UniProtKB - Q8WYJ6 (SEPT1_HUMAN)
Septin-1
SEPTIN1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 66 | GTPBy similarity | 1 | |
Binding sitei | 92 | GTP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 229 | GTP; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 245 | GTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 32 – 39 | GTPBy similarity | 8 | |
Nucleotide bindingi | 171 – 179 | GTPBy similarity | 9 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- molecular adaptor activity Source: GO_Central
GO - Biological processi
- cellular protein localization Source: GO_Central
- cytoskeleton-dependent cytokinesis Source: GO_Central
- regulation of exocytosis Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WYJ6 |
Names & Taxonomyi
Protein namesi | Recommended name: Septin-1Alternative name(s): LARP Peanut-like protein 3 Serologically defined breast cancer antigen NY-BR-24 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2879, SEPTIN1 |
MIMi | 612897, gene |
neXtProti | NX_Q8WYJ6 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
- centrosome
Other locations
Note: Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis.
Cytoskeleton
- microtubule cytoskeleton Source: GO_Central
- microtubule organizing center Source: UniProtKB-SubCell
- septin complex Source: GO_Central
- septin ring Source: GO_Central
Other locations
- cell division site Source: GO_Central
- midbody Source: HGNC
- synaptic vesicle Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 19 | S → A: No effect on phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 206 | S → A: No effect on phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 248 | S → A: Great reduction in phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 307 | S → A: Great reduction in phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 312 | S → A: No effect on phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 315 | S → A: Great reduction in phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1731 |
OpenTargetsi | ENSG00000180096 |
PharmGKBi | PA24354 |
Miscellaneous databases
Pharosi | Q8WYJ6, Tdark |
Polymorphism and mutation databases
BioMutai | SEPT1 |
DMDMi | 20178107 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173513 | 1 – 367 | Septin-1Add BLAST | 367 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 248 | Phosphoserine; by AURKBCombined sources1 Publication | 1 | |
Modified residuei | 251 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 307 | Phosphoserine; by AURKB1 Publication | 1 | |
Modified residuei | 315 | Phosphoserine; by AURKBCombined sources1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8WYJ6 |
jPOSTi | Q8WYJ6 |
MassIVEi | Q8WYJ6 |
MaxQBi | Q8WYJ6 |
PaxDbi | Q8WYJ6 |
PeptideAtlasi | Q8WYJ6 |
PRIDEi | Q8WYJ6 |
ProteomicsDBi | 75160 [Q8WYJ6-1] 75161 [Q8WYJ6-2] |
PTM databases
iPTMneti | Q8WYJ6 |
MetOSitei | Q8WYJ6 |
PhosphoSitePlusi | Q8WYJ6 |
Expressioni
Tissue specificityi
Gene expression databases
ExpressionAtlasi | Q8WYJ6, baseline and differential |
Interactioni
Subunit structurei
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
Interacts with AURKB.
By similarity1 PublicationBinary interactionsi
Hide detailsQ8WYJ6
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 108075, 36 interactors |
IntActi | Q8WYJ6, 42 interactors |
STRINGi | 9606.ENSP00000324511 |
Miscellaneous databases
RNActi | Q8WYJ6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 296 | Septin-type GPROSITE-ProRule annotationAdd BLAST | 275 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 39 | G1 motifPROSITE-ProRule annotation | 8 | |
Regioni | 89 – 92 | G3 motifPROSITE-ProRule annotation | 4 | |
Regioni | 170 – 173 | G4 motifPROSITE-ProRule annotation | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2655, Eukaryota |
GeneTreei | ENSGT00940000161794 |
InParanoidi | Q8WYJ6 |
OrthoDBi | 845354at2759 |
PhylomeDBi | Q8WYJ6 |
TreeFami | TF101079 |
Family and domain databases
CDDi | cd01850, CDC_Septin, 1 hit |
InterProi | View protein in InterPro IPR030379, G_SEPTIN_dom IPR027417, P-loop_NTPase IPR016491, Septin |
Pfami | View protein in Pfam PF00735, Septin, 1 hit |
PIRSFi | PIRSF006698, Septin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51719, G_SEPTIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPEAS ARLTQTLAIE RRGVEIEEGG VKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVKFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALMPQET QALKQKIRDQ LKEEEIHIYQ
210 220 230 240 250
FPECDSDEDE DFKRQDAEMK ESIPFAVVGS CEVVRDGGNR PVRGRRYSWG
260 270 280 290 300
TVEVENPHHC DFLNLRRMLV QTHLQDLKEV THDLLYEGYR ARCLQSLARP
310 320 330 340 350
GARDRASRSK LSRQSATEIP LPMLPLADTE KLIREKDEEL RRMQEMLEKM
360
QAQMQQSQAQ GEQSDAL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KNL2 | J3KNL2_HUMAN | Septin-1 | SEPTIN1 | 414 | Annotation score: | ||
I3L2M1 | I3L2M1_HUMAN | Septin-1 | SEPTIN1 | 65 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | S → G in AAL40393 (Ref. 1) Curated | 1 | |
Sequence conflicti | 148 – 150 | LRP → SR in AAL40393 (Ref. 1) Curated | 3 | |
Sequence conflicti | 240 – 241 | RP → GL in AAL40393 (Ref. 1) Curated | 2 | |
Sequence conflicti | 324 | L → P in AAL40393 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051934 | 80 | G → V. Corresponds to variant dbSNP:rs34518080Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038269 | 148 – 167 | LRPLD…VNIIP → SGGGILGAGAFREGWGVSAP in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_038270 | 168 – 367 | Missing in isoform 2. 1 PublicationAdd BLAST | 200 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF085235 mRNA Translation: AAL40393.1 AY034176 mRNA Translation: AAK61491.1 Different initiation. AK301045 mRNA Translation: BAG62658.1 BC012161 mRNA Translation: AAH12161.1 AL833004 mRNA Translation: CAH56484.1 AF308288 Genomic DNA Translation: AAG48256.1 |
RefSeqi | NP_443070.5, NM_052838.4 |
Genome annotation databases
Ensembli | ENST00000652617; ENSP00000498586; ENSG00000180096 [Q8WYJ6-1] |
GeneIDi | 1731 |
KEGGi | hsa:1731 |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF085235 mRNA Translation: AAL40393.1 AY034176 mRNA Translation: AAK61491.1 Different initiation. AK301045 mRNA Translation: BAG62658.1 BC012161 mRNA Translation: AAH12161.1 AL833004 mRNA Translation: CAH56484.1 AF308288 Genomic DNA Translation: AAG48256.1 |
RefSeqi | NP_443070.5, NM_052838.4 |
3D structure databases
SMRi | Q8WYJ6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108075, 36 interactors |
IntActi | Q8WYJ6, 42 interactors |
STRINGi | 9606.ENSP00000324511 |
PTM databases
iPTMneti | Q8WYJ6 |
MetOSitei | Q8WYJ6 |
PhosphoSitePlusi | Q8WYJ6 |
Polymorphism and mutation databases
BioMutai | SEPT1 |
DMDMi | 20178107 |
Proteomic databases
EPDi | Q8WYJ6 |
jPOSTi | Q8WYJ6 |
MassIVEi | Q8WYJ6 |
MaxQBi | Q8WYJ6 |
PaxDbi | Q8WYJ6 |
PeptideAtlasi | Q8WYJ6 |
PRIDEi | Q8WYJ6 |
ProteomicsDBi | 75160 [Q8WYJ6-1] 75161 [Q8WYJ6-2] |
Protocols and materials databases
Antibodypediai | 27233, 257 antibodies |
DNASUi | 1731 |
Genome annotation databases
Ensembli | ENST00000652617; ENSP00000498586; ENSG00000180096 [Q8WYJ6-1] |
GeneIDi | 1731 |
KEGGi | hsa:1731 |
Organism-specific databases
CTDi | 1731 |
DisGeNETi | 1731 |
GeneCardsi | SEPTIN1 |
HGNCi | HGNC:2879, SEPTIN1 |
MIMi | 612897, gene |
neXtProti | NX_Q8WYJ6 |
OpenTargetsi | ENSG00000180096 |
PharmGKBi | PA24354 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2655, Eukaryota |
GeneTreei | ENSGT00940000161794 |
InParanoidi | Q8WYJ6 |
OrthoDBi | 845354at2759 |
PhylomeDBi | Q8WYJ6 |
TreeFami | TF101079 |
Enzyme and pathway databases
PathwayCommonsi | Q8WYJ6 |
Miscellaneous databases
BioGRID-ORCSi | 1731, 0 hits in 770 CRISPR screens |
ChiTaRSi | SEPT1, human |
GeneWikii | SEPT1 |
GenomeRNAii | 1731 |
Pharosi | Q8WYJ6, Tdark |
PROi | PR:Q8WYJ6 |
RNActi | Q8WYJ6, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | Q8WYJ6, baseline and differential |
Family and domain databases
CDDi | cd01850, CDC_Septin, 1 hit |
InterProi | View protein in InterPro IPR030379, G_SEPTIN_dom IPR027417, P-loop_NTPase IPR016491, Septin |
Pfami | View protein in Pfam PF00735, Septin, 1 hit |
PIRSFi | PIRSF006698, Septin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51719, G_SEPTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SEPT1_HUMAN | |
Accessioni | Q8WYJ6Primary (citable) accession number: Q8WYJ6 Secondary accession number(s): B4DVE6 Q9H285 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | April 16, 2002 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations