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Protein

BRI3-binding protein

Gene

BRI3BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function by stabilizing p53/TP53.1 Publication

Protein family/group databases

TCDBi1.A.74.2.2 the mitsugumin 23 (mg23) family

Names & Taxonomyi

Protein namesi
Recommended name:
BRI3-binding protein
Short name:
I3-binding protein
Alternative name(s):
Cervical cancer 1 proto-oncogene-binding protein KG19
HCCRBP-1
Gene namesi
Name:BRI3BPImported
Synonyms:KG19Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000184992.10
HGNCiHGNC:14251 BRI3BP
MIMi615627 gene
neXtProtiNX_Q8WY22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi140707
OpenTargetsiENSG00000184992
PharmGKBiPA25423

Polymorphism and mutation databases

BioMutaiBRI3BP
DMDMi74730999

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297471 – 251BRI3-binding proteinAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229N6-acetyllysineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8WY22
MaxQBiQ8WY22
PaxDbiQ8WY22
PeptideAtlasiQ8WY22
PRIDEiQ8WY22
ProteomicsDBi75123
TopDownProteomicsiQ8WY22

PTM databases

iPTMnetiQ8WY22
PhosphoSitePlusiQ8WY22
SwissPalmiQ8WY22

Expressioni

Tissue specificityi

Most abundantly expressed in brain, liver and kidney (PubMed:11860200). Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas (PubMed:17943721).2 Publications

Gene expression databases

BgeeiENSG00000184992
CleanExiHS_BRI3BP
GenevisibleiQ8WY22 HS

Organism-specific databases

HPAiHPA014957

Interactioni

Subunit structurei

Interacts with LETMD1 (PubMed:17943721). Interacts with BRI3 (PubMed:11860200).2 Publications

Protein-protein interaction databases

BioGridi126665, 28 interactors
IntActiQ8WY22, 8 interactors
STRINGi9606.ENSP00000340761

Structurei

3D structure databases

ProteinModelPortaliQ8WY22
SMRiQ8WY22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili217 – 247Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ5B Eukaryota
ENOG410ZDYG LUCA
GeneTreeiENSGT00390000002024
HOGENOMiHOG000285949
HOVERGENiHBG058925
InParanoidiQ8WY22
OMAiSCLYILQ
OrthoDBiEOG091G0P3Q
PhylomeDBiQ8WY22
TreeFamiTF332238

Family and domain databases

InterProiView protein in InterPro
IPR033367 BRI3BP
PANTHERiPTHR31253 PTHR31253, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WY22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASGGPL ARAGLLLLLL LLLLLGLLAP GAQGARGRGG AEKNSYRRTV
60 70 80 90 100
NTFSQSVSSL FGEDNVRAAQ KFLARLTERF VLGVDMFVET LWKVWTELLD
110 120 130 140 150
VLGLDVSNLS QYFSPASVSS SPARALLLVG VVLLAYWFLS LTLGFTFSVL
160 170 180 190 200
HVVFGRFFWI VRVVLFSMSC VYILHKYEGE PENAVLPLCF VVAVYFMTGP
210 220 230 240 250
MGFYWRSSPS GPSNPSNPSV EEKLEHLEKQ VRLLNIRLNR VLESLDRSKD

K
Length:251
Mass (Da):27,836
Last modified:March 1, 2002 - v1
Checksum:iDBC7ECB411010F71
GO

Sequence cautioni

The sequence AAL33003 differs from that shown. Reason: Frameshift at positions 43, 47 and 59.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87F → S in AAL33003 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284094 mRNA Translation: AAL54382.1
AC093719 Genomic DNA No translation available.
AC122688 Genomic DNA No translation available.
BC034525 mRNA Translation: AAH34525.1
AF283671 mRNA Translation: AAL33003.2 Frameshift.
CCDSiCCDS9262.1
RefSeqiNP_542193.3, NM_080626.5
UniGeneiHs.596464

Genome annotation databases

EnsembliENST00000341446; ENSP00000340761; ENSG00000184992
GeneIDi140707
KEGGihsa:140707
UCSCiuc001uha.2 human

Similar proteinsi

Entry informationi

Entry nameiBRI3B_HUMAN
AccessioniPrimary (citable) accession number: Q8WY22
Secondary accession number(s): Q8WY23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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