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Entry version 139 (08 May 2019)
Sequence version 1 (01 Mar 2002)
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Protein

HMG box transcription factor BBX

Gene

BBX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that is necessary for cell cycle progression from G1 to S phase.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi80 – 148HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HMG box transcription factor BBX
Alternative name(s):
Bobby sox homolog
HMG box-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BBX
Synonyms:HBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14422 BBX

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WY36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56987

Open Targets

More...
OpenTargetsi
ENSG00000114439

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25280

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BBX

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74724044

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002328851 – 941HMG box transcription factor BBXAdd BLAST941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei243PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki385Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei478PhosphoserineBy similarity1
Modified residuei485PhosphoserineCombined sources1
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki696Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei704PhosphoserineCombined sources1
Modified residuei822PhosphoserineCombined sources1
Modified residuei844PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WY36

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WY36

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WY36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WY36

PeptideAtlas

More...
PeptideAtlasi
Q8WY36

PRoteomics IDEntifications database

More...
PRIDEi
Q8WY36

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75124
75125 [Q8WY36-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WY36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WY36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114439 Expressed in 246 organ(s), highest expression level in corpus epididymis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WY36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8WY36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006049
HPA050646

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121304, 42 interactors

Protein interaction database and analysis system

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IntActi
Q8WY36, 11 interactors

Molecular INTeraction database

More...
MINTi
Q8WY36

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319974

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WY36

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili326 – 370Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 50Poly-Glu10
Compositional biasi446 – 542Lys-richAdd BLAST97
Compositional biasi671 – 773Lys-richAdd BLAST103

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITBH Eukaryota
ENOG410Y941 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158592

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236273

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WY36

KEGG Orthology (KO)

More...
KOi
K21643

Identification of Orthologs from Complete Genome Data

More...
OMAi
MENVHRS

Database of Orthologous Groups

More...
OrthoDBi
1641977at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WY36

TreeFam database of animal gene trees

More...
TreeFami
TF106402

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR019102 TF_HMG_box_BBX_DUF2028

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09667 DUF2028, 1 hit
PF00505 HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WY36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGSNRNKDH SAEGEGVGKR PKRKCLQWHP LLAKKLLDFS EEEEEEDEEE
60 70 80 90 100
DIDKVQLLGA DGLEQDVGET EDDESPEQRA RRPMNAFLLF CKRHRSLVRQ
110 120 130 140 150
EHPRLDNRGA TKILADWWAV LDPKEKQKYT DMAKEYKDAF MKANPGYKWC
160 170 180 190 200
PTTNKPVKSP TPTVNPRKKL WAFPSDSSRD LPSPKKAKTE EMPQLNFGMA
210 220 230 240 250
DPTQMGGLSM LLLAGEHALG TPEVSSGTCR PDVSESPELR QKSPLFQFAE
260 270 280 290 300
ISSSTSHSDA STKQCQTSAL FQFAEISSNT SQLGGAEPVK RCGKSALFQL
310 320 330 340 350
AEMCLASEGM KMEESKLIKA KESDGGRIKE LEKGKEEKEI KMEKTDETRL
360 370 380 390 400
QKEAEFEKSA KENLRDSKEL RNFEALQIDD IMAIKMEDPK EIRKEELEED
410 420 430 440 450
HKCSHFPDFS YSASSKIIIS DVPSRKDHMC HPHGIMIIED PAALNKPEKL
460 470 480 490 500
KKKKKKSKMD RHGNDKSTPK KTCKKRQSSE SDIESVIYTI EAVAKGDWGI
510 520 530 540 550
EKLGDTPRKK VRTSSSGKGS ILDAKPPKKK VKSREKKMSK EKSSDTTKES
560 570 580 590 600
RPPDFISISA SKNISGETPE GIKAEPLTPM EDALPPSLSG QAKPEDSDCH
610 620 630 640 650
RKIETCGSRK SERSCKGALY KTLVSEGMLT SLRANVDRGK RSSGKGNSSD
660 670 680 690 700
HEGCWNEESW TFSQSGTSGS KKFKKTKPKE DCLLGSAKLD EEFEKKFNSL
710 720 730 740 750
PQYSPVTFDR KCVPVPRKKK KTGNVSSEPT KTSKGPFQSQ KKNLFHKIVS
760 770 780 790 800
KYKHKKEKPN VPEKGSGDKW SNKQLFLDAI HPTEAIFSED RNTMEPVHKV
810 820 830 840 850
KNIPSIFNTP EPTTTQEPLV GSQKRKARKT KITHLVRTAD GRVSPAGGTL
860 870 880 890 900
DDKPKEQLQR SLPKATETDC NDKCSHNTEV GETRSSTPEM PAVSAFFSLA
910 920 930 940
ALAEVAAMEN VHRGQRSTPL THDGQPKEMP QAPVLISCAD Q
Length:941
Mass (Da):105,130
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE45B359A602B5D8D
GO
Isoform 2 (identifier: Q8WY36-2) [UniParc]FASTAAdd to basket
Also known as: BBXa

The sequence of this isoform differs from the canonical sequence as follows:
     735-764: Missing.

Show »
Length:911
Mass (Da):101,555
Checksum:i3D048BF5C0076D37
GO
Isoform 3 (identifier: Q8WY36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-628: MCLASEGMKM...LYKTLVSEGM → ENEAQEKETP...YPSLVFTEGC
     629-941: Missing.

Note: No experimental confirmation available.
Show »
Length:628
Mass (Da):71,487
Checksum:i5635A9387F0EBD10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JA69C9JA69_HUMAN
HMG box transcription factor BBX
BBX
891Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8D0C9J8D0_HUMAN
HMG box transcription factor BBX
BBX
448Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYU6C9JYU6_HUMAN
HMG box transcription factor BBX
BBX
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZA0C9JZA0_HUMAN
HMG box transcription factor BBX
BBX
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0D1C9K0D1_HUMAN
HMG box transcription factor BBX
BBX
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNU3C9JNU3_HUMAN
HMG box transcription factor BBX
BBX
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIZ2C9JIZ2_HUMAN
HMG box transcription factor BBX
BBX
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSH4C9JSH4_HUMAN
HMG box transcription factor BBX
BBX
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0J4C9J0J4_HUMAN
HMG box transcription factor BBX
BBX
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1Q0H7C1Q0_HUMAN
HMG box transcription factor BBX
BBX
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI10904 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061264576P → S. Corresponds to variant dbSNP:rs59781647Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054880303 – 628MCLAS…VSEGM → ENEAQEKETPLIMKGVGMKK AGHLVRVGPVGARSSRRQSQ KKTVSLAPQSWMKNLKKNST ASLNIVLLHLTGNVYLSQEK RRRLEMCPQNRLKPAKVLSS LRKRTYSTKLSANISTKRRS PMFRKKEVGINGQTSNSSWM PFTLQKPYFQKTETPWSLFI RLKISHPFSTLQSQQQRKNL WWAAKREKQGKPRLHTLSGQ QMAGYHQQEVLWMTNQRNNC RGVSLKQLRQTAMTNAHTTP RSGRRGAVLQKCLPCLRSLA SLRWLKWQPWKMCTEVRGQL RSPMMDSQKKCRRLLYLFPA LTSEAPFHCKTLCFTYYPSL VFTEGC in isoform 3. 1 PublicationAdd BLAST326
Alternative sequenceiVSP_054881629 – 941Missing in isoform 3. 1 PublicationAdd BLAST313
Alternative sequenceiVSP_018006735 – 764Missing in isoform 2. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF276948 mRNA Translation: AAL68984.1
AF276949 mRNA Translation: AAL68985.1
AF454941 mRNA Translation: AAL58870.1
AF454942 mRNA Translation: AAL58871.1
AL136769 mRNA Translation: CAB66703.1
AL834307 mRNA Translation: CAD38977.1
AC068765 Genomic DNA No translation available.
AC072044 Genomic DNA No translation available.
AC117477 Genomic DNA No translation available.
BC012837 mRNA Translation: AAH12837.2
BC110903 mRNA Translation: AAI10904.1 Sequence problems.
BC131718 mRNA Translation: AAI31719.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2950.1 [Q8WY36-2]
CCDS46881.1 [Q8WY36-1]
CCDS63712.1 [Q8WY36-3]

NCBI Reference Sequences

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RefSeqi
NP_001136040.1, NM_001142568.2 [Q8WY36-1]
NP_001263215.1, NM_001276286.1 [Q8WY36-3]
NP_064620.2, NM_020235.6 [Q8WY36-2]
XP_005247699.1, XM_005247642.3 [Q8WY36-1]
XP_005247700.1, XM_005247643.3 [Q8WY36-1]
XP_005247701.1, XM_005247644.3 [Q8WY36-1]
XP_011511302.1, XM_011513000.1 [Q8WY36-1]
XP_011511303.1, XM_011513001.1 [Q8WY36-1]
XP_011511306.1, XM_011513004.2 [Q8WY36-2]
XP_016862370.1, XM_017006881.1 [Q8WY36-1]
XP_016862371.1, XM_017006882.1 [Q8WY36-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000325805; ENSP00000319974; ENSG00000114439 [Q8WY36-1]
ENST00000406780; ENSP00000385530; ENSG00000114439 [Q8WY36-2]
ENST00000415149; ENSP00000408358; ENSG00000114439 [Q8WY36-2]
ENST00000416476; ENSP00000403860; ENSG00000114439 [Q8WY36-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56987

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56987

UCSC genome browser

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UCSCi
uc003dwk.6 human [Q8WY36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276948 mRNA Translation: AAL68984.1
AF276949 mRNA Translation: AAL68985.1
AF454941 mRNA Translation: AAL58870.1
AF454942 mRNA Translation: AAL58871.1
AL136769 mRNA Translation: CAB66703.1
AL834307 mRNA Translation: CAD38977.1
AC068765 Genomic DNA No translation available.
AC072044 Genomic DNA No translation available.
AC117477 Genomic DNA No translation available.
BC012837 mRNA Translation: AAH12837.2
BC110903 mRNA Translation: AAI10904.1 Sequence problems.
BC131718 mRNA Translation: AAI31719.1
CCDSiCCDS2950.1 [Q8WY36-2]
CCDS46881.1 [Q8WY36-1]
CCDS63712.1 [Q8WY36-3]
RefSeqiNP_001136040.1, NM_001142568.2 [Q8WY36-1]
NP_001263215.1, NM_001276286.1 [Q8WY36-3]
NP_064620.2, NM_020235.6 [Q8WY36-2]
XP_005247699.1, XM_005247642.3 [Q8WY36-1]
XP_005247700.1, XM_005247643.3 [Q8WY36-1]
XP_005247701.1, XM_005247644.3 [Q8WY36-1]
XP_011511302.1, XM_011513000.1 [Q8WY36-1]
XP_011511303.1, XM_011513001.1 [Q8WY36-1]
XP_011511306.1, XM_011513004.2 [Q8WY36-2]
XP_016862370.1, XM_017006881.1 [Q8WY36-1]
XP_016862371.1, XM_017006882.1 [Q8WY36-2]

3D structure databases

SMRiQ8WY36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121304, 42 interactors
IntActiQ8WY36, 11 interactors
MINTiQ8WY36
STRINGi9606.ENSP00000319974

PTM databases

iPTMnetiQ8WY36
PhosphoSitePlusiQ8WY36

Polymorphism and mutation databases

BioMutaiBBX
DMDMi74724044

Proteomic databases

EPDiQ8WY36
jPOSTiQ8WY36
MaxQBiQ8WY36
PaxDbiQ8WY36
PeptideAtlasiQ8WY36
PRIDEiQ8WY36
ProteomicsDBi75124
75125 [Q8WY36-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
56987
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325805; ENSP00000319974; ENSG00000114439 [Q8WY36-1]
ENST00000406780; ENSP00000385530; ENSG00000114439 [Q8WY36-2]
ENST00000415149; ENSP00000408358; ENSG00000114439 [Q8WY36-2]
ENST00000416476; ENSP00000403860; ENSG00000114439 [Q8WY36-3]
GeneIDi56987
KEGGihsa:56987
UCSCiuc003dwk.6 human [Q8WY36-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56987
DisGeNETi56987

GeneCards: human genes, protein and diseases

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GeneCardsi
BBX
HGNCiHGNC:14422 BBX
HPAiHPA006049
HPA050646
neXtProtiNX_Q8WY36
OpenTargetsiENSG00000114439
PharmGKBiPA25280

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITBH Eukaryota
ENOG410Y941 LUCA
GeneTreeiENSGT00940000158592
HOGENOMiHOG000236273
InParanoidiQ8WY36
KOiK21643
OMAiMENVHRS
OrthoDBi1641977at2759
PhylomeDBiQ8WY36
TreeFamiTF106402

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BBX human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BBX_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56987

Protein Ontology

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PROi
PR:Q8WY36

Gene expression databases

BgeeiENSG00000114439 Expressed in 246 organ(s), highest expression level in corpus epididymis
ExpressionAtlasiQ8WY36 baseline and differential
GenevisibleiQ8WY36 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR019102 TF_HMG_box_BBX_DUF2028
PfamiView protein in Pfam
PF09667 DUF2028, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBBX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WY36
Secondary accession number(s): A2RRM7
, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q9H0J6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: May 8, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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