UniProtKB - Q8WXX0 (DYH7_HUMAN)
Protein
Dynein heavy chain 7, axonemal
Gene
DNAH7
Organism
Homo sapiens (Human)
Status
Functioni
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 132 – 139 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 1328 – 1335 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 1609 – 1616 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 1976 – 1983 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 2341 – 2348 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP-dependent microtubule motor activity, minus-end-directed Source: GO_Central
- calcium ion binding Source: InterPro
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
- microtubule motor activity Source: UniProtKB
GO - Biological processi
- cilium-dependent cell motility Source: UniProtKB
- cilium movement Source: SYSCILIA_CCNET
- inner dynein arm assembly Source: SYSCILIA_CCNET
- microtubule-based movement Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8WXX0 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynein heavy chain 7, axonemalAlternative name(s): Axonemal beta dynein heavy chain 7 Ciliary dynein heavy chain 7 Dynein heavy chain-like protein 2 hDHC2 |
Gene namesi | Name:DNAH7 Synonyms:KIAA0944 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18661, DNAH7 |
MIMi | 610061, gene |
neXtProti | NX_Q8WXX0 |
VEuPathDBi | HostDB:ENSG00000118997.13 |
Subcellular locationi
Cytoskeleton
- cilium axoneme 1 Publication
Cytoskeleton
- axonemal dynein complex Source: GO_Central
- dynein complex Source: GO_Central
- inner dynein arm Source: SYSCILIA_CCNET
- microtubule Source: UniProtKB-KW
Cytosol
- cytosol Source: HPA
Other locations
- cilium Source: MGI
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 56171 |
MalaCardsi | DNAH7 |
OpenTargetsi | ENSG00000118997 |
PharmGKBi | PA38625 |
Miscellaneous databases
Pharosi | Q8WXX0, Tbio |
Genetic variation databases
BioMutai | DNAH7 |
DMDMi | 311033375 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317666 | 1 – 4024 | Dynein heavy chain 7, axonemalAdd BLAST | 4024 |
Proteomic databases
EPDi | Q8WXX0 |
jPOSTi | Q8WXX0 |
MassIVEi | Q8WXX0 |
MaxQBi | Q8WXX0 |
PaxDbi | Q8WXX0 |
PeptideAtlasi | Q8WXX0 |
PRIDEi | Q8WXX0 |
ProteomicsDBi | 75108 [Q8WXX0-1] 75109 [Q8WXX0-2] 75110 [Q8WXX0-3] 75111 [Q8WXX0-4] |
PTM databases
GlyGeni | Q8WXX0, 1 site |
iPTMneti | Q8WXX0 |
PhosphoSitePlusi | Q8WXX0 |
Expressioni
Tissue specificityi
Detected in brain, testis and trachea. Detected in bronchial cells (at protein level).2 Publications
Inductioni
Up-regulated during ciliogenesis (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000118997, Expressed in right uterine tube and 168 other tissues |
ExpressionAtlasi | Q8WXX0, baseline and differential |
Genevisiblei | Q8WXX0, HS |
Organism-specific databases
HPAi | ENSG00000118997, Tissue enhanced (brain, fallopian tube, pituitary gland) |
Interactioni
Subunit structurei
The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.
By similarityGO - Molecular functioni
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 121102, 6 interactors |
IntActi | Q8WXX0, 2 interactors |
MINTi | Q8WXX0 |
STRINGi | 9606.ENSP00000311273 |
Miscellaneous databases
RNActi | Q8WXX0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 1289 | StemBy similarityAdd BLAST | 1289 | |
Regioni | 1290 – 1511 | AAA 1By similarityAdd BLAST | 222 | |
Regioni | 1571 – 1802 | AAA 2By similarityAdd BLAST | 232 | |
Regioni | 1938 – 2189 | AAA 3By similarityAdd BLAST | 252 | |
Regioni | 2302 – 2555 | AAA 4By similarityAdd BLAST | 254 | |
Regioni | 2572 – 2873 | StalkBy similarityAdd BLAST | 302 | |
Regioni | 2954 – 3184 | AAA 5By similarityAdd BLAST | 231 | |
Regioni | 3397 – 3620 | AAA 6By similarityAdd BLAST | 224 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 685 – 745 | Sequence analysisAdd BLAST | 61 | |
Coiled coili | 2827 – 2883 | Sequence analysisAdd BLAST | 57 |
Domaini
Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity
Sequence similaritiesi
Belongs to the dynein heavy chain family.Curated
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG3595, Eukaryota |
GeneTreei | ENSGT00940000155282 |
HOGENOMi | CLU_000038_1_3_1 |
InParanoidi | Q8WXX0 |
OMAi | DKSMYTI |
OrthoDBi | 2079at2759 |
PhylomeDBi | Q8WXX0 |
TreeFami | TF316836 |
Family and domain databases
Gene3Di | 1.10.8.710, 1 hit 1.10.8.720, 1 hit 1.20.140.100, 1 hit 3.10.490.20, 1 hit 3.20.180.20, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR035699, AAA_6 IPR035706, AAA_9 IPR041658, AAA_lid_11 IPR042219, AAA_lid_11_sf IPR041589, DNAH3_AAA_lid_1 IPR042228, Dynein_2_C IPR042222, Dynein_2_N IPR043157, Dynein_AAA1S IPR041466, Dynein_AAA5_ext IPR041228, Dynein_C IPR043160, Dynein_C_barrel IPR024743, Dynein_HC_stalk IPR024317, Dynein_heavy_chain_D4_dom IPR004273, Dynein_heavy_D6_P-loop IPR013602, Dynein_heavy_dom-2 IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF12774, AAA_6, 1 hit PF12780, AAA_8, 1 hit PF12781, AAA_9, 1 hit PF17857, AAA_lid_1, 1 hit PF18198, AAA_lid_11, 1 hit PF08393, DHC_N2, 1 hit PF17852, Dynein_AAA_lid, 1 hit PF18199, Dynein_C, 1 hit PF03028, Dynein_heavy, 1 hit PF12777, MT, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 4 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WXX0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSEQDKSAS KEKSKKPVRF LPQLSMEKLA SKEKFKAPAR ALPQLSMVST
60 70 80 90 100
KPHWQQAAPS FHLSVKQDDE SPEPFSVKNE QSHAEYMERF GKKGKLPHQV
110 120 130 140 150
DDSYVGPSTS KSKGKSPHKE RENFRSTLVN VIMQQDADLD SAVPDGSTIP
160 170 180 190 200
KPTASAIEKD ILRYYYYIHH GIDTDHVAPM EDSWLEHVLD LVPQHLKVFT
210 220 230 240 250
DSIVTLSDEM REDYLLSVRK SIVDFVLKDP REKGDDKKTD ELPAHRAEME
260 270 280 290 300
ILPKPWRKSF LAASSYIRDH LNAMNPTMLA VLDLWHTNFK KLRLVDIKEF
310 320 330 340 350
HNCQDALELS SFQNIIMRHM DSAKETLLKM WFPEVQNIYY QGNKKKQLPT
360 370 380 390 400
GDSSAKLESF FNCAAALMTL QLQDLTLVSM QDFTDLIAQP PDSVRAFEHP
410 420 430 440 450
GFIMRLILDN DTIKFEPELS DYIDIFLNVY DVMIKAVSFV PRVETKLYSK
460 470 480 490 500
WESKSKPTTL KPIILNEIVD AHKEKIKEVI MKESVAPTEH LRLYDKYDFL
510 520 530 540 550
ITRKAERDVD NFLAENHSYE KIIDEICKYQ KLIEEIQYTS IKTIRLGMFE
560 570 580 590 600
MHCEELIRAL VKRADIICGK LLAKMFRDHQ EVNTRLCDEF ERIAEKALST
610 620 630 640 650
PPNTAELMEM KAYIQKVEVT DMIELEQRLV DSKNCLAFLI EYVNFSPADM
660 670 680 690 700
RLNNSVFQWY GRMGEIFEEH RKIIKEKIEQ YQEGLKLRCE RFVEELESYA
710 720 730 740 750
KQSEEFYSFG DLQDVQRYLK KAQILNGKLD LAADKIEQFN AEEEAFGWLP
760 770 780 790 800
SVYPQRKKIQ DGLNPYLRLY ETAVEFSSNY RAWTEGPYHK VNPDQVEADI
810 820 830 840 850
GNYWRGLYKL EKTFHDSPYA LAMTKKVRSK VEDFKQHIPL IQVICNPGLR
860 870 880 890 900
PRHWEAMSAI VGYPLQPSDD STVSSFLDMN LEPYIDRFEG ISEAASKEYS
910 920 930 940 950
LEKAMEKMIT EWDAVEFVIH SYRETGTFIL ASVDEIQMLL DDHIIKTQTM
960 970 980 990 1000
RGSPFIKPYE KQMREWEGKL LLLQEILDEW LKVQATWLYL EPIFSSPDIM
1010 1020 1030 1040 1050
SQMPEEGRRF TAVDKTWRDI MRSVMQDKHV LTVVTIDRML ERLKKSNELL
1060 1070 1080 1090 1100
ELILKGLNEY LEKKRLFFPR FFFLSNDELL EILSETKDPT RVQPHLKKCF
1110 1120 1130 1140 1150
EGIAKVEFTE TLDITHMKSS EGEVVELIEI ISTAKARGQV EKWLVELERV
1160 1170 1180 1190 1200
MINSIHKVTG DATFAYTKYE RINWVRDWPG QTVLCVSQIF WTKEVQTAIP
1210 1220 1230 1240 1250
MGIKALEQYL KTCNRQIDDI VTLVRGKLSM QNRVTLGALV VLDVHARDVL
1260 1270 1280 1290 1300
SSLVKKNISD DSDFEWLSQL RYYWQENHLE TKMINAGLRY GYEYLGNSPR
1310 1320 1330 1340 1350
LVITPLTDRC YRTLFGALHL HLGGAPEGPA GTGKTETTKD LAKAVAKQCV
1360 1370 1380 1390 1400
VFNCSDGLDY LALGKFFKGL LSCGAWACFD EFNRIDLEVL SVVAQQILTI
1410 1420 1430 1440 1450
QRGINAGADI LMFEGTELKL DPTCAVFITM NPGYAGRSEL PDNLKALFRT
1460 1470 1480 1490 1500
VAMMVPDYAM IAEIVLYSCG FVTARPLSVK IVATYRLCSE QLSSQHHYDY
1510 1520 1530 1540 1550
GMRAVKSVLT AAGNLKLKYP NENEEILLLR SIIDVNLPKF LSHDLPLFEG
1560 1570 1580 1590 1600
ITSDLFPGVK LPKPDYNDLL AAIKDNCASM NLQMTAFFSE KILQVYEMMI
1610 1620 1630 1640 1650
VRHGFMIVGE PFGGKTSAYR VLAGALNDIC EKGLMEENKV QITVLNPKSV
1660 1670 1680 1690 1700
TMGQLYGQFD SVSHEWSDGV LAVSFRAFAS SVTPDRKWLI FDGPVDAVWI
1710 1720 1730 1740 1750
ENMNTVLDDN KKLCLMSGEI IQMSPQMNLI FEPMDLEVAS PATVSRCGMI
1760 1770 1780 1790 1800
YMEPHMLGWR PLMLSWVNLL PASVSVIQKE FIMGLFDRMV PVSVEFIRKH
1810 1820 1830 1840 1850
TKELSPTSDT NLVRSLMNLI DCFMDDFADE VKLKERNDRE TYSLLEGIFL
1860 1870 1880 1890 1900
FSLIWSVGAS CTDDDRLKFN KILRELMESP ISDRTRNTFK LQSGTEQTSS
1910 1920 1930 1940 1950
KALTVPFPEK GTIYDYQFVT EGIGKWEPWI KKLKEAPPIP KDVMFNEIIV
1960 1970 1980 1990 2000
PTLDTIRYSA LMELLTTHQK PSIFVGPTGT GKSVYITNFL LNQLNKEIYK
2010 2020 2030 2040 2050
PLLINFSAQT TAAQTQNIVM SKLDKRRKGV FGPPLGKRMV VFVDDVNMPA
2060 2070 2080 2090 2100
REVYGAQPPI ELLRQWLDHW NWYDLKDCSM IKLVDIQIMC AMGPPGGGRN
2110 2120 2130 2140 2150
PVTPRYMRHF NIITINEFSD KSMYTIFSRI LTWHLEICYK FPDEFLDLTT
2160 2170 2180 2190 2200
QIVNGTMTLY KEAMKNLLPT PAKSHYLFNL RDFSRVIQGV CLSRPETTET
2210 2220 2230 2240 2250
TEVIKRLWVH EVLRVYYDRL LDNTDRSWLI NYIQEILRNY MYEDFHELFQ
2260 2270 2280 2290 2300
RLDFDNDGMV EADDLRSLMF CDFHDPKRED TNYREIADVD NLRMIVEIHL
2310 2320 2330 2340 2350
EEYNNISKKP MNLVLFRFAI EHISRISRIL KQPRSHALLV GVGGSGRQSV
2360 2370 2380 2390 2400
TRLAAHMADY SVFQVEISKG YDTTEWHEDL KVILRKCAEG EMQGVFLFTD
2410 2420 2430 2440 2450
TQIKEESFLE DVSNLLNAGE IPNLFALDEK QEICDKMRQL DRQRDKTKQT
2460 2470 2480 2490 2500
DGSPIALFNM FIDHCRSQLH VVLAMSPIGD AFRNRLRKFP ALVNCCTIDW
2510 2520 2530 2540 2550
FQSWPEDALQ AVASRFLEEI EMSEEIRDGC IDMCKSFHTS TIDLSKSFFV
2560 2570 2580 2590 2600
ELQRYNYVTP TSYLELISTF KLLLEKKRSE VMKMKKRYEV GLEKLDSASS
2610 2620 2630 2640 2650
QVATMQMELE ALHPQLKVAS KEVDEMMIMI EKESVEVAKT EKIVKADETI
2660 2670 2680 2690 2700
ANEQAMASKA IKDECDADLA GALPILESAL AALDTLTAQD ITVVKSMKSP
2710 2720 2730 2740 2750
PAGVKLVMEA ICILKGIKAD KIPDPTGSGK KIEDFWGPAK RLLGDMRFLQ
2760 2770 2780 2790 2800
SLHEYDKDNI PPAYMNIIRK NYIPNPDFVP EKIRNASTAA EGLCKWVIAM
2810 2820 2830 2840 2850
DSYDKVAKIV APKKIKLAAA EGELKIAMDG LRKKQAALKE VQDKLARLQD
2860 2870 2880 2890 2900
TLELNKQKKA DLENQVDLCS KKLERAEQLI GGLGGEKTRW SHTALELGQL
2910 2920 2930 2940 2950
YINLTGDILI SSGVVAYLGA FTSTYRQNQT KEWTTLCKGR DIPCSDDCSL
2960 2970 2980 2990 3000
MGTLGEAVTI RTWNIAGLPS DSFSIDNGII IMNARRWPLM IDPQSQANKW
3010 3020 3030 3040 3050
IKNMEKANSL YVIKLSEPDY VRTLENCIQF GTPVLLENVG EELDPILEPL
3060 3070 3080 3090 3100
LLKQTFKQGG STCIRLGDST IEYAPDFRFY ITTKLRNPHY LPETSVKVTL
3110 3120 3130 3140 3150
LNFMITPEGM QDQLLGIVVA QERPDLEEEK QALILQGAEN KRQLKEIEDK
3160 3170 3180 3190 3200
ILEVLSSSEG NILEDETAIK ILSSSKALAN EISQKQEVAE ETEKKIDTTR
3210 3220 3230 3240 3250
MGYRPIAIHS SILFFSLADL ANIEPMYQYS LTWFINLFIL SIENSEKSEI
3260 3270 3280 3290 3300
LAKRLQILKD HFTYSLYVNV CRSLFEKDKL LFSFCLTINL LLHERAINKA
3310 3320 3330 3340 3350
EWRFLLTGGI GLDNPYANLC TWLPQKSWDE ICRLDDLPAF KTIRREFMRL
3360 3370 3380 3390 3400
KDGWKKVYDS LEPHHEVFPE EWEDKANEFQ RMLIIRCLRP DKVIPMLQEF
3410 3420 3430 3440 3450
IINRLGRAFI EPPPFDLAKA FGDSNCCAPL IFVLSPGADP MAALLKFADD
3460 3470 3480 3490 3500
QGYGGSKLSS LSLGQGQGPI AMKMLEKAVK EGTWVVLQNC HLATSWMPTL
3510 3520 3530 3540 3550
EKVCEELSPE STHPDFRMWL TSYPSPNFPV SVLQNGVKMT NEAPKGLRAN
3560 3570 3580 3590 3600
IIRSYLMDPI SDPEFFGSCK KPEEFKKLLY GLCFFHALVQ ERRKFGPLGW
3610 3620 3630 3640 3650
NIPYEFNETD LRISVQQLHM FLNQYEELPY EALRYMTGEC NYGGRVTDDW
3660 3670 3680 3690 3700
DRRTLRSILN KFFNPELVEN SDYKFDSSGI YFVPPSGDHK SYIEYTKTLP
3710 3720 3730 3740 3750
LTPAPEIFGM NANADITKDQ SETQLLFDNI LLTQSRSAGA GAKSSDEVVN
3760 3770 3780 3790 3800
EVASDILGKL PNNFDIEAAM RRYPTTYTQS MNTVLVQEMG RFNKLLKTIR
3810 3820 3830 3840 3850
DSCVNIQKAI KGLAVMSTDL EEVVSSILNV KIPEMWMGKS YPSLKPLGSY
3860 3870 3880 3890 3900
VNDFLARLKF LQQWYEVGPP PVFWLSGFFF TQAFLTGAQQ NYARKYTIPI
3910 3920 3930 3940 3950
DLLGFDYEVM EDKEYKHPPE DGVFIHGLFL DGASWNRKIK KLAESHPKIL
3960 3970 3980 3990 4000
YDTVPVMWLK PCKRADIPKR PSYVAPLYKT SERRGVLSTT GHSTNFVIAM
4010 4020
TLPSDQPKEH WIGRGVALLC QLNS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JUY3 | C9JUY3_HUMAN | Dynein heavy chain 7, axonemal | DNAH7 | 121 | Annotation score: | ||
H7C362 | H7C362_HUMAN | Dynein heavy chain 7, axonemal | DNAH7 | 56 | Annotation score: |
Sequence cautioni
The sequence BAA76788 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAB06055 differs from that shown. Reason: Frameshift.Curated
The sequence CAH18445 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAH18445 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 433 | M → V in BAC04372 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1020 | I → T in BAA76788 (PubMed:10231032).Curated | 1 | |
Sequence conflicti | 1292 | Y → F in CAA10557 (PubMed:11175280).Curated | 1 | |
Sequence conflicti | 1353 | N → D in CAB06055 (PubMed:9373155).Curated | 1 | |
Sequence conflicti | 1355 | S → P in CAB06055 (PubMed:9373155).Curated | 1 | |
Sequence conflicti | 1467 | Y → H in CAH18445 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1502 | M → L in CAB06055 (PubMed:9373155).Curated | 1 | |
Sequence conflicti | 3563 | P → L in AAH29567 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038580 | 169 | H → P. Corresponds to variant dbSNP:rs1072599Ensembl. | 1 | |
Natural variantiVAR_038581 | 280 | A → T. Corresponds to variant dbSNP:rs2375643Ensembl. | 1 | |
Natural variantiVAR_038582 | 315 | I → V. Corresponds to variant dbSNP:rs17838596Ensembl. | 1 | |
Natural variantiVAR_038583 | 438 | S → N. Corresponds to variant dbSNP:rs16843720EnsemblClinVar. | 1 | |
Natural variantiVAR_038584 | 545 | R → C1 PublicationCorresponds to variant dbSNP:rs10931715EnsemblClinVar. | 1 | |
Natural variantiVAR_038585 | 565 | D → H. Corresponds to variant dbSNP:rs2635718Ensembl. | 1 | |
Natural variantiVAR_038586 | 675 | K → E. Corresponds to variant dbSNP:rs10198893EnsemblClinVar. | 1 | |
Natural variantiVAR_038587 | 825 | K → E. Corresponds to variant dbSNP:rs6719500Ensembl. | 1 | |
Natural variantiVAR_038588 | 1422 | P → T. Corresponds to variant dbSNP:rs168192EnsemblClinVar. | 1 | |
Natural variantiVAR_038589 | 1525 | E → K. Corresponds to variant dbSNP:rs13415574Ensembl. | 1 | |
Natural variantiVAR_038590 | 1886 | R → Q. Corresponds to variant dbSNP:rs13034775Ensembl. | 1 | |
Natural variantiVAR_038591 | 1940 | P → L. Corresponds to variant dbSNP:rs2375544Ensembl. | 1 | |
Natural variantiVAR_038592 | 1971 | P → L. Corresponds to variant dbSNP:rs2889109Ensembl. | 1 | |
Natural variantiVAR_038593 | 2020 | M → T. Corresponds to variant dbSNP:rs10184131EnsemblClinVar. | 1 | |
Natural variantiVAR_038594 | 2459 | N → K. Corresponds to variant dbSNP:rs16841199EnsemblClinVar. | 1 | |
Natural variantiVAR_038595 | 2569 | T → I. Corresponds to variant dbSNP:rs2293066Ensembl. | 1 | |
Natural variantiVAR_038596 | 2809 | I → V. Corresponds to variant dbSNP:rs16841018Ensembl. | 1 | |
Natural variantiVAR_038597 | 3319 | L → P2 PublicationsCorresponds to variant dbSNP:rs13411834EnsemblClinVar. | 1 | |
Natural variantiVAR_038598 | 3386 | R → H. Corresponds to variant dbSNP:rs6708527Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031131 | 1 – 3517 | Missing in isoform 2. 1 PublicationAdd BLAST | 3517 | |
Alternative sequenceiVSP_031132 | 1 – 1452 | Missing in isoform 3. 1 PublicationAdd BLAST | 1452 | |
Alternative sequenceiVSP_031133 | 452 – 501 | ESKSK…YDFLI → RNKAKPGHFYFSHIQRSVTF QHSEVSSPQNSHFKIVSPFS VLGFTWRCQL in isoform 4. 1 PublicationAdd BLAST | 50 | |
Alternative sequenceiVSP_031134 | 502 – 4024 | Missing in isoform 4. 1 PublicationAdd BLAST | 3523 | |
Alternative sequenceiVSP_031135 | 1633 – 1639 | GLMEENK → ASILLMH in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_031136 | 1640 – 4024 | Missing in isoform 3. 1 PublicationAdd BLAST | 2385 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF327442 mRNA Translation: AAL37427.1 AB023161 mRNA Translation: BAA76788.2 Different initiation. AK094515 mRNA Translation: BAC04372.1 CR749651 mRNA Translation: CAH18445.1 Sequence problems. AC013274 Genomic DNA Translation: AAY14776.1 AC068919 Genomic DNA Translation: AAY14995.1 AC104600 Genomic DNA Translation: AAY24051.1 AC114760 Genomic DNA No translation available. BC029567 mRNA Translation: AAH29567.1 AJ132084 mRNA Translation: CAA10557.1 AJ132093 Genomic DNA Translation: CAB46444.1 Z83801 mRNA Translation: CAB06055.1 Frameshift. |
CCDSi | CCDS42794.1 [Q8WXX0-1] |
RefSeqi | NP_061720.2, NM_018897.2 [Q8WXX0-1] XP_011509789.1, XM_011511487.2 |
Genome annotation databases
Ensembli | ENST00000312428; ENSP00000311273; ENSG00000118997 [Q8WXX0-1] ENST00000409063; ENSP00000386912; ENSG00000118997 [Q8WXX0-2] ENST00000410072; ENSP00000386260; ENSG00000118997 [Q8WXX0-4] |
GeneIDi | 56171 |
KEGGi | hsa:56171 |
UCSCi | uc002uti.5, human [Q8WXX0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF327442 mRNA Translation: AAL37427.1 AB023161 mRNA Translation: BAA76788.2 Different initiation. AK094515 mRNA Translation: BAC04372.1 CR749651 mRNA Translation: CAH18445.1 Sequence problems. AC013274 Genomic DNA Translation: AAY14776.1 AC068919 Genomic DNA Translation: AAY14995.1 AC104600 Genomic DNA Translation: AAY24051.1 AC114760 Genomic DNA No translation available. BC029567 mRNA Translation: AAH29567.1 AJ132084 mRNA Translation: CAA10557.1 AJ132093 Genomic DNA Translation: CAB46444.1 Z83801 mRNA Translation: CAB06055.1 Frameshift. |
CCDSi | CCDS42794.1 [Q8WXX0-1] |
RefSeqi | NP_061720.2, NM_018897.2 [Q8WXX0-1] XP_011509789.1, XM_011511487.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6RZA | electron microscopy | 5.40 | X | 2675-2812 | [»] | |
SMRi | Q8WXX0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121102, 6 interactors |
IntActi | Q8WXX0, 2 interactors |
MINTi | Q8WXX0 |
STRINGi | 9606.ENSP00000311273 |
PTM databases
GlyGeni | Q8WXX0, 1 site |
iPTMneti | Q8WXX0 |
PhosphoSitePlusi | Q8WXX0 |
Genetic variation databases
BioMutai | DNAH7 |
DMDMi | 311033375 |
Proteomic databases
EPDi | Q8WXX0 |
jPOSTi | Q8WXX0 |
MassIVEi | Q8WXX0 |
MaxQBi | Q8WXX0 |
PaxDbi | Q8WXX0 |
PeptideAtlasi | Q8WXX0 |
PRIDEi | Q8WXX0 |
ProteomicsDBi | 75108 [Q8WXX0-1] 75109 [Q8WXX0-2] 75110 [Q8WXX0-3] 75111 [Q8WXX0-4] |
Protocols and materials databases
Antibodypediai | 49680, 37 antibodies |
Genome annotation databases
Ensembli | ENST00000312428; ENSP00000311273; ENSG00000118997 [Q8WXX0-1] ENST00000409063; ENSP00000386912; ENSG00000118997 [Q8WXX0-2] ENST00000410072; ENSP00000386260; ENSG00000118997 [Q8WXX0-4] |
GeneIDi | 56171 |
KEGGi | hsa:56171 |
UCSCi | uc002uti.5, human [Q8WXX0-1] |
Organism-specific databases
CTDi | 56171 |
DisGeNETi | 56171 |
GeneCardsi | DNAH7 |
HGNCi | HGNC:18661, DNAH7 |
HPAi | ENSG00000118997, Tissue enhanced (brain, fallopian tube, pituitary gland) |
MalaCardsi | DNAH7 |
MIMi | 610061, gene |
neXtProti | NX_Q8WXX0 |
OpenTargetsi | ENSG00000118997 |
PharmGKBi | PA38625 |
VEuPathDBi | HostDB:ENSG00000118997.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3595, Eukaryota |
GeneTreei | ENSGT00940000155282 |
HOGENOMi | CLU_000038_1_3_1 |
InParanoidi | Q8WXX0 |
OMAi | DKSMYTI |
OrthoDBi | 2079at2759 |
PhylomeDBi | Q8WXX0 |
TreeFami | TF316836 |
Enzyme and pathway databases
PathwayCommonsi | Q8WXX0 |
Miscellaneous databases
BioGRID-ORCSi | 56171, 3 hits in 874 CRISPR screens |
ChiTaRSi | DNAH7, human |
GenomeRNAii | 56171 |
Pharosi | Q8WXX0, Tbio |
PROi | PR:Q8WXX0 |
RNActi | Q8WXX0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118997, Expressed in right uterine tube and 168 other tissues |
ExpressionAtlasi | Q8WXX0, baseline and differential |
Genevisiblei | Q8WXX0, HS |
Family and domain databases
Gene3Di | 1.10.8.710, 1 hit 1.10.8.720, 1 hit 1.20.140.100, 1 hit 3.10.490.20, 1 hit 3.20.180.20, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR035699, AAA_6 IPR035706, AAA_9 IPR041658, AAA_lid_11 IPR042219, AAA_lid_11_sf IPR041589, DNAH3_AAA_lid_1 IPR042228, Dynein_2_C IPR042222, Dynein_2_N IPR043157, Dynein_AAA1S IPR041466, Dynein_AAA5_ext IPR041228, Dynein_C IPR043160, Dynein_C_barrel IPR024743, Dynein_HC_stalk IPR024317, Dynein_heavy_chain_D4_dom IPR004273, Dynein_heavy_D6_P-loop IPR013602, Dynein_heavy_dom-2 IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF12774, AAA_6, 1 hit PF12780, AAA_8, 1 hit PF12781, AAA_9, 1 hit PF17857, AAA_lid_1, 1 hit PF18198, AAA_lid_11, 1 hit PF08393, DHC_N2, 1 hit PF17852, Dynein_AAA_lid, 1 hit PF18199, Dynein_C, 1 hit PF03028, Dynein_heavy, 1 hit PF12777, MT, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DYH7_HUMAN | |
Accessioni | Q8WXX0Primary (citable) accession number: Q8WXX0 Secondary accession number(s): B8ZZX8 Q9Y2F3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants