UniProtKB - Q8WXX0 (DYH7_HUMAN)

>sp|Q8WXX0|DYH7_HUMAN Dynein heavy chain 7, axonemal OS=Homo sapiens OX=9606 GN=DNAH7 PE=1 SV=2
MSSEQDKSASKEKSKKPVRFLPQLSMEKLASKEKFKAPARALPQLSMVSTKPHWQQAAPS
FHLSVKQDDESPEPFSVKNEQSHAEYMERFGKKGKLPHQVDDSYVGPSTSKSKGKSPHKE
RENFRSTLVNVIMQQDADLDSAVPDGSTIPKPTASAIEKDILRYYYYIHHGIDTDHVAPM
EDSWLEHVLDLVPQHLKVFTDSIVTLSDEMREDYLLSVRKSIVDFVLKDPREKGDDKKTD
ELPAHRAEMEILPKPWRKSFLAASSYIRDHLNAMNPTMLAVLDLWHTNFKKLRLVDIKEF
HNCQDALELSSFQNIIMRHMDSAKETLLKMWFPEVQNIYYQGNKKKQLPTGDSSAKLESF
FNCAAALMTLQLQDLTLVSMQDFTDLIAQPPDSVRAFEHPGFIMRLILDNDTIKFEPELS
DYIDIFLNVYDVMIKAVSFVPRVETKLYSKWESKSKPTTLKPIILNEIVDAHKEKIKEVI
MKESVAPTEHLRLYDKYDFLITRKAERDVDNFLAENHSYEKIIDEICKYQKLIEEIQYTS
IKTIRLGMFEMHCEELIRALVKRADIICGKLLAKMFRDHQEVNTRLCDEFERIAEKALST
PPNTAELMEMKAYIQKVEVTDMIELEQRLVDSKNCLAFLIEYVNFSPADMRLNNSVFQWY
GRMGEIFEEHRKIIKEKIEQYQEGLKLRCERFVEELESYAKQSEEFYSFGDLQDVQRYLK
KAQILNGKLDLAADKIEQFNAEEEAFGWLPSVYPQRKKIQDGLNPYLRLYETAVEFSSNY
RAWTEGPYHKVNPDQVEADIGNYWRGLYKLEKTFHDSPYALAMTKKVRSKVEDFKQHIPL
IQVICNPGLRPRHWEAMSAIVGYPLQPSDDSTVSSFLDMNLEPYIDRFEGISEAASKEYS
LEKAMEKMITEWDAVEFVIHSYRETGTFILASVDEIQMLLDDHIIKTQTMRGSPFIKPYE
KQMREWEGKLLLLQEILDEWLKVQATWLYLEPIFSSPDIMSQMPEEGRRFTAVDKTWRDI
MRSVMQDKHVLTVVTIDRMLERLKKSNELLELILKGLNEYLEKKRLFFPRFFFLSNDELL
EILSETKDPTRVQPHLKKCFEGIAKVEFTETLDITHMKSSEGEVVELIEIISTAKARGQV
EKWLVELERVMINSIHKVTGDATFAYTKYERINWVRDWPGQTVLCVSQIFWTKEVQTAIP
MGIKALEQYLKTCNRQIDDIVTLVRGKLSMQNRVTLGALVVLDVHARDVLSSLVKKNISD
DSDFEWLSQLRYYWQENHLETKMINAGLRYGYEYLGNSPRLVITPLTDRCYRTLFGALHL
HLGGAPEGPAGTGKTETTKDLAKAVAKQCVVFNCSDGLDYLALGKFFKGLLSCGAWACFD
EFNRIDLEVLSVVAQQILTIQRGINAGADILMFEGTELKLDPTCAVFITMNPGYAGRSEL
PDNLKALFRTVAMMVPDYAMIAEIVLYSCGFVTARPLSVKIVATYRLCSEQLSSQHHYDY
GMRAVKSVLTAAGNLKLKYPNENEEILLLRSIIDVNLPKFLSHDLPLFEGITSDLFPGVK
LPKPDYNDLLAAIKDNCASMNLQMTAFFSEKILQVYEMMIVRHGFMIVGEPFGGKTSAYR
VLAGALNDICEKGLMEENKVQITVLNPKSVTMGQLYGQFDSVSHEWSDGVLAVSFRAFAS
SVTPDRKWLIFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSPQMNLIFEPMDLEVAS
PATVSRCGMIYMEPHMLGWRPLMLSWVNLLPASVSVIQKEFIMGLFDRMVPVSVEFIRKH
TKELSPTSDTNLVRSLMNLIDCFMDDFADEVKLKERNDRETYSLLEGIFLFSLIWSVGAS
CTDDDRLKFNKILRELMESPISDRTRNTFKLQSGTEQTSSKALTVPFPEKGTIYDYQFVT
EGIGKWEPWIKKLKEAPPIPKDVMFNEIIVPTLDTIRYSALMELLTTHQKPSIFVGPTGT
GKSVYITNFLLNQLNKEIYKPLLINFSAQTTAAQTQNIVMSKLDKRRKGVFGPPLGKRMV
VFVDDVNMPAREVYGAQPPIELLRQWLDHWNWYDLKDCSMIKLVDIQIMCAMGPPGGGRN
PVTPRYMRHFNIITINEFSDKSMYTIFSRILTWHLEICYKFPDEFLDLTTQIVNGTMTLY
KEAMKNLLPTPAKSHYLFNLRDFSRVIQGVCLSRPETTETTEVIKRLWVHEVLRVYYDRL
LDNTDRSWLINYIQEILRNYMYEDFHELFQRLDFDNDGMVEADDLRSLMFCDFHDPKRED
TNYREIADVDNLRMIVEIHLEEYNNISKKPMNLVLFRFAIEHISRISRILKQPRSHALLV
GVGGSGRQSVTRLAAHMADYSVFQVEISKGYDTTEWHEDLKVILRKCAEGEMQGVFLFTD
TQIKEESFLEDVSNLLNAGEIPNLFALDEKQEICDKMRQLDRQRDKTKQTDGSPIALFNM
FIDHCRSQLHVVLAMSPIGDAFRNRLRKFPALVNCCTIDWFQSWPEDALQAVASRFLEEI
EMSEEIRDGCIDMCKSFHTSTIDLSKSFFVELQRYNYVTPTSYLELISTFKLLLEKKRSE
VMKMKKRYEVGLEKLDSASSQVATMQMELEALHPQLKVASKEVDEMMIMIEKESVEVAKT
EKIVKADETIANEQAMASKAIKDECDADLAGALPILESALAALDTLTAQDITVVKSMKSP
PAGVKLVMEAICILKGIKADKIPDPTGSGKKIEDFWGPAKRLLGDMRFLQSLHEYDKDNI
PPAYMNIIRKNYIPNPDFVPEKIRNASTAAEGLCKWVIAMDSYDKVAKIVAPKKIKLAAA
EGELKIAMDGLRKKQAALKEVQDKLARLQDTLELNKQKKADLENQVDLCSKKLERAEQLI
GGLGGEKTRWSHTALELGQLYINLTGDILISSGVVAYLGAFTSTYRQNQTKEWTTLCKGR
DIPCSDDCSLMGTLGEAVTIRTWNIAGLPSDSFSIDNGIIIMNARRWPLMIDPQSQANKW
IKNMEKANSLYVIKLSEPDYVRTLENCIQFGTPVLLENVGEELDPILEPLLLKQTFKQGG
STCIRLGDSTIEYAPDFRFYITTKLRNPHYLPETSVKVTLLNFMITPEGMQDQLLGIVVA
QERPDLEEEKQALILQGAENKRQLKEIEDKILEVLSSSEGNILEDETAIKILSSSKALAN
EISQKQEVAEETEKKIDTTRMGYRPIAIHSSILFFSLADLANIEPMYQYSLTWFINLFIL
SIENSEKSEILAKRLQILKDHFTYSLYVNVCRSLFEKDKLLFSFCLTINLLLHERAINKA
EWRFLLTGGIGLDNPYANLCTWLPQKSWDEICRLDDLPAFKTIRREFMRLKDGWKKVYDS
LEPHHEVFPEEWEDKANEFQRMLIIRCLRPDKVIPMLQEFIINRLGRAFIEPPPFDLAKA
FGDSNCCAPLIFVLSPGADPMAALLKFADDQGYGGSKLSSLSLGQGQGPIAMKMLEKAVK
EGTWVVLQNCHLATSWMPTLEKVCEELSPESTHPDFRMWLTSYPSPNFPVSVLQNGVKMT
NEAPKGLRANIIRSYLMDPISDPEFFGSCKKPEEFKKLLYGLCFFHALVQERRKFGPLGW
NIPYEFNETDLRISVQQLHMFLNQYEELPYEALRYMTGECNYGGRVTDDWDRRTLRSILN
KFFNPELVENSDYKFDSSGIYFVPPSGDHKSYIEYTKTLPLTPAPEIFGMNANADITKDQ
SETQLLFDNILLTQSRSAGAGAKSSDEVVNEVASDILGKLPNNFDIEAAMRRYPTTYTQS
MNTVLVQEMGRFNKLLKTIRDSCVNIQKAIKGLAVMSTDLEEVVSSILNVKIPEMWMGKS
YPSLKPLGSYVNDFLARLKFLQQWYEVGPPPVFWLSGFFFTQAFLTGAQQNYARKYTIPI
DLLGFDYEVMEDKEYKHPPEDGVFIHGLFLDGASWNRKIKKLAESHPKILYDTVPVMWLK
PCKRADIPKRPSYVAPLYKTSERRGVLSTTGHSTNFVIAMTLPSDQPKEHWIGRGVALLC
QLNS

Entry version 139 (18 Sep 2019)
Sequence version 2 (02 Nov 2010)
Previous versions | rss

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Protein

Dynein heavy chain 7, axonemal

Gene

DNAH7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	132 – 139	ATPSequence analysis	8
Nucleotide bindingⁱ	1328 – 1335	ATPSequence analysis	8
Nucleotide bindingⁱ	1609 – 1616	ATPSequence analysis	8
Nucleotide bindingⁱ	1976 – 1983	ATPSequence analysis	8
Nucleotide bindingⁱ	2341 – 2348	ATPSequence analysis	8

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Motor protein
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dynein heavy chain 7, axonemal Alternative name(s): Axonemal beta dynein heavy chain 7 Ciliary dynein heavy chain 7 Dynein heavy chain-like protein 2 hDHC2
Gene namesⁱ	Name:DNAH7 Synonyms:KIAA0944
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18661 DNAH7
MIMⁱ	610061 gene
neXtProtⁱ	NX_Q8WXX0

Keywords - Cellular componentⁱ

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56171
MalaCards human disease database More...MalaCardsⁱ	DNAH7
Open Targets More...OpenTargetsⁱ	ENSG00000118997
PharmGKBⁱ	PA38625

Polymorphism and mutation databases

BioMutaⁱ	DNAH7
DMDMⁱ	311033375

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000317666	1 – 4024	Dynein heavy chain 7, axonemalAdd BLAST		4024

Proteomic databases

EPDⁱ	Q8WXX0
jPOSTⁱ	Q8WXX0
MassIVEⁱ	Q8WXX0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WXX0
PaxDbⁱ	Q8WXX0
PeptideAtlas More...PeptideAtlasⁱ	Q8WXX0
PRIDEⁱ	Q8WXX0
ProteomicsDBⁱ	75108 [Q8WXX0-1] 75109 [Q8WXX0-2] 75110 [Q8WXX0-3] 75111 [Q8WXX0-4]

PTM databases

iPTMnetⁱ	Q8WXX0
PhosphoSitePlusⁱ	Q8WXX0

Expressionⁱ

Tissue specificityⁱ

Detected in brain, testis and trachea. Detected in bronchial cells (at protein level).2 Publications

Inductionⁱ

Up-regulated during ciliogenesis (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000118997 Expressed in 155 organ(s), highest expression level in right uterine tube
ExpressionAtlasⁱ	Q8WXX0 baseline and differential
Genevisibleⁱ	Q8WXX0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA034724 HPA044070

HPAⁱ

HPA034724
HPA044070

Interactionⁱ

Subunit structureⁱ

The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.

By similarity

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121102, 4 interactors
IntActⁱ	Q8WXX0, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q8WXX0
STRINGⁱ	9606.ENSP00000311273

Structureⁱ

3D structure databases

SMRⁱ	Q8WXX0
ModBaseⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 1289	StemBy similarityAdd BLAST	1289
Regionⁱ	1290 – 1511	AAA 1By similarityAdd BLAST	222
Regionⁱ	1571 – 1802	AAA 2By similarityAdd BLAST	232
Regionⁱ	1938 – 2189	AAA 3By similarityAdd BLAST	252
Regionⁱ	2302 – 2555	AAA 4By similarityAdd BLAST	254
Regionⁱ	2572 – 2873	StalkBy similarityAdd BLAST	302
Regionⁱ	2954 – 3184	AAA 5By similarityAdd BLAST	231
Regionⁱ	3397 – 3620	AAA 6By similarityAdd BLAST	224

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	685 – 745	Sequence analysisAdd BLAST		61
Coiled coilⁱ	2827 – 2883	Sequence analysisAdd BLAST		57

Domainⁱ

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the dynein heavy chain family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG3595 Eukaryota COG5245 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155282
InParanoidⁱ	Q8WXX0
KEGG Orthology (KO) More...KOⁱ	K10408
OMAⁱ	RKCAEGE
Database of Orthologous Groups More...OrthoDBⁱ	2079at2759
PhylomeDBⁱ	Q8WXX0
TreeFamⁱ	TF316836

Family and domain databases

Gene3Dⁱ	1.10.8.720, 1 hit 1.20.140.100, 1 hit 3.20.180.20, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR035699 AAA_6 IPR035706 AAA_9 IPR041658 AAA_lid_11 IPR042219 AAA_lid_11_sf IPR026983 DHC_fam IPR041589 DNAH3_AAA_lid_1 IPR042228 Dynein_2_C IPR042222 Dynein_2_N IPR041466 Dynein_AAA5_ext IPR041228 Dynein_C IPR024743 Dynein_HC_stalk IPR024317 Dynein_heavy_chain_D4_dom IPR004273 Dynein_heavy_D6_P-loop IPR013602 Dynein_heavy_dom-2 IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10676 PTHR10676, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12774 AAA_6, 1 hit PF12780 AAA_8, 1 hit PF12781 AAA_9, 1 hit PF17857 AAA_lid_1, 1 hit PF18198 AAA_lid_11, 1 hit PF08393 DHC_N2, 1 hit PF17852 Dynein_AAA_lid, 1 hit PF18199 Dynein_C, 1 hit PF03028 Dynein_heavy, 1 hit PF12777 MT, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 4 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8WXX0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSSEQDKSAS KEKSKKPVRF LPQLSMEKLA SKEKFKAPAR ALPQLSMVST 
        60         70         80         90        100
KPHWQQAAPS FHLSVKQDDE SPEPFSVKNE QSHAEYMERF GKKGKLPHQV 
       110        120        130        140        150
DDSYVGPSTS KSKGKSPHKE RENFRSTLVN VIMQQDADLD SAVPDGSTIP 
       160        170        180        190        200
KPTASAIEKD ILRYYYYIHH GIDTDHVAPM EDSWLEHVLD LVPQHLKVFT 
       210        220        230        240        250
DSIVTLSDEM REDYLLSVRK SIVDFVLKDP REKGDDKKTD ELPAHRAEME 
       260        270        280        290        300
ILPKPWRKSF LAASSYIRDH LNAMNPTMLA VLDLWHTNFK KLRLVDIKEF 
       310        320        330        340        350
HNCQDALELS SFQNIIMRHM DSAKETLLKM WFPEVQNIYY QGNKKKQLPT 
       360        370        380        390        400
GDSSAKLESF FNCAAALMTL QLQDLTLVSM QDFTDLIAQP PDSVRAFEHP 
       410        420        430        440        450
GFIMRLILDN DTIKFEPELS DYIDIFLNVY DVMIKAVSFV PRVETKLYSK 
       460        470        480        490        500
WESKSKPTTL KPIILNEIVD AHKEKIKEVI MKESVAPTEH LRLYDKYDFL 
       510        520        530        540        550
ITRKAERDVD NFLAENHSYE KIIDEICKYQ KLIEEIQYTS IKTIRLGMFE 
       560        570        580        590        600
MHCEELIRAL VKRADIICGK LLAKMFRDHQ EVNTRLCDEF ERIAEKALST 
       610        620        630        640        650
PPNTAELMEM KAYIQKVEVT DMIELEQRLV DSKNCLAFLI EYVNFSPADM 
       660        670        680        690        700
RLNNSVFQWY GRMGEIFEEH RKIIKEKIEQ YQEGLKLRCE RFVEELESYA 
       710        720        730        740        750
KQSEEFYSFG DLQDVQRYLK KAQILNGKLD LAADKIEQFN AEEEAFGWLP 
       760        770        780        790        800
SVYPQRKKIQ DGLNPYLRLY ETAVEFSSNY RAWTEGPYHK VNPDQVEADI 
       810        820        830        840        850
GNYWRGLYKL EKTFHDSPYA LAMTKKVRSK VEDFKQHIPL IQVICNPGLR 
       860        870        880        890        900
PRHWEAMSAI VGYPLQPSDD STVSSFLDMN LEPYIDRFEG ISEAASKEYS 
       910        920        930        940        950
LEKAMEKMIT EWDAVEFVIH SYRETGTFIL ASVDEIQMLL DDHIIKTQTM 
       960        970        980        990       1000
RGSPFIKPYE KQMREWEGKL LLLQEILDEW LKVQATWLYL EPIFSSPDIM 
      1010       1020       1030       1040       1050
SQMPEEGRRF TAVDKTWRDI MRSVMQDKHV LTVVTIDRML ERLKKSNELL 
      1060       1070       1080       1090       1100
ELILKGLNEY LEKKRLFFPR FFFLSNDELL EILSETKDPT RVQPHLKKCF 
      1110       1120       1130       1140       1150
EGIAKVEFTE TLDITHMKSS EGEVVELIEI ISTAKARGQV EKWLVELERV 
      1160       1170       1180       1190       1200
MINSIHKVTG DATFAYTKYE RINWVRDWPG QTVLCVSQIF WTKEVQTAIP 
      1210       1220       1230       1240       1250
MGIKALEQYL KTCNRQIDDI VTLVRGKLSM QNRVTLGALV VLDVHARDVL 
      1260       1270       1280       1290       1300
SSLVKKNISD DSDFEWLSQL RYYWQENHLE TKMINAGLRY GYEYLGNSPR 
      1310       1320       1330       1340       1350
LVITPLTDRC YRTLFGALHL HLGGAPEGPA GTGKTETTKD LAKAVAKQCV 
      1360       1370       1380       1390       1400
VFNCSDGLDY LALGKFFKGL LSCGAWACFD EFNRIDLEVL SVVAQQILTI 
      1410       1420       1430       1440       1450
QRGINAGADI LMFEGTELKL DPTCAVFITM NPGYAGRSEL PDNLKALFRT 
      1460       1470       1480       1490       1500
VAMMVPDYAM IAEIVLYSCG FVTARPLSVK IVATYRLCSE QLSSQHHYDY 
      1510       1520       1530       1540       1550
GMRAVKSVLT AAGNLKLKYP NENEEILLLR SIIDVNLPKF LSHDLPLFEG 
      1560       1570       1580       1590       1600
ITSDLFPGVK LPKPDYNDLL AAIKDNCASM NLQMTAFFSE KILQVYEMMI 
      1610       1620       1630       1640       1650
VRHGFMIVGE PFGGKTSAYR VLAGALNDIC EKGLMEENKV QITVLNPKSV 
      1660       1670       1680       1690       1700
TMGQLYGQFD SVSHEWSDGV LAVSFRAFAS SVTPDRKWLI FDGPVDAVWI 
      1710       1720       1730       1740       1750
ENMNTVLDDN KKLCLMSGEI IQMSPQMNLI FEPMDLEVAS PATVSRCGMI 
      1760       1770       1780       1790       1800
YMEPHMLGWR PLMLSWVNLL PASVSVIQKE FIMGLFDRMV PVSVEFIRKH 
      1810       1820       1830       1840       1850
TKELSPTSDT NLVRSLMNLI DCFMDDFADE VKLKERNDRE TYSLLEGIFL 
      1860       1870       1880       1890       1900
FSLIWSVGAS CTDDDRLKFN KILRELMESP ISDRTRNTFK LQSGTEQTSS 
      1910       1920       1930       1940       1950
KALTVPFPEK GTIYDYQFVT EGIGKWEPWI KKLKEAPPIP KDVMFNEIIV 
      1960       1970       1980       1990       2000
PTLDTIRYSA LMELLTTHQK PSIFVGPTGT GKSVYITNFL LNQLNKEIYK 
      2010       2020       2030       2040       2050
PLLINFSAQT TAAQTQNIVM SKLDKRRKGV FGPPLGKRMV VFVDDVNMPA 
      2060       2070       2080       2090       2100
REVYGAQPPI ELLRQWLDHW NWYDLKDCSM IKLVDIQIMC AMGPPGGGRN 
      2110       2120       2130       2140       2150
PVTPRYMRHF NIITINEFSD KSMYTIFSRI LTWHLEICYK FPDEFLDLTT 
      2160       2170       2180       2190       2200
QIVNGTMTLY KEAMKNLLPT PAKSHYLFNL RDFSRVIQGV CLSRPETTET 
      2210       2220       2230       2240       2250
TEVIKRLWVH EVLRVYYDRL LDNTDRSWLI NYIQEILRNY MYEDFHELFQ 
      2260       2270       2280       2290       2300
RLDFDNDGMV EADDLRSLMF CDFHDPKRED TNYREIADVD NLRMIVEIHL 
      2310       2320       2330       2340       2350
EEYNNISKKP MNLVLFRFAI EHISRISRIL KQPRSHALLV GVGGSGRQSV 
      2360       2370       2380       2390       2400
TRLAAHMADY SVFQVEISKG YDTTEWHEDL KVILRKCAEG EMQGVFLFTD 
      2410       2420       2430       2440       2450
TQIKEESFLE DVSNLLNAGE IPNLFALDEK QEICDKMRQL DRQRDKTKQT 
      2460       2470       2480       2490       2500
DGSPIALFNM FIDHCRSQLH VVLAMSPIGD AFRNRLRKFP ALVNCCTIDW 
      2510       2520       2530       2540       2550
FQSWPEDALQ AVASRFLEEI EMSEEIRDGC IDMCKSFHTS TIDLSKSFFV 
      2560       2570       2580       2590       2600
ELQRYNYVTP TSYLELISTF KLLLEKKRSE VMKMKKRYEV GLEKLDSASS 
      2610       2620       2630       2640       2650
QVATMQMELE ALHPQLKVAS KEVDEMMIMI EKESVEVAKT EKIVKADETI 
      2660       2670       2680       2690       2700
ANEQAMASKA IKDECDADLA GALPILESAL AALDTLTAQD ITVVKSMKSP 
      2710       2720       2730       2740       2750
PAGVKLVMEA ICILKGIKAD KIPDPTGSGK KIEDFWGPAK RLLGDMRFLQ 
      2760       2770       2780       2790       2800
SLHEYDKDNI PPAYMNIIRK NYIPNPDFVP EKIRNASTAA EGLCKWVIAM 
      2810       2820       2830       2840       2850
DSYDKVAKIV APKKIKLAAA EGELKIAMDG LRKKQAALKE VQDKLARLQD 
      2860       2870       2880       2890       2900
TLELNKQKKA DLENQVDLCS KKLERAEQLI GGLGGEKTRW SHTALELGQL 
      2910       2920       2930       2940       2950
YINLTGDILI SSGVVAYLGA FTSTYRQNQT KEWTTLCKGR DIPCSDDCSL 
      2960       2970       2980       2990       3000
MGTLGEAVTI RTWNIAGLPS DSFSIDNGII IMNARRWPLM IDPQSQANKW 
      3010       3020       3030       3040       3050
IKNMEKANSL YVIKLSEPDY VRTLENCIQF GTPVLLENVG EELDPILEPL 
      3060       3070       3080       3090       3100
LLKQTFKQGG STCIRLGDST IEYAPDFRFY ITTKLRNPHY LPETSVKVTL 
      3110       3120       3130       3140       3150
LNFMITPEGM QDQLLGIVVA QERPDLEEEK QALILQGAEN KRQLKEIEDK 
      3160       3170       3180       3190       3200
ILEVLSSSEG NILEDETAIK ILSSSKALAN EISQKQEVAE ETEKKIDTTR 
      3210       3220       3230       3240       3250
MGYRPIAIHS SILFFSLADL ANIEPMYQYS LTWFINLFIL SIENSEKSEI 
      3260       3270       3280       3290       3300
LAKRLQILKD HFTYSLYVNV CRSLFEKDKL LFSFCLTINL LLHERAINKA 
      3310       3320       3330       3340       3350
EWRFLLTGGI GLDNPYANLC TWLPQKSWDE ICRLDDLPAF KTIRREFMRL 
      3360       3370       3380       3390       3400
KDGWKKVYDS LEPHHEVFPE EWEDKANEFQ RMLIIRCLRP DKVIPMLQEF 
      3410       3420       3430       3440       3450
IINRLGRAFI EPPPFDLAKA FGDSNCCAPL IFVLSPGADP MAALLKFADD 
      3460       3470       3480       3490       3500
QGYGGSKLSS LSLGQGQGPI AMKMLEKAVK EGTWVVLQNC HLATSWMPTL 
      3510       3520       3530       3540       3550
EKVCEELSPE STHPDFRMWL TSYPSPNFPV SVLQNGVKMT NEAPKGLRAN 
      3560       3570       3580       3590       3600
IIRSYLMDPI SDPEFFGSCK KPEEFKKLLY GLCFFHALVQ ERRKFGPLGW 
      3610       3620       3630       3640       3650
NIPYEFNETD LRISVQQLHM FLNQYEELPY EALRYMTGEC NYGGRVTDDW 
      3660       3670       3680       3690       3700
DRRTLRSILN KFFNPELVEN SDYKFDSSGI YFVPPSGDHK SYIEYTKTLP 
      3710       3720       3730       3740       3750
LTPAPEIFGM NANADITKDQ SETQLLFDNI LLTQSRSAGA GAKSSDEVVN 
      3760       3770       3780       3790       3800
EVASDILGKL PNNFDIEAAM RRYPTTYTQS MNTVLVQEMG RFNKLLKTIR 
      3810       3820       3830       3840       3850
DSCVNIQKAI KGLAVMSTDL EEVVSSILNV KIPEMWMGKS YPSLKPLGSY 
      3860       3870       3880       3890       3900
VNDFLARLKF LQQWYEVGPP PVFWLSGFFF TQAFLTGAQQ NYARKYTIPI 
      3910       3920       3930       3940       3950
DLLGFDYEVM EDKEYKHPPE DGVFIHGLFL DGASWNRKIK KLAESHPKIL 
      3960       3970       3980       3990       4000
YDTVPVMWLK PCKRADIPKR PSYVAPLYKT SERRGVLSTT GHSTNFVIAM 
      4010       4020 
TLPSDQPKEH WIGRGVALLC QLNS

Length:4,024

Mass (Da):461,159

Last modified:November 2, 2010 - v2

Checksum:ⁱ3C2E3B2D7B886540

Isoform 2 (identifier: Q8WXX0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-3517: Missing.

« Hide

        10         20         30         40         50
MWLTSYPSPN FPVSVLQNGV KMTNEAPKGL RANIIRSYLM DPISDPEFFG 
        60         70         80         90        100
SCKKPEEFKK LLYGLCFFHA LVQERRKFGP LGWNIPYEFN ETDLRISVQQ 
       110        120        130        140        150
LHMFLNQYEE LPYEALRYMT GECNYGGRVT DDWDRRTLRS ILNKFFNPEL 
       160        170        180        190        200
VENSDYKFDS SGIYFVPPSG DHKSYIEYTK TLPLTPAPEI FGMNANADIT 
       210        220        230        240        250
KDQSETQLLF DNILLTQSRS AGAGAKSSDE VVNEVASDIL GKLPNNFDIE 
       260        270        280        290        300
AAMRRYPTTY TQSMNTVLVQ EMGRFNKLLK TIRDSCVNIQ KAIKGLAVMS 
       310        320        330        340        350
TDLEEVVSSI LNVKIPEMWM GKSYPSLKPL GSYVNDFLAR LKFLQQWYEV 
       360        370        380        390        400
GPPPVFWLSG FFFTQAFLTG AQQNYARKYT IPIDLLGFDY EVMEDKEYKH 
       410        420        430        440        450
PPEDGVFIHG LFLDGASWNR KIKKLAESHP KILYDTVPVM WLKPCKRADI 
       460        470        480        490        500
PKRPSYVAPL YKTSERRGVL STTGHSTNFV IAMTLPSDQP KEHWIGRGVA 

LLCQLNS

Show »

Length:507

Mass (Da):57,974

Checksum:ⁱAB5707A34AB8C4A9

Isoform 3 (identifier: Q8WXX0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1452: Missing.
     1633-1639: GLMEENK → ASILLMH
     1640-4024: Missing.

« Hide

        10         20         30         40         50
MMVPDYAMIA EIVLYSCGFV TARPLSVKIV ATYRLCSEQL SSQHHYDYGM 
        60         70         80         90        100
RAVKSVLTAA GNLKLKYPNE NEEILLLRSI IDVNLPKFLS HDLPLFEGIT 
       110        120        130        140        150
SDLFPGVKLP KPDYNDLLAA IKDNCASMNL QMTAFFSEKI LQVYEMMIVR 
       160        170        180 
HGFMIVGEPF GGKTSAYRVL AGALNDICEK ASILLMH

Note: No experimental confirmation available.

Show »

Length:187

Mass (Da):20,899

Checksum:ⁱ6E20B0069EADFBBB

Isoform 4 (identifier: Q8WXX0-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
452-501: ESKSKPTTLK...RLYDKYDFLI → RNKAKPGHFY...VLGFTWRCQL
502-4024: Missing.

« Hide

        10         20         30         40         50
MSSEQDKSAS KEKSKKPVRF LPQLSMEKLA SKEKFKAPAR ALPQLSMVST 
        60         70         80         90        100
KPHWQQAAPS FHLSVKQDDE SPEPFSVKNE QSHAEYMERF GKKGKLPHQV 
       110        120        130        140        150
DDSYVGPSTS KSKGKSPHKE RENFRSTLVN VIMQQDADLD SAVPDGSTIP 
       160        170        180        190        200
KPTASAIEKD ILRYYYYIHH GIDTDHVAPM EDSWLEHVLD LVPQHLKVFT 
       210        220        230        240        250
DSIVTLSDEM REDYLLSVRK SIVDFVLKDP REKGDDKKTD ELPAHRAEME 
       260        270        280        290        300
ILPKPWRKSF LAASSYIRDH LNAMNPTMLA VLDLWHTNFK KLRLVDIKEF 
       310        320        330        340        350
HNCQDALELS SFQNIIMRHM DSAKETLLKM WFPEVQNIYY QGNKKKQLPT 
       360        370        380        390        400
GDSSAKLESF FNCAAALMTL QLQDLTLVSM QDFTDLIAQP PDSVRAFEHP 
       410        420        430        440        450
GFIMRLILDN DTIKFEPELS DYIDIFLNVY DVMIKAVSFV PRVETKLYSK 
       460        470        480        490        500
WRNKAKPGHF YFSHIQRSVT FQHSEVSSPQ NSHFKIVSPF SVLGFTWRCQ 

L

Note: No experimental confirmation available.

Show »

Length:501

Mass (Da):57,686

Checksum:ⁱ003C7D9464323C5D

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JUY3	C9JUY3_HUMAN	Dynein heavy chain 7, axonemal Dynein heavy chain 7, axonemal	DNAH7	121	Annotation score:
H7C362	H7C362_HUMAN	Dynein heavy chain 7, axonemal Dynein heavy chain 7, axonemal	DNAH7	56	Annotation score:

Sequence cautionⁱ

The sequence BAA76788 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAB06055 differs from that shown. Reason: Frameshift at position 1502.Curated

The sequence CAH18445 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAH18445 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	433	M → V in BAC04372 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1020	I → T in BAA76788 (PubMed:10231032).Curated	1
Sequence conflictⁱ	1292	Y → F in CAA10557 (PubMed:11175280).Curated	1
Sequence conflictⁱ	1353	N → D in CAB06055 (PubMed:9373155).Curated	1
Sequence conflictⁱ	1355	S → P in CAB06055 (PubMed:9373155).Curated	1
Sequence conflictⁱ	1467	Y → H in CAH18445 (PubMed:17974005).Curated	1
Sequence conflictⁱ	1502	M → L in CAB06055 (PubMed:9373155).Curated	1
Sequence conflictⁱ	3563	P → L in AAH29567 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_038580	169	H → P. Corresponds to variant dbSNP:rs1072599Ensembl.	1
Natural variantⁱVAR_038581	280	A → T. Corresponds to variant dbSNP:rs2375643Ensembl.	1
Natural variantⁱVAR_038582	315	I → V. Corresponds to variant dbSNP:rs17838596Ensembl.	1
Natural variantⁱVAR_038583	438	S → N. Corresponds to variant dbSNP:rs16843720Ensembl.	1
Natural variantⁱVAR_038584	545	R → C1 PublicationCorresponds to variant dbSNP:rs10931715EnsemblClinVar.	1
Natural variantⁱVAR_038585	565	D → H. Corresponds to variant dbSNP:rs2635718Ensembl.	1
Natural variantⁱVAR_038586	675	K → E. Corresponds to variant dbSNP:rs10198893Ensembl.	1
Natural variantⁱVAR_038587	825	K → E. Corresponds to variant dbSNP:rs6719500Ensembl.	1
Natural variantⁱVAR_038588	1422	P → T. Corresponds to variant dbSNP:rs168192Ensembl.	1
Natural variantⁱVAR_038589	1525	E → K. Corresponds to variant dbSNP:rs13415574Ensembl.	1
Natural variantⁱVAR_038590	1886	R → Q. Corresponds to variant dbSNP:rs13034775Ensembl.	1
Natural variantⁱVAR_038591	1940	P → L. Corresponds to variant dbSNP:rs2375544Ensembl.	1
Natural variantⁱVAR_038592	1971	P → L. Corresponds to variant dbSNP:rs2889109Ensembl.	1
Natural variantⁱVAR_038593	2020	M → T. Corresponds to variant dbSNP:rs10184131Ensembl.	1
Natural variantⁱVAR_038594	2459	N → K. Corresponds to variant dbSNP:rs16841199Ensembl.	1
Natural variantⁱVAR_038595	2569	T → I. Corresponds to variant dbSNP:rs2293066Ensembl.	1
Natural variantⁱVAR_038596	2809	I → V. Corresponds to variant dbSNP:rs16841018Ensembl.	1
Natural variantⁱVAR_038597	3319	L → P2 PublicationsCorresponds to variant dbSNP:rs13411834EnsemblClinVar.	1
Natural variantⁱVAR_038598	3386	R → H. Corresponds to variant dbSNP:rs6708527Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_031131	1 – 3517	Missing in isoform 2. 1 PublicationAdd BLAST	3517
Alternative sequenceⁱVSP_031132	1 – 1452	Missing in isoform 3. 1 PublicationAdd BLAST	1452
Alternative sequenceⁱVSP_031133	452 – 501	ESKSK…YDFLI → RNKAKPGHFYFSHIQRSVTF QHSEVSSPQNSHFKIVSPFS VLGFTWRCQL in isoform 4. 1 PublicationAdd BLAST	50
Alternative sequenceⁱVSP_031134	502 – 4024	Missing in isoform 4. 1 PublicationAdd BLAST	3523
Alternative sequenceⁱVSP_031135	1633 – 1639	GLMEENK → ASILLMH in isoform 3. 1 Publication	7
Alternative sequenceⁱVSP_031136	1640 – 4024	Missing in isoform 3. 1 PublicationAdd BLAST	2385

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF327442 mRNA Translation: AAL37427.1 AB023161 mRNA Translation: BAA76788.2 Different initiation. AK094515 mRNA Translation: BAC04372.1 CR749651 mRNA Translation: CAH18445.1 Sequence problems. AC013274 Genomic DNA Translation: AAY14776.1 AC068919 Genomic DNA Translation: AAY14995.1 AC104600 Genomic DNA Translation: AAY24051.1 AC114760 Genomic DNA No translation available. BC029567 mRNA Translation: AAH29567.1 AJ132084 mRNA Translation: CAA10557.1 AJ132093 Genomic DNA Translation: CAB46444.1 Z83801 mRNA Translation: CAB06055.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42794.1 [Q8WXX0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_061720.2, NM_018897.2 [Q8WXX0-1] XP_011509789.1, XM_011511487.2

Genome annotation databases

Ensemblⁱ	ENST00000312428; ENSP00000311273; ENSG00000118997 [Q8WXX0-1] ENST00000409063; ENSP00000386912; ENSG00000118997 [Q8WXX0-2] ENST00000410072; ENSP00000386260; ENSG00000118997 [Q8WXX0-4]
GeneIDⁱ	56171
KEGGⁱ	hsa:56171
UCSC genome browser More...UCSCⁱ	uc002uti.5 human [Q8WXX0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8WXX0	Isoform 2 of Dynein heavy chain 7, axonemal		HUMAN		507	UniRef100_Q8WXX0
Dynein heavy chain 7, axonemal (Fragment)		HUMAN		121
UPI0005CFF810		HUMAN		3978
UPI0005CFF7CA		HUMAN		2148

Protein	Similar proteins		Species	Score	Length	Source
Q8WXX0	Isoform 2 of Dynein heavy chain 7, axonemal		HUMAN		507	UniRef90_Q8WXX0
EF-hand domain-containing protein		CAPHI		4124
EF-hand domain-containing protein		MACFA		4024
EF-hand domain-containing protein		PAPAN		4024
Dynein axonemal heavy chain 7		GORGO		4024
+41
Q8WXX0-4	DNAH7 isoform 7		PANTR		501	UniRef90_Q8WXX0-4
Uncharacterized protein		PAPAN		501
Uncharacterized protein		CERAT		501
Dynein axonemal heavy chain 7		GORGO		501
Uncharacterized protein		MANLE		500
+9

Protein	Similar proteins		Species	Score	Length	Source
Q8WXX0	Dynein heavy chain 7, axonemal		RAT		4057	UniRef50_Q8WXX0
Isoform 2 of Dynein heavy chain 7, axonemal		HUMAN		507
EF-hand domain-containing protein		CAPHI		4124
EF-hand domain-containing protein		MACFA		4024
DNAH7 isoform 1		PANTR		4024
+323
Q8WXX0-4	Uncharacterized protein		CERAT		501	UniRef50_Q8WXX0-4
Dynein axonemal heavy chain 7		GORGO		501
DNAH7 isoform 7		PANTR		501
Uncharacterized protein		PAPAN		501
Uncharacterized protein		MANLE		500
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF327442 mRNA Translation: AAL37427.1 AB023161 mRNA Translation: BAA76788.2 Different initiation. AK094515 mRNA Translation: BAC04372.1 CR749651 mRNA Translation: CAH18445.1 Sequence problems. AC013274 Genomic DNA Translation: AAY14776.1 AC068919 Genomic DNA Translation: AAY14995.1 AC104600 Genomic DNA Translation: AAY24051.1 AC114760 Genomic DNA No translation available. BC029567 mRNA Translation: AAH29567.1 AJ132084 mRNA Translation: CAA10557.1 AJ132093 Genomic DNA Translation: CAB46444.1 Z83801 mRNA Translation: CAB06055.1 Frameshift.
CCDSⁱ	CCDS42794.1 [Q8WXX0-1]
RefSeqⁱ	NP_061720.2, NM_018897.2 [Q8WXX0-1] XP_011509789.1, XM_011511487.2

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6RZA	electron microscopy	5.40	X	2675-2812	[»]
SMRⁱ	Q8WXX0
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121102, 4 interactors
IntActⁱ	Q8WXX0, 2 interactors
MINTⁱ	Q8WXX0
STRINGⁱ	9606.ENSP00000311273

PTM databases

iPTMnetⁱ	Q8WXX0
PhosphoSitePlusⁱ	Q8WXX0

Polymorphism and mutation databases

BioMutaⁱ	DNAH7
DMDMⁱ	311033375

Proteomic databases

EPDⁱ	Q8WXX0
jPOSTⁱ	Q8WXX0
MassIVEⁱ	Q8WXX0
MaxQBⁱ	Q8WXX0
PaxDbⁱ	Q8WXX0
PeptideAtlasⁱ	Q8WXX0
PRIDEⁱ	Q8WXX0
ProteomicsDBⁱ	75108 [Q8WXX0-1] 75109 [Q8WXX0-2] 75110 [Q8WXX0-3] 75111 [Q8WXX0-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000312428; ENSP00000311273; ENSG00000118997 [Q8WXX0-1] ENST00000409063; ENSP00000386912; ENSG00000118997 [Q8WXX0-2] ENST00000410072; ENSP00000386260; ENSG00000118997 [Q8WXX0-4]
GeneIDⁱ	56171
KEGGⁱ	hsa:56171
UCSCⁱ	uc002uti.5 human [Q8WXX0-1]

Organism-specific databases

CTDⁱ	56171
DisGeNETⁱ	56171
GeneCardsⁱ	DNAH7
HGNCⁱ	HGNC:18661 DNAH7
HPAⁱ	HPA034724 HPA044070
MalaCardsⁱ	DNAH7
MIMⁱ	610061 gene
neXtProtⁱ	NX_Q8WXX0
OpenTargetsⁱ	ENSG00000118997
PharmGKBⁱ	PA38625
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3595 Eukaryota COG5245 LUCA
GeneTreeⁱ	ENSGT00940000155282
InParanoidⁱ	Q8WXX0
KOⁱ	K10408
OMAⁱ	RKCAEGE
OrthoDBⁱ	2079at2759
PhylomeDBⁱ	Q8WXX0
TreeFamⁱ	TF316836

Miscellaneous databases

ChiTaRSⁱ	DNAH7 human
GenomeRNAiⁱ	56171
Pharos More...Pharosⁱ	Q8WXX0
Protein Ontology More...PROⁱ	PR:Q8WXX0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118997 Expressed in 155 organ(s), highest expression level in right uterine tube
ExpressionAtlasⁱ	Q8WXX0 baseline and differential
Genevisibleⁱ	Q8WXX0 HS

Family and domain databases

Gene3Dⁱ	1.10.8.720, 1 hit 1.20.140.100, 1 hit 3.20.180.20, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR035699 AAA_6 IPR035706 AAA_9 IPR041658 AAA_lid_11 IPR042219 AAA_lid_11_sf IPR026983 DHC_fam IPR041589 DNAH3_AAA_lid_1 IPR042228 Dynein_2_C IPR042222 Dynein_2_N IPR041466 Dynein_AAA5_ext IPR041228 Dynein_C IPR024743 Dynein_HC_stalk IPR024317 Dynein_heavy_chain_D4_dom IPR004273 Dynein_heavy_D6_P-loop IPR013602 Dynein_heavy_dom-2 IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10676 PTHR10676, 1 hit
Pfamⁱ	View protein in Pfam PF12774 AAA_6, 1 hit PF12780 AAA_8, 1 hit PF12781 AAA_9, 1 hit PF17857 AAA_lid_1, 1 hit PF18198 AAA_lid_11, 1 hit PF08393 DHC_N2, 1 hit PF17852 Dynein_AAA_lid, 1 hit PF18199 Dynein_C, 1 hit PF03028 Dynein_heavy, 1 hit PF12777 MT, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 4 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DYH7_HUMAN
Accessionⁱ	Q8WXX0Primary (citable) accession number: Q8WXX0 Secondary accession number(s): B8ZZX8 Q9Y2F3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	November 2, 2010
	Last modified:	September 18, 2019
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - Q8WXX0 (DYH7_HUMAN)

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Dynein heavy chain 7, axonemal

DNAH7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Cytoskeleton

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ