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UniProtKB - Q8WXX0 (DYH7_HUMAN)

Entry version 147 (10 Feb 2021)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
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Protein

Dynein heavy chain 7, axonemal

Gene

DNAH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi132 – 139ATPSequence analysis8
Nucleotide bindingi1328 – 1335ATPSequence analysis8
Nucleotide bindingi1609 – 1616ATPSequence analysis8
Nucleotide bindingi1976 – 1983ATPSequence analysis8
Nucleotide bindingi2341 – 2348ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8WXX0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 7, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 7
Ciliary dynein heavy chain 7
Dynein heavy chain-like protein 2
hDHC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH7
Synonyms:KIAA0944
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18661, DNAH7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610061, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WXX0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000118997.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56171

MalaCards human disease database

More...MalaCardsi		DNAH7

Open Targets

More...OpenTargetsi		ENSG00000118997

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8WXX0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNAH7

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033375

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176661 – 4024Dynein heavy chain 7, axonemalAdd BLAST4024

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WXX0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8WXX0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8WXX0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WXX0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WXX0

PeptideAtlas

More...PeptideAtlasi		Q8WXX0

PRoteomics IDEntifications database

More...PRIDEi		Q8WXX0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75108 [Q8WXX0-1]
75109 [Q8WXX0-2]
75110 [Q8WXX0-3]
75111 [Q8WXX0-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8WXX0, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WXX0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WXX0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, testis and trachea. Detected in bronchial cells (at protein level).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during ciliogenesis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118997, Expressed in right uterine tube and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8WXX0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WXX0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118997, Tissue enhanced (brain, fallopian tube, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121102, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q8WXX0, 2 interactors

Molecular INTeraction database

More...MINTi		Q8WXX0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000311273

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8WXX0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WXX0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1289StemBy similarityAdd BLAST1289
Regioni1290 – 1511AAA 1By similarityAdd BLAST222
Regioni1571 – 1802AAA 2By similarityAdd BLAST232
Regioni1938 – 2189AAA 3By similarityAdd BLAST252
Regioni2302 – 2555AAA 4By similarityAdd BLAST254
Regioni2572 – 2873StalkBy similarityAdd BLAST302
Regioni2954 – 3184AAA 5By similarityAdd BLAST231
Regioni3397 – 3620AAA 6By similarityAdd BLAST224

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili685 – 745Sequence analysisAdd BLAST61
Coiled coili2827 – 2883Sequence analysisAdd BLAST57

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3595, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155282

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000038_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WXX0

Identification of Orthologs from Complete Genome Data

More...OMAi		DKSMYTI

Database of Orthologous Groups

More...OrthoDBi		2079at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WXX0

TreeFam database of animal gene trees

More...TreeFami		TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_dom-2
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSEQDKSAS KEKSKKPVRF LPQLSMEKLA SKEKFKAPAR ALPQLSMVST 
        60         70         80         90        100
KPHWQQAAPS FHLSVKQDDE SPEPFSVKNE QSHAEYMERF GKKGKLPHQV 
       110        120        130        140        150
DDSYVGPSTS KSKGKSPHKE RENFRSTLVN VIMQQDADLD SAVPDGSTIP 
       160        170        180        190        200
KPTASAIEKD ILRYYYYIHH GIDTDHVAPM EDSWLEHVLD LVPQHLKVFT 
       210        220        230        240        250
DSIVTLSDEM REDYLLSVRK SIVDFVLKDP REKGDDKKTD ELPAHRAEME 
       260        270        280        290        300
ILPKPWRKSF LAASSYIRDH LNAMNPTMLA VLDLWHTNFK KLRLVDIKEF 
       310        320        330        340        350
HNCQDALELS SFQNIIMRHM DSAKETLLKM WFPEVQNIYY QGNKKKQLPT 
       360        370        380        390        400
GDSSAKLESF FNCAAALMTL QLQDLTLVSM QDFTDLIAQP PDSVRAFEHP 
       410        420        430        440        450
GFIMRLILDN DTIKFEPELS DYIDIFLNVY DVMIKAVSFV PRVETKLYSK 
       460        470        480        490        500
WESKSKPTTL KPIILNEIVD AHKEKIKEVI MKESVAPTEH LRLYDKYDFL 
       510        520        530        540        550
ITRKAERDVD NFLAENHSYE KIIDEICKYQ KLIEEIQYTS IKTIRLGMFE 
       560        570        580        590        600
MHCEELIRAL VKRADIICGK LLAKMFRDHQ EVNTRLCDEF ERIAEKALST 
       610        620        630        640        650
PPNTAELMEM KAYIQKVEVT DMIELEQRLV DSKNCLAFLI EYVNFSPADM 
       660        670        680        690        700
RLNNSVFQWY GRMGEIFEEH RKIIKEKIEQ YQEGLKLRCE RFVEELESYA 
       710        720        730        740        750
KQSEEFYSFG DLQDVQRYLK KAQILNGKLD LAADKIEQFN AEEEAFGWLP 
       760        770        780        790        800
SVYPQRKKIQ DGLNPYLRLY ETAVEFSSNY RAWTEGPYHK VNPDQVEADI 
       810        820        830        840        850
GNYWRGLYKL EKTFHDSPYA LAMTKKVRSK VEDFKQHIPL IQVICNPGLR 
       860        870        880        890        900
PRHWEAMSAI VGYPLQPSDD STVSSFLDMN LEPYIDRFEG ISEAASKEYS 
       910        920        930        940        950
LEKAMEKMIT EWDAVEFVIH SYRETGTFIL ASVDEIQMLL DDHIIKTQTM 
       960        970        980        990       1000
RGSPFIKPYE KQMREWEGKL LLLQEILDEW LKVQATWLYL EPIFSSPDIM 
      1010       1020       1030       1040       1050
SQMPEEGRRF TAVDKTWRDI MRSVMQDKHV LTVVTIDRML ERLKKSNELL 
      1060       1070       1080       1090       1100
ELILKGLNEY LEKKRLFFPR FFFLSNDELL EILSETKDPT RVQPHLKKCF 
      1110       1120       1130       1140       1150
EGIAKVEFTE TLDITHMKSS EGEVVELIEI ISTAKARGQV EKWLVELERV 
      1160       1170       1180       1190       1200
MINSIHKVTG DATFAYTKYE RINWVRDWPG QTVLCVSQIF WTKEVQTAIP 
      1210       1220       1230       1240       1250
MGIKALEQYL KTCNRQIDDI VTLVRGKLSM QNRVTLGALV VLDVHARDVL 
      1260       1270       1280       1290       1300
SSLVKKNISD DSDFEWLSQL RYYWQENHLE TKMINAGLRY GYEYLGNSPR 
      1310       1320       1330       1340       1350
LVITPLTDRC YRTLFGALHL HLGGAPEGPA GTGKTETTKD LAKAVAKQCV 
      1360       1370       1380       1390       1400
VFNCSDGLDY LALGKFFKGL LSCGAWACFD EFNRIDLEVL SVVAQQILTI 
      1410       1420       1430       1440       1450
QRGINAGADI LMFEGTELKL DPTCAVFITM NPGYAGRSEL PDNLKALFRT 
      1460       1470       1480       1490       1500
VAMMVPDYAM IAEIVLYSCG FVTARPLSVK IVATYRLCSE QLSSQHHYDY 
      1510       1520       1530       1540       1550
GMRAVKSVLT AAGNLKLKYP NENEEILLLR SIIDVNLPKF LSHDLPLFEG 
      1560       1570       1580       1590       1600
ITSDLFPGVK LPKPDYNDLL AAIKDNCASM NLQMTAFFSE KILQVYEMMI 
      1610       1620       1630       1640       1650
VRHGFMIVGE PFGGKTSAYR VLAGALNDIC EKGLMEENKV QITVLNPKSV 
      1660       1670       1680       1690       1700
TMGQLYGQFD SVSHEWSDGV LAVSFRAFAS SVTPDRKWLI FDGPVDAVWI 
      1710       1720       1730       1740       1750
ENMNTVLDDN KKLCLMSGEI IQMSPQMNLI FEPMDLEVAS PATVSRCGMI 
      1760       1770       1780       1790       1800
YMEPHMLGWR PLMLSWVNLL PASVSVIQKE FIMGLFDRMV PVSVEFIRKH 
      1810       1820       1830       1840       1850
TKELSPTSDT NLVRSLMNLI DCFMDDFADE VKLKERNDRE TYSLLEGIFL 
      1860       1870       1880       1890       1900
FSLIWSVGAS CTDDDRLKFN KILRELMESP ISDRTRNTFK LQSGTEQTSS 
      1910       1920       1930       1940       1950
KALTVPFPEK GTIYDYQFVT EGIGKWEPWI KKLKEAPPIP KDVMFNEIIV 
      1960       1970       1980       1990       2000
PTLDTIRYSA LMELLTTHQK PSIFVGPTGT GKSVYITNFL LNQLNKEIYK 
      2010       2020       2030       2040       2050
PLLINFSAQT TAAQTQNIVM SKLDKRRKGV FGPPLGKRMV VFVDDVNMPA 
      2060       2070       2080       2090       2100
REVYGAQPPI ELLRQWLDHW NWYDLKDCSM IKLVDIQIMC AMGPPGGGRN 
      2110       2120       2130       2140       2150
PVTPRYMRHF NIITINEFSD KSMYTIFSRI LTWHLEICYK FPDEFLDLTT 
      2160       2170       2180       2190       2200
QIVNGTMTLY KEAMKNLLPT PAKSHYLFNL RDFSRVIQGV CLSRPETTET 
      2210       2220       2230       2240       2250
TEVIKRLWVH EVLRVYYDRL LDNTDRSWLI NYIQEILRNY MYEDFHELFQ 
      2260       2270       2280       2290       2300
RLDFDNDGMV EADDLRSLMF CDFHDPKRED TNYREIADVD NLRMIVEIHL 
      2310       2320       2330       2340       2350
EEYNNISKKP MNLVLFRFAI EHISRISRIL KQPRSHALLV GVGGSGRQSV 
      2360       2370       2380       2390       2400
TRLAAHMADY SVFQVEISKG YDTTEWHEDL KVILRKCAEG EMQGVFLFTD 
      2410       2420       2430       2440       2450
TQIKEESFLE DVSNLLNAGE IPNLFALDEK QEICDKMRQL DRQRDKTKQT 
      2460       2470       2480       2490       2500
DGSPIALFNM FIDHCRSQLH VVLAMSPIGD AFRNRLRKFP ALVNCCTIDW 
      2510       2520       2530       2540       2550
FQSWPEDALQ AVASRFLEEI EMSEEIRDGC IDMCKSFHTS TIDLSKSFFV 
      2560       2570       2580       2590       2600
ELQRYNYVTP TSYLELISTF KLLLEKKRSE VMKMKKRYEV GLEKLDSASS 
      2610       2620       2630       2640       2650
QVATMQMELE ALHPQLKVAS KEVDEMMIMI EKESVEVAKT EKIVKADETI 
      2660       2670       2680       2690       2700
ANEQAMASKA IKDECDADLA GALPILESAL AALDTLTAQD ITVVKSMKSP 
      2710       2720       2730       2740       2750
PAGVKLVMEA ICILKGIKAD KIPDPTGSGK KIEDFWGPAK RLLGDMRFLQ 
      2760       2770       2780       2790       2800
SLHEYDKDNI PPAYMNIIRK NYIPNPDFVP EKIRNASTAA EGLCKWVIAM 
      2810       2820       2830       2840       2850
DSYDKVAKIV APKKIKLAAA EGELKIAMDG LRKKQAALKE VQDKLARLQD 
      2860       2870       2880       2890       2900
TLELNKQKKA DLENQVDLCS KKLERAEQLI GGLGGEKTRW SHTALELGQL 
      2910       2920       2930       2940       2950
YINLTGDILI SSGVVAYLGA FTSTYRQNQT KEWTTLCKGR DIPCSDDCSL 
      2960       2970       2980       2990       3000
MGTLGEAVTI RTWNIAGLPS DSFSIDNGII IMNARRWPLM IDPQSQANKW 
      3010       3020       3030       3040       3050
IKNMEKANSL YVIKLSEPDY VRTLENCIQF GTPVLLENVG EELDPILEPL 
      3060       3070       3080       3090       3100
LLKQTFKQGG STCIRLGDST IEYAPDFRFY ITTKLRNPHY LPETSVKVTL 
      3110       3120       3130       3140       3150
LNFMITPEGM QDQLLGIVVA QERPDLEEEK QALILQGAEN KRQLKEIEDK 
      3160       3170       3180       3190       3200
ILEVLSSSEG NILEDETAIK ILSSSKALAN EISQKQEVAE ETEKKIDTTR 
      3210       3220       3230       3240       3250
MGYRPIAIHS SILFFSLADL ANIEPMYQYS LTWFINLFIL SIENSEKSEI 
      3260       3270       3280       3290       3300
LAKRLQILKD HFTYSLYVNV CRSLFEKDKL LFSFCLTINL LLHERAINKA 
      3310       3320       3330       3340       3350
EWRFLLTGGI GLDNPYANLC TWLPQKSWDE ICRLDDLPAF KTIRREFMRL 
      3360       3370       3380       3390       3400
KDGWKKVYDS LEPHHEVFPE EWEDKANEFQ RMLIIRCLRP DKVIPMLQEF 
      3410       3420       3430       3440       3450
IINRLGRAFI EPPPFDLAKA FGDSNCCAPL IFVLSPGADP MAALLKFADD 
      3460       3470       3480       3490       3500
QGYGGSKLSS LSLGQGQGPI AMKMLEKAVK EGTWVVLQNC HLATSWMPTL 
      3510       3520       3530       3540       3550
EKVCEELSPE STHPDFRMWL TSYPSPNFPV SVLQNGVKMT NEAPKGLRAN 
      3560       3570       3580       3590       3600
IIRSYLMDPI SDPEFFGSCK KPEEFKKLLY GLCFFHALVQ ERRKFGPLGW 
      3610       3620       3630       3640       3650
NIPYEFNETD LRISVQQLHM FLNQYEELPY EALRYMTGEC NYGGRVTDDW 
      3660       3670       3680       3690       3700
DRRTLRSILN KFFNPELVEN SDYKFDSSGI YFVPPSGDHK SYIEYTKTLP 
      3710       3720       3730       3740       3750
LTPAPEIFGM NANADITKDQ SETQLLFDNI LLTQSRSAGA GAKSSDEVVN 
      3760       3770       3780       3790       3800
EVASDILGKL PNNFDIEAAM RRYPTTYTQS MNTVLVQEMG RFNKLLKTIR 
      3810       3820       3830       3840       3850
DSCVNIQKAI KGLAVMSTDL EEVVSSILNV KIPEMWMGKS YPSLKPLGSY 
      3860       3870       3880       3890       3900
VNDFLARLKF LQQWYEVGPP PVFWLSGFFF TQAFLTGAQQ NYARKYTIPI 
      3910       3920       3930       3940       3950
DLLGFDYEVM EDKEYKHPPE DGVFIHGLFL DGASWNRKIK KLAESHPKIL 
      3960       3970       3980       3990       4000
YDTVPVMWLK PCKRADIPKR PSYVAPLYKT SERRGVLSTT GHSTNFVIAM 
      4010       4020 
TLPSDQPKEH WIGRGVALLC QLNS
Length:4,024
Mass (Da):461,159
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C2E3B2D7B886540
GO
Isoform 2 (identifier: Q8WXX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3517: Missing.

Show »
Length:507
Mass (Da):57,974
Checksum:iAB5707A34AB8C4A9
GO
Isoform 3 (identifier: Q8WXX0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1452: Missing.
     1633-1639: GLMEENK → ASILLMH
     1640-4024: Missing.

Show »
Length:187
Mass (Da):20,899
Checksum:i6E20B0069EADFBBB
GO
Isoform 4 (identifier: Q8WXX0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-501: ESKSKPTTLK...RLYDKYDFLI → RNKAKPGHFY...VLGFTWRCQL
     502-4024: Missing.

Show »
Length:501
Mass (Da):57,686
Checksum:i003C7D9464323C5D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUY3C9JUY3_HUMAN
Dynein heavy chain 7, axonemal
DNAH7
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C362H7C362_HUMAN
Dynein heavy chain 7, axonemal
DNAH7
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76788 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAB06055 differs from that shown. Reason: Frameshift.Curated
The sequence CAH18445 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAH18445 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti433M → V in BAC04372 (PubMed:14702039).Curated1
Sequence conflicti1020I → T in BAA76788 (PubMed:10231032).Curated1
Sequence conflicti1292Y → F in CAA10557 (PubMed:11175280).Curated1
Sequence conflicti1353N → D in CAB06055 (PubMed:9373155).Curated1
Sequence conflicti1355S → P in CAB06055 (PubMed:9373155).Curated1
Sequence conflicti1467Y → H in CAH18445 (PubMed:17974005).Curated1
Sequence conflicti1502M → L in CAB06055 (PubMed:9373155).Curated1
Sequence conflicti3563P → L in AAH29567 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038580169H → P. Corresponds to variant dbSNP:rs1072599Ensembl.1
Natural variantiVAR_038581280A → T. Corresponds to variant dbSNP:rs2375643Ensembl.1
Natural variantiVAR_038582315I → V. Corresponds to variant dbSNP:rs17838596Ensembl.1
Natural variantiVAR_038583438S → N. Corresponds to variant dbSNP:rs16843720EnsemblClinVar.1
Natural variantiVAR_038584545R → C1 PublicationCorresponds to variant dbSNP:rs10931715EnsemblClinVar.1
Natural variantiVAR_038585565D → H. Corresponds to variant dbSNP:rs2635718Ensembl.1
Natural variantiVAR_038586675K → E. Corresponds to variant dbSNP:rs10198893EnsemblClinVar.1
Natural variantiVAR_038587825K → E. Corresponds to variant dbSNP:rs6719500Ensembl.1
Natural variantiVAR_0385881422P → T. Corresponds to variant dbSNP:rs168192EnsemblClinVar.1
Natural variantiVAR_0385891525E → K. Corresponds to variant dbSNP:rs13415574Ensembl.1
Natural variantiVAR_0385901886R → Q. Corresponds to variant dbSNP:rs13034775Ensembl.1
Natural variantiVAR_0385911940P → L. Corresponds to variant dbSNP:rs2375544Ensembl.1
Natural variantiVAR_0385921971P → L. Corresponds to variant dbSNP:rs2889109Ensembl.1
Natural variantiVAR_0385932020M → T. Corresponds to variant dbSNP:rs10184131EnsemblClinVar.1
Natural variantiVAR_0385942459N → K. Corresponds to variant dbSNP:rs16841199EnsemblClinVar.1
Natural variantiVAR_0385952569T → I. Corresponds to variant dbSNP:rs2293066Ensembl.1
Natural variantiVAR_0385962809I → V. Corresponds to variant dbSNP:rs16841018Ensembl.1
Natural variantiVAR_0385973319L → P2 PublicationsCorresponds to variant dbSNP:rs13411834EnsemblClinVar.1
Natural variantiVAR_0385983386R → H. Corresponds to variant dbSNP:rs6708527Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0311311 – 3517Missing in isoform 2. 1 PublicationAdd BLAST3517
Alternative sequenceiVSP_0311321 – 1452Missing in isoform 3. 1 PublicationAdd BLAST1452
Alternative sequenceiVSP_031133452 – 501ESKSK…YDFLI → RNKAKPGHFYFSHIQRSVTF QHSEVSSPQNSHFKIVSPFS VLGFTWRCQL in isoform 4. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_031134502 – 4024Missing in isoform 4. 1 PublicationAdd BLAST3523
Alternative sequenceiVSP_0311351633 – 1639GLMEENK → ASILLMH in isoform 3. 1 Publication7
Alternative sequenceiVSP_0311361640 – 4024Missing in isoform 3. 1 PublicationAdd BLAST2385

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF327442 mRNA Translation: AAL37427.1
AB023161 mRNA Translation: BAA76788.2 Different initiation.
AK094515 mRNA Translation: BAC04372.1
CR749651 mRNA Translation: CAH18445.1 Sequence problems.
AC013274 Genomic DNA Translation: AAY14776.1
AC068919 Genomic DNA Translation: AAY14995.1
AC104600 Genomic DNA Translation: AAY24051.1
AC114760 Genomic DNA No translation available.
BC029567 mRNA Translation: AAH29567.1
AJ132084 mRNA Translation: CAA10557.1
AJ132093 Genomic DNA Translation: CAB46444.1
Z83801 mRNA Translation: CAB06055.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42794.1 [Q8WXX0-1]

NCBI Reference Sequences

More...RefSeqi		NP_061720.2, NM_018897.2 [Q8WXX0-1]
XP_011509789.1, XM_011511487.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000312428; ENSP00000311273; ENSG00000118997 [Q8WXX0-1]
ENST00000409063; ENSP00000386912; ENSG00000118997 [Q8WXX0-2]
ENST00000410072; ENSP00000386260; ENSG00000118997 [Q8WXX0-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56171

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56171

UCSC genome browser

More...UCSCi		uc002uti.5, human [Q8WXX0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327442 mRNA Translation: AAL37427.1
AB023161 mRNA Translation: BAA76788.2 Different initiation.
AK094515 mRNA Translation: BAC04372.1
CR749651 mRNA Translation: CAH18445.1 Sequence problems.
AC013274 Genomic DNA Translation: AAY14776.1
AC068919 Genomic DNA Translation: AAY14995.1
AC104600 Genomic DNA Translation: AAY24051.1
AC114760 Genomic DNA No translation available.
BC029567 mRNA Translation: AAH29567.1
AJ132084 mRNA Translation: CAA10557.1
AJ132093 Genomic DNA Translation: CAB46444.1
Z83801 mRNA Translation: CAB06055.1 Frameshift.
CCDSiCCDS42794.1 [Q8WXX0-1]
RefSeqiNP_061720.2, NM_018897.2 [Q8WXX0-1]
XP_011509789.1, XM_011511487.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6RZAelectron microscopy5.40X2675-2812[»]
SMRiQ8WXX0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121102, 6 interactors
IntActiQ8WXX0, 2 interactors
MINTiQ8WXX0
STRINGi9606.ENSP00000311273

PTM databases

GlyGeniQ8WXX0, 1 site
iPTMnetiQ8WXX0
PhosphoSitePlusiQ8WXX0

Genetic variation databases

BioMutaiDNAH7
DMDMi311033375

Proteomic databases

EPDiQ8WXX0
jPOSTiQ8WXX0
MassIVEiQ8WXX0
MaxQBiQ8WXX0
PaxDbiQ8WXX0
PeptideAtlasiQ8WXX0
PRIDEiQ8WXX0
ProteomicsDBi75108 [Q8WXX0-1]
75109 [Q8WXX0-2]
75110 [Q8WXX0-3]
75111 [Q8WXX0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49680, 37 antibodies

Genome annotation databases

EnsembliENST00000312428; ENSP00000311273; ENSG00000118997 [Q8WXX0-1]
ENST00000409063; ENSP00000386912; ENSG00000118997 [Q8WXX0-2]
ENST00000410072; ENSP00000386260; ENSG00000118997 [Q8WXX0-4]
GeneIDi56171
KEGGihsa:56171
UCSCiuc002uti.5, human [Q8WXX0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56171
DisGeNETi56171

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNAH7
HGNCiHGNC:18661, DNAH7
HPAiENSG00000118997, Tissue enhanced (brain, fallopian tube, pituitary gland)
MalaCardsiDNAH7
MIMi610061, gene
neXtProtiNX_Q8WXX0
OpenTargetsiENSG00000118997
PharmGKBiPA38625
VEuPathDBiHostDB:ENSG00000118997.13

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000155282
HOGENOMiCLU_000038_1_3_1
InParanoidiQ8WXX0
OMAiDKSMYTI
OrthoDBi2079at2759
PhylomeDBiQ8WXX0
TreeFamiTF316836

Enzyme and pathway databases

PathwayCommonsiQ8WXX0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56171, 3 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNAH7, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56171
PharosiQ8WXX0, Tbio

Protein Ontology

More...PROi		PR:Q8WXX0
RNActiQ8WXX0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118997, Expressed in right uterine tube and 168 other tissues
ExpressionAtlasiQ8WXX0, baseline and differential
GenevisibleiQ8WXX0, HS

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_dom-2
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXX0
Secondary accession number(s): B8ZZX8
, O00433, O95492, Q4G152, Q53QX7, Q53S64, Q53T02, Q68CY5, Q8N1Z2, Q9UMS3, Q9Y2F3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 2, 2010
Last modified: February 10, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with genetic variants
    List of human entries with genetic variants
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