NANOS1

Functionⁱ

May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	213 – 267	Nanos-typePROSITE-ProRule annotationAdd BLAST		55

GO - Molecular functionⁱ

RNA binding Source: UniProtKB-KW
translation repressor activity Source: UniProtKB
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 18223680
cerebellar neuron development Source: Ensembl
epithelial cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 17047063
negative regulation of translation
Source: BHF-UCL
Inferred from direct assayⁱ
- 24736845
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Source: BHF-UCL
Inferred from direct assayⁱ
- 24736845
posttranscriptional regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 25100735
regulation of cell growth Source: Ensembl
tissue homeostasis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor, RNA-binding
Biological process	Translation regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nanos homolog 1 Short name: NOS-1 Alternative name(s): EC_Rep1a
Gene namesⁱ	Name:NANOS1 Synonyms:NOS1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188613.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23044 NANOS1
MIMⁱ	608226 gene
neXtProtⁱ	NX_Q8WY41

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spermatogenic failure 12 (SPGF12)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_070570	78	Missing in SPGF12. 1 Publication		1
Natural variantⁱVAR_070571	173	Missing in SPGF12. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	340719
MalaCards human disease database More...MalaCardsⁱ	NANOS1
MIMⁱ	615413 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000188613
Orphanetⁱ	399805 Male infertility with azoospermia or oligozoospermia due to single gene mutation 399808 Male infertility with teratozoospermia due to single gene mutation
PharmGKBⁱ	PA134876543

Polymorphism and mutation databases

BioMutaⁱ	NANOS1
DMDMⁱ	41688589

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000207685	1 – 292	Nanos homolog 1Add BLAST		292

Proteomic databases

PaxDbⁱ	Q8WY41
PeptideAtlas More...PeptideAtlasⁱ	Q8WY41
PRIDEⁱ	Q8WY41
ProteomicsDBⁱ	75126

PTM databases

iPTMnetⁱ	Q8WY41
PhosphoSitePlusⁱ	Q8WY41

Expressionⁱ

Tissue specificityⁱ

Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.5 Publications

Developmental stageⁱ

Fetal ovary and fetal testis (at protein level).1 Publication

Inductionⁱ

Down-regulated by E-cadherin.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000188613
CleanExⁱ	HS_NANOS1 HS_NOS1
ExpressionAtlasⁱ	Q8WY41 baseline and differential
Genevisibleⁱ	Q8WY41 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB012219

HPAⁱ

CAB012219

Interactionⁱ

Subunit structureⁱ

Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1. Interacts with DDX20 (via N-terminal region).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CTNND1	O60716-21	2	EBI-9630165,EBI-9634525

With

Entry

#Exp.

IntAct

Notes

CTNND1

O60716-21

2

EBI-9630165,EBI-9634525

Protein-protein interaction databases

BioGridⁱ	131092, 3 interactors
ELMⁱ	Q8WY41
IntActⁱ	Q8WY41, 1 interactor
STRINGⁱ	9606.ENSP00000393275

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	43 – 47	Combined sources		5
Turnⁱ	51 – 53	Combined sources		3

3D structure databases

ProteinModelPortalⁱ	Q8WY41
SMRⁱ	Q8WY41
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	40 – 56	Essential for its translational repressor activityBy similarityAdd BLAST		17

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	214 – 241	C2HC 1Add BLAST		28
Motifⁱ	249 – 265	C2HC 2Add BLAST		17

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	136 – 204	Ala-richAdd BLAST		69

Domainⁱ

The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.PROSITE-ProRule annotation

The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.

Sequence similaritiesⁱ

Belongs to the nanos family.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	213 – 267	Nanos-typePROSITE-ProRule annotationAdd BLAST		55

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4602 Eukaryota ENOG41121KZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00640000091383
HOGENOMⁱ	HOG000113729
HOVERGENⁱ	HBG052574
InParanoidⁱ	Q8WY41
KEGG Orthology (KO) More...KOⁱ	K18741
OMAⁱ	LCAGPAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JUB
PhylomeDBⁱ	Q8WY41
TreeFamⁱ	TF326882

Family and domain databases

Gene3Dⁱ	1.10.150.680, 1 hit
InterProⁱ	View protein in InterPro IPR008705 Nanos/Xcar2 IPR038129 Nanos_sf IPR024161 Znf_nanos-typ
PANTHERⁱ	PTHR12887 PTHR12887, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05741 zf-nanos, 1 hit
PROSITEⁱ	View protein in PROSITE PS51522 ZF_NANOS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WY41-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAFPWAPRS PRRGRAPPPM ALVPSARYVS APGPAHPQPF SSWNDYLGLA 
        60         70         80         90        100
TLITKAVDGE PRFGCARGGN GGGGSPPSSS SSSCCSPHTG AGPGALGPAL 
       110        120        130        140        150
GPPDYDEDDD DDSDEPGSRG RYLGSALELR ALELCAGPAE AGLLEERFAE 
       160        170        180        190        200
LSPFAGRAAA VLLGCAPAAA AAATTTSEAT PREERAPAWA AEPRLHAASG 
       210        220        230        240        250
AAAARLLKPE LQVCVFCRNN KEAMALYTTH ILKGPDGRVL CPVLRRYTCP 
       260        270        280        290 
LCGASGDNAH TIKYCPLSKV PPPPARPPPR SARDGPPGKK LR

Length:292

Mass (Da):30,230

Last modified:February 2, 2004 - v2

Checksum:ⁱ1E41AAE68992CDD7

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_070569	34	P → T1 PublicationCorresponds to variant dbSNP:rs191267549Ensembl.	1
Natural variantⁱVAR_070570	78	Missing in SPGF12. 1 Publication	1
Natural variantⁱVAR_070571	173	Missing in SPGF12. 1 Publication	1
Natural variantⁱVAR_070572	246	R → H Found in a patient affected by oligo-astheno-teratozoospermia also carrying Y-276 on the same allele; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777767EnsemblClinVar.	1
Natural variantⁱVAR_070573	276	R → Y Found in a patient affected by oligo-astheno-teratozoospermia also carrying H-246 on the same allele; requires 2 nucleotide substitutions; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777768EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF275269 mRNA Translation: AAL36982.2 AF458985 mRNA Translation: AAQ04765.1 AL157788 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7607.1
NCBI Reference Sequences More...RefSeqⁱ	NP_955631.1, NM_199461.3
UniGeneⁱ	Hs.591918

Genome annotation databases

Ensemblⁱ	ENST00000425699; ENSP00000393275; ENSG00000188613
GeneIDⁱ	340719
KEGGⁱ	hsa:340719
UCSC genome browser More...UCSCⁱ	uc009xzf.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8WY41	UPI0009812670		CASCN		303
NANOS1 isoform 1		PONAB		294
UPI000C2FA330		FELCA		294
UPI000D5326BD		BOVIN		293
UPI0008476010		CAPHI		292
+19

Protein	Similar proteins		Species	Score	Length
Q8WY41	UPI0009812670		CASCN		303
NANOS1 isoform 1		PONAB		294
UPI000C2FA330		FELCA		294
UPI000D5326BD		BOVIN		293
UPI0008476010		CAPHI		292
+35

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF275269 mRNA Translation: AAL36982.2 AF458985 mRNA Translation: AAQ04765.1 AL157788 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7607.1
NCBI Reference Sequences More...RefSeqⁱ	NP_955631.1, NM_199461.3
UniGeneⁱ	Hs.591918

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4CQO	X-ray	2.80	B/D	40-56	[»]
ProteinModelPortalⁱ	Q8WY41
SMRⁱ	Q8WY41
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131092, 3 interactors
ELMⁱ	Q8WY41
IntActⁱ	Q8WY41, 1 interactor
STRINGⁱ	9606.ENSP00000393275

PTM databases

iPTMnetⁱ	Q8WY41
PhosphoSitePlusⁱ	Q8WY41

Polymorphism and mutation databases

BioMutaⁱ	NANOS1
DMDMⁱ	41688589

Proteomic databases

PaxDbⁱ	Q8WY41
PeptideAtlas More...PeptideAtlasⁱ	Q8WY41
PRIDEⁱ	Q8WY41
ProteomicsDBⁱ	75126

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	340719
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000425699; ENSP00000393275; ENSG00000188613
GeneIDⁱ	340719
KEGGⁱ	hsa:340719
UCSC genome browser More...UCSCⁱ	uc009xzf.2 human

Organism-specific databases

CTDⁱ	340719
DisGeNET More...DisGeNETⁱ	340719
EuPathDBⁱ	HostDB:ENSG00000188613.6
GeneCardsⁱ	NANOS1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23044 NANOS1
Human Protein Atlas More...HPAⁱ	CAB012219
MalaCards human disease database More...MalaCardsⁱ	NANOS1
MIMⁱ	608226 gene 615413 phenotype
neXtProtⁱ	NX_Q8WY41
Open Targets More...OpenTargetsⁱ	ENSG00000188613
Orphanetⁱ	399805 Male infertility with azoospermia or oligozoospermia due to single gene mutation 399808 Male infertility with teratozoospermia due to single gene mutation
PharmGKBⁱ	PA134876543
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4602 Eukaryota ENOG41121KZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00640000091383
HOGENOMⁱ	HOG000113729
HOVERGENⁱ	HBG052574
InParanoidⁱ	Q8WY41
KEGG Orthology (KO) More...KOⁱ	K18741
OMAⁱ	LCAGPAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JUB
PhylomeDBⁱ	Q8WY41
TreeFamⁱ	TF326882

Miscellaneous databases

ChiTaRSⁱ	NANOS1 human
GenomeRNAiⁱ	340719
Protein Ontology More...PROⁱ	PR:Q8WY41
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188613
CleanExⁱ	HS_NANOS1 HS_NOS1
ExpressionAtlasⁱ	Q8WY41 baseline and differential
Genevisibleⁱ	Q8WY41 HS

Family and domain databases

Gene3Dⁱ	1.10.150.680, 1 hit
InterProⁱ	View protein in InterPro IPR008705 Nanos/Xcar2 IPR038129 Nanos_sf IPR024161 Znf_nanos-typ
PANTHERⁱ	PTHR12887 PTHR12887, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05741 zf-nanos, 1 hit
PROSITEⁱ	View protein in PROSITE PS51522 ZF_NANOS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NANO1_HUMAN
Accessionⁱ	Q8WY41Primary (citable) accession number: Q8WY41
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
	Last sequence update:	February 2, 2004
	Last modified:	June 20, 2018
	This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8WY41 (NANO1_HUMAN)

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Nanos homolog 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ