UniProtKB - Q8WY07 (CTR3_HUMAN)
Protein
Cationic amino acid transporter 3
Gene
SLC7A3
Organism
Homo sapiens (Human)
Status
Functioni
Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
- arginine transmembrane transporter activity Source: GO_Central
- L-arginine transmembrane transporter activity Source: ARUK-UCL
- L-lysine transmembrane transporter activity Source: ARUK-UCL
- L-ornithine transmembrane transporter activity Source: ARUK-UCL
GO - Biological processi
- amino acid transport Source: GO_Central
- L-arginine import across plasma membrane Source: ARUK-UCL
- L-lysine import across plasma membrane Source: ARUK-UCL
- L-ornithine import across plasma membrane Source: ARUK-UCL
- L-ornithine transmembrane transport Source: GO_Central
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8WY07 |
Reactomei | R-HSA-352230, Amino acid transport across the plasma membrane |
Protein family/group databases
TCDBi | 2.A.3.3.10, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cationic amino acid transporter 3Short name: CAT-3 Short name: CAT3 Alternative name(s): Cationic amino acid transporter y+ Solute carrier family 7 member 3 |
Gene namesi | Name:SLC7A3 Synonyms:ATRC3, CAT3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11061, SLC7A3 |
MIMi | 300443, gene |
neXtProti | NX_Q8WY07 |
VEuPathDBi | HostDB:ENSG00000165349.11 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: ARUK-UCL
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 37 – 57 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 58 – 61 | ExtracellularSequence analysis | 4 | |
Transmembranei | 62 – 82 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 83 – 107 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 108 – 128 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 162 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 163 – 183 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 191 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 192 – 212 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 233 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 234 – 254 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 285 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 286 – 306 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 307 – 335 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 336 – 356 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 357 – 382 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 383 – 403 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 404 – 406 | ExtracellularSequence analysis | 3 | |
Transmembranei | 407 – 427 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 475 | CytoplasmicSequence analysisAdd BLAST | 48 | |
Transmembranei | 476 – 496 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 497 – 506 | ExtracellularSequence analysis | 10 | |
Transmembranei | 507 – 527 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 528 – 540 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 541 – 561 | Helical; Name=13Sequence analysisAdd BLAST | 21 | |
Topological domaini | 562 – 569 | ExtracellularSequence analysis | 8 | |
Transmembranei | 570 – 590 | Helical; Name=14Sequence analysisAdd BLAST | 21 | |
Topological domaini | 591 – 619 | CytoplasmicSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84889 |
OpenTargetsi | ENSG00000165349 |
PharmGKBi | PA35921 |
Miscellaneous databases
Pharosi | Q8WY07, Tbio |
Chemistry databases
DrugBanki | DB00125, Arginine DB13146, Fluciclovine (18F) DB00123, L-Lysine |
Genetic variation databases
BioMutai | SLC7A3 |
DMDMi | 41016908 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054266 | 1 – 619 | Cationic amino acid transporter 3Add BLAST | 619 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 606 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 618 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8WY07 |
jPOSTi | Q8WY07 |
MassIVEi | Q8WY07 |
PaxDbi | Q8WY07 |
PeptideAtlasi | Q8WY07 |
PRIDEi | Q8WY07 |
ProteomicsDBi | 75116 |
PTM databases
GlyGeni | Q8WY07, 1 site |
iPTMneti | Q8WY07 |
PhosphoSitePlusi | Q8WY07 |
Expressioni
Tissue specificityi
Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala.1 Publication
Gene expression databases
Bgeei | ENSG00000165349, Expressed in cauda epididymis and 94 other tissues |
Genevisiblei | Q8WY07, HS |
Organism-specific databases
HPAi | ENSG00000165349, Tissue enriched (lymphoid) |
Interactioni
Binary interactionsi
Hide detailsQ8WY07
With | #Exp. | IntAct |
---|---|---|
SLC10A1 [Q14973] | 3 | EBI-13066314,EBI-3923031 |
TMEM237 - isoform 2 [Q96Q45-2] | 3 | EBI-13066314,EBI-10982110 |
Protein-protein interaction databases
BioGRIDi | 124329, 22 interactors |
IntActi | Q8WY07, 15 interactors |
STRINGi | 9606.ENSP00000363417 |
Miscellaneous databases
RNActi | Q8WY07, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000154651 |
HOGENOMi | CLU_007946_15_7_1 |
InParanoidi | Q8WY07 |
OMAi | DILTWVR |
OrthoDBi | 439017at2759 |
PhylomeDBi | Q8WY07 |
TreeFami | TF315212 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR015606, CAT3 IPR004755, Cat_AA_permease IPR029485, CAT_C |
PANTHERi | PTHR43243:SF20, PTHR43243:SF20, 1 hit |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WY07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISKTLQG
160 170 180 190 200
SIALHVPHVL AEYPDFFALG LVLLLTGLLA LGASESALVT KVFTGVNLLV
210 220 230 240 250
LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL GSGGFVPFGF
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF
310 320 330 340 350
AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVI YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL
410 420 430 440 450
FKLTDLVDLM SIGTLLAYSL VSICVLILRY QPDQETKTGE EVELQEEAIT
460 470 480 490 500
TESEKLTLWG LFFPLNSIPT PLSGQIVYVC SSLLAVLLTA LCLVLAQWSV
510 520 530 540 550
PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK VPALPLLPLM
560 570 580 590 600
SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR
610
KSRAKTVDLD PGTLYVHSV
Sequence cautioni
The sequence BAB55118 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | K → R in AAH33816 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 221 | E → G in BAC11253 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064754 | 356 | M → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_048154 | 508 | L → V1 PublicationCorresponds to variant dbSNP:rs6525447Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF320612 mRNA Translation: AAL37184.1 AK027447 mRNA Translation: BAB55118.1 Different initiation. AK074865 mRNA Translation: BAC11253.1 AK075014 mRNA Translation: BAC11353.1 AL627071 Genomic DNA No translation available. CH471132 Genomic DNA Translation: EAX05329.1 CH471132 Genomic DNA Translation: EAX05330.1 BC033816 mRNA Translation: AAH33816.1 |
CCDSi | CCDS14404.1 |
RefSeqi | NP_001041629.1, NM_001048164.2 NP_116192.4, NM_032803.5 XP_016885401.1, XM_017029912.1 |
Genome annotation databases
Ensembli | ENST00000298085; ENSP00000298085; ENSG00000165349 ENST00000374299; ENSP00000363417; ENSG00000165349 |
GeneIDi | 84889 |
KEGGi | hsa:84889 |
UCSCi | uc004dyn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF320612 mRNA Translation: AAL37184.1 AK027447 mRNA Translation: BAB55118.1 Different initiation. AK074865 mRNA Translation: BAC11253.1 AK075014 mRNA Translation: BAC11353.1 AL627071 Genomic DNA No translation available. CH471132 Genomic DNA Translation: EAX05329.1 CH471132 Genomic DNA Translation: EAX05330.1 BC033816 mRNA Translation: AAH33816.1 |
CCDSi | CCDS14404.1 |
RefSeqi | NP_001041629.1, NM_001048164.2 NP_116192.4, NM_032803.5 XP_016885401.1, XM_017029912.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124329, 22 interactors |
IntActi | Q8WY07, 15 interactors |
STRINGi | 9606.ENSP00000363417 |
Chemistry databases
DrugBanki | DB00125, Arginine DB13146, Fluciclovine (18F) DB00123, L-Lysine |
Protein family/group databases
TCDBi | 2.A.3.3.10, the amino acid-polyamine-organocation (apc) family |
PTM databases
GlyGeni | Q8WY07, 1 site |
iPTMneti | Q8WY07 |
PhosphoSitePlusi | Q8WY07 |
Genetic variation databases
BioMutai | SLC7A3 |
DMDMi | 41016908 |
Proteomic databases
EPDi | Q8WY07 |
jPOSTi | Q8WY07 |
MassIVEi | Q8WY07 |
PaxDbi | Q8WY07 |
PeptideAtlasi | Q8WY07 |
PRIDEi | Q8WY07 |
ProteomicsDBi | 75116 |
Protocols and materials databases
Antibodypediai | 586, 68 antibodies |
DNASUi | 84889 |
Genome annotation databases
Ensembli | ENST00000298085; ENSP00000298085; ENSG00000165349 ENST00000374299; ENSP00000363417; ENSG00000165349 |
GeneIDi | 84889 |
KEGGi | hsa:84889 |
UCSCi | uc004dyn.4, human |
Organism-specific databases
CTDi | 84889 |
DisGeNETi | 84889 |
GeneCardsi | SLC7A3 |
HGNCi | HGNC:11061, SLC7A3 |
HPAi | ENSG00000165349, Tissue enriched (lymphoid) |
MIMi | 300443, gene |
neXtProti | NX_Q8WY07 |
OpenTargetsi | ENSG00000165349 |
PharmGKBi | PA35921 |
VEuPathDBi | HostDB:ENSG00000165349.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000154651 |
HOGENOMi | CLU_007946_15_7_1 |
InParanoidi | Q8WY07 |
OMAi | DILTWVR |
OrthoDBi | 439017at2759 |
PhylomeDBi | Q8WY07 |
TreeFami | TF315212 |
Enzyme and pathway databases
PathwayCommonsi | Q8WY07 |
Reactomei | R-HSA-352230, Amino acid transport across the plasma membrane |
Miscellaneous databases
BioGRID-ORCSi | 84889, 8 hits in 501 CRISPR screens |
GeneWikii | SLC7A3 |
GenomeRNAii | 84889 |
Pharosi | Q8WY07, Tbio |
PROi | PR:Q8WY07 |
RNActi | Q8WY07, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165349, Expressed in cauda epididymis and 94 other tissues |
Genevisiblei | Q8WY07, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR015606, CAT3 IPR004755, Cat_AA_permease IPR029485, CAT_C |
PANTHERi | PTHR43243:SF20, PTHR43243:SF20, 1 hit |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTR3_HUMAN | |
Accessioni | Q8WY07Primary (citable) accession number: Q8WY07 Secondary accession number(s): D3DVU7 Q96SZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants