UniProtKB - Q8WYH8 (ING5_HUMAN)
Inhibitor of growth protein 5
ING5
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 188 | Histone H3K4me3 bindingCombined sources1 Publication | 1 | |
Metal bindingi | 189 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 191 | Zinc 1Combined sources1 Publication | 1 | |
Sitei | 199 | Histone H3K4me3 bindingCombined sources1 Publication | 1 | |
Metal bindingi | 202 | Zinc 2Combined sources1 Publication | 1 | |
Sitei | 203 | Histone H3K4me3 bindingCombined sources1 Publication | 1 | |
Metal bindingi | 207 | Zinc 2Combined sources1 Publication | 1 | |
Sitei | 211 | Histone H3K4me3 bindingCombined sources1 Publication | 1 | |
Metal bindingi | 213 | Zinc 1; via pros nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 216 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 229 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 232 | Zinc 2Combined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 186 – 235 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
GO - Molecular functioni
- chromatin binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- methylated histone binding Source: UniProtKB
GO - Biological processi
- DNA replication Source: UniProtKB
- histone H3 acetylation Source: UniProtKB
- histone H3-K14 acetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of growth Source: UniProtKB
- positive regulation of apoptotic process Source: MGI
- positive regulation of apoptotic signaling pathway Source: GO_Central
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein acetylation Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: Reactome
Keywordsi
Molecular function | Activator, Chromatin regulator |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8WYH8 |
Reactomei | R-HSA-3214847, HATs acetylate histones R-HSA-6804758, Regulation of TP53 Activity through Acetylation |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibitor of growth protein 5Alternative name(s): p28ING5 |
Gene namesi | Name:ING5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19421, ING5 |
MIMi | 608525, gene |
neXtProti | NX_Q8WYH8 |
VEuPathDBi | HostDB:ENSG00000168395.14 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome 1 Publication
Note: Localizes to transcription start sites.1 Publication
Nucleus
- histone acetyltransferase complex Source: UniProtKB
- MOZ/MORF histone acetyltransferase complex Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84289 |
OpenTargetsi | ENSG00000168395 |
PharmGKBi | PA134935441 |
Miscellaneous databases
Pharosi | Q8WYH8, Tbio |
Genetic variation databases
BioMutai | ING5 |
DMDMi | 57012960 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212671 | 1 – 240 | Inhibitor of growth protein 5Add BLAST | 240 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 114 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 118 | PhosphoserineCombined sources | 1 | |
Modified residuei | 126 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q8WYH8 |
jPOSTi | Q8WYH8 |
MassIVEi | Q8WYH8 |
MaxQBi | Q8WYH8 |
PaxDbi | Q8WYH8 |
PeptideAtlasi | Q8WYH8 |
PRIDEi | Q8WYH8 |
ProteomicsDBi | 75158 [Q8WYH8-1] 75159 [Q8WYH8-2] |
PTM databases
iPTMneti | Q8WYH8 |
PhosphoSitePlusi | Q8WYH8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000168395, Expressed in sural nerve and 208 other tissues |
ExpressionAtlasi | Q8WYH8, baseline and differential |
Genevisiblei | Q8WYH8, HS |
Organism-specific databases
HPAi | ENSG00000168395, Low tissue specificity |
Interactioni
Subunit structurei
Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:16387653, PubMed:24065767).
Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (PubMed:16387653, PubMed:18794358).
Interacts with H3K4me3 and to a lesser extent with H3K4me2 (PubMed:16728974, PubMed:18623064).
Interacts with EP300 and p53/TP53 (PubMed:12750254).
Interacts with INCA1 (PubMed:21750715).
7 PublicationsBinary interactionsi
Hide detailsQ8WYH8
Isoform 2 [Q8WYH8-2]
GO - Molecular functioni
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 124016, 77 interactors |
ComplexPortali | CPX-721, HBO1-5.1 histone acetyltransferase complex CPX-722, HBO1-5.2 histone acetyltransferase complex CPX-723, HBO1-5.3 histone acetyltransferase complex CPX-727, MOZ1 histone acetyltransferase complex CPX-733, MOZ2 histone acetyltransferase complex CPX-736, MOZ3 histone acetyltransferase complex CPX-738, MORF1 histone acetyltransferase complex CPX-739, MORF2 histone acetyltransferase complex CPX-740, MORF3 histone acetyltransferase complex |
CORUMi | Q8WYH8 |
DIPi | DIP-32511N |
IntActi | Q8WYH8, 63 interactors |
MINTi | Q8WYH8 |
STRINGi | 9606.ENSP00000322142 |
Miscellaneous databases
RNActi | Q8WYH8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8WYH8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WYH8 |
Family & Domainsi
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 186 – 235 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1973, Eukaryota |
GeneTreei | ENSGT00940000158159 |
HOGENOMi | CLU_031900_5_1_1 |
InParanoidi | Q8WYH8 |
OMAi | NPTGMEL |
OrthoDBi | 1434088at2759 |
PhylomeDBi | Q8WYH8 |
TreeFami | TF352014 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028638, ING4/ING5 IPR028651, ING_fam IPR024610, ING_N_histone-binding IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 1 hit PTHR10333:SF41, PTHR10333:SF41, 1 hit |
Pfami | View protein in Pfam PF12998, ING, 1 hit |
SMARTi | View protein in SMART SM01408, ING, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATAMYLEHY LDSIENLPCE LQRNFQLMRE LDQRTEDKKA EIDILAAEYI
60 70 80 90 100
STVKTLSPDQ RVERLQKIQN AYSKCKEYSD DKVQLAMQTY EMVDKHIRRL
110 120 130 140 150
DADLARFEAD LKDKMEGSDF ESSGGRGLKK GRGQKEKRGS RGRGRRTSEE
160 170 180 190 200
DTPKKKKHKG GSEFTDTILS VHPSDVLDMP VDPNEPTYCL CHQVSYGEMI
210 220 230 240
GCDNPDCPIE WFHFACVDLT TKPKGKWFCP RCVQEKRKKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GW41 | A0A1B0GW41_HUMAN | Inhibitor of growth protein 5 | ING5 | 254 | Annotation score: | ||
E9PEN0 | E9PEN0_HUMAN | Inhibitor of growth protein 5 | ING5 | 142 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012528 | 227 – 240 | Missing in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF189286 mRNA Translation: AAL68979.1 AK074422 mRNA Translation: BAB85078.1 AK289958 mRNA Translation: BAF82647.1 AC114730 Genomic DNA Translation: AAX82019.1 AC133528 Genomic DNA Translation: AAY14921.1 BC005370 mRNA Translation: AAH05370.1 BC071899 mRNA Translation: AAH71899.1 |
CCDSi | CCDS33425.1 [Q8WYH8-1] CCDS82586.1 [Q8WYH8-2] |
RefSeqi | NP_001317091.1, NM_001330162.1 [Q8WYH8-2] NP_115705.2, NM_032329.5 [Q8WYH8-1] |
Genome annotation databases
Ensembli | ENST00000313552; ENSP00000322142; ENSG00000168395 [Q8WYH8-1] ENST00000406941; ENSP00000385937; ENSG00000168395 [Q8WYH8-2] |
GeneIDi | 84289 |
KEGGi | hsa:84289 |
UCSCi | uc002wcd.4, human [Q8WYH8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF189286 mRNA Translation: AAL68979.1 AK074422 mRNA Translation: BAB85078.1 AK289958 mRNA Translation: BAF82647.1 AC114730 Genomic DNA Translation: AAX82019.1 AC133528 Genomic DNA Translation: AAY14921.1 BC005370 mRNA Translation: AAH05370.1 BC071899 mRNA Translation: AAH71899.1 |
CCDSi | CCDS33425.1 [Q8WYH8-1] CCDS82586.1 [Q8WYH8-2] |
RefSeqi | NP_001317091.1, NM_001330162.1 [Q8WYH8-2] NP_115705.2, NM_032329.5 [Q8WYH8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3C6W | X-ray | 1.75 | A/C | 184-236 | [»] | |
5ME8 | X-ray | 3.20 | A/B | 1-105 | [»] | |
5MTO | X-ray | 3.10 | A/B | 1-105 | [»] | |
SMRi | Q8WYH8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124016, 77 interactors |
ComplexPortali | CPX-721, HBO1-5.1 histone acetyltransferase complex CPX-722, HBO1-5.2 histone acetyltransferase complex CPX-723, HBO1-5.3 histone acetyltransferase complex CPX-727, MOZ1 histone acetyltransferase complex CPX-733, MOZ2 histone acetyltransferase complex CPX-736, MOZ3 histone acetyltransferase complex CPX-738, MORF1 histone acetyltransferase complex CPX-739, MORF2 histone acetyltransferase complex CPX-740, MORF3 histone acetyltransferase complex |
CORUMi | Q8WYH8 |
DIPi | DIP-32511N |
IntActi | Q8WYH8, 63 interactors |
MINTi | Q8WYH8 |
STRINGi | 9606.ENSP00000322142 |
PTM databases
iPTMneti | Q8WYH8 |
PhosphoSitePlusi | Q8WYH8 |
Genetic variation databases
BioMutai | ING5 |
DMDMi | 57012960 |
Proteomic databases
EPDi | Q8WYH8 |
jPOSTi | Q8WYH8 |
MassIVEi | Q8WYH8 |
MaxQBi | Q8WYH8 |
PaxDbi | Q8WYH8 |
PeptideAtlasi | Q8WYH8 |
PRIDEi | Q8WYH8 |
ProteomicsDBi | 75158 [Q8WYH8-1] 75159 [Q8WYH8-2] |
Protocols and materials databases
Antibodypediai | 34573, 229 antibodies |
DNASUi | 84289 |
Genome annotation databases
Ensembli | ENST00000313552; ENSP00000322142; ENSG00000168395 [Q8WYH8-1] ENST00000406941; ENSP00000385937; ENSG00000168395 [Q8WYH8-2] |
GeneIDi | 84289 |
KEGGi | hsa:84289 |
UCSCi | uc002wcd.4, human [Q8WYH8-1] |
Organism-specific databases
CTDi | 84289 |
DisGeNETi | 84289 |
GeneCardsi | ING5 |
HGNCi | HGNC:19421, ING5 |
HPAi | ENSG00000168395, Low tissue specificity |
MIMi | 608525, gene |
neXtProti | NX_Q8WYH8 |
OpenTargetsi | ENSG00000168395 |
PharmGKBi | PA134935441 |
VEuPathDBi | HostDB:ENSG00000168395.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1973, Eukaryota |
GeneTreei | ENSGT00940000158159 |
HOGENOMi | CLU_031900_5_1_1 |
InParanoidi | Q8WYH8 |
OMAi | NPTGMEL |
OrthoDBi | 1434088at2759 |
PhylomeDBi | Q8WYH8 |
TreeFami | TF352014 |
Enzyme and pathway databases
PathwayCommonsi | Q8WYH8 |
Reactomei | R-HSA-3214847, HATs acetylate histones R-HSA-6804758, Regulation of TP53 Activity through Acetylation |
Miscellaneous databases
BioGRID-ORCSi | 84289, 18 hits in 1001 CRISPR screens |
EvolutionaryTracei | Q8WYH8 |
GeneWikii | ING5 |
GenomeRNAii | 84289 |
Pharosi | Q8WYH8, Tbio |
PROi | PR:Q8WYH8 |
RNActi | Q8WYH8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168395, Expressed in sural nerve and 208 other tissues |
ExpressionAtlasi | Q8WYH8, baseline and differential |
Genevisiblei | Q8WYH8, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028638, ING4/ING5 IPR028651, ING_fam IPR024610, ING_N_histone-binding IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 1 hit PTHR10333:SF41, PTHR10333:SF41, 1 hit |
Pfami | View protein in Pfam PF12998, ING, 1 hit |
SMARTi | View protein in SMART SM01408, ING, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ING5_HUMAN | |
Accessioni | Q8WYH8Primary (citable) accession number: Q8WYH8 Secondary accession number(s): A8K1P3 Q9BS30 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families