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Entry version 154 (16 Oct 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Beta-catenin-like protein 1

Gene

CTNNBL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mRNA splicing, via spliceosome Source: Reactome
  • positive regulation of apoptotic process Source: UniProtKB
  • somatic diversification of immunoglobulins Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-catenin-like protein 1
Alternative name(s):
Nuclear-associated protein
Short name:
NAP
Testis development protein NYD-SP19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTNNBL1
Synonyms:C20orf33
ORF Names:PP8304
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15879 CTNNBL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611537 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WYA6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi16 – 33Missing : Nuclear and cytoplasmic localization. 1 PublicationAdd BLAST18
Mutagenesisi521 – 563Missing : No change in NLS binding nor folding. 1 PublicationAdd BLAST43

Organism-specific databases

DisGeNET

More...
DisGeNETi
56259

Open Targets

More...
OpenTargetsi
ENSG00000132792

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27015

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WYA6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTNNBL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29840792

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794901 – 563Beta-catenin-like protein 1Add BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei91N6-acetyllysineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WYA6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WYA6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8WYA6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WYA6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WYA6

PeptideAtlas

More...
PeptideAtlasi
Q8WYA6

PRoteomics IDEntifications database

More...
PRIDEi
Q8WYA6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75151 [Q8WYA6-1]
75152 [Q8WYA6-2]
75153 [Q8WYA6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WYA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WYA6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8WYA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132792 Expressed in 221 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WYA6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WYA6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004742
HPA027907

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8.

Interacts directly with CWC15 and CDC5L in the complex.

Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA.

Interacts with PRPF31 (via its NLS).

Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121123, 120 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8WYA6

Protein interaction database and analysis system

More...
IntActi
Q8WYA6, 48 interactors

Molecular INTeraction database

More...
MINTi
Q8WYA6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355050

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1563
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WYA6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati79 – 129HEAT 1Add BLAST51
Repeati134 – 176HEAT 2Add BLAST43
Repeati178 – 228ARM 1Add BLAST51
Repeati229 – 273ARM 2Add BLAST45
Repeati274 – 323ARM 3Add BLAST50
Repeati325 – 363ARM 4Add BLAST39
Repeati364 – 417ARM 5Add BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili476 – 5401 PublicationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi16 – 33Nuclear localization signalAdd BLAST18
Motifi130 – 140Nuclear export signal (NES)CuratedAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 25Poly-Glu4
Compositional biasi68 – 75Poly-Glu8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding.1 Publication

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2734 Eukaryota
ENOG410XPFW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006931

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WYA6

KEGG Orthology (KO)

More...
KOi
K12864

Database of Orthologous Groups

More...
OrthoDBi
724270at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WYA6

TreeFam database of animal gene trees

More...
TreeFami
TF314294

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039678 CTNNBL1
IPR013180 CTNNBL1_N

The PANTHER Classification System

More...
PANTHERi
PTHR14978 PTHR14978, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08216 CTNNBL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01156 DUF1716, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVGELLSYQ PNRGTKRPRD DEEEEQKMRR KQTGTRERGR YREEEMTVVE
60 70 80 90 100
EADDDKKRLL QIIDRDGEEE EEEEEPLDES SVKKMILTFE KRSYKNQELR
110 120 130 140 150
IKFPDNPEKF MESELDLNDI IQEMHVVATM PDLYHLLVEL NAVQSLLGLL
160 170 180 190 200
GHDNTDVSIA VVDLLQELTD IDTLHESEEG AEVLIDALVD GQVVALLVQN
210 220 230 240 250
LERLDESVKE EADGVHNTLA IVENMAEFRP EMCTEGAQQG LLQWLLKRLK
260 270 280 290 300
AKMPFDANKL YCSEVLAILL QDNDENRELL GELDGIDVLL QQLSVFKRHN
310 320 330 340 350
PSTAEEQEMM ENLFDSLCSC LMLSSNRERF LKGEGLQLMN LMLREKKISR
360 370 380 390 400
SSALKVLDHA MIGPEGTDNC HKFVDILGLR TIFPLFMKSP RKIKKVGTTE
410 420 430 440 450
KEHEEHVCSI LASLLRNLRG QQRTRLLNKF TENDSEKVDR LMELHFKYLG
460 470 480 490 500
AMQVADKKIE GEKHDMVRRG EIIDNDTEEE FYLRRLDAGL FVLQHICYIM
510 520 530 540 550
AEICNANVPQ IRQRVHQILN MRGSSIKIVR HIIKEYAENI GDGRSPEFRE
560
NEQKRILGLL ENF
Length:563
Mass (Da):65,173
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i791BAFCEC5916B5A
GO
Isoform 2 (identifier: Q8WYA6-2) [UniParc]FASTAAdd to basket
Also known as: NYD-SP19

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.
     188-188: L → M

Show »
Length:376
Mass (Da):43,392
Checksum:i54E26219D2AA8496
GO
Isoform 3 (identifier: Q8WYA6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.

Note: Gene prediction based on EST data.
Show »
Length:311
Mass (Da):36,103
Checksum:iBEF11FF9CAF56C86
GO
Isoform 4 (identifier: Q8WYA6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):61,971
Checksum:i6508EC207D3688FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUB9A0A087WUB9_HUMAN
Beta-catenin-like protein 1
CTNNBL1
568Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A2P1A2A2P1_HUMAN
Beta-catenin-like protein 1
CTNNBL1
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ15267 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14992 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti222V → A in AAI21006 (PubMed:15489334).Curated1
Sequence conflicti329R → L in BAB14992 (PubMed:14702039).Curated1
Sequence conflicti340N → Y in BAC11121 (PubMed:14702039).Curated1
Sequence conflicti439D → N in BAB14992 (PubMed:14702039).Curated1
Sequence conflicti439D → N in BAD96312 (Ref. 7) Curated1
Sequence conflicti445H → Q in BAB14992 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059638507N → D. Corresponds to variant dbSNP:rs4811236Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0151821 – 252Missing in isoform 3. CuratedAdd BLAST252
Alternative sequenceiVSP_0040581 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_0552611 – 27Missing in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_004059188L → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF239607 mRNA Translation: AAL69567.1
AF367471 mRNA Translation: AAK53407.1
AF370431 mRNA Translation: AAQ15267.1 Frameshift.
AK074663 mRNA Translation: BAC11121.1
AK293420 mRNA Translation: BAG56927.1
AK024761 mRNA Translation: BAB14992.1 Different initiation.
AL118499 Genomic DNA No translation available.
AL109964 Genomic DNA No translation available.
AL023804 Genomic DNA No translation available.
BC022802 mRNA Translation: AAH22802.1
BC121005 mRNA Translation: AAI21006.1
BC121006 mRNA Translation: AAI21007.1
AK222592 mRNA Translation: BAD96312.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13298.1 [Q8WYA6-1]
CCDS63269.1 [Q8WYA6-4]

NCBI Reference Sequences

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RefSeqi
NP_001268424.1, NM_001281495.1 [Q8WYA6-4]
NP_110517.2, NM_030877.4 [Q8WYA6-1]
XP_011527219.1, XM_011528917.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000361383; ENSP00000355050; ENSG00000132792 [Q8WYA6-1]
ENST00000373469; ENSP00000362568; ENSG00000132792 [Q8WYA6-3]
ENST00000373473; ENSP00000362572; ENSG00000132792 [Q8WYA6-2]
ENST00000405275; ENSP00000384355; ENSG00000132792 [Q8WYA6-4]
ENST00000628103; ENSP00000487198; ENSG00000132792 [Q8WYA6-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56259

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56259

UCSC genome browser

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UCSCi
uc002xhh.4 human [Q8WYA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239607 mRNA Translation: AAL69567.1
AF367471 mRNA Translation: AAK53407.1
AF370431 mRNA Translation: AAQ15267.1 Frameshift.
AK074663 mRNA Translation: BAC11121.1
AK293420 mRNA Translation: BAG56927.1
AK024761 mRNA Translation: BAB14992.1 Different initiation.
AL118499 Genomic DNA No translation available.
AL109964 Genomic DNA No translation available.
AL023804 Genomic DNA No translation available.
BC022802 mRNA Translation: AAH22802.1
BC121005 mRNA Translation: AAI21006.1
BC121006 mRNA Translation: AAI21007.1
AK222592 mRNA Translation: BAD96312.1
CCDSiCCDS13298.1 [Q8WYA6-1]
CCDS63269.1 [Q8WYA6-4]
RefSeqiNP_001268424.1, NM_001281495.1 [Q8WYA6-4]
NP_110517.2, NM_030877.4 [Q8WYA6-1]
XP_011527219.1, XM_011528917.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CB8X-ray2.90A77-563[»]
4CB9X-ray3.00A1-563[»]
4CBAX-ray3.10A77-563[»]
4HM9X-ray3.10A1-563[»]
4HNMX-ray2.90A75-563[»]
4MFUX-ray2.74A77-563[»]
4MFVX-ray2.92A/B33-563[»]
SMRiQ8WYA6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121123, 120 interactors
CORUMiQ8WYA6
IntActiQ8WYA6, 48 interactors
MINTiQ8WYA6
STRINGi9606.ENSP00000355050

PTM databases

iPTMnetiQ8WYA6
PhosphoSitePlusiQ8WYA6
SwissPalmiQ8WYA6

Polymorphism and mutation databases

BioMutaiCTNNBL1
DMDMi29840792

Proteomic databases

EPDiQ8WYA6
jPOSTiQ8WYA6
MassIVEiQ8WYA6
MaxQBiQ8WYA6
PaxDbiQ8WYA6
PeptideAtlasiQ8WYA6
PRIDEiQ8WYA6
ProteomicsDBi75151 [Q8WYA6-1]
75152 [Q8WYA6-2]
75153 [Q8WYA6-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
56259

Genome annotation databases

EnsembliENST00000361383; ENSP00000355050; ENSG00000132792 [Q8WYA6-1]
ENST00000373469; ENSP00000362568; ENSG00000132792 [Q8WYA6-3]
ENST00000373473; ENSP00000362572; ENSG00000132792 [Q8WYA6-2]
ENST00000405275; ENSP00000384355; ENSG00000132792 [Q8WYA6-4]
ENST00000628103; ENSP00000487198; ENSG00000132792 [Q8WYA6-4]
GeneIDi56259
KEGGihsa:56259
UCSCiuc002xhh.4 human [Q8WYA6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56259
DisGeNETi56259

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTNNBL1
HGNCiHGNC:15879 CTNNBL1
HPAiHPA004742
HPA027907
MIMi611537 gene
neXtProtiNX_Q8WYA6
OpenTargetsiENSG00000132792
PharmGKBiPA27015

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2734 Eukaryota
ENOG410XPFW LUCA
GeneTreeiENSGT00390000006931
InParanoidiQ8WYA6
KOiK12864
OrthoDBi724270at2759
PhylomeDBiQ8WYA6
TreeFamiTF314294

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CTNNBL1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CTNNBL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56259
PharosiQ8WYA6

Protein Ontology

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PROi
PR:Q8WYA6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132792 Expressed in 221 organ(s), highest expression level in testis
ExpressionAtlasiQ8WYA6 baseline and differential
GenevisibleiQ8WYA6 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039678 CTNNBL1
IPR013180 CTNNBL1_N
PANTHERiPTHR14978 PTHR14978, 1 hit
PfamiView protein in Pfam
PF08216 CTNNBL, 1 hit
SMARTiView protein in SMART
SM01156 DUF1716, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTBL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYA6
Secondary accession number(s): B4DE16
, Q0VAL9, Q0VAM0, Q53HI8, Q5JWZ2, Q5JWZ3, Q5JWZ7, Q5JWZ8, Q8N454, Q8NCL2, Q8TBD6, Q96KD2, Q9H7A5, Q9NQF9, Q9NTX0, Q9Y3M7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: October 16, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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