    Synonyms:CACH, CACH1, STARD15
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:24436 ACOT12

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    614315 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8WYK0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    134526

    Open Targets

    More...
    OpenTargetsi
    ENSG00000172497

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA142672657

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8WYK0

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ACOT12

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    25008183

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538091 – 555Acetyl-coenzyme A thioesteraseAdd BLAST555

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33N6-succinyllysineBy similarity1
    Modified residuei159N6-succinyllysineBy similarity1
    Modified residuei228N6-succinyllysineBy similarity1

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8WYK0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8WYK0

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8WYK0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8WYK0

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    62810
    75162 [Q8WYK0-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8WYK0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8WYK0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000172497 Expressed in 49 organ(s), highest expression level in right lobe of liver

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8WYK0 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA037723
    HPA037724

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer or homotetramer.

    By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    ZBTB8AQ96BR93EBI-11954993,EBI-742740

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    126405, 6 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8WYK0, 14 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000303246

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1555
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8WYK0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q8WYK0

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 117HotDog ACOT-type 1PROSITE-ProRule annotationAdd BLAST113
    Domaini179 – 294HotDog ACOT-type 2PROSITE-ProRule annotationAdd BLAST116
    Domaini340 – 549STARTPROSITE-ProRule annotationAdd BLAST210

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 55Coenzyme A binding3
    Regioni82 – 84Coenzyme A binding3
    Regioni234 – 236Coenzyme A binding3

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2763 Eukaryota
    COG1607 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160328

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000232032

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8WYK0

    KEGG Orthology (KO)

    More...
    KOi
    K01067

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PLWDPHY

    Database of Orthologous Groups

    More...
    OrthoDBi
    776852at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8WYK0

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF328368

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.530.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR040170 Cytosol_ACT
    IPR033120 HOTDOG_ACOT
    IPR029069 HotDog_dom_sf
    IPR023393 START-like_dom_sf
    IPR002913 START_lipid-bd_dom
    IPR006683 Thioestr_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11049 PTHR11049, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03061 4HBT, 2 hits
    PF01852 START, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF54637 SSF54637, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51770 HOTDOG_ACOT, 2 hits
    PS50848 START, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: Q8WYK0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MERPAPGEVV MSQAIQPAHA TARGELSAGQ LLKWIDTTAC LAAEKHAGVS
    60 70 80 90 100
    CVTASVDDIQ FEETARVGQV ITIKAKVTRA FSTSMEISIK VMVQDMLTGI
    110 120 130 140 150
    EKLVSVAFST FVAKPVGKEK IHLKPVTLLT EQDHVEHNLA AERRKVRLQH
    160 170 180 190 200
    EDTFNNLMKE SSKFDDLIFD EEEGAVSTRG TSVQSIELVL PPHANHHGNT
    210 220 230 240 250
    FGGQIMAWME TVATISASRL CWAHPFLKSV DMFKFRGPST VGDRLVFTAI
    260 270 280 290 300
    VNNTFQTCVE VGVRVEAFDC QEWAEGRGRH INSAFLIYNA ADDKENLITF
    310 320 330 340 350
    PRIQPISKDD FRRYRGAIAR KRIRLGRKYV ISHKEEVPLC IHWDISKQAS
    360 370 380 390 400
    LSDSNVEALK KLAAKRGWEV TSTVEKIKIY TLEEHDVLSV WVEKHVGSPA
    410 420 430 440 450
    HLAYRLLSDF TKRPLWDPHF VSCEVIDWVS EDDQLYHITC PILNDDKPKD
    460 470 480 490 500
    LVVLVSRRKP LKDGNTYTVA VKSVILPSVP PSPQYIRSEI ICAGFLIHAI
    510 520 530 540 550
    DSNSCIVSYF NHMSASILPY FAGNLGGWSK SIEETAASCI QFLENPPDDG

    FVSTF
    Length:555
    Mass (Da):62,034
    Last modified:March 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i707560D55504732C
    GO
    Isoform 2 (identifier: Q8WYK0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         166-167: DL → GQ
         168-555: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:167
    Mass (Da):18,327
    Checksum:i58CB03F09579E5A4
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064691190L → H Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication1
    Natural variantiVAR_048192230V → I. Corresponds to variant dbSNP:rs34607174Ensembl.1
    Natural variantiVAR_048193403A → T. Corresponds to variant dbSNP:rs10371Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055785166 – 167DL → GQ in isoform 2. 1 Publication2
    Alternative sequenceiVSP_055786168 – 555Missing in isoform 2. 1 PublicationAdd BLAST388

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB078619 mRNA Translation: BAB84022.1
    AK122960 mRNA Translation: BAG53821.1
    AC008411 Genomic DNA No translation available.
    AC010623 Genomic DNA No translation available.
    CH471084 Genomic DNA Translation: EAW95875.1
    BC089437 mRNA Translation: AAH89437.1
    BC075010 mRNA Translation: AAH75010.1
    BC075011 mRNA Translation: AAH75011.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4055.1 [Q8WYK0-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_570123.1, NM_130767.2 [Q8WYK0-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000307624; ENSP00000303246; ENSG00000172497 [Q8WYK0-1]
    ENST00000513751; ENSP00000421628; ENSG00000172497 [Q8WYK0-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    134526

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:134526

    UCSC genome browser

    More...
    UCSCi
    uc003khl.5 human [Q8WYK0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB078619 mRNA Translation: BAB84022.1
    AK122960 mRNA Translation: BAG53821.1
    AC008411 Genomic DNA No translation available.
    AC010623 Genomic DNA No translation available.
    CH471084 Genomic DNA Translation: EAW95875.1
    BC089437 mRNA Translation: AAH89437.1
    BC075010 mRNA Translation: AAH75010.1
    BC075011 mRNA Translation: AAH75011.1
    CCDSiCCDS4055.1 [Q8WYK0-1]
    RefSeqiNP_570123.1, NM_130767.2 [Q8WYK0-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3B7KX-ray2.70A/B/C7-316[»]
    4MOBX-ray2.40A7-336[»]
    4MOCX-ray2.50A7-336[»]
    SMRiQ8WYK0
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi126405, 6 interactors
    IntActiQ8WYK0, 14 interactors
    STRINGi9606.ENSP00000303246

    Chemistry databases

    SwissLipidsiSLP:000001187

    Protein family/group databases

    TCDBi4.C.3.1.2 the acyl-coa thioesterase (acot) family

    PTM databases

    iPTMnetiQ8WYK0
    PhosphoSitePlusiQ8WYK0

    Polymorphism and mutation databases

    BioMutaiACOT12
    DMDMi25008183

    Proteomic databases

    MassIVEiQ8WYK0
    PaxDbiQ8WYK0
    PeptideAtlasiQ8WYK0
    PRIDEiQ8WYK0
    ProteomicsDBi62810
    75162 [Q8WYK0-1]

    Genome annotation databases

    EnsembliENST00000307624; ENSP00000303246; ENSG00000172497 [Q8WYK0-1]
    ENST00000513751; ENSP00000421628; ENSG00000172497 [Q8WYK0-2]
    GeneIDi134526
    KEGGihsa:134526
    UCSCiuc003khl.5 human [Q8WYK0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    134526
    DisGeNETi134526

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ACOT12
    HGNCiHGNC:24436 ACOT12
    HPAiHPA037723
    HPA037724
    MIMi614315 gene
    neXtProtiNX_Q8WYK0
    OpenTargetsiENSG00000172497
    PharmGKBiPA142672657

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2763 Eukaryota
    COG1607 LUCA
    GeneTreeiENSGT00940000160328
    HOGENOMiHOG000232032
    InParanoidiQ8WYK0
    KOiK01067
    OMAiPLWDPHY
    OrthoDBi776852at2759
    PhylomeDBiQ8WYK0
    TreeFamiTF328368

    Enzyme and pathway databases

    UniPathwayiUPA00199
    BRENDAi3.1.2.1 2681
    ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ACOT12 human
    EvolutionaryTraceiQ8WYK0

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ACOT12

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    134526
    PharosiQ8WYK0

    Protein Ontology

    More...
    PROi
    PR:Q8WYK0

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000172497 Expressed in 49 organ(s), highest expression level in right lobe of liver
    GenevisibleiQ8WYK0 HS

    Family and domain databases

    Gene3Di3.30.530.20, 1 hit
    InterProiView protein in InterPro
    IPR040170 Cytosol_ACT
    IPR033120 HOTDOG_ACOT
    IPR029069 HotDog_dom_sf
    IPR023393 START-like_dom_sf
    IPR002913 START_lipid-bd_dom
    IPR006683 Thioestr_dom
    PANTHERiPTHR11049 PTHR11049, 1 hit
    PfamiView protein in Pfam
    PF03061 4HBT, 2 hits
    PF01852 START, 1 hit
    SUPFAMiSSF54637 SSF54637, 2 hits
    PROSITEiView protein in PROSITE
    PS51770 HOTDOG_ACOT, 2 hits
    PS50848 START, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACO12_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYK0
    Secondary accession number(s): B3KVK9, Q5FWE9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: March 1, 2002
    Last modified: October 16, 2019
    This is version 150 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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