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UniProtKB - Q8WY07 (CTR3_HUMAN)

Entry version 161 (10 Feb 2021)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
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Protein

Cationic amino acid transporter 3

Gene

SLC7A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WY07

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-352230, Amino acid transport across the plasma membrane

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.3.3.10, the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC7A3
Synonyms:ATRC3, CAT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11061, SLC7A3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300443, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WY07

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165349.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 107CytoplasmicSequence analysisAdd BLAST25
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 162ExtracellularSequence analysisAdd BLAST34
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 233ExtracellularSequence analysisAdd BLAST21
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 285CytoplasmicSequence analysisAdd BLAST31
Transmembranei286 – 306Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini307 – 335ExtracellularSequence analysisAdd BLAST29
Transmembranei336 – 356Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini357 – 382CytoplasmicSequence analysisAdd BLAST26
Transmembranei383 – 403Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini404 – 406ExtracellularSequence analysis3
Transmembranei407 – 427Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini428 – 475CytoplasmicSequence analysisAdd BLAST48
Transmembranei476 – 496Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini497 – 506ExtracellularSequence analysis10
Transmembranei507 – 527Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini528 – 540CytoplasmicSequence analysisAdd BLAST13
Transmembranei541 – 561Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini562 – 569ExtracellularSequence analysis8
Transmembranei570 – 590Helical; Name=14Sequence analysisAdd BLAST21
Topological domaini591 – 619CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84889

Open Targets

More...OpenTargetsi		ENSG00000165349

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35921

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WY07, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00125, Arginine
DB13146, Fluciclovine (18F)
DB00123, L-Lysine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC7A3

Domain mapping of disease mutations (DMDM)

More...DMDMi		41016908

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542661 – 619Cationic amino acid transporter 3Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei606PhosphothreonineCombined sources1
Modified residuei618PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WY07

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WY07

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WY07

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WY07

PeptideAtlas

More...PeptideAtlasi		Q8WY07

PRoteomics IDEntifications database

More...PRIDEi		Q8WY07

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75116

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8WY07, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WY07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WY07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165349, Expressed in cauda epididymis and 94 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WY07, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165349, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124329, 22 interactors

Protein interaction database and analysis system

More...IntActi		Q8WY07, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363417

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WY07, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1286, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007946_15_7_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WY07

Identification of Orthologs from Complete Genome Data

More...OMAi		DILTWVR

Database of Orthologous Groups

More...OrthoDBi		439017at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WY07

TreeFam database of animal gene trees

More...TreeFami		TF315212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002293, AA/rel_permease1
IPR015606, CAT3
IPR004755, Cat_AA_permease
IPR029485, CAT_C

The PANTHER Classification System

More...PANTHERi		PTHR43243:SF20, PTHR43243:SF20, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13520, AA_permease_2, 1 hit
PF13906, AA_permease_C, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00906, 2A0303, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WY07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV 
        60         70         80         90        100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY 
       110        120        130        140        150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISKTLQG 
       160        170        180        190        200
SIALHVPHVL AEYPDFFALG LVLLLTGLLA LGASESALVT KVFTGVNLLV 
       210        220        230        240        250
LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL GSGGFVPFGF 
       260        270        280        290        300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF 
       310        320        330        340        350
AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL 
       360        370        380        390        400
GSMFPMPRVI YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL 
       410        420        430        440        450
FKLTDLVDLM SIGTLLAYSL VSICVLILRY QPDQETKTGE EVELQEEAIT 
       460        470        480        490        500
TESEKLTLWG LFFPLNSIPT PLSGQIVYVC SSLLAVLLTA LCLVLAQWSV 
       510        520        530        540        550
PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK VPALPLLPLM 
       560        570        580        590        600
SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR 
       610 
KSRAKTVDLD PGTLYVHSV
Length:619
Mass (Da):67,169
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i211254FA87D43978
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55118 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191K → R in AAH33816 (PubMed:15489334).Curated1
Sequence conflicti221E → G in BAC11253 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064754356M → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_048154508L → V1 PublicationCorresponds to variant dbSNP:rs6525447Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF320612 mRNA Translation: AAL37184.1
AK027447 mRNA Translation: BAB55118.1 Different initiation.
AK074865 mRNA Translation: BAC11253.1
AK075014 mRNA Translation: BAC11353.1
AL627071 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05329.1
CH471132 Genomic DNA Translation: EAX05330.1
BC033816 mRNA Translation: AAH33816.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14404.1

NCBI Reference Sequences

More...RefSeqi		NP_001041629.1, NM_001048164.2
NP_116192.4, NM_032803.5
XP_016885401.1, XM_017029912.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000298085; ENSP00000298085; ENSG00000165349
ENST00000374299; ENSP00000363417; ENSG00000165349

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84889

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84889

UCSC genome browser

More...UCSCi		uc004dyn.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320612 mRNA Translation: AAL37184.1
AK027447 mRNA Translation: BAB55118.1 Different initiation.
AK074865 mRNA Translation: BAC11253.1
AK075014 mRNA Translation: BAC11353.1
AL627071 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05329.1
CH471132 Genomic DNA Translation: EAX05330.1
BC033816 mRNA Translation: AAH33816.1
CCDSiCCDS14404.1
RefSeqiNP_001041629.1, NM_001048164.2
NP_116192.4, NM_032803.5
XP_016885401.1, XM_017029912.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124329, 22 interactors
IntActiQ8WY07, 15 interactors
STRINGi9606.ENSP00000363417

Chemistry databases

DrugBankiDB00125, Arginine
DB13146, Fluciclovine (18F)
DB00123, L-Lysine

Protein family/group databases

TCDBi2.A.3.3.10, the amino acid-polyamine-organocation (apc) family

PTM databases

GlyGeniQ8WY07, 1 site
iPTMnetiQ8WY07
PhosphoSitePlusiQ8WY07

Genetic variation databases

BioMutaiSLC7A3
DMDMi41016908

Proteomic databases

EPDiQ8WY07
jPOSTiQ8WY07
MassIVEiQ8WY07
PaxDbiQ8WY07
PeptideAtlasiQ8WY07
PRIDEiQ8WY07
ProteomicsDBi75116

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		586, 68 antibodies

The DNASU plasmid repository

More...DNASUi		84889

Genome annotation databases

EnsembliENST00000298085; ENSP00000298085; ENSG00000165349
ENST00000374299; ENSP00000363417; ENSG00000165349
GeneIDi84889
KEGGihsa:84889
UCSCiuc004dyn.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84889
DisGeNETi84889

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC7A3
HGNCiHGNC:11061, SLC7A3
HPAiENSG00000165349, Tissue enriched (lymphoid)
MIMi300443, gene
neXtProtiNX_Q8WY07
OpenTargetsiENSG00000165349
PharmGKBiPA35921
VEuPathDBiHostDB:ENSG00000165349.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1286, Eukaryota
GeneTreeiENSGT00940000154651
HOGENOMiCLU_007946_15_7_1
InParanoidiQ8WY07
OMAiDILTWVR
OrthoDBi439017at2759
PhylomeDBiQ8WY07
TreeFamiTF315212

Enzyme and pathway databases

PathwayCommonsiQ8WY07
ReactomeiR-HSA-352230, Amino acid transport across the plasma membrane

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84889, 8 hits in 501 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC7A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84889
PharosiQ8WY07, Tbio

Protein Ontology

More...PROi		PR:Q8WY07
RNActiQ8WY07, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165349, Expressed in cauda epididymis and 94 other tissues
GenevisibleiQ8WY07, HS

Family and domain databases

InterProiView protein in InterPro
IPR002293, AA/rel_permease1
IPR015606, CAT3
IPR004755, Cat_AA_permease
IPR029485, CAT_C
PANTHERiPTHR43243:SF20, PTHR43243:SF20, 1 hit
PfamiView protein in Pfam
PF13520, AA_permease_2, 1 hit
PF13906, AA_permease_C, 1 hit
TIGRFAMsiTIGR00906, 2A0303, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WY07
Secondary accession number(s): D3DVU7
, Q5JQR2, Q8N185, Q8NCA7, Q96SZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: February 10, 2021
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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