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Entry version 160 (22 Apr 2020)
Sequence version 2 (23 Jan 2007)
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Protein

Aryl hydrocarbon receptor nuclear translocator-like protein 2

Gene

ARNTL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8WYA1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Alternative name(s):
Basic-helix-loop-helix-PAS protein MOP9
Brain and muscle ARNT-like 2
CYCLE-like factor
Short name:
CLIF
Class E basic helix-loop-helix protein 6
Short name:
bHLHe6
Member of PAS protein 9
PAS domain-containing protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARNTL2
Synonyms:BHLHE6, BMAL2, CLIF, MOP9, PASD9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18984 ARNTL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614517 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WYA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56938

Open Targets

More...
OpenTargetsi
ENSG00000029153

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134896555

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WYA1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARNTL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124007121

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002736311 – 636Aryl hydrocarbon receptor nuclear translocator-like protein 2Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)By similarity
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WYA1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WYA1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WYA1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WYA1

PeptideAtlas

More...
PeptideAtlasi
Q8WYA1

PRoteomics IDEntifications database

More...
PRIDEi
Q8WYA1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
26427
75143 [Q8WYA1-1]
75144 [Q8WYA1-2]
75145 [Q8WYA1-3]
75146 [Q8WYA1-4]
75147 [Q8WYA1-5]
75148 [Q8WYA1-6]
75149 [Q8WYA1-7]
75150 [Q8WYA1-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WYA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WYA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Constitutively expressed. Has no circadian rhythm expression pattern.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000029153 Expressed in lower esophagus mucosa and 137 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WYA1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WYA1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000029153 Tissue enhanced (esophagus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins.

Interacts directly with CLOCK to form the ARNTL2/BMAL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator.

Interacts with NPAS2 and HIF1A.

Interacts with PER2 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121263, 23 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3230 CLOCK-BMAL2 transcription complex

Protein interaction database and analysis system

More...
IntActi
Q8WYA1, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266503

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WYA1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1636
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WYA1

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini107 – 160bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini178 – 250PAS 1PROSITE-ProRule annotationAdd BLAST73
Domaini357 – 427PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini432 – 475PACAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 258Interaction with PER2By similarityAdd BLAST213

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi49 – 54Nuclear localization signalBy similarity6
Motifi177 – 187Nuclear export signal 1By similarityAdd BLAST11
Motifi392 – 400Nuclear export signal 2By similarity9

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3561 Eukaryota
ENOG410XRJI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011864_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WYA1

KEGG Orthology (KO)

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KOi
K09099

Identification of Orthologs from Complete Genome Data

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OMAi
FAMDGKF

Database of Orthologous Groups

More...
OrthoDBi
331262at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WYA1

TreeFam database of animal gene trees

More...
TreeFami
TF319983

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit
cd00130 PAS, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00785 NCTRNSLOCATR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00229 sensory_box, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WYA1-1) [UniParc]FASTAAdd to basket
Also known as: BMAL2a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR
60 70 80 90 100
KRKGSDSDPS QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSRVEDGE
110 120 130 140 150
HQVKMKAFRE AHSQTEKRRR DKMNNLIEEL SAMIPQCNPM ARKLDKLTVL
160 170 180 190 200
RMAVQHLRSL KGLTNSYVGS NYRPSFLQDN ELRHLILKTA EGFLFVVGCE
210 220 230 240 250
RGKILFVSKS VSKILNYDQA SLTGQSLFDF LHPKDVAKVK EQLSSFDISP
260 270 280 290 300
REKLIDAKTG LQVHSNLHAG RTRVYSGSRR SFFCRIKSCK ISVKEEHGCL
310 320 330 340 350
PNSKKKEHRK FYTIHCTGYL RSWPPNIVGM EEERNSKKDN SNFTCLVAIG
360 370 380 390 400
RLQPYIVPQN SGEINVKPTE FITRFAVNGK FVYVDQRATA ILGYLPQELL
410 420 430 440 450
GTSCYEYFHQ DDHNNLTDKH KAVLQSKEKI LTDSYKFRAK DGSFVTLKSQ
460 470 480 490 500
WFSFTNPWTK ELEYIVSVNT LVLGHSEPGE ASFLPCSSQS SEESSRQSCM
510 520 530 540 550
SVPGMSTGTV LGAGSIGTDI ANEILDLQRL QSSSYLDDSS PTGLMKDTHT
560 570 580 590 600
VNCRSMSNKE LFPPSPSEMG ELEATRQNQS TVAVHSHEPL LSDGAQLDFD
610 620 630
ALCDNDDTAM AAFMNYLEAE GGLGDPGDFS DIQWTL
Length:636
Mass (Da):70,887
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i972CE2BC5B05B1F3
GO
Isoform 2 (identifier: Q8WYA1-2) [UniParc]FASTAAdd to basket
Also known as: BMAL2b

The sequence of this isoform differs from the canonical sequence as follows:
     96-109: Missing.

Show »
Length:622
Mass (Da):69,231
Checksum:iEE042DBFFB87BC63
GO
Isoform 3 (identifier: Q8WYA1-3) [UniParc]FASTAAdd to basket
Also known as: BMAL2c

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: G → GEVAGGEATAPG
     62-95: Missing.
     96-109: Missing.

Show »
Length:599
Mass (Da):66,493
Checksum:iA5B1B84DBC4B5B40
GO
Isoform 4 (identifier: Q8WYA1-4) [UniParc]FASTAAdd to basket
Also known as: BMAL2d

The sequence of this isoform differs from the canonical sequence as follows:
     62-95: Missing.
     96-109: Missing.

Show »
Length:588
Mass (Da):65,553
Checksum:i3D49ACC111064FD8
GO
Isoform 5 (identifier: Q8WYA1-5) [UniParc]FASTAAdd to basket
Also known as: CLIF

The sequence of this isoform differs from the canonical sequence as follows:
     62-95: Missing.

Show »
Length:602
Mass (Da):67,209
Checksum:iAD8937DD526D8B45
GO
Isoform 6 (identifier: Q8WYA1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     62-95: Missing.
     96-109: Missing.

Show »
Length:551
Mass (Da):61,788
Checksum:iF845E3F54FFA39B0
GO
Isoform 7 (identifier: Q8WYA1-7) [UniParc]FASTAAdd to basket
Also known as: MOP9 long form

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     96-109: Missing.

Show »
Length:585
Mass (Da):65,466
Checksum:iEE2E576065881B01
GO
Isoform 8 (identifier: Q8WYA1-8) [UniParc]FASTAAdd to basket
Also known as: MOP9 short form

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     61-61: Q → H
     62-74: Missing.
     96-109: Missing.

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Length:572
Mass (Da):64,072
Checksum:iFDDF781F6E2FDBC5
GO
Isoform 9 (identifier: Q8WYA1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: G → GEVAGGEATAPG
     62-95: Missing.
     96-109: Missing.
     556-635: MSNKELFPPS...PGDFSDIQWT → VMVHSWISMPYVTMMTQPWLH

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Length:540
Mass (Da):60,390
Checksum:i9C6DF2CB4CE1BB8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5R1H0Y5R1_HUMAN
Aryl hydrocarbon receptor nuclear t...
ARNTL2
588Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41F → S in BAB01485 (PubMed:10964693).Curated1
Sequence conflicti173R → G in BAH12415 (PubMed:14702039).Curated1
Sequence conflicti257A → T in AAF71306 (PubMed:10864977).Curated1
Sequence conflicti257A → T in AAF71307 (PubMed:10864977).Curated1
Sequence conflicti276S → F in AAF71306 (PubMed:10864977).Curated1
Sequence conflicti276S → F in AAF71307 (PubMed:10864977).Curated1
Sequence conflicti304K → R in BAH12415 (PubMed:14702039).Curated1
Sequence conflicti324P → R in BAB01485 (PubMed:10964693).Curated1
Sequence conflicti527L → I in BAB01485 (PubMed:10964693).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030158340N → S. Corresponds to variant dbSNP:rs1037921Ensembl.1
Natural variantiVAR_030159574A → V. Corresponds to variant dbSNP:rs11049005Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0225801 – 37Missing in isoform 6, isoform 7 and isoform 8. 2 PublicationsAdd BLAST37
Alternative sequenceiVSP_02258511G → GEVAGGEATAPG in isoform 3 and isoform 9. 3 Publications1
Alternative sequenceiVSP_02258261Q → H in isoform 8. 1 Publication1
Alternative sequenceiVSP_02258162 – 95Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 9. 5 PublicationsAdd BLAST34
Alternative sequenceiVSP_02258362 – 74Missing in isoform 8. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_02258496 – 109Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 7, isoform 8 and isoform 9. 5 PublicationsAdd BLAST14
Alternative sequenceiVSP_044773556 – 635MSNKE…DIQWT → VMVHSWISMPYVTMMTQPWL H in isoform 9. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB039921 mRNA Translation: BAB01485.1
AF256215 mRNA Translation: AAG34652.1
AF231338 mRNA Translation: AAF71306.1
AF231339 mRNA Translation: AAF71307.1
AF246960 mRNA Translation: AAL50339.1
AF246961 mRNA Translation: AAL50340.1
AF246962 mRNA Translation: AAL50341.1
AF246963 mRNA Translation: AAL50342.1
AK296706 mRNA Translation: BAH12415.1
AC068794 Genomic DNA No translation available.
AC092829 Genomic DNA No translation available.
BC000172 mRNA Translation: AAH00172.3
BC125061 mRNA Translation: AAI25062.1
BC125062 mRNA Translation: AAI25063.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58219.1 [Q8WYA1-2]
CCDS58220.1 [Q8WYA1-4]
CCDS58221.1 [Q8WYA1-3]
CCDS58222.1 [Q8WYA1-9]
CCDS8712.1 [Q8WYA1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001234931.1, NM_001248002.1 [Q8WYA1-2]
NP_001234932.1, NM_001248003.1 [Q8WYA1-3]
NP_001234933.1, NM_001248004.1 [Q8WYA1-4]
NP_001234934.1, NM_001248005.1 [Q8WYA1-9]
NP_064568.3, NM_020183.4 [Q8WYA1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261178; ENSP00000261178; ENSG00000029153 [Q8WYA1-4]
ENST00000266503; ENSP00000266503; ENSG00000029153 [Q8WYA1-1]
ENST00000311001; ENSP00000312247; ENSG00000029153 [Q8WYA1-2]
ENST00000395901; ENSP00000379238; ENSG00000029153 [Q8WYA1-3]
ENST00000542388; ENSP00000445836; ENSG00000029153 [Q8WYA1-6]
ENST00000544915; ENSP00000442438; ENSG00000029153 [Q8WYA1-5]
ENST00000546179; ENSP00000438545; ENSG00000029153 [Q8WYA1-9]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56938

UCSC genome browser

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UCSCi
uc001rht.3 human [Q8WYA1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039921 mRNA Translation: BAB01485.1
AF256215 mRNA Translation: AAG34652.1
AF231338 mRNA Translation: AAF71306.1
AF231339 mRNA Translation: AAF71307.1
AF246960 mRNA Translation: AAL50339.1
AF246961 mRNA Translation: AAL50340.1
AF246962 mRNA Translation: AAL50341.1
AF246963 mRNA Translation: AAL50342.1
AK296706 mRNA Translation: BAH12415.1
AC068794 Genomic DNA No translation available.
AC092829 Genomic DNA No translation available.
BC000172 mRNA Translation: AAH00172.3
BC125061 mRNA Translation: AAI25062.1
BC125062 mRNA Translation: AAI25063.1
CCDSiCCDS58219.1 [Q8WYA1-2]
CCDS58220.1 [Q8WYA1-4]
CCDS58221.1 [Q8WYA1-3]
CCDS58222.1 [Q8WYA1-9]
CCDS8712.1 [Q8WYA1-1]
RefSeqiNP_001234931.1, NM_001248002.1 [Q8WYA1-2]
NP_001234932.1, NM_001248003.1 [Q8WYA1-3]
NP_001234933.1, NM_001248004.1 [Q8WYA1-4]
NP_001234934.1, NM_001248005.1 [Q8WYA1-9]
NP_064568.3, NM_020183.4 [Q8WYA1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KDKNMR-A360-477[»]
SMRiQ8WYA1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121263, 23 interactors
ComplexPortaliCPX-3230 CLOCK-BMAL2 transcription complex
IntActiQ8WYA1, 23 interactors
STRINGi9606.ENSP00000266503

PTM databases

iPTMnetiQ8WYA1
PhosphoSitePlusiQ8WYA1

Polymorphism and mutation databases

BioMutaiARNTL2
DMDMi124007121

Proteomic databases

EPDiQ8WYA1
MassIVEiQ8WYA1
MaxQBiQ8WYA1
PaxDbiQ8WYA1
PeptideAtlasiQ8WYA1
PRIDEiQ8WYA1
ProteomicsDBi26427
75143 [Q8WYA1-1]
75144 [Q8WYA1-2]
75145 [Q8WYA1-3]
75146 [Q8WYA1-4]
75147 [Q8WYA1-5]
75148 [Q8WYA1-6]
75149 [Q8WYA1-7]
75150 [Q8WYA1-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12657 114 antibodies

Genome annotation databases

EnsembliENST00000261178; ENSP00000261178; ENSG00000029153 [Q8WYA1-4]
ENST00000266503; ENSP00000266503; ENSG00000029153 [Q8WYA1-1]
ENST00000311001; ENSP00000312247; ENSG00000029153 [Q8WYA1-2]
ENST00000395901; ENSP00000379238; ENSG00000029153 [Q8WYA1-3]
ENST00000542388; ENSP00000445836; ENSG00000029153 [Q8WYA1-6]
ENST00000544915; ENSP00000442438; ENSG00000029153 [Q8WYA1-5]
ENST00000546179; ENSP00000438545; ENSG00000029153 [Q8WYA1-9]
GeneIDi56938
KEGGihsa:56938
UCSCiuc001rht.3 human [Q8WYA1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56938
DisGeNETi56938

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARNTL2
HGNCiHGNC:18984 ARNTL2
HPAiENSG00000029153 Tissue enhanced (esophagus)
MIMi614517 gene
neXtProtiNX_Q8WYA1
OpenTargetsiENSG00000029153
PharmGKBiPA134896555

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3561 Eukaryota
ENOG410XRJI LUCA
GeneTreeiENSGT00940000160423
HOGENOMiCLU_011864_2_2_1
InParanoidiQ8WYA1
KOiK09099
OMAiFAMDGKF
OrthoDBi331262at2759
PhylomeDBiQ8WYA1
TreeFamiTF319983

Enzyme and pathway databases

ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
SIGNORiQ8WYA1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARNTL2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARNTL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56938
PharosiQ8WYA1 Tbio

Protein Ontology

More...
PROi
PR:Q8WYA1
RNActiQ8WYA1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000029153 Expressed in lower esophagus mucosa and 137 other tissues
ExpressionAtlasiQ8WYA1 baseline and differential
GenevisibleiQ8WYA1 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBMAL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WYA1
Secondary accession number(s): B7Z429
, F5H402, Q8WYA2, Q8WYA3, Q8WYA4, Q96J63, Q9H2M4, Q9NS70, Q9NYQ4, Q9NYQ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 22, 2020
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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