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Protein

Septin-1

Gene

SEPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66GTPBy similarity1
Binding sitei92GTP; via amide nitrogenBy similarity1
Binding sitei229GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei245GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi171 – 179GTPBy similarity9

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-1
Alternative name(s):
LARP
Peanut-like protein 3
Serologically defined breast cancer antigen NY-BR-24
Gene namesi
Name:SEPT1
Synonyms:DIFF6, PNUTL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2879 SEPT1
MIMi612897 gene
neXtProtiNX_Q8WYJ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19S → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi206S → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi248S → A: Great reduction in phosphorylation. 1 Publication1
Mutagenesisi307S → A: Great reduction in phosphorylation. 1 Publication1
Mutagenesisi312S → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi315S → A: Great reduction in phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi1731
PharmGKBiPA24354

Polymorphism and mutation databases

DMDMi20178107

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735131 – 367Septin-1Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineCombined sources1
Modified residuei248Phosphoserine; by AURKBCombined sources1 Publication1
Modified residuei251PhosphothreonineBy similarity1
Modified residuei307Phosphoserine; by AURKB1 Publication1
Modified residuei315Phosphoserine; by AURKBCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WYJ6
MaxQBiQ8WYJ6
PaxDbiQ8WYJ6
PeptideAtlasiQ8WYJ6
PRIDEiQ8WYJ6
ProteomicsDBi75160
75161 [Q8WYJ6-2]

PTM databases

iPTMnetiQ8WYJ6
PhosphoSitePlusiQ8WYJ6

Expressioni

Tissue specificityi

Expressed at high levels in lymphoid and hematopoietic tissues.1 Publication

Gene expression databases

CleanExiHS_SEPT1

Organism-specific databases

HPAiHPA041566
HPA060339

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi108075, 22 interactors
IntActiQ8WYJ6, 26 interactors
STRINGi9606.ENSP00000460441

Structurei

3D structure databases

ProteinModelPortaliQ8WYJ6
SMRiQ8WYJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 296Septin-type GPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 39G1 motifPROSITE-ProRule annotation8
Regioni89 – 92G3 motifPROSITE-ProRule annotation4
Regioni170 – 173G4 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ8WYJ6
KOiK13737
PhylomeDBiQ8WYJ6
TreeFamiTF101079

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WYJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPEAS ARLTQTLAIE RRGVEIEEGG VKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVKFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALMPQET QALKQKIRDQ LKEEEIHIYQ
210 220 230 240 250
FPECDSDEDE DFKRQDAEMK ESIPFAVVGS CEVVRDGGNR PVRGRRYSWG
260 270 280 290 300
TVEVENPHHC DFLNLRRMLV QTHLQDLKEV THDLLYEGYR ARCLQSLARP
310 320 330 340 350
GARDRASRSK LSRQSATEIP LPMLPLADTE KLIREKDEEL RRMQEMLEKM
360
QAQMQQSQAQ GEQSDAL
Length:367
Mass (Da):41,971
Last modified:April 16, 2002 - v2
Checksum:iE9C6BEF373CB0FC4
GO
Isoform 2 (identifier: Q8WYJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-167: LRPLDVAFLRAVHEKVNIIP → SGGGILGAGAFREGWGVSAP
     168-367: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,354
Checksum:i2C7A515F1236AAC4
GO

Sequence cautioni

The sequence AAK61491 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60S → G in AAL40393 (Ref. 1) Curated1
Sequence conflicti148 – 150LRP → SR in AAL40393 (Ref. 1) Curated3
Sequence conflicti240 – 241RP → GL in AAL40393 (Ref. 1) Curated2
Sequence conflicti324L → P in AAL40393 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05193480G → V. Corresponds to variant dbSNP:rs34518080Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038269148 – 167LRPLD…VNIIP → SGGGILGAGAFREGWGVSAP in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_038270168 – 367Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085235 mRNA Translation: AAL40393.1
AY034176 mRNA Translation: AAK61491.1 Different initiation.
AK301045 mRNA Translation: BAG62658.1
BC012161 mRNA Translation: AAH12161.1
AL833004 mRNA Translation: CAH56484.1
AF308288 Genomic DNA Translation: AAG48256.1
RefSeqiNP_443070.5, NM_052838.4
UniGeneiHs.632176

Genome annotation databases

EnsembliENST00000571393; ENSP00000460441; ENSG00000180096
GeneIDi1731
KEGGihsa:1731

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSEPT1_HUMAN
AccessioniPrimary (citable) accession number: Q8WYJ6
Secondary accession number(s): B4DVE6
, Q658T1, Q8NEZ1, Q96EL4, Q9H285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: July 18, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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