UniProtKB - Q8WXX5 (DNJC9_HUMAN)
Protein
DnaJ homolog subfamily C member 9
Gene
DNAJC9
Organism
Homo sapiens (Human)
Status
Functioni
May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.1 Publication
GO - Molecular functioni
- heat shock protein binding Source: UniProtKB
GO - Biological processi
- positive regulation of ATPase activity Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q8WXX5 |
Names & Taxonomyi
Protein namesi | Recommended name: DnaJ homolog subfamily C member 9Short name: HDJC91 Publication Alternative name(s): DnaJ protein SB73 |
Gene namesi | Name:DNAJC9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19123, DNAJC9 |
MIMi | 611206, gene |
neXtProti | NX_Q8WXX5 |
VEuPathDBi | HostDB:ENSG00000213551.4 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Note: Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock.1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular space Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23234 |
OpenTargetsi | ENSG00000213551 |
PharmGKBi | PA38797 |
Miscellaneous databases
Pharosi | Q8WXX5, Tbio |
Genetic variation databases
BioMutai | DNAJC9 |
DMDMi | 52782787 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071063 | 1 – 260 | DnaJ homolog subfamily C member 9Add BLAST | 260 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 109 | PhosphoserineCombined sources | 1 | |
Modified residuei | 215 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8WXX5 |
jPOSTi | Q8WXX5 |
MassIVEi | Q8WXX5 |
MaxQBi | Q8WXX5 |
PaxDbi | Q8WXX5 |
PeptideAtlasi | Q8WXX5 |
PRIDEi | Q8WXX5 |
ProteomicsDBi | 75112 |
PTM databases
iPTMneti | Q8WXX5 |
PhosphoSitePlusi | Q8WXX5 |
SwissPalmi | Q8WXX5 |
Expressioni
Tissue specificityi
Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.1 Publication
Inductioni
By heat shock, bacterial lipopolysaccharides (LPS), phorbol 12-myristate 13-acetate (PMA), and the cytokine TNF (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000213551, Expressed in subventricular zone (inner) (primate) and 125 other tissues |
ExpressionAtlasi | Q8WXX5, baseline and differential |
Genevisiblei | Q8WXX5, HS |
Organism-specific databases
HPAi | ENSG00000213551, Tissue enhanced (bone) |
Interactioni
Subunit structurei
Interacts (via J domain) with HSPA1A, HSPA1B and HSPA8.
1 PublicationBinary interactionsi
Hide detailsQ8WXX5
With | #Exp. | IntAct |
---|---|---|
H3-5 [Q6NXT2] | 3 | EBI-2349100,EBI-2868501 |
H3C12 [P68431] | 6 | EBI-2349100,EBI-79722 |
MORN4 [Q8NDC4] | 3 | EBI-2349100,EBI-10269566 |
GO - Molecular functioni
- heat shock protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116839, 90 interactors |
IntActi | Q8WXX5, 38 interactors |
MINTi | Q8WXX5 |
STRINGi | 9606.ENSP00000362041 |
Miscellaneous databases
RNActi | Q8WXX5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 82 | JPROSITE-ProRule annotationAdd BLAST | 68 |
Phylogenomic databases
eggNOGi | KOG0719, Eukaryota |
GeneTreei | ENSGT00390000014549 |
HOGENOMi | CLU_055868_1_0_1 |
InParanoidi | Q8WXX5 |
OMAi | RHQKYAR |
OrthoDBi | 1416483at2759 |
PhylomeDBi | Q8WXX5 |
TreeFami | TF105168 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR018253, DnaJ_domain_CS IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit |
PROSITEi | View protein in PROSITE PS00636, DNAJ_1, 1 hit PS50076, DNAJ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WXX5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLLDLCEEV FGTADLYRVL GVRREASDGE VRRGYHKVSL QVHPDRVGEG
60 70 80 90 100
DKEDATRRFQ ILGKVYSVLS DREQRAVYDE QGTVDEDSPV LTQDRDWEAY
110 120 130 140 150
WRLLFKKISL EDIQAFEKTY KGSEEELADI KQAYLDFKGD MDQIMESVLC
160 170 180 190 200
VQYTEEPRIR NIIQQAIDAG EVPSYNAFVK ESKQKMNARK RRAQEEAKEA
210 220 230 240 250
EMSRKELGLD EGVDSLKAAI QSRQKDRQKE MDNFLAQMEA KYCKSSKGGG
260
KKSALKKEKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF327347 mRNA Translation: AAL56008.1 AK074420 mRNA Translation: BAB85076.1 AK094162 mRNA Translation: BAG52832.1 CH471083 Genomic DNA Translation: EAW54483.1 BC136507 mRNA Translation: AAI36508.1 |
CCDSi | CCDS7322.1 |
RefSeqi | NP_056005.1, NM_015190.4 |
Genome annotation databases
Ensembli | ENST00000372950; ENSP00000362041; ENSG00000213551 |
GeneIDi | 23234 |
KEGGi | hsa:23234 |
UCSCi | uc010qkg.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF327347 mRNA Translation: AAL56008.1 AK074420 mRNA Translation: BAB85076.1 AK094162 mRNA Translation: BAG52832.1 CH471083 Genomic DNA Translation: EAW54483.1 BC136507 mRNA Translation: AAI36508.1 |
CCDSi | CCDS7322.1 |
RefSeqi | NP_056005.1, NM_015190.4 |
3D structure databases
SMRi | Q8WXX5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116839, 90 interactors |
IntActi | Q8WXX5, 38 interactors |
MINTi | Q8WXX5 |
STRINGi | 9606.ENSP00000362041 |
PTM databases
iPTMneti | Q8WXX5 |
PhosphoSitePlusi | Q8WXX5 |
SwissPalmi | Q8WXX5 |
Genetic variation databases
BioMutai | DNAJC9 |
DMDMi | 52782787 |
Proteomic databases
EPDi | Q8WXX5 |
jPOSTi | Q8WXX5 |
MassIVEi | Q8WXX5 |
MaxQBi | Q8WXX5 |
PaxDbi | Q8WXX5 |
PeptideAtlasi | Q8WXX5 |
PRIDEi | Q8WXX5 |
ProteomicsDBi | 75112 |
Protocols and materials databases
Antibodypediai | 29351, 132 antibodies |
Genome annotation databases
Ensembli | ENST00000372950; ENSP00000362041; ENSG00000213551 |
GeneIDi | 23234 |
KEGGi | hsa:23234 |
UCSCi | uc010qkg.2, human |
Organism-specific databases
CTDi | 23234 |
DisGeNETi | 23234 |
GeneCardsi | DNAJC9 |
HGNCi | HGNC:19123, DNAJC9 |
HPAi | ENSG00000213551, Tissue enhanced (bone) |
MIMi | 611206, gene |
neXtProti | NX_Q8WXX5 |
OpenTargetsi | ENSG00000213551 |
PharmGKBi | PA38797 |
VEuPathDBi | HostDB:ENSG00000213551.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0719, Eukaryota |
GeneTreei | ENSGT00390000014549 |
HOGENOMi | CLU_055868_1_0_1 |
InParanoidi | Q8WXX5 |
OMAi | RHQKYAR |
OrthoDBi | 1416483at2759 |
PhylomeDBi | Q8WXX5 |
TreeFami | TF105168 |
Enzyme and pathway databases
PathwayCommonsi | Q8WXX5 |
Miscellaneous databases
BioGRID-ORCSi | 23234, 571 hits in 989 CRISPR screens |
ChiTaRSi | DNAJC9, human |
GenomeRNAii | 23234 |
Pharosi | Q8WXX5, Tbio |
PROi | PR:Q8WXX5 |
RNActi | Q8WXX5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213551, Expressed in subventricular zone (inner) (primate) and 125 other tissues |
ExpressionAtlasi | Q8WXX5, baseline and differential |
Genevisiblei | Q8WXX5, HS |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR018253, DnaJ_domain_CS IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit |
PROSITEi | View protein in PROSITE PS00636, DNAJ_1, 1 hit PS50076, DNAJ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNJC9_HUMAN | |
Accessioni | Q8WXX5Primary (citable) accession number: Q8WXX5 Secondary accession number(s): B2RMW6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot