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Entry version 169 (16 Oct 2019)
Sequence version 3 (03 Apr 2007)
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Protein

Histone acetyltransferase KAT6B

Gene

KAT6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei891Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei895Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri213 – 272PHD-type 1PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri269 – 320PHD-type 2PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri748 – 773C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.3.1.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214847 HATs acetylate histones

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8WYB5

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q8WYB5 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone acetyltransferase KAT6B (EC:2.3.1.481 Publication)
Alternative name(s):
Histone acetyltransferase MOZ2
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
Short name:
MYST-4
Monocytic leukemia zinc finger protein-related factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KAT6B
Synonyms:KIAA0383, MORF, MOZ2, MYST4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17582 KAT6B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605880 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WYB5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving KAT6B may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.1 Publication
Ohdo syndrome, SBBYS variant (SBBYSS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by distinctive facial appearance with severe blepharophimosis, an immobile mask-like face, a bulbous nasal tip, and a small mouth with a thin upper lip. The condition presents in infancy with severe hypotonia and feeding problems. Associated skeletal problems include joint laxity, abnormally long thumbs and great toes, and dislocated or hypoplastic patellae. Structural cardiac defects are present in around 50% of cases, and dental anomalies, including small and pointed teeth, are common. Optic atrophy and conductive or sensorineural deafness are repeatedly reported. Many affected individuals have abnormalities of thyroid structure or function. SBBYSS is usually associated with severe mental retardation, delayed motor milestones, and significantly impaired speech.
Related information in OMIM
Genitopatellar syndrome (GTPTS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder consisting of microcephaly, severe psychomotor retardation, and characteristic coarse facial features, including broad nose and small or retracted chin, associated with congenital flexion contractures of the lower extremities, abnormal or missing patellae, and urogenital anomalies.
Related information in OMIM

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1222 – 1223Breakpoint for translocation to form KAT6B-CREBBP2

Organism-specific databases

DisGeNET

More...
DisGeNETi
23522

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
KAT6B

MalaCards human disease database

More...
MalaCardsi
KAT6B
MIMi603736 phenotype
606170 phenotype

Open Targets

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OpenTargetsi
ENSG00000156650

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3047 Blepharophimosis-intellectual disability syndrome, SBBYS type
85201 Genitopatellar syndrome
648 Noonan syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134880712

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WYB5

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3774300

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KAT6B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811424

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000515751 – 2073Histone acetyltransferase KAT6BAdd BLAST2073

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei355PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei815N6-acetyllysine; by autocatalysisBy similarity1
Modified residuei1038N6-acetyllysineCombined sources1
Modified residuei1042N6-acetyllysineCombined sources1
Modified residuei1044N6-acetyllysineCombined sources1
Modified residuei1048PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoacetylated (PubMed:10497217 and PubMed:11965546). Autoacetylation at Lys-815 is required for proper function.By similarity2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8WYB5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8WYB5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8WYB5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8WYB5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WYB5

PeptideAtlas

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PeptideAtlasi
Q8WYB5

PRoteomics IDEntifications database

More...
PRIDEi
Q8WYB5

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
75154 [Q8WYB5-1]
75155 [Q8WYB5-2]
75156 [Q8WYB5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WYB5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WYB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156650 Expressed in 243 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WYB5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WYB5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006104

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.

Interacts with RUNX1 and RUNX2.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117069, 13 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-738 MORF1 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8WYB5

Protein interaction database and analysis system

More...
IntActi
Q8WYB5, 60 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000287239

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12073
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WYB5

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 176H15PROSITE-ProRule annotationAdd BLAST74
Domaini715 – 989MYST-type HATPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni361 – 717Negatively regulates HAT activityAdd BLAST357
Regioni718 – 1008CatalyticAdd BLAST291
Regioni752 – 1008Interaction with BRPF11 PublicationAdd BLAST257
Regioni856 – 860Acetyl-CoA bindingBy similarity5
Regioni865 – 871Acetyl-CoA bindingBy similarity7
Regioni1560 – 2073Interaction with RUNX1 and RUNX21 PublicationAdd BLAST514

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi492 – 533Ser-richAdd BLAST42
Compositional biasi521 – 524Poly-Ser4
Compositional biasi599 – 605Poly-Ser7
Compositional biasi1070 – 1104Poly-GluAdd BLAST35
Compositional biasi1204 – 1207Poly-Glu4
Compositional biasi1351 – 1373Poly-GluAdd BLAST23
Compositional biasi1409 – 1417Poly-Glu9
Compositional biasi1594 – 1763Ser-richAdd BLAST170
Compositional biasi1961 – 2061Met-richAdd BLAST101

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri213 – 272PHD-type 1PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri269 – 320PHD-type 2PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri748 – 773C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2747 Eukaryota
COG5027 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157372

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WYB5

KEGG Orthology (KO)

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KOi
K11306

Identification of Orthologs from Complete Genome Data

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OMAi
KQGWPKG

Database of Orthologous Groups

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OrthoDBi
1344247at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8WYB5

TreeFam database of animal gene trees

More...
TreeFami
TF106483

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR005818 Histone_H1/H5_H15
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR040706 Zf-MYST
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF00628 PHD, 1 hit
PF17772 zf-MYST, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00526 H15, 1 hit
SM00249 PHD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF55729 SSF55729, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51504 H15, 1 hit
PS51726 MYST_HAT, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYB5-1) [UniParc]FASTAAdd to basket
Also known as: Beta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKLANPLYT EWILEAIQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ
60 70 80 90 100
LELSVQDGSV LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK SAKGSRGSCN
110 120 130 140 150
DLRNVDWNKL LRRAIEGLEE PNGSSLKNIE KYLRSQSDLT STTNNPAFQQ
160 170 180 190 200
RLRLGAKRAV NNGRLLKDGP QYRVNYGSLD GKGAPQYPSA FPSSLPPVSL
210 220 230 240 250
LPHEKDQPRA DPIPICSFCL GTKESNREKK PEELLSCADC GSSGHPSCLK
260 270 280 290 300
FCPELTTNVK ALRWQCIECK TCSACRVQGR NADNMLFCDS CDRGFHMECC
310 320 330 340 350
DPPLSRMPKG MWICQVCRPK KKGRKLLHEK AAQIKRRYAK PIGRPKNKLK
360 370 380 390 400
QRLLSVTSDE GSMNAFTGRG SPGRGQKTKV CTTPSSGHAA SGKDSSSRLA
410 420 430 440 450
VTDPTRPGAT TKITTTSTYI SASTLKVNKK TKGLIDGLTK FFTPSPDGRR
460 470 480 490 500
SRGEIIDFSK HYRPRKKVSQ KQSCTSHVLA TGTTQKLKPP PSSLPPPTPI
510 520 530 540 550
SGQSPSSQKS STATSSPSPQ SSSSQCSVPS LSSLTTNSQL KALFDGLSHI
560 570 580 590 600
YTTQGQSRKK GHPSYAPPKR MRRKTELSST AKSKAHFFGK RDIRSRFISH
610 620 630 640 650
SSSSSWGMAR GSIFKAIAHF KRTTFLKKHR MLGRLKYKVT PQMGTPSPGK
660 670 680 690 700
GSLTDGRIKP DQDDDTEIKI NIKQESADVN VIGNKDVVTE EDLDVFKQAQ
710 720 730 740 750
ELSWEKIECE SGVEDCGRYP SVIEFGKYEI QTWYSSPYPQ EYARLPKLYL
760 770 780 790 800
CEFCLKYMKS KNILLRHSKK CGWFHPPANE IYRRKDLSVF EVDGNMSKIY
810 820 830 840 850
CQNLCLLAKL FLDHKTLYYD VEPFLFYVLT KNDEKGCHLV GYFSKEKLCQ
860 870 880 890 900
QKYNVSCIMI MPQHQRQGFG RFLIDFSYLL SRREGQAGSP EKPLSDLGRL
910 920 930 940 950
SYLAYWKSVI LEYLYHHHER HISIKAISRA TGMCPHDIAT TLQHLHMIDK
960 970 980 990 1000
RDGRFVIIRR EKLILSHMEK LKTCSRANEL DPDSLRWTPI LISNAAVSEE
1010 1020 1030 1040 1050
EREAEKEAER LMEQASCWEK EEQEILSTRA NSRQSPAKVQ SKNKYLHSPE
1060 1070 1080 1090 1100
SRPVTGERGQ LLELSKESSE EEEEEEDEEE EEEEEEEEED EEEEEEEEEE
1110 1120 1130 1140 1150
EEEENIQSSP PRLTKPQSVA IKRKRPFVLK KKRGRKRRRI NSSVTTETIS
1160 1170 1180 1190 1200
ETTEVLNEPF DNSDEERPMP QLEPTCEIEV EEDGRKPVLR KAFQHQPGKK
1210 1220 1230 1240 1250
RQTEEEEGKD NHCFKNADPC RNNMNDDSSN LKEGSKDNPE PLKCKQVWPK
1260 1270 1280 1290 1300
GTKRGLSKWR QNKERKTGFK LNLYTPPETP MEPDEQVTVE EQKETSEGKT
1310 1320 1330 1340 1350
SPSPIRIEEE VKETGEALLP QEENRREETC APVSPNTSPG EKPEDDLIKP
1360 1370 1380 1390 1400
EEEEEEEEEE EEEEEEEEGE EEEGGGNVEK DPDGAKSQEK EEPEISTEKE
1410 1420 1430 1440 1450
DSARLDDHEE EEEEDEEPSH NEDHDADDED DSHMESAEVE KEELPRESFK
1460 1470 1480 1490 1500
EVLENQETFL DLNVQPGHSN PEVLMDCGVD LTASCNSEPK ELAGDPEAVP
1510 1520 1530 1540 1550
ESDEEPPPGE QAQKQDQKNS KEVDTEFKEG NPATMEIDSE TVQAVQSLTQ
1560 1570 1580 1590 1600
ESSEQDDTFQ DCAETQEACR SLQNYTRADQ SPQIATTLDD CQQSDHSSPV
1610 1620 1630 1640 1650
SSVHSHPGQS VRSVNSPSVP ALENSYAQIS PDQSAISVPS LQNMETSPMM
1660 1670 1680 1690 1700
DVPSVSDHSQ QVVDSGFSDL GSIESTTENY ENPSSYDSTM GGSICGNGSS
1710 1720 1730 1740 1750
QNSCSYSNLT SSSLTQSSCA VTQQMSNISG SCSMLQQTSI SSPPTCSVKS
1760 1770 1780 1790 1800
PQGCVVERPP SSSQQLAQCS MAANFTPPMQ LAEIPETSNA NIGLYERMGQ
1810 1820 1830 1840 1850
SDFGAGHYPQ PSATFSLAKL QQLTNTLIDH SLPYSHSAAV TSYANSASLS
1860 1870 1880 1890 1900
TPLSNTGLVQ LSQSPHSVPG GPQAQATMTP PPNLTPPPMN LPPPLLQRNM
1910 1920 1930 1940 1950
AASNIGISHS QRLQTQIASK GHISMRTKSA SLSPAAATHQ SQIYGRSQTV
1960 1970 1980 1990 2000
AMQGPARTLT MQRGMNMSVN LMPAPAYNVN SVNMNMNTLN AMNGYSMSQP
2010 2020 2030 2040 2050
MMNSGYHSNH GYMNQTPQYP MQMQMGMMGT QPYAQQPMQT PPHGNMMYTA
2060 2070
PGHHGYMNTG MSKQSLNGSY MRR
Length:2,073
Mass (Da):231,378
Last modified:April 3, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEE267B9DA444B08
GO
Isoform 2 (identifier: Q8WYB5-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     482-664: Missing.

Show »
Length:1,890
Mass (Da):211,537
Checksum:i9AD95D653693CFBA
GO
Isoform 3 (identifier: Q8WYB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-664: Missing.

Show »
Length:1,781
Mass (Da):199,858
Checksum:i895F7DE8B12455E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IS73A0A3B3IS73_HUMAN
Histone acetyltransferase
KAT6B
800Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISD5A0A3B3ISD5_HUMAN
Histone acetyltransferase
KAT6B
733Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISF5A0A3B3ISF5_HUMAN
Histone acetyltransferase
KAT6B
796Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISI1A0A3B3ISI1_HUMAN
Histone acetyltransferase
KAT6B
1,387Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISW3A0A3B3ISW3_HUMAN
Histone acetyltransferase
KAT6B
713Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IT19A0A3B3IT19_HUMAN
Histone acetyltransferase
KAT6B
991Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IT63A0A3B3IT63_HUMAN
Histone acetyltransferase
KAT6B
799Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITA4A0A3B3ITA4_HUMAN
Histone acetyltransferase
KAT6B
633Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITI0A0A3B3ITI0_HUMAN
Histone acetyltransferase
KAT6B
1,182Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU93A0A3B3IU93_HUMAN
Histone acetyltransferase
KAT6B
945Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF00100 differs from that shown. Reason: Frameshift.Curated
The sequence AAH14143 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH48199 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123G → R in AAL56647 (Ref. 2) Curated1
Sequence conflicti231P → A in AAL56647 (Ref. 2) Curated1
Sequence conflicti843F → L in AAF00095 (PubMed:10497217).Curated1
Sequence conflicti843F → L in AAF00099 (PubMed:10497217).Curated1
Sequence conflicti843F → L in AAF00100 (PubMed:10497217).Curated1
Sequence conflicti843F → L in BAA20837 (PubMed:9205841).Curated1
Sequence conflicti931 – 933TGM → RHV in AAL56647 (Ref. 2) Curated3
Sequence conflicti934Missing in AAL56647 (Ref. 2) Curated1
Sequence conflicti1152T → S in AAL56647 (Ref. 2) Curated1
Sequence conflicti1625S → T in AAL56647 (Ref. 2) Curated1
Sequence conflicti1731S → T in AAL56647 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067315360E → K1 Publication1
Natural variantiVAR_036361483T → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0613671217A → S. Corresponds to variant dbSNP:rs57372986EnsemblClinVar.1
Natural variantiVAR_0502171499V → I. Corresponds to variant dbSNP:rs3740321EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014586373 – 664Missing in isoform 3. 2 PublicationsAdd BLAST292
Alternative sequenceiVSP_014587482 – 664Missing in isoform 2. 1 PublicationAdd BLAST183

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF113514 mRNA Translation: AAF00095.1
AF119230 mRNA Translation: AAF00099.1
AF119231 mRNA Translation: AAF00100.1 Frameshift.
AF217500 mRNA Translation: AAL56647.1
AB002381 mRNA Translation: BAA20837.2
BC014143 mRNA Translation: AAH14143.1 Sequence problems.
BC021128 mRNA Translation: AAH21128.1
BC048199 mRNA Translation: AAH48199.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58084.1 [Q8WYB5-3]
CCDS58085.1 [Q8WYB5-2]
CCDS7345.1 [Q8WYB5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001243397.1, NM_001256468.1 [Q8WYB5-2]
NP_001243398.1, NM_001256469.1 [Q8WYB5-3]
NP_036462.2, NM_012330.3 [Q8WYB5-1]
XP_005269721.1, XM_005269664.2 [Q8WYB5-1]
XP_016871489.1, XM_017016000.1
XP_016871490.1, XM_017016001.1
XP_016871491.1, XM_017016002.1
XP_016871492.1, XM_017016003.1 [Q8WYB5-1]
XP_016871494.1, XM_017016005.1
XP_016871495.1, XM_017016006.1
XP_016871496.1, XM_017016007.1
XP_016871497.1, XM_017016008.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287239; ENSP00000287239; ENSG00000156650 [Q8WYB5-1]
ENST00000372711; ENSP00000361796; ENSG00000156650 [Q8WYB5-2]
ENST00000372714; ENSP00000361799; ENSG00000156650 [Q8WYB5-3]
ENST00000372724; ENSP00000361809; ENSG00000156650 [Q8WYB5-2]
ENST00000372725; ENSP00000361810; ENSG00000156650 [Q8WYB5-3]
ENST00000628038; ENSP00000485896; ENSG00000281813 [Q8WYB5-3]
ENST00000628523; ENSP00000487238; ENSG00000281813 [Q8WYB5-2]
ENST00000629233; ENSP00000487219; ENSG00000281813 [Q8WYB5-3]
ENST00000629879; ENSP00000486731; ENSG00000281813 [Q8WYB5-2]
ENST00000630001; ENSP00000486595; ENSG00000281813 [Q8WYB5-1]
ENST00000647630; ENSP00000497352; ENSG00000281813 [Q8WYB5-1]
ENST00000648605; ENSP00000497718; ENSG00000281813 [Q8WYB5-1]
ENST00000648725; ENSP00000497841; ENSG00000156650 [Q8WYB5-1]
ENST00000648892; ENSP00000497048; ENSG00000156650 [Q8WYB5-3]
ENST00000649006; ENSP00000498139; ENSG00000156650 [Q8WYB5-3]
ENST00000649463; ENSP00000497166; ENSG00000156650 [Q8WYB5-1]
ENST00000649574; ENSP00000497416; ENSG00000281813 [Q8WYB5-3]
ENST00000650575; ENSP00000497453; ENSG00000281813 [Q8WYB5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23522

UCSC genome browser

More...
UCSCi
uc001jwm.3 human [Q8WYB5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113514 mRNA Translation: AAF00095.1
AF119230 mRNA Translation: AAF00099.1
AF119231 mRNA Translation: AAF00100.1 Frameshift.
AF217500 mRNA Translation: AAL56647.1
AB002381 mRNA Translation: BAA20837.2
BC014143 mRNA Translation: AAH14143.1 Sequence problems.
BC021128 mRNA Translation: AAH21128.1
BC048199 mRNA Translation: AAH48199.1 Sequence problems.
CCDSiCCDS58084.1 [Q8WYB5-3]
CCDS58085.1 [Q8WYB5-2]
CCDS7345.1 [Q8WYB5-1]
RefSeqiNP_001243397.1, NM_001256468.1 [Q8WYB5-2]
NP_001243398.1, NM_001256469.1 [Q8WYB5-3]
NP_036462.2, NM_012330.3 [Q8WYB5-1]
XP_005269721.1, XM_005269664.2 [Q8WYB5-1]
XP_016871489.1, XM_017016000.1
XP_016871490.1, XM_017016001.1
XP_016871491.1, XM_017016002.1
XP_016871492.1, XM_017016003.1 [Q8WYB5-1]
XP_016871494.1, XM_017016005.1
XP_016871495.1, XM_017016006.1
XP_016871496.1, XM_017016007.1
XP_016871497.1, XM_017016008.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5U2JX-ray1.60A/B211-320[»]
SMRiQ8WYB5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117069, 13 interactors
ComplexPortaliCPX-738 MORF1 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex
CORUMiQ8WYB5
IntActiQ8WYB5, 60 interactors
STRINGi9606.ENSP00000287239

Chemistry databases

ChEMBLiCHEMBL3774300

Protein family/group databases

MoonDBiQ8WYB5 Predicted

PTM databases

iPTMnetiQ8WYB5
PhosphoSitePlusiQ8WYB5

Polymorphism and mutation databases

BioMutaiKAT6B
DMDMi143811424

Proteomic databases

EPDiQ8WYB5
jPOSTiQ8WYB5
MassIVEiQ8WYB5
MaxQBiQ8WYB5
PaxDbiQ8WYB5
PeptideAtlasiQ8WYB5
PRIDEiQ8WYB5
ProteomicsDBi75154 [Q8WYB5-1]
75155 [Q8WYB5-2]
75156 [Q8WYB5-3]

Genome annotation databases

EnsembliENST00000287239; ENSP00000287239; ENSG00000156650 [Q8WYB5-1]
ENST00000372711; ENSP00000361796; ENSG00000156650 [Q8WYB5-2]
ENST00000372714; ENSP00000361799; ENSG00000156650 [Q8WYB5-3]
ENST00000372724; ENSP00000361809; ENSG00000156650 [Q8WYB5-2]
ENST00000372725; ENSP00000361810; ENSG00000156650 [Q8WYB5-3]
ENST00000628038; ENSP00000485896; ENSG00000281813 [Q8WYB5-3]
ENST00000628523; ENSP00000487238; ENSG00000281813 [Q8WYB5-2]
ENST00000629233; ENSP00000487219; ENSG00000281813 [Q8WYB5-3]
ENST00000629879; ENSP00000486731; ENSG00000281813 [Q8WYB5-2]
ENST00000630001; ENSP00000486595; ENSG00000281813 [Q8WYB5-1]
ENST00000647630; ENSP00000497352; ENSG00000281813 [Q8WYB5-1]
ENST00000648605; ENSP00000497718; ENSG00000281813 [Q8WYB5-1]
ENST00000648725; ENSP00000497841; ENSG00000156650 [Q8WYB5-1]
ENST00000648892; ENSP00000497048; ENSG00000156650 [Q8WYB5-3]
ENST00000649006; ENSP00000498139; ENSG00000156650 [Q8WYB5-3]
ENST00000649463; ENSP00000497166; ENSG00000156650 [Q8WYB5-1]
ENST00000649574; ENSP00000497416; ENSG00000281813 [Q8WYB5-3]
ENST00000650575; ENSP00000497453; ENSG00000281813 [Q8WYB5-3]
GeneIDi23522
KEGGihsa:23522
UCSCiuc001jwm.3 human [Q8WYB5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23522
DisGeNETi23522

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KAT6B
GeneReviewsiKAT6B
HGNCiHGNC:17582 KAT6B
HPAiHPA006104
MalaCardsiKAT6B
MIMi603736 phenotype
605880 gene
606170 phenotype
neXtProtiNX_Q8WYB5
OpenTargetsiENSG00000156650
Orphaneti3047 Blepharophimosis-intellectual disability syndrome, SBBYS type
85201 Genitopatellar syndrome
648 Noonan syndrome
PharmGKBiPA134880712

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
GeneTreeiENSGT00940000157372
InParanoidiQ8WYB5
KOiK11306
OMAiKQGWPKG
OrthoDBi1344247at2759
PhylomeDBiQ8WYB5
TreeFamiTF106483

Enzyme and pathway databases

BRENDAi2.3.1.48 2681
ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiQ8WYB5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KAT6B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYST4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23522
PharosiQ8WYB5

Protein Ontology

More...
PROi
PR:Q8WYB5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156650 Expressed in 243 organ(s), highest expression level in forebrain
ExpressionAtlasiQ8WYB5 baseline and differential
GenevisibleiQ8WYB5 HS

Family and domain databases

Gene3Di1.10.10.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR005818 Histone_H1/H5_H15
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR040706 Zf-MYST
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF00628 PHD, 1 hit
PF17772 zf-MYST, 1 hit
SMARTiView protein in SMART
SM00526 H15, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55729 SSF55729, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
PS51726 MYST_HAT, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAT6B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYB5
Secondary accession number(s): O15087
, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: April 3, 2007
Last modified: October 16, 2019
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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