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Entry version 136 (13 Feb 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Protein phosphatase 1E

Gene

PPM1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi273Manganese 1By similarity1
Metal bindingi273Manganese 2By similarity1
Metal bindingi274Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi435Manganese 2By similarity1
Metal bindingi479Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • magnesium-dependent protein serine/threonine phosphatase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8WY54

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1E (EC:3.1.3.16)
Alternative name(s):
Ca(2+)/calmodulin-dependent protein kinase phosphatase N
Short name:
CaMKP-N
CaMKP-nucleus
Short name:
CaMKN
Partner of PIX 1
Partner of PIX-alpha
Short name:
Partner of PIXA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPM1E
Synonyms:CAMKN, KIAA1072, POPX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175175.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19322 PPM1E

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WY54

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22843

Open Targets

More...
OpenTargetsi
ENSG00000175175

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134943567

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPM1E

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033412

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002868201 – 755Protein phosphatase 1EAdd BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei535PhosphoserineBy similarity1
Modified residuei548PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WY54

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WY54

PeptideAtlas

More...
PeptideAtlasi
Q8WY54

PRoteomics IDEntifications database

More...
PRIDEi
Q8WY54

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75128
75129 [Q8WY54-2]
75130 [Q8WY54-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q8WY54

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8WY54

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8WY54

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000175175 Expressed in 113 organ(s), highest expression level in endothelial cell

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WY54 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018462
HPA019263

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116515, 29 interactors

Protein interaction database and analysis system

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IntActi
Q8WY54, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000312411

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WY54

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WY54

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati31 – 3212
Repeati33 – 3422
Repeati35 – 3632
Repeati37 – 3842
Repeati39 – 4052
Repeati41 – 4262
Repeati43 – 4472
Repeati45 – 468; approximate2
Repeati47 – 4892
Repeati49 – 50102
Repeati51 – 52112
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini231 – 488PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 5211 X 2 AA tandem repeats of P-EAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 100Glu-richAdd BLAST94

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0698 Eukaryota
COG0631 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157884

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059266

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG098260

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WY54

KEGG Orthology (KO)

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KOi
K17501

Identification of Orthologs from Complete Genome Data

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OMAi
HYSKKWH

Database of Orthologous Groups

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OrthoDBi
1044139at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8WY54

TreeFam database of animal gene trees

More...
TreeFami
TF317617

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00143 PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13832 PTHR13832, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00481 PP2C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00332 PP2Cc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81606 SSF81606, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q8WY54-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGCIPEEKT YRRFLELFLG EFRGPCGGGE PEPEPEPEPE PEPESEPEPE
60 70 80 90 100
PELVEAEAAE ASVEEPGEEA ATVAATEEGD QEQDPEPEEE AAVEGEEEEE
110 120 130 140 150
GAATAAAAPG HSAVPPPPPQ LPPLPPLPRP LSERITREEV EGESLDLCLQ
160 170 180 190 200
QLYKYNCPSF LAAALARATS DEVLQSDLSA HYIPKETDGT EGTVEIETVK
210 220 230 240 250
LARSVFSKLH EICCSWVKDF PLRRRPQLYY ETSIHAIKNM RRKMEDKHVC
260 270 280 290 300
IPDFNMLFNL EDQEEQAYFA VFDGHGGVDA AIYASIHLHV NLVRQEMFPH
310 320 330 340 350
DPAEALCRAF RVTDERFVQK AARESLRCGT TGVVTFIRGN MLHVAWVGDS
360 370 380 390 400
QVMLVRKGQA VELMKPHKPD REDEKQRIEA LGGCVVWFGA WRVNGSLSVS
410 420 430 440 450
RAIGDAEHKP YICGDADSAS TVLDGTEDYL ILACDGFYDT VNPDEAVKVV
460 470 480 490 500
SDHLKENNGD SSMVAHKLVA SARDAGSSDN ITVIVVFLRD MNKAVNVSEE
510 520 530 540 550
SDWTENSFQG GQEDGGDDKE NHGECKRPWP QHQCSAPADL GYDGRVDSFT
560 570 580 590 600
DRTSLSPGSQ INVLEDPGYL DLTQIEASKP HSAQFLLPVE MFGPGAPKKA
610 620 630 640 650
NLINELMMEK KSVQSSLPEW SGAGEFPTAF NLGSTGEQIY RMQSLSPVCS
660 670 680 690 700
GLENEQFKSP GNRVSRLSHL RHHYSKKWHR FRFNPKFYSF LSAQEPSHKI
710 720 730 740 750
GTSLSSLTGS GKRNRIRSSL PWRQNSWKGY SENMRKLRKT HDIPCPDLPW

SYKIE
Length:755
Mass (Da):83,952
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC24C64A0A1BC1091
GO
Isoform 3 (identifier: Q8WY54-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-261: MAGCIPEEKT...PDFNMLFNLE → MKSFRVIFLHIISQRKRMAQKGLW

Note: No experimental confirmation available.
Show »
Length:518
Mass (Da):58,021
Checksum:i61334BB8591B377E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF70325 differs from that shown. Contains a 27 bp insertion which does not match the genome.Curated
The sequence BAA83024 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53L → P in DA497512 (PubMed:16344560).Curated1
Sequence conflicti385V → I in AAF70325 (Ref. 2) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-Pro-Glu stretch is polymorphic.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06376944E → EPE7 Publications1
Natural variantiVAR_036518222L → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036519311R → G in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0251981 – 261MAGCI…LFNLE → MKSFRVIFLHIISQRKRMAQ KGLW in isoform 3. 1 PublicationAdd BLAST261

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF520614 mRNA Translation: AAM76058.1
AF260269 mRNA Translation: AAF70325.1 Sequence problems.
AB028995 mRNA Translation: BAA83024.2 Different initiation.
AK289966 mRNA Translation: BAF82655.1
CR749253 mRNA Translation: CAH18109.1
AC025521 Genomic DNA No translation available.
AC100832 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94429.1
BC136290 mRNA Translation: AAI36291.1
BC151228 mRNA Translation: AAI51229.1
DA497512 mRNA No translation available.
DA791319 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11613.1 [Q8WY54-2]

NCBI Reference Sequences

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RefSeqi
NP_055721.3, NM_014906.4 [Q8WY54-2]
XP_005257226.1, XM_005257169.4
XP_011522836.1, XM_011524534.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.245044

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308249; ENSP00000312411; ENSG00000175175 [Q8WY54-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22843

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22843

UCSC genome browser

More...
UCSCi
uc002iwx.5 human [Q8WY54-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520614 mRNA Translation: AAM76058.1
AF260269 mRNA Translation: AAF70325.1 Sequence problems.
AB028995 mRNA Translation: BAA83024.2 Different initiation.
AK289966 mRNA Translation: BAF82655.1
CR749253 mRNA Translation: CAH18109.1
AC025521 Genomic DNA No translation available.
AC100832 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94429.1
BC136290 mRNA Translation: AAI36291.1
BC151228 mRNA Translation: AAI51229.1
DA497512 mRNA No translation available.
DA791319 mRNA No translation available.
CCDSiCCDS11613.1 [Q8WY54-2]
RefSeqiNP_055721.3, NM_014906.4 [Q8WY54-2]
XP_005257226.1, XM_005257169.4
XP_011522836.1, XM_011524534.2
UniGeneiHs.245044

3D structure databases

ProteinModelPortaliQ8WY54
SMRiQ8WY54
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116515, 29 interactors
IntActiQ8WY54, 1 interactor
STRINGi9606.ENSP00000312411

PTM databases

DEPODiQ8WY54
iPTMnetiQ8WY54
PhosphoSitePlusiQ8WY54

Polymorphism and mutation databases

BioMutaiPPM1E
DMDMi311033412

Proteomic databases

EPDiQ8WY54
PaxDbiQ8WY54
PeptideAtlasiQ8WY54
PRIDEiQ8WY54
ProteomicsDBi75128
75129 [Q8WY54-2]
75130 [Q8WY54-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
22843
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308249; ENSP00000312411; ENSG00000175175 [Q8WY54-2]
GeneIDi22843
KEGGihsa:22843
UCSCiuc002iwx.5 human [Q8WY54-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22843
DisGeNETi22843
EuPathDBiHostDB:ENSG00000175175.5

GeneCards: human genes, protein and diseases

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GeneCardsi
PPM1E

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0014038
HGNCiHGNC:19322 PPM1E
HPAiHPA018462
HPA019263
neXtProtiNX_Q8WY54
OpenTargetsiENSG00000175175
PharmGKBiPA134943567

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00940000157884
HOGENOMiHOG000059266
HOVERGENiHBG098260
InParanoidiQ8WY54
KOiK17501
OMAiHYSKKWH
OrthoDBi1044139at2759
PhylomeDBiQ8WY54
TreeFamiTF317617

Enzyme and pathway databases

ReactomeiR-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission
SIGNORiQ8WY54

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPM1E human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22843

Protein Ontology

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PROi
PR:Q8WY54

Gene expression databases

BgeeiENSG00000175175 Expressed in 113 organ(s), highest expression level in endothelial cell
GenevisibleiQ8WY54 HS

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPM1E_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WY54
Secondary accession number(s): A7E2X1
, Q68DW1, Q7LAF3, Q9UPT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 28, 2018
Last modified: February 13, 2019
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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