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Entry version 156 (22 Apr 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Cationic amino acid transporter 3

Gene

SLC7A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.3.10 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC7A3
Synonyms:ATRC3, CAT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11061 SLC7A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300443 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WY07

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 107CytoplasmicSequence analysisAdd BLAST25
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 162ExtracellularSequence analysisAdd BLAST34
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 233ExtracellularSequence analysisAdd BLAST21
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 285CytoplasmicSequence analysisAdd BLAST31
Transmembranei286 – 306Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini307 – 335ExtracellularSequence analysisAdd BLAST29
Transmembranei336 – 356Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini357 – 382CytoplasmicSequence analysisAdd BLAST26
Transmembranei383 – 403Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini404 – 406ExtracellularSequence analysis3
Transmembranei407 – 427Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini428 – 475CytoplasmicSequence analysisAdd BLAST48
Transmembranei476 – 496Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini497 – 506ExtracellularSequence analysis10
Transmembranei507 – 527Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini528 – 540CytoplasmicSequence analysisAdd BLAST13
Transmembranei541 – 561Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini562 – 569ExtracellularSequence analysis8
Transmembranei570 – 590Helical; Name=14Sequence analysisAdd BLAST21
Topological domaini591 – 619CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84889

Open Targets

More...
OpenTargetsi
ENSG00000165349

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35921

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WY07 Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00125 Arginine
DB13146 Fluciclovine (18F)
DB00123 L-Lysine
DB00129 Ornithine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC7A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41016908

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542661 – 619Cationic amino acid transporter 3Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei606PhosphothreonineCombined sources1
Modified residuei618PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WY07

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WY07

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WY07

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WY07

PeptideAtlas

More...
PeptideAtlasi
Q8WY07

PRoteomics IDEntifications database

More...
PRIDEi
Q8WY07

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75116

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WY07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WY07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165349 Expressed in cauda epididymis and 73 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WY07 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165349 Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124329, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WY07, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363417

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WY07 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1286 Eukaryota
COG0531 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007946_15_7_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WY07

KEGG Orthology (KO)

More...
KOi
K13865

Identification of Orthologs from Complete Genome Data

More...
OMAi
DILTWVR

Database of Orthologous Groups

More...
OrthoDBi
439017at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WY07

TreeFam database of animal gene trees

More...
TreeFami
TF315212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002293 AA/rel_permease1
IPR015606 CAT3
IPR004755 Cat_AA_permease
IPR029485 CAT_C

The PANTHER Classification System

More...
PANTHERi
PTHR43243:SF20 PTHR43243:SF20, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00906 2A0303, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WY07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISKTLQG
160 170 180 190 200
SIALHVPHVL AEYPDFFALG LVLLLTGLLA LGASESALVT KVFTGVNLLV
210 220 230 240 250
LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL GSGGFVPFGF
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF
310 320 330 340 350
AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVI YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL
410 420 430 440 450
FKLTDLVDLM SIGTLLAYSL VSICVLILRY QPDQETKTGE EVELQEEAIT
460 470 480 490 500
TESEKLTLWG LFFPLNSIPT PLSGQIVYVC SSLLAVLLTA LCLVLAQWSV
510 520 530 540 550
PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK VPALPLLPLM
560 570 580 590 600
SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR
610
KSRAKTVDLD PGTLYVHSV
Length:619
Mass (Da):67,169
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i211254FA87D43978
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55118 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191K → R in AAH33816 (PubMed:15489334).Curated1
Sequence conflicti221E → G in BAC11253 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064754356M → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_048154508L → V1 PublicationCorresponds to variant dbSNP:rs6525447Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF320612 mRNA Translation: AAL37184.1
AK027447 mRNA Translation: BAB55118.1 Different initiation.
AK074865 mRNA Translation: BAC11253.1
AK075014 mRNA Translation: BAC11353.1
AL627071 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05329.1
CH471132 Genomic DNA Translation: EAX05330.1
BC033816 mRNA Translation: AAH33816.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14404.1

NCBI Reference Sequences

More...
RefSeqi
NP_001041629.1, NM_001048164.2
NP_116192.4, NM_032803.5
XP_016885401.1, XM_017029912.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298085; ENSP00000298085; ENSG00000165349
ENST00000374299; ENSP00000363417; ENSG00000165349

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84889

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84889

UCSC genome browser

More...
UCSCi
uc004dyn.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320612 mRNA Translation: AAL37184.1
AK027447 mRNA Translation: BAB55118.1 Different initiation.
AK074865 mRNA Translation: BAC11253.1
AK075014 mRNA Translation: BAC11353.1
AL627071 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05329.1
CH471132 Genomic DNA Translation: EAX05330.1
BC033816 mRNA Translation: AAH33816.1
CCDSiCCDS14404.1
RefSeqiNP_001041629.1, NM_001048164.2
NP_116192.4, NM_032803.5
XP_016885401.1, XM_017029912.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124329, 20 interactors
IntActiQ8WY07, 15 interactors
STRINGi9606.ENSP00000363417

Chemistry databases

DrugBankiDB00125 Arginine
DB13146 Fluciclovine (18F)
DB00123 L-Lysine
DB00129 Ornithine

Protein family/group databases

TCDBi2.A.3.3.10 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiQ8WY07
PhosphoSitePlusiQ8WY07

Polymorphism and mutation databases

BioMutaiSLC7A3
DMDMi41016908

Proteomic databases

EPDiQ8WY07
jPOSTiQ8WY07
MassIVEiQ8WY07
PaxDbiQ8WY07
PeptideAtlasiQ8WY07
PRIDEiQ8WY07
ProteomicsDBi75116

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
586 67 antibodies

The DNASU plasmid repository

More...
DNASUi
84889

Genome annotation databases

EnsembliENST00000298085; ENSP00000298085; ENSG00000165349
ENST00000374299; ENSP00000363417; ENSG00000165349
GeneIDi84889
KEGGihsa:84889
UCSCiuc004dyn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84889
DisGeNETi84889

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC7A3
HGNCiHGNC:11061 SLC7A3
HPAiENSG00000165349 Tissue enriched (lymphoid)
MIMi300443 gene
neXtProtiNX_Q8WY07
OpenTargetsiENSG00000165349
PharmGKBiPA35921

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00940000154651
HOGENOMiCLU_007946_15_7_1
InParanoidiQ8WY07
KOiK13865
OMAiDILTWVR
OrthoDBi439017at2759
PhylomeDBiQ8WY07
TreeFamiTF315212

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC7A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84889
PharosiQ8WY07 Tbio

Protein Ontology

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PROi
PR:Q8WY07
RNActiQ8WY07 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165349 Expressed in cauda epididymis and 73 other tissues
GenevisibleiQ8WY07 HS

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR015606 CAT3
IPR004755 Cat_AA_permease
IPR029485 CAT_C
PANTHERiPTHR43243:SF20 PTHR43243:SF20, 1 hit
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00906 2A0303, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WY07
Secondary accession number(s): D3DVU7
, Q5JQR2, Q8N185, Q8NCA7, Q96SZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: April 22, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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