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Protein

Histone acetyltransferase KAT6B

Gene

KAT6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.3 Publications

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei891Proton donor/acceptorBy similarity1
Binding sitei895Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri213 – 272PHD-type 1PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri269 – 320PHD-type 2PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri748 – 773C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • acetyltransferase activity Source: UniProtKB
  • DNA binding Source: InterPro
  • H4 histone acetyltransferase activity Source: GO_Central
  • histone acetyltransferase activity Source: UniProtKB
  • histone binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.3.1.48 2681
ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiQ8WYB5

Protein family/group databases

MoonDBiQ8WYB5 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT6B (EC:2.3.1.481 Publication)
Alternative name(s):
Histone acetyltransferase MOZ2
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
Short name:
MYST-4
Monocytic leukemia zinc finger protein-related factor
Gene namesi
Name:KAT6B
Synonyms:KIAA0383, MORF, MOZ2, MYST4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000156650.12
HGNCiHGNC:17582 KAT6B
MIMi605880 gene
neXtProtiNX_Q8WYB5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving KAT6B may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.1 Publication
Ohdo syndrome, SBBYS variant (SBBYSS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by distinctive facial appearance with severe blepharophimosis, an immobile mask-like face, a bulbous nasal tip, and a small mouth with a thin upper lip. The condition presents in infancy with severe hypotonia and feeding problems. Associated skeletal problems include joint laxity, abnormally long thumbs and great toes, and dislocated or hypoplastic patellae. Structural cardiac defects are present in around 50% of cases, and dental anomalies, including small and pointed teeth, are common. Optic atrophy and conductive or sensorineural deafness are repeatedly reported. Many affected individuals have abnormalities of thyroid structure or function. SBBYSS is usually associated with severe mental retardation, delayed motor milestones, and significantly impaired speech.
See also OMIM:603736
Genitopatellar syndrome (GTPTS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder consisting of microcephaly, severe psychomotor retardation, and characteristic coarse facial features, including broad nose and small or retracted chin, associated with congenital flexion contractures of the lower extremities, abnormal or missing patellae, and urogenital anomalies.
See also OMIM:606170

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1222 – 1223Breakpoint for translocation to form KAT6B-CREBBP2

Organism-specific databases

DisGeNETi23522
GeneReviewsiKAT6B
MalaCardsiKAT6B
MIMi603736 phenotype
606170 phenotype
OpenTargetsiENSG00000156650
Orphaneti3047 Blepharophimosis-intellectual disability syndrome, SBBYS type
85201 Genitopatellar syndrome
648 Noonan syndrome
PharmGKBiPA134880712

Chemistry databases

ChEMBLiCHEMBL3774300

Polymorphism and mutation databases

BioMutaiKAT6B
DMDMi143811424

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515751 – 2073Histone acetyltransferase KAT6BAdd BLAST2073

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei355PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei815N6-acetyllysine; by autocatalysisBy similarity1
Modified residuei1038N6-acetyllysineCombined sources1
Modified residuei1042N6-acetyllysineCombined sources1
Modified residuei1044N6-acetyllysineCombined sources1
Modified residuei1048PhosphoserineCombined sources1

Post-translational modificationi

Autoacetylated (PubMed:10497217 and PubMed:11965546). Autoacetylation at Lys-815 is required for proper function.By similarity2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WYB5
MaxQBiQ8WYB5
PaxDbiQ8WYB5
PeptideAtlasiQ8WYB5
PRIDEiQ8WYB5
ProteomicsDBi75154
75155 [Q8WYB5-2]
75156 [Q8WYB5-3]

PTM databases

iPTMnetiQ8WYB5
PhosphoSitePlusiQ8WYB5

Expressioni

Tissue specificityi

Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.1 Publication

Gene expression databases

BgeeiENSG00000156650 Expressed in 243 organ(s), highest expression level in forebrain
CleanExiHS_MYST4
GenevisibleiQ8WYB5 HS

Organism-specific databases

HPAiHPA006104

Interactioni

Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117069, 11 interactors
ComplexPortaliCPX-738 MORF1 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex
CORUMiQ8WYB5
IntActiQ8WYB5, 56 interactors
STRINGi9606.ENSP00000287239

Structurei

Secondary structure

12073
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WYB5
SMRiQ8WYB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 176H15PROSITE-ProRule annotationAdd BLAST74
Domaini715 – 989MYST-type HATPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni361 – 717Negatively regulates HAT activityAdd BLAST357
Regioni718 – 1008CatalyticAdd BLAST291
Regioni752 – 1008Interaction with BRPF11 PublicationAdd BLAST257
Regioni856 – 860Acetyl-CoA bindingBy similarity5
Regioni865 – 871Acetyl-CoA bindingBy similarity7
Regioni1560 – 2073Interaction with RUNX1 and RUNX21 PublicationAdd BLAST514

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi492 – 533Ser-richAdd BLAST42
Compositional biasi521 – 524Poly-Ser4
Compositional biasi599 – 605Poly-Ser7
Compositional biasi1070 – 1104Poly-GluAdd BLAST35
Compositional biasi1204 – 1207Poly-Glu4
Compositional biasi1351 – 1373Poly-GluAdd BLAST23
Compositional biasi1409 – 1417Poly-Glu9
Compositional biasi1594 – 1763Ser-richAdd BLAST170
Compositional biasi1961 – 2061Met-richAdd BLAST101

Domaini

The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.1 Publication

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri213 – 272PHD-type 1PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri269 – 320PHD-type 2PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri748 – 773C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
GeneTreeiENSGT00930000150839
HOVERGENiHBG052563
InParanoidiQ8WYB5
KOiK11306
OMAiQSSCAVT
OrthoDBiEOG091G00D2
PhylomeDBiQ8WYB5
TreeFamiTF106483

Family and domain databases

Gene3Di1.10.10.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR005818 Histone_H1/H5_H15
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00526 H15, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55729 SSF55729, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
PS51726 MYST_HAT, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WYB5-1) [UniParc]FASTAAdd to basket
Also known as: Beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKLANPLYT EWILEAIQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ
60 70 80 90 100
LELSVQDGSV LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK SAKGSRGSCN
110 120 130 140 150
DLRNVDWNKL LRRAIEGLEE PNGSSLKNIE KYLRSQSDLT STTNNPAFQQ
160 170 180 190 200
RLRLGAKRAV NNGRLLKDGP QYRVNYGSLD GKGAPQYPSA FPSSLPPVSL
210 220 230 240 250
LPHEKDQPRA DPIPICSFCL GTKESNREKK PEELLSCADC GSSGHPSCLK
260 270 280 290 300
FCPELTTNVK ALRWQCIECK TCSACRVQGR NADNMLFCDS CDRGFHMECC
310 320 330 340 350
DPPLSRMPKG MWICQVCRPK KKGRKLLHEK AAQIKRRYAK PIGRPKNKLK
360 370 380 390 400
QRLLSVTSDE GSMNAFTGRG SPGRGQKTKV CTTPSSGHAA SGKDSSSRLA
410 420 430 440 450
VTDPTRPGAT TKITTTSTYI SASTLKVNKK TKGLIDGLTK FFTPSPDGRR
460 470 480 490 500
SRGEIIDFSK HYRPRKKVSQ KQSCTSHVLA TGTTQKLKPP PSSLPPPTPI
510 520 530 540 550
SGQSPSSQKS STATSSPSPQ SSSSQCSVPS LSSLTTNSQL KALFDGLSHI
560 570 580 590 600
YTTQGQSRKK GHPSYAPPKR MRRKTELSST AKSKAHFFGK RDIRSRFISH
610 620 630 640 650
SSSSSWGMAR GSIFKAIAHF KRTTFLKKHR MLGRLKYKVT PQMGTPSPGK
660 670 680 690 700
GSLTDGRIKP DQDDDTEIKI NIKQESADVN VIGNKDVVTE EDLDVFKQAQ
710 720 730 740 750
ELSWEKIECE SGVEDCGRYP SVIEFGKYEI QTWYSSPYPQ EYARLPKLYL
760 770 780 790 800
CEFCLKYMKS KNILLRHSKK CGWFHPPANE IYRRKDLSVF EVDGNMSKIY
810 820 830 840 850
CQNLCLLAKL FLDHKTLYYD VEPFLFYVLT KNDEKGCHLV GYFSKEKLCQ
860 870 880 890 900
QKYNVSCIMI MPQHQRQGFG RFLIDFSYLL SRREGQAGSP EKPLSDLGRL
910 920 930 940 950
SYLAYWKSVI LEYLYHHHER HISIKAISRA TGMCPHDIAT TLQHLHMIDK
960 970 980 990 1000
RDGRFVIIRR EKLILSHMEK LKTCSRANEL DPDSLRWTPI LISNAAVSEE
1010 1020 1030 1040 1050
EREAEKEAER LMEQASCWEK EEQEILSTRA NSRQSPAKVQ SKNKYLHSPE
1060 1070 1080 1090 1100
SRPVTGERGQ LLELSKESSE EEEEEEDEEE EEEEEEEEED EEEEEEEEEE
1110 1120 1130 1140 1150
EEEENIQSSP PRLTKPQSVA IKRKRPFVLK KKRGRKRRRI NSSVTTETIS
1160 1170 1180 1190 1200
ETTEVLNEPF DNSDEERPMP QLEPTCEIEV EEDGRKPVLR KAFQHQPGKK
1210 1220 1230 1240 1250
RQTEEEEGKD NHCFKNADPC RNNMNDDSSN LKEGSKDNPE PLKCKQVWPK
1260 1270 1280 1290 1300
GTKRGLSKWR QNKERKTGFK LNLYTPPETP MEPDEQVTVE EQKETSEGKT
1310 1320 1330 1340 1350
SPSPIRIEEE VKETGEALLP QEENRREETC APVSPNTSPG EKPEDDLIKP
1360 1370 1380 1390 1400
EEEEEEEEEE EEEEEEEEGE EEEGGGNVEK DPDGAKSQEK EEPEISTEKE
1410 1420 1430 1440 1450
DSARLDDHEE EEEEDEEPSH NEDHDADDED DSHMESAEVE KEELPRESFK
1460 1470 1480 1490 1500
EVLENQETFL DLNVQPGHSN PEVLMDCGVD LTASCNSEPK ELAGDPEAVP
1510 1520 1530 1540 1550
ESDEEPPPGE QAQKQDQKNS KEVDTEFKEG NPATMEIDSE TVQAVQSLTQ
1560 1570 1580 1590 1600
ESSEQDDTFQ DCAETQEACR SLQNYTRADQ SPQIATTLDD CQQSDHSSPV
1610 1620 1630 1640 1650
SSVHSHPGQS VRSVNSPSVP ALENSYAQIS PDQSAISVPS LQNMETSPMM
1660 1670 1680 1690 1700
DVPSVSDHSQ QVVDSGFSDL GSIESTTENY ENPSSYDSTM GGSICGNGSS
1710 1720 1730 1740 1750
QNSCSYSNLT SSSLTQSSCA VTQQMSNISG SCSMLQQTSI SSPPTCSVKS
1760 1770 1780 1790 1800
PQGCVVERPP SSSQQLAQCS MAANFTPPMQ LAEIPETSNA NIGLYERMGQ
1810 1820 1830 1840 1850
SDFGAGHYPQ PSATFSLAKL QQLTNTLIDH SLPYSHSAAV TSYANSASLS
1860 1870 1880 1890 1900
TPLSNTGLVQ LSQSPHSVPG GPQAQATMTP PPNLTPPPMN LPPPLLQRNM
1910 1920 1930 1940 1950
AASNIGISHS QRLQTQIASK GHISMRTKSA SLSPAAATHQ SQIYGRSQTV
1960 1970 1980 1990 2000
AMQGPARTLT MQRGMNMSVN LMPAPAYNVN SVNMNMNTLN AMNGYSMSQP
2010 2020 2030 2040 2050
MMNSGYHSNH GYMNQTPQYP MQMQMGMMGT QPYAQQPMQT PPHGNMMYTA
2060 2070
PGHHGYMNTG MSKQSLNGSY MRR
Length:2,073
Mass (Da):231,378
Last modified:April 3, 2007 - v3
Checksum:iAEE267B9DA444B08
GO
Isoform 2 (identifier: Q8WYB5-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     482-664: Missing.

Show »
Length:1,890
Mass (Da):211,537
Checksum:i9AD95D653693CFBA
GO
Isoform 3 (identifier: Q8WYB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-664: Missing.

Show »
Length:1,781
Mass (Da):199,858
Checksum:i895F7DE8B12455E8
GO

Sequence cautioni

The sequence AAF00100 differs from that shown. Reason: Frameshift at positions 550 and 562.Curated
The sequence AAH14143 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH48199 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123G → R in AAL56647 (Ref. 2) Curated1
Sequence conflicti231P → A in AAL56647 (Ref. 2) Curated1
Sequence conflicti843F → L in AAF00095 (PubMed:10497217).Curated1
Sequence conflicti843F → L in AAF00099 (PubMed:10497217).Curated1
Sequence conflicti843F → L in AAF00100 (PubMed:10497217).Curated1
Sequence conflicti843F → L in BAA20837 (PubMed:9205841).Curated1
Sequence conflicti931 – 933TGM → RHV in AAL56647 (Ref. 2) Curated3
Sequence conflicti934Missing in AAL56647 (Ref. 2) Curated1
Sequence conflicti1152T → S in AAL56647 (Ref. 2) Curated1
Sequence conflicti1625S → T in AAL56647 (Ref. 2) Curated1
Sequence conflicti1731S → T in AAL56647 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067315360E → K1 Publication1
Natural variantiVAR_036361483T → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0613671217A → S. Corresponds to variant dbSNP:rs57372986EnsemblClinVar.1
Natural variantiVAR_0502171499V → I. Corresponds to variant dbSNP:rs3740321EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014586373 – 664Missing in isoform 3. 2 PublicationsAdd BLAST292
Alternative sequenceiVSP_014587482 – 664Missing in isoform 2. 1 PublicationAdd BLAST183

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113514 mRNA Translation: AAF00095.1
AF119230 mRNA Translation: AAF00099.1
AF119231 mRNA Translation: AAF00100.1 Frameshift.
AF217500 mRNA Translation: AAL56647.1
AB002381 mRNA Translation: BAA20837.2
BC014143 mRNA Translation: AAH14143.1 Sequence problems.
BC021128 mRNA Translation: AAH21128.1
BC048199 mRNA Translation: AAH48199.1 Sequence problems.
CCDSiCCDS58084.1 [Q8WYB5-3]
CCDS58085.1 [Q8WYB5-2]
CCDS7345.1 [Q8WYB5-1]
RefSeqiNP_001243397.1, NM_001256468.1 [Q8WYB5-2]
NP_001243398.1, NM_001256469.1 [Q8WYB5-3]
NP_036462.2, NM_012330.3 [Q8WYB5-1]
XP_005269721.1, XM_005269664.2 [Q8WYB5-1]
XP_016871489.1, XM_017016000.1 [Q8WYB5-1]
XP_016871490.1, XM_017016001.1
XP_016871491.1, XM_017016002.1 [Q8WYB5-1]
XP_016871492.1, XM_017016003.1 [Q8WYB5-1]
XP_016871494.1, XM_017016005.1 [Q8WYB5-2]
XP_016871495.1, XM_017016006.1 [Q8WYB5-3]
XP_016871496.1, XM_017016007.1
XP_016871497.1, XM_017016008.1 [Q8WYB5-3]
UniGeneiHs.35758
Hs.599543
Hs.740873

Genome annotation databases

EnsembliENST00000287239; ENSP00000287239; ENSG00000156650 [Q8WYB5-1]
ENST00000372711; ENSP00000361796; ENSG00000156650 [Q8WYB5-2]
ENST00000372714; ENSP00000361799; ENSG00000156650 [Q8WYB5-3]
ENST00000372724; ENSP00000361809; ENSG00000156650 [Q8WYB5-3]
ENST00000372725; ENSP00000361810; ENSG00000156650 [Q8WYB5-3]
ENST00000628038; ENSP00000485896; ENSG00000281813 [Q8WYB5-3]
ENST00000628523; ENSP00000487238; ENSG00000281813 [Q8WYB5-3]
ENST00000629233; ENSP00000487219; ENSG00000281813 [Q8WYB5-3]
ENST00000629879; ENSP00000486731; ENSG00000281813 [Q8WYB5-2]
ENST00000630001; ENSP00000486595; ENSG00000281813 [Q8WYB5-1]
GeneIDi23522
KEGGihsa:23522
UCSCiuc001jwm.3 human [Q8WYB5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113514 mRNA Translation: AAF00095.1
AF119230 mRNA Translation: AAF00099.1
AF119231 mRNA Translation: AAF00100.1 Frameshift.
AF217500 mRNA Translation: AAL56647.1
AB002381 mRNA Translation: BAA20837.2
BC014143 mRNA Translation: AAH14143.1 Sequence problems.
BC021128 mRNA Translation: AAH21128.1
BC048199 mRNA Translation: AAH48199.1 Sequence problems.
CCDSiCCDS58084.1 [Q8WYB5-3]
CCDS58085.1 [Q8WYB5-2]
CCDS7345.1 [Q8WYB5-1]
RefSeqiNP_001243397.1, NM_001256468.1 [Q8WYB5-2]
NP_001243398.1, NM_001256469.1 [Q8WYB5-3]
NP_036462.2, NM_012330.3 [Q8WYB5-1]
XP_005269721.1, XM_005269664.2 [Q8WYB5-1]
XP_016871489.1, XM_017016000.1 [Q8WYB5-1]
XP_016871490.1, XM_017016001.1
XP_016871491.1, XM_017016002.1 [Q8WYB5-1]
XP_016871492.1, XM_017016003.1 [Q8WYB5-1]
XP_016871494.1, XM_017016005.1 [Q8WYB5-2]
XP_016871495.1, XM_017016006.1 [Q8WYB5-3]
XP_016871496.1, XM_017016007.1
XP_016871497.1, XM_017016008.1 [Q8WYB5-3]
UniGeneiHs.35758
Hs.599543
Hs.740873

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5U2JX-ray1.60A/B211-320[»]
ProteinModelPortaliQ8WYB5
SMRiQ8WYB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117069, 11 interactors
ComplexPortaliCPX-738 MORF1 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex
CORUMiQ8WYB5
IntActiQ8WYB5, 56 interactors
STRINGi9606.ENSP00000287239

Chemistry databases

ChEMBLiCHEMBL3774300

Protein family/group databases

MoonDBiQ8WYB5 Predicted

PTM databases

iPTMnetiQ8WYB5
PhosphoSitePlusiQ8WYB5

Polymorphism and mutation databases

BioMutaiKAT6B
DMDMi143811424

Proteomic databases

EPDiQ8WYB5
MaxQBiQ8WYB5
PaxDbiQ8WYB5
PeptideAtlasiQ8WYB5
PRIDEiQ8WYB5
ProteomicsDBi75154
75155 [Q8WYB5-2]
75156 [Q8WYB5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287239; ENSP00000287239; ENSG00000156650 [Q8WYB5-1]
ENST00000372711; ENSP00000361796; ENSG00000156650 [Q8WYB5-2]
ENST00000372714; ENSP00000361799; ENSG00000156650 [Q8WYB5-3]
ENST00000372724; ENSP00000361809; ENSG00000156650 [Q8WYB5-3]
ENST00000372725; ENSP00000361810; ENSG00000156650 [Q8WYB5-3]
ENST00000628038; ENSP00000485896; ENSG00000281813 [Q8WYB5-3]
ENST00000628523; ENSP00000487238; ENSG00000281813 [Q8WYB5-3]
ENST00000629233; ENSP00000487219; ENSG00000281813 [Q8WYB5-3]
ENST00000629879; ENSP00000486731; ENSG00000281813 [Q8WYB5-2]
ENST00000630001; ENSP00000486595; ENSG00000281813 [Q8WYB5-1]
GeneIDi23522
KEGGihsa:23522
UCSCiuc001jwm.3 human [Q8WYB5-1]

Organism-specific databases

CTDi23522
DisGeNETi23522
EuPathDBiHostDB:ENSG00000156650.12
GeneCardsiKAT6B
GeneReviewsiKAT6B
HGNCiHGNC:17582 KAT6B
HPAiHPA006104
MalaCardsiKAT6B
MIMi603736 phenotype
605880 gene
606170 phenotype
neXtProtiNX_Q8WYB5
OpenTargetsiENSG00000156650
Orphaneti3047 Blepharophimosis-intellectual disability syndrome, SBBYS type
85201 Genitopatellar syndrome
648 Noonan syndrome
PharmGKBiPA134880712
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
GeneTreeiENSGT00930000150839
HOVERGENiHBG052563
InParanoidiQ8WYB5
KOiK11306
OMAiQSSCAVT
OrthoDBiEOG091G00D2
PhylomeDBiQ8WYB5
TreeFamiTF106483

Enzyme and pathway databases

BRENDAi2.3.1.48 2681
ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiQ8WYB5

Miscellaneous databases

ChiTaRSiKAT6B human
GeneWikiiMYST4
GenomeRNAii23522
PROiPR:Q8WYB5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156650 Expressed in 243 organ(s), highest expression level in forebrain
CleanExiHS_MYST4
GenevisibleiQ8WYB5 HS

Family and domain databases

Gene3Di1.10.10.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR005818 Histone_H1/H5_H15
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00526 H15, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55729 SSF55729, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
PS51726 MYST_HAT, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKAT6B_HUMAN
AccessioniPrimary (citable) accession number: Q8WYB5
Secondary accession number(s): O15087
, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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