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UniProtKB - Q8WXX0 (DYH7_HUMAN)

Protein

Dynein heavy chain 7, axonemal

Gene

DNAH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi132 – 139ATPSequence analysis8
Nucleotide bindingi1328 – 1335ATPSequence analysis8
Nucleotide bindingi1609 – 1616ATPSequence analysis8
Nucleotide bindingi1976 – 1983ATPSequence analysis8
Nucleotide bindingi2341 – 2348ATPSequence analysis8

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cilium-dependent cell motility Source: UniProtKB
  • cilium movement Source: SYSCILIA_CCNET
  • inner dynein arm assembly Source: SYSCILIA_CCNET
  • microtubule-based movement Source: GO_Central
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 7, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 7
Ciliary dynein heavy chain 7
Dynein heavy chain-like protein 2
hDHC2
Gene namesi
Name:DNAH7
Synonyms:KIAA0944
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000118997.13
HGNCiHGNC:18661 DNAH7
MIMi610061 gene
neXtProtiNX_Q8WXX0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi56171
MalaCardsiDNAH7
OpenTargetsiENSG00000118997
PharmGKBiPA38625

Polymorphism and mutation databases

BioMutaiDNAH7
DMDMi311033375

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176661 – 4024Dynein heavy chain 7, axonemalAdd BLAST4024

Proteomic databases

EPDiQ8WXX0
MaxQBiQ8WXX0
PaxDbiQ8WXX0
PeptideAtlasiQ8WXX0
PRIDEiQ8WXX0
ProteomicsDBi75108
75109 [Q8WXX0-2]
75110 [Q8WXX0-3]
75111 [Q8WXX0-4]

PTM databases

iPTMnetiQ8WXX0
PhosphoSitePlusiQ8WXX0

Expressioni

Tissue specificityi

Detected in brain, testis and trachea. Detected in bronchial cells (at protein level).2 Publications

Inductioni

Up-regulated during ciliogenesis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000118997 Expressed in 155 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ8WXX0 baseline and differential
GenevisibleiQ8WXX0 HS

Organism-specific databases

HPAiHPA034724
HPA044070

Interactioni

Subunit structurei

The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi121102, 3 interactors
IntActiQ8WXX0, 1 interactor
MINTiQ8WXX0
STRINGi9606.ENSP00000311273

Structurei

3D structure databases

ProteinModelPortaliQ8WXX0
SMRiQ8WXX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 1289StemBy similarityAdd BLAST1289
Regioni1290 – 1511AAA 1By similarityAdd BLAST222
Regioni1571 – 1802AAA 2By similarityAdd BLAST232
Regioni1938 – 2189AAA 3By similarityAdd BLAST252
Regioni2302 – 2555AAA 4By similarityAdd BLAST254
Regioni2572 – 2873StalkBy similarityAdd BLAST302
Regioni2954 – 3184AAA 5By similarityAdd BLAST231
Regioni3397 – 3620AAA 6By similarityAdd BLAST224

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili685 – 745Sequence analysisAdd BLAST61
Coiled coili2827 – 2883Sequence analysisAdd BLAST57

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00760000118964
HOVERGENiHBG107830
InParanoidiQ8WXX0
KOiK10408
OMAiRKCAEGE
OrthoDBiEOG091G00FO
PhylomeDBiQ8WXX0
TreeFamiTF316836

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_dom
IPR013602 Dynein_heavy_dom-2
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 4 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSEQDKSAS KEKSKKPVRF LPQLSMEKLA SKEKFKAPAR ALPQLSMVST 
        60         70         80         90        100
KPHWQQAAPS FHLSVKQDDE SPEPFSVKNE QSHAEYMERF GKKGKLPHQV 
       110        120        130        140        150
DDSYVGPSTS KSKGKSPHKE RENFRSTLVN VIMQQDADLD SAVPDGSTIP 
       160        170        180        190        200
KPTASAIEKD ILRYYYYIHH GIDTDHVAPM EDSWLEHVLD LVPQHLKVFT 
       210        220        230        240        250
DSIVTLSDEM REDYLLSVRK SIVDFVLKDP REKGDDKKTD ELPAHRAEME 
       260        270        280        290        300
ILPKPWRKSF LAASSYIRDH LNAMNPTMLA VLDLWHTNFK KLRLVDIKEF 
       310        320        330        340        350
HNCQDALELS SFQNIIMRHM DSAKETLLKM WFPEVQNIYY QGNKKKQLPT 
       360        370        380        390        400
GDSSAKLESF FNCAAALMTL QLQDLTLVSM QDFTDLIAQP PDSVRAFEHP 
       410        420        430        440        450
GFIMRLILDN DTIKFEPELS DYIDIFLNVY DVMIKAVSFV PRVETKLYSK 
       460        470        480        490        500
WESKSKPTTL KPIILNEIVD AHKEKIKEVI MKESVAPTEH LRLYDKYDFL 
       510        520        530        540        550
ITRKAERDVD NFLAENHSYE KIIDEICKYQ KLIEEIQYTS IKTIRLGMFE 
       560        570        580        590        600
MHCEELIRAL VKRADIICGK LLAKMFRDHQ EVNTRLCDEF ERIAEKALST 
       610        620        630        640        650
PPNTAELMEM KAYIQKVEVT DMIELEQRLV DSKNCLAFLI EYVNFSPADM 
       660        670        680        690        700
RLNNSVFQWY GRMGEIFEEH RKIIKEKIEQ YQEGLKLRCE RFVEELESYA 
       710        720        730        740        750
KQSEEFYSFG DLQDVQRYLK KAQILNGKLD LAADKIEQFN AEEEAFGWLP 
       760        770        780        790        800
SVYPQRKKIQ DGLNPYLRLY ETAVEFSSNY RAWTEGPYHK VNPDQVEADI 
       810        820        830        840        850
GNYWRGLYKL EKTFHDSPYA LAMTKKVRSK VEDFKQHIPL IQVICNPGLR 
       860        870        880        890        900
PRHWEAMSAI VGYPLQPSDD STVSSFLDMN LEPYIDRFEG ISEAASKEYS 
       910        920        930        940        950
LEKAMEKMIT EWDAVEFVIH SYRETGTFIL ASVDEIQMLL DDHIIKTQTM 
       960        970        980        990       1000
RGSPFIKPYE KQMREWEGKL LLLQEILDEW LKVQATWLYL EPIFSSPDIM 
      1010       1020       1030       1040       1050
SQMPEEGRRF TAVDKTWRDI MRSVMQDKHV LTVVTIDRML ERLKKSNELL 
      1060       1070       1080       1090       1100
ELILKGLNEY LEKKRLFFPR FFFLSNDELL EILSETKDPT RVQPHLKKCF 
      1110       1120       1130       1140       1150
EGIAKVEFTE TLDITHMKSS EGEVVELIEI ISTAKARGQV EKWLVELERV 
      1160       1170       1180       1190       1200
MINSIHKVTG DATFAYTKYE RINWVRDWPG QTVLCVSQIF WTKEVQTAIP 
      1210       1220       1230       1240       1250
MGIKALEQYL KTCNRQIDDI VTLVRGKLSM QNRVTLGALV VLDVHARDVL 
      1260       1270       1280       1290       1300
SSLVKKNISD DSDFEWLSQL RYYWQENHLE TKMINAGLRY GYEYLGNSPR 
      1310       1320       1330       1340       1350
LVITPLTDRC YRTLFGALHL HLGGAPEGPA GTGKTETTKD LAKAVAKQCV 
      1360       1370       1380       1390       1400
VFNCSDGLDY LALGKFFKGL LSCGAWACFD EFNRIDLEVL SVVAQQILTI 
      1410       1420       1430       1440       1450
QRGINAGADI LMFEGTELKL DPTCAVFITM NPGYAGRSEL PDNLKALFRT 
      1460       1470       1480       1490       1500
VAMMVPDYAM IAEIVLYSCG FVTARPLSVK IVATYRLCSE QLSSQHHYDY 
      1510       1520       1530       1540       1550
GMRAVKSVLT AAGNLKLKYP NENEEILLLR SIIDVNLPKF LSHDLPLFEG 
      1560       1570       1580       1590       1600
ITSDLFPGVK LPKPDYNDLL AAIKDNCASM NLQMTAFFSE KILQVYEMMI 
      1610       1620       1630       1640       1650
VRHGFMIVGE PFGGKTSAYR VLAGALNDIC EKGLMEENKV QITVLNPKSV 
      1660       1670       1680       1690       1700
TMGQLYGQFD SVSHEWSDGV LAVSFRAFAS SVTPDRKWLI FDGPVDAVWI 
      1710       1720       1730       1740       1750
ENMNTVLDDN KKLCLMSGEI IQMSPQMNLI FEPMDLEVAS PATVSRCGMI 
      1760       1770       1780       1790       1800
YMEPHMLGWR PLMLSWVNLL PASVSVIQKE FIMGLFDRMV PVSVEFIRKH 
      1810       1820       1830       1840       1850
TKELSPTSDT NLVRSLMNLI DCFMDDFADE VKLKERNDRE TYSLLEGIFL 
      1860       1870       1880       1890       1900
FSLIWSVGAS CTDDDRLKFN KILRELMESP ISDRTRNTFK LQSGTEQTSS 
      1910       1920       1930       1940       1950
KALTVPFPEK GTIYDYQFVT EGIGKWEPWI KKLKEAPPIP KDVMFNEIIV 
      1960       1970       1980       1990       2000
PTLDTIRYSA LMELLTTHQK PSIFVGPTGT GKSVYITNFL LNQLNKEIYK 
      2010       2020       2030       2040       2050
PLLINFSAQT TAAQTQNIVM SKLDKRRKGV FGPPLGKRMV VFVDDVNMPA 
      2060       2070       2080       2090       2100
REVYGAQPPI ELLRQWLDHW NWYDLKDCSM IKLVDIQIMC AMGPPGGGRN 
      2110       2120       2130       2140       2150
PVTPRYMRHF NIITINEFSD KSMYTIFSRI LTWHLEICYK FPDEFLDLTT 
      2160       2170       2180       2190       2200
QIVNGTMTLY KEAMKNLLPT PAKSHYLFNL RDFSRVIQGV CLSRPETTET 
      2210       2220       2230       2240       2250
TEVIKRLWVH EVLRVYYDRL LDNTDRSWLI NYIQEILRNY MYEDFHELFQ 
      2260       2270       2280       2290       2300
RLDFDNDGMV EADDLRSLMF CDFHDPKRED TNYREIADVD NLRMIVEIHL 
      2310       2320       2330       2340       2350
EEYNNISKKP MNLVLFRFAI EHISRISRIL KQPRSHALLV GVGGSGRQSV 
      2360       2370       2380       2390       2400
TRLAAHMADY SVFQVEISKG YDTTEWHEDL KVILRKCAEG EMQGVFLFTD 
      2410       2420       2430       2440       2450
TQIKEESFLE DVSNLLNAGE IPNLFALDEK QEICDKMRQL DRQRDKTKQT 
      2460       2470       2480       2490       2500
DGSPIALFNM FIDHCRSQLH VVLAMSPIGD AFRNRLRKFP ALVNCCTIDW 
      2510       2520       2530       2540       2550
FQSWPEDALQ AVASRFLEEI EMSEEIRDGC IDMCKSFHTS TIDLSKSFFV 
      2560       2570       2580       2590       2600
ELQRYNYVTP TSYLELISTF KLLLEKKRSE VMKMKKRYEV GLEKLDSASS 
      2610       2620       2630       2640       2650
QVATMQMELE ALHPQLKVAS KEVDEMMIMI EKESVEVAKT EKIVKADETI 
      2660       2670       2680       2690       2700
ANEQAMASKA IKDECDADLA GALPILESAL AALDTLTAQD ITVVKSMKSP 
      2710       2720       2730       2740       2750
PAGVKLVMEA ICILKGIKAD KIPDPTGSGK KIEDFWGPAK RLLGDMRFLQ 
      2760       2770       2780       2790       2800
SLHEYDKDNI PPAYMNIIRK NYIPNPDFVP EKIRNASTAA EGLCKWVIAM 
      2810       2820       2830       2840       2850
DSYDKVAKIV APKKIKLAAA EGELKIAMDG LRKKQAALKE VQDKLARLQD 
      2860       2870       2880       2890       2900
TLELNKQKKA DLENQVDLCS KKLERAEQLI GGLGGEKTRW SHTALELGQL 
      2910       2920       2930       2940       2950
YINLTGDILI SSGVVAYLGA FTSTYRQNQT KEWTTLCKGR DIPCSDDCSL 
      2960       2970       2980       2990       3000
MGTLGEAVTI RTWNIAGLPS DSFSIDNGII IMNARRWPLM IDPQSQANKW 
      3010       3020       3030       3040       3050
IKNMEKANSL YVIKLSEPDY VRTLENCIQF GTPVLLENVG EELDPILEPL 
      3060       3070       3080       3090       3100
LLKQTFKQGG STCIRLGDST IEYAPDFRFY ITTKLRNPHY LPETSVKVTL 
      3110       3120       3130       3140       3150
LNFMITPEGM QDQLLGIVVA QERPDLEEEK QALILQGAEN KRQLKEIEDK 
      3160       3170       3180       3190       3200
ILEVLSSSEG NILEDETAIK ILSSSKALAN EISQKQEVAE ETEKKIDTTR 
      3210       3220       3230       3240       3250
MGYRPIAIHS SILFFSLADL ANIEPMYQYS LTWFINLFIL SIENSEKSEI 
      3260       3270       3280       3290       3300
LAKRLQILKD HFTYSLYVNV CRSLFEKDKL LFSFCLTINL LLHERAINKA 
      3310       3320       3330       3340       3350
EWRFLLTGGI GLDNPYANLC TWLPQKSWDE ICRLDDLPAF KTIRREFMRL 
      3360       3370       3380       3390       3400
KDGWKKVYDS LEPHHEVFPE EWEDKANEFQ RMLIIRCLRP DKVIPMLQEF 
      3410       3420       3430       3440       3450
IINRLGRAFI EPPPFDLAKA FGDSNCCAPL IFVLSPGADP MAALLKFADD 
      3460       3470       3480       3490       3500
QGYGGSKLSS LSLGQGQGPI AMKMLEKAVK EGTWVVLQNC HLATSWMPTL 
      3510       3520       3530       3540       3550
EKVCEELSPE STHPDFRMWL TSYPSPNFPV SVLQNGVKMT NEAPKGLRAN 
      3560       3570       3580       3590       3600
IIRSYLMDPI SDPEFFGSCK KPEEFKKLLY GLCFFHALVQ ERRKFGPLGW 
      3610       3620       3630       3640       3650
NIPYEFNETD LRISVQQLHM FLNQYEELPY EALRYMTGEC NYGGRVTDDW 
      3660       3670       3680       3690       3700
DRRTLRSILN KFFNPELVEN SDYKFDSSGI YFVPPSGDHK SYIEYTKTLP 
      3710       3720       3730       3740       3750
LTPAPEIFGM NANADITKDQ SETQLLFDNI LLTQSRSAGA GAKSSDEVVN 
      3760       3770       3780       3790       3800
EVASDILGKL PNNFDIEAAM RRYPTTYTQS MNTVLVQEMG RFNKLLKTIR 
      3810       3820       3830       3840       3850
DSCVNIQKAI KGLAVMSTDL EEVVSSILNV KIPEMWMGKS YPSLKPLGSY 
      3860       3870       3880       3890       3900
VNDFLARLKF LQQWYEVGPP PVFWLSGFFF TQAFLTGAQQ NYARKYTIPI 
      3910       3920       3930       3940       3950
DLLGFDYEVM EDKEYKHPPE DGVFIHGLFL DGASWNRKIK KLAESHPKIL 
      3960       3970       3980       3990       4000
YDTVPVMWLK PCKRADIPKR PSYVAPLYKT SERRGVLSTT GHSTNFVIAM 
      4010       4020 
TLPSDQPKEH WIGRGVALLC QLNS
Length:4,024
Mass (Da):461,159
Last modified:November 2, 2010 - v2
Checksum:i3C2E3B2D7B886540
GO
Isoform 2 (identifier: Q8WXX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3517: Missing.

Show »
Length:507
Mass (Da):57,974
Checksum:iAB5707A34AB8C4A9
GO
Isoform 3 (identifier: Q8WXX0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1452: Missing.
     1633-1639: GLMEENK → ASILLMH
     1640-4024: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):20,899
Checksum:i6E20B0069EADFBBB
GO
Isoform 4 (identifier: Q8WXX0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-501: ESKSKPTTLK...RLYDKYDFLI → RNKAKPGHFY...VLGFTWRCQL
     502-4024: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):57,686
Checksum:i003C7D9464323C5D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUY3C9JUY3_HUMAN
Dynein heavy chain 7, axonemal
DNAH7
121Annotation score:
H7C362H7C362_HUMAN
Dynein heavy chain 7, axonemal
DNAH7
56Annotation score:

Sequence cautioni

The sequence BAA76788 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB06055 differs from that shown. Reason: Frameshift at position 1502.Curated
The sequence CAH18445 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH18445 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti433M → V in BAC04372 (PubMed:14702039).Curated1
Sequence conflicti1020I → T in BAA76788 (PubMed:10231032).Curated1
Sequence conflicti1292Y → F in CAA10557 (PubMed:11175280).Curated1
Sequence conflicti1353N → D in CAB06055 (PubMed:9373155).Curated1
Sequence conflicti1355S → P in CAB06055 (PubMed:9373155).Curated1
Sequence conflicti1467Y → H in CAH18445 (PubMed:17974005).Curated1
Sequence conflicti1502M → L in CAB06055 (PubMed:9373155).Curated1
Sequence conflicti3563P → L in AAH29567 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038580169H → P. Corresponds to variant dbSNP:rs1072599Ensembl.1
Natural variantiVAR_038581280A → T. Corresponds to variant dbSNP:rs2375643Ensembl.1
Natural variantiVAR_038582315I → V. Corresponds to variant dbSNP:rs17838596Ensembl.1
Natural variantiVAR_038583438S → N. Corresponds to variant dbSNP:rs16843720Ensembl.1
Natural variantiVAR_038584545R → C1 PublicationCorresponds to variant dbSNP:rs10931715EnsemblClinVar.1
Natural variantiVAR_038585565D → H. Corresponds to variant dbSNP:rs2635718Ensembl.1
Natural variantiVAR_038586675K → E. Corresponds to variant dbSNP:rs10198893Ensembl.1
Natural variantiVAR_038587825K → E. Corresponds to variant dbSNP:rs6719500Ensembl.1
Natural variantiVAR_0385881422P → T. Corresponds to variant dbSNP:rs168192Ensembl.1
Natural variantiVAR_0385891525E → K. Corresponds to variant dbSNP:rs13415574Ensembl.1
Natural variantiVAR_0385901886R → Q. Corresponds to variant dbSNP:rs13034775Ensembl.1
Natural variantiVAR_0385911940P → L. Corresponds to variant dbSNP:rs2375544Ensembl.1
Natural variantiVAR_0385921971P → L. Corresponds to variant dbSNP:rs2889109Ensembl.1
Natural variantiVAR_0385932020M → T. Corresponds to variant dbSNP:rs10184131Ensembl.1
Natural variantiVAR_0385942459N → K. Corresponds to variant dbSNP:rs16841199Ensembl.1
Natural variantiVAR_0385952569T → I. Corresponds to variant dbSNP:rs2293066Ensembl.1
Natural variantiVAR_0385962809I → V. Corresponds to variant dbSNP:rs16841018Ensembl.1
Natural variantiVAR_0385973319L → P2 PublicationsCorresponds to variant dbSNP:rs13411834EnsemblClinVar.1
Natural variantiVAR_0385983386R → H. Corresponds to variant dbSNP:rs6708527Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0311311 – 3517Missing in isoform 2. 1 PublicationAdd BLAST3517
Alternative sequenceiVSP_0311321 – 1452Missing in isoform 3. 1 PublicationAdd BLAST1452
Alternative sequenceiVSP_031133452 – 501ESKSK…YDFLI → RNKAKPGHFYFSHIQRSVTF QHSEVSSPQNSHFKIVSPFS VLGFTWRCQL in isoform 4. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_031134502 – 4024Missing in isoform 4. 1 PublicationAdd BLAST3523
Alternative sequenceiVSP_0311351633 – 1639GLMEENK → ASILLMH in isoform 3. 1 Publication7
Alternative sequenceiVSP_0311361640 – 4024Missing in isoform 3. 1 PublicationAdd BLAST2385

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327442 mRNA Translation: AAL37427.1
AB023161 mRNA Translation: BAA76788.2 Different initiation.
AK094515 mRNA Translation: BAC04372.1
CR749651 mRNA Translation: CAH18445.1 Sequence problems.
AC013274 Genomic DNA Translation: AAY14776.1
AC068919 Genomic DNA Translation: AAY14995.1
AC104600 Genomic DNA Translation: AAY24051.1
AC114760 Genomic DNA No translation available.
BC029567 mRNA Translation: AAH29567.1
AJ132084 mRNA Translation: CAA10557.1
AJ132093 Genomic DNA Translation: CAB46444.1
Z83801 mRNA Translation: CAB06055.1 Frameshift.
CCDSiCCDS42794.1 [Q8WXX0-1]
RefSeqiNP_061720.2, NM_018897.2 [Q8WXX0-1]
XP_011509789.1, XM_011511487.2
UniGeneiHs.97403

Genome annotation databases

EnsembliENST00000312428; ENSP00000311273; ENSG00000118997 [Q8WXX0-1]
ENST00000409063; ENSP00000386912; ENSG00000118997 [Q8WXX0-2]
ENST00000410072; ENSP00000386260; ENSG00000118997 [Q8WXX0-4]
GeneIDi56171
KEGGihsa:56171
UCSCiuc002uti.5 human [Q8WXX0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327442 mRNA Translation: AAL37427.1
AB023161 mRNA Translation: BAA76788.2 Different initiation.
AK094515 mRNA Translation: BAC04372.1
CR749651 mRNA Translation: CAH18445.1 Sequence problems.
AC013274 Genomic DNA Translation: AAY14776.1
AC068919 Genomic DNA Translation: AAY14995.1
AC104600 Genomic DNA Translation: AAY24051.1
AC114760 Genomic DNA No translation available.
BC029567 mRNA Translation: AAH29567.1
AJ132084 mRNA Translation: CAA10557.1
AJ132093 Genomic DNA Translation: CAB46444.1
Z83801 mRNA Translation: CAB06055.1 Frameshift.
CCDSiCCDS42794.1 [Q8WXX0-1]
RefSeqiNP_061720.2, NM_018897.2 [Q8WXX0-1]
XP_011509789.1, XM_011511487.2
UniGeneiHs.97403

3D structure databases

ProteinModelPortaliQ8WXX0
SMRiQ8WXX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121102, 3 interactors
IntActiQ8WXX0, 1 interactor
MINTiQ8WXX0
STRINGi9606.ENSP00000311273

PTM databases

iPTMnetiQ8WXX0
PhosphoSitePlusiQ8WXX0

Polymorphism and mutation databases

BioMutaiDNAH7
DMDMi311033375

Proteomic databases

EPDiQ8WXX0
MaxQBiQ8WXX0
PaxDbiQ8WXX0
PeptideAtlasiQ8WXX0
PRIDEiQ8WXX0
ProteomicsDBi75108
75109 [Q8WXX0-2]
75110 [Q8WXX0-3]
75111 [Q8WXX0-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312428; ENSP00000311273; ENSG00000118997 [Q8WXX0-1]
ENST00000409063; ENSP00000386912; ENSG00000118997 [Q8WXX0-2]
ENST00000410072; ENSP00000386260; ENSG00000118997 [Q8WXX0-4]
GeneIDi56171
KEGGihsa:56171
UCSCiuc002uti.5 human [Q8WXX0-1]

Organism-specific databases

CTDi56171
DisGeNETi56171
EuPathDBiHostDB:ENSG00000118997.13
GeneCardsiDNAH7
H-InvDBiHIX0002692
HGNCiHGNC:18661 DNAH7
HPAiHPA034724
HPA044070
MalaCardsiDNAH7
MIMi610061 gene
neXtProtiNX_Q8WXX0
OpenTargetsiENSG00000118997
PharmGKBiPA38625
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00760000118964
HOVERGENiHBG107830
InParanoidiQ8WXX0
KOiK10408
OMAiRKCAEGE
OrthoDBiEOG091G00FO
PhylomeDBiQ8WXX0
TreeFamiTF316836

Miscellaneous databases

ChiTaRSiDNAH7 human
GenomeRNAii56171
PROiPR:Q8WXX0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118997 Expressed in 155 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ8WXX0 baseline and differential
GenevisibleiQ8WXX0 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_dom
IPR013602 Dynein_heavy_dom-2
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDYH7_HUMAN
AccessioniPrimary (citable) accession number: Q8WXX0
Secondary accession number(s): B8ZZX8
, O00433, O95492, Q4G152, Q53QX7, Q53S64, Q53T02, Q68CY5, Q8N1Z2, Q9UMS3, Q9Y2F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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