UniProtKB - Q8WYA1 (BMAL2_HUMAN)
Aryl hydrocarbon receptor nuclear translocator-like protein 2
ARNTL2
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- E-box binding Source: UniProtKB
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
GO - Biological processi
- circadian rhythm Source: MGI
- entrainment of circadian clock Source: UniProtKB
- positive regulation of circadian rhythm Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8WYA1 |
Reactomei | R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression |
SIGNORi | Q8WYA1 |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptor nuclear translocator-like protein 2Alternative name(s): Basic-helix-loop-helix-PAS protein MOP9 Brain and muscle ARNT-like 2 CYCLE-like factor Short name: CLIF Class E basic helix-loop-helix protein 6 Short name: bHLHe6 Member of PAS protein 9 PAS domain-containing protein 9 |
Gene namesi | Name:ARNTL2 Synonyms:BHLHE6, BMAL2, CLIF, MOP9, PASD9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000029153.14 |
HGNCi | HGNC:18984, ARNTL2 |
MIMi | 614517, gene |
neXtProti | NX_Q8WYA1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- cytoplasm Source: InterPro
- transcription regulator complex Source: InterPro
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 56938 |
OpenTargetsi | ENSG00000029153 |
PharmGKBi | PA134896555 |
Miscellaneous databases
Pharosi | Q8WYA1, Tbio |
Polymorphism and mutation databases
BioMutai | ARNTL2 |
DMDMi | 124007121 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273631 | 1 – 636 | Aryl hydrocarbon receptor nuclear translocator-like protein 2Add BLAST | 636 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 287 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)By similarity | ||
Cross-linki | 294 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q8WYA1 |
jPOSTi | Q8WYA1 |
MassIVEi | Q8WYA1 |
MaxQBi | Q8WYA1 |
PaxDbi | Q8WYA1 |
PeptideAtlasi | Q8WYA1 |
PRIDEi | Q8WYA1 |
ProteomicsDBi | 26427 75143 [Q8WYA1-1] 75144 [Q8WYA1-2] 75145 [Q8WYA1-3] 75146 [Q8WYA1-4] 75147 [Q8WYA1-5] 75148 [Q8WYA1-6] 75149 [Q8WYA1-7] 75150 [Q8WYA1-8] |
PTM databases
iPTMneti | Q8WYA1 |
PhosphoSitePlusi | Q8WYA1 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000029153, Expressed in lower esophagus mucosa and 155 other tissues |
ExpressionAtlasi | Q8WYA1, baseline and differential |
Genevisiblei | Q8WYA1, HS |
Organism-specific databases
HPAi | ENSG00000029153, Tissue enhanced (esophagus) |
Interactioni
Subunit structurei
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins.
Interacts directly with CLOCK to form the ARNTL2/BMAL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator.
Interacts with NPAS2 and HIF1A.
Interacts with PER2 (By similarity).
By similarity2 PublicationsBinary interactionsi
Hide detailsIsoform 3 [Q8WYA1-3]
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 121263, 26 interactors |
ComplexPortali | CPX-3230, CLOCK-BMAL2 transcription complex |
IntActi | Q8WYA1, 23 interactors |
STRINGi | 9606.ENSP00000266503 |
Miscellaneous databases
RNActi | Q8WYA1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8WYA1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 107 – 160 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 178 – 250 | PAS 1PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 357 – 427 | PAS 2PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 432 – 475 | PACAdd BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 46 – 258 | Interaction with PER2By similarityAdd BLAST | 213 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 49 – 54 | Nuclear localization signalBy similarity | 6 | |
Motifi | 177 – 187 | Nuclear export signal 1By similarityAdd BLAST | 11 | |
Motifi | 392 – 400 | Nuclear export signal 2By similarity | 9 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000160423 |
HOGENOMi | CLU_011864_2_2_1 |
InParanoidi | Q8WYA1 |
OMAi | IPQCNPV |
OrthoDBi | 331262at2759 |
PhylomeDBi | Q8WYA1 |
TreeFami | TF319983 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
s (9+)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR
60 70 80 90 100
KRKGSDSDPS QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSRVEDGE
110 120 130 140 150
HQVKMKAFRE AHSQTEKRRR DKMNNLIEEL SAMIPQCNPM ARKLDKLTVL
160 170 180 190 200
RMAVQHLRSL KGLTNSYVGS NYRPSFLQDN ELRHLILKTA EGFLFVVGCE
210 220 230 240 250
RGKILFVSKS VSKILNYDQA SLTGQSLFDF LHPKDVAKVK EQLSSFDISP
260 270 280 290 300
REKLIDAKTG LQVHSNLHAG RTRVYSGSRR SFFCRIKSCK ISVKEEHGCL
310 320 330 340 350
PNSKKKEHRK FYTIHCTGYL RSWPPNIVGM EEERNSKKDN SNFTCLVAIG
360 370 380 390 400
RLQPYIVPQN SGEINVKPTE FITRFAVNGK FVYVDQRATA ILGYLPQELL
410 420 430 440 450
GTSCYEYFHQ DDHNNLTDKH KAVLQSKEKI LTDSYKFRAK DGSFVTLKSQ
460 470 480 490 500
WFSFTNPWTK ELEYIVSVNT LVLGHSEPGE ASFLPCSSQS SEESSRQSCM
510 520 530 540 550
SVPGMSTGTV LGAGSIGTDI ANEILDLQRL QSSSYLDDSS PTGLMKDTHT
560 570 580 590 600
VNCRSMSNKE LFPPSPSEMG ELEATRQNQS TVAVHSHEPL LSDGAQLDFD
610 620 630
ALCDNDDTAM AAFMNYLEAE GGLGDPGDFS DIQWTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y5R1 | H0Y5R1_HUMAN | Aryl hydrocarbon receptor nuclear t... | ARNTL2 | 588 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | F → S in BAB01485 (PubMed:10964693).Curated | 1 | |
Sequence conflicti | 173 | R → G in BAH12415 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 257 | A → T in AAF71306 (PubMed:10864977).Curated | 1 | |
Sequence conflicti | 257 | A → T in AAF71307 (PubMed:10864977).Curated | 1 | |
Sequence conflicti | 276 | S → F in AAF71306 (PubMed:10864977).Curated | 1 | |
Sequence conflicti | 276 | S → F in AAF71307 (PubMed:10864977).Curated | 1 | |
Sequence conflicti | 304 | K → R in BAH12415 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 324 | P → R in BAB01485 (PubMed:10964693).Curated | 1 | |
Sequence conflicti | 527 | L → I in BAB01485 (PubMed:10964693).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030158 | 340 | N → S. Corresponds to variant dbSNP:rs1037921Ensembl. | 1 | |
Natural variantiVAR_030159 | 574 | A → V. Corresponds to variant dbSNP:rs11049005Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022580 | 1 – 37 | Missing in isoform 6, isoform 7 and isoform 8. 2 PublicationsAdd BLAST | 37 | |
Alternative sequenceiVSP_022585 | 11 | G → GEVAGGEATAPG in isoform 3 and isoform 9. 3 Publications | 1 | |
Alternative sequenceiVSP_022582 | 61 | Q → H in isoform 8. 1 Publication | 1 | |
Alternative sequenceiVSP_022581 | 62 – 95 | Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 9. 5 PublicationsAdd BLAST | 34 | |
Alternative sequenceiVSP_022583 | 62 – 74 | Missing in isoform 8. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_022584 | 96 – 109 | Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 7, isoform 8 and isoform 9. 5 PublicationsAdd BLAST | 14 | |
Alternative sequenceiVSP_044773 | 556 – 635 | MSNKE…DIQWT → VMVHSWISMPYVTMMTQPWL H in isoform 9. 1 PublicationAdd BLAST | 80 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB039921 mRNA Translation: BAB01485.1 AF256215 mRNA Translation: AAG34652.1 AF231338 mRNA Translation: AAF71306.1 AF231339 mRNA Translation: AAF71307.1 AF246960 mRNA Translation: AAL50339.1 AF246961 mRNA Translation: AAL50340.1 AF246962 mRNA Translation: AAL50341.1 AF246963 mRNA Translation: AAL50342.1 AK296706 mRNA Translation: BAH12415.1 AC068794 Genomic DNA No translation available. AC092829 Genomic DNA No translation available. BC000172 mRNA Translation: AAH00172.3 BC125061 mRNA Translation: AAI25062.1 BC125062 mRNA Translation: AAI25063.1 |
CCDSi | CCDS58219.1 [Q8WYA1-2] CCDS58220.1 [Q8WYA1-4] CCDS58221.1 [Q8WYA1-3] CCDS58222.1 [Q8WYA1-9] CCDS8712.1 [Q8WYA1-1] |
RefSeqi | NP_001234931.1, NM_001248002.1 [Q8WYA1-2] NP_001234932.1, NM_001248003.1 [Q8WYA1-3] NP_001234933.1, NM_001248004.1 [Q8WYA1-4] NP_001234934.1, NM_001248005.1 [Q8WYA1-9] NP_064568.3, NM_020183.4 [Q8WYA1-1] |
Genome annotation databases
Ensembli | ENST00000261178; ENSP00000261178; ENSG00000029153 [Q8WYA1-4] ENST00000266503; ENSP00000266503; ENSG00000029153 [Q8WYA1-1] ENST00000311001; ENSP00000312247; ENSG00000029153 [Q8WYA1-2] ENST00000395901; ENSP00000379238; ENSG00000029153 [Q8WYA1-3] ENST00000542388; ENSP00000445836; ENSG00000029153 [Q8WYA1-6] ENST00000544915; ENSP00000442438; ENSG00000029153 [Q8WYA1-5] ENST00000546179; ENSP00000438545; ENSG00000029153 [Q8WYA1-9] |
GeneIDi | 56938 |
KEGGi | hsa:56938 |
UCSCi | uc001rht.3, human [Q8WYA1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB039921 mRNA Translation: BAB01485.1 AF256215 mRNA Translation: AAG34652.1 AF231338 mRNA Translation: AAF71306.1 AF231339 mRNA Translation: AAF71307.1 AF246960 mRNA Translation: AAL50339.1 AF246961 mRNA Translation: AAL50340.1 AF246962 mRNA Translation: AAL50341.1 AF246963 mRNA Translation: AAL50342.1 AK296706 mRNA Translation: BAH12415.1 AC068794 Genomic DNA No translation available. AC092829 Genomic DNA No translation available. BC000172 mRNA Translation: AAH00172.3 BC125061 mRNA Translation: AAI25062.1 BC125062 mRNA Translation: AAI25063.1 |
CCDSi | CCDS58219.1 [Q8WYA1-2] CCDS58220.1 [Q8WYA1-4] CCDS58221.1 [Q8WYA1-3] CCDS58222.1 [Q8WYA1-9] CCDS8712.1 [Q8WYA1-1] |
RefSeqi | NP_001234931.1, NM_001248002.1 [Q8WYA1-2] NP_001234932.1, NM_001248003.1 [Q8WYA1-3] NP_001234933.1, NM_001248004.1 [Q8WYA1-4] NP_001234934.1, NM_001248005.1 [Q8WYA1-9] NP_064568.3, NM_020183.4 [Q8WYA1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KDK | NMR | - | A | 360-477 | [»] | |
SMRi | Q8WYA1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121263, 26 interactors |
ComplexPortali | CPX-3230, CLOCK-BMAL2 transcription complex |
IntActi | Q8WYA1, 23 interactors |
STRINGi | 9606.ENSP00000266503 |
PTM databases
iPTMneti | Q8WYA1 |
PhosphoSitePlusi | Q8WYA1 |
Polymorphism and mutation databases
BioMutai | ARNTL2 |
DMDMi | 124007121 |
Proteomic databases
EPDi | Q8WYA1 |
jPOSTi | Q8WYA1 |
MassIVEi | Q8WYA1 |
MaxQBi | Q8WYA1 |
PaxDbi | Q8WYA1 |
PeptideAtlasi | Q8WYA1 |
PRIDEi | Q8WYA1 |
ProteomicsDBi | 26427 75143 [Q8WYA1-1] 75144 [Q8WYA1-2] 75145 [Q8WYA1-3] 75146 [Q8WYA1-4] 75147 [Q8WYA1-5] 75148 [Q8WYA1-6] 75149 [Q8WYA1-7] 75150 [Q8WYA1-8] |
Protocols and materials databases
Antibodypediai | 12657, 116 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 56938 |
DisGeNETi | 56938 |
EuPathDBi | HostDB:ENSG00000029153.14 |
GeneCardsi | ARNTL2 |
HGNCi | HGNC:18984, ARNTL2 |
HPAi | ENSG00000029153, Tissue enhanced (esophagus) |
MIMi | 614517, gene |
neXtProti | NX_Q8WYA1 |
OpenTargetsi | ENSG00000029153 |
PharmGKBi | PA134896555 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000160423 |
HOGENOMi | CLU_011864_2_2_1 |
InParanoidi | Q8WYA1 |
OMAi | IPQCNPV |
OrthoDBi | 331262at2759 |
PhylomeDBi | Q8WYA1 |
TreeFami | TF319983 |
Enzyme and pathway databases
PathwayCommonsi | Q8WYA1 |
Reactomei | R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression |
SIGNORi | Q8WYA1 |
Miscellaneous databases
BioGRID-ORCSi | 56938, 11 hits in 866 CRISPR screens |
ChiTaRSi | ARNTL2, human |
GeneWikii | ARNTL2 |
GenomeRNAii | 56938 |
Pharosi | Q8WYA1, Tbio |
PROi | PR:Q8WYA1 |
RNActi | Q8WYA1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000029153, Expressed in lower esophagus mucosa and 155 other tissues |
ExpressionAtlasi | Q8WYA1, baseline and differential |
Genevisiblei | Q8WYA1, HS |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMAL2_HUMAN | |
Accessioni | Q8WYA1Primary (citable) accession number: Q8WYA1 Secondary accession number(s): B7Z429 Q9NYQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations