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UniProtKB - Q8WXS8 (ATS14_HUMAN)

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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 14

Gene

ADAMTS14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi398Zinc; catalyticPROSITE-ProRule annotation1
Active sitei399PROSITE-ProRule annotation1
Metal bindingi402Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi408Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCollagen degradation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPSiM12.024

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 14 (EC:3.4.24.-)
Short name:
ADAM-TS 14
Short name:
ADAM-TS14
Short name:
ADAMTS-14
Gene namesi
Name:ADAMTS14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138316.10
HGNCiHGNC:14899 ADAMTS14
MIMi607506 gene
neXtProtiNX_Q8WXS8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi140766
OpenTargetsiENSG00000138316
PharmGKBiPA24540

Polymorphism and mutation databases

BioMutaiADAMTS14
DMDMi317373325

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000002919023 – 252By similarityAdd BLAST230
ChainiPRO_0000029191253 – 1223A disintegrin and metalloproteinase with thrombospondin motifs 14Add BLAST971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi336 ↔ 382By similarity
Disulfide bondi376 ↔ 455By similarity
Disulfide bondi415 ↔ 441By similarity
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi482 ↔ 507By similarity
Disulfide bondi493 ↔ 516By similarity
Disulfide bondi502 ↔ 535By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi564 ↔ 601By similarity
Disulfide bondi568 ↔ 606By similarity
Disulfide bondi579 ↔ 591By similarity
Glycosylationi941N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi980 ↔ 1016By similarity
Disulfide bondi984 ↔ 1021By similarity
Disulfide bondi995 ↔ 1005By similarity
Glycosylationi1027N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ8WXS8
PeptideAtlasiQ8WXS8
PRIDEiQ8WXS8
ProteomicsDBi75096
75097 [Q8WXS8-2]
75098 [Q8WXS8-3]
75099 [Q8WXS8-4]

PTM databases

iPTMnetiQ8WXS8
PhosphoSitePlusiQ8WXS8

Expressioni

Tissue specificityi

Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues.

Gene expression databases

BgeeiENSG00000138316
CleanExiHS_ADAMTS14
GenevisibleiQ8WXS8 HS

Organism-specific databases

HPAiHPA034605

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362304

Structurei

3D structure databases

ProteinModelPortaliQ8WXS8
SMRiQ8WXS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 460Peptidase M12BPROSITE-ProRule annotationAdd BLAST202
Domaini461 – 551DisintegrinAdd BLAST91
Domaini552 – 607TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini847 – 907TSP type-1 2PROSITE-ProRule annotationAdd BLAST61
Domaini908 – 967TSP type-1 3PROSITE-ProRule annotationAdd BLAST60
Domaini968 – 1022TSP type-1 4PROSITE-ProRule annotationAdd BLAST55
Domaini1059 – 1097PLACPROSITE-ProRule annotationAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni730 – 846SpacerAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi608 – 729Cys-richAdd BLAST122
Compositional biasi875 – 878Poly-Arg4
Compositional biasi1100 – 1221Pro-richAdd BLAST122

Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00900000140815
HOGENOMiHOG000034222
HOVERGENiHBG004314
InParanoidiQ8WXS8
KOiK08628
OMAiLPSYDCL
OrthoDBiEOG091G0790
PhylomeDBiQ8WXS8
TreeFamiTF313537

Family and domain databases

Gene3Di2.20.100.10, 4 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR010294 ADAM_spacer1
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 4 hits
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00209 TSP1, 4 hits
SUPFAMiSSF82895 SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 4 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform A (identifier: Q8WXS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPLRALLSY LLPLHCALCA AAGSRTPELH LSGKLSDYGV TVPCSTDFRG 
        60         70         80         90        100
RFLSHVVSGP AAASAGSMVV DTPPTLPRHS SHLRVARSPL HPGGTLWPGR 
       110        120        130        140        150
VGRHSLYFNV TVFGKELHLR LRPNRRLVVP GSSVEWQEDF RELFRQPLRQ 
       160        170        180        190        200
ECVYTGGVTG MPGAAVAISN CDGLAGLIRT DSTDFFIEPL ERGQQEKEAS 
       210        220        230        240        250
GRTHVVYRRE AVQQEWAEPD GDLHNEAFGL GDLPNLLGLV GDQLGDTERK 
       260        270        280        290        300
RRHAKPGSYS IEVLLVVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL 
       310        320        330        340        350
GVHINIALVR LIMVGYRQSL SLIERGNPSR SLEQVCRWAH SQQRQDPSHA 
       360        370        380        390        400
EHHDHVVFLT RQDFGPSGYA PVTGMCHPLR SCALNHEDGF SSAFVIAHET 
       410        420        430        440        450
GHVLGMEHDG QGNGCADETS LGSVMAPLVQ AAFHRFHWSR CSKLELSRYL 
       460        470        480        490        500
PSYDCLLDDP FDPAWPQPPE LPGINYSMDE QCRFDFGSGY QTCLAFRTFE 
       510        520        530        540        550
PCKQLWCSHP DNPYFCKTKK GPPLDGTECA PGKWCFKGHC IWKSPEQTYG 
       560        570        580        590        600
QDGGWSSWTK FGSCSRSCGG GVRSRSRSCN NPSPAYGGRL CLGPMFEYQV 
       610        620        630        640        650
CNSEECPGTY EDFRAQQCAK RNSYYVHQNA KHSWVPYEPD DDAQKCELIC 
       660        670        680        690        700
QSADTGDVVF MNQVVHDGTR CSYRDPYSVC ARGECVPVGC DKEVGSMKAD 
       710        720        730        740        750
DKCGVCGGDN SHCRTVKGTL GKASKQAGAL KLVQIPAGAR HIQIEALEKS 
       760        770        780        790        800
PHRIVVKNQV TGSFILNPKG KEATSRTFTA MGLEWEDAVE DAKESLKTSG 
       810        820        830        840        850
PLPEAIAILA LPPTEGGPRS SLAYKYVIHE DLLPLIGSNN VLLEEMDTYE 
       860        870        880        890        900
WALKSWAPCS KACGGGIQFT KYGCRRRRDH HMVQRHLCDH KKRPKPIRRR 
       910        920        930        940        950
CNQHPCSQPV WVTEEWGACS RSCGKLGVQT RGIQCLLPLS NGTHKVMPAK 
       960        970        980        990       1000
ACAGDRPEAR RPCLRVPCPA QWRLGAWSQC SATCGEGIQQ RQVVCRTNAN 
      1010       1020       1030       1040       1050
SLGHCEGDRP DTVQVCSLPA CGGNHQNSTV RADVWELGTP EGQWVPQSEP 
      1060       1070       1080       1090       1100
LHPINKISST EPCTGDRSVF CQMEVLDRYC SIPGYHRLCC VSCIKKASGP 
      1110       1120       1130       1140       1150
NPGPDPGPTS LPPFSTPGSP LPGPQDPADA AEPPGKPTGS EDHQHGRATQ 
      1160       1170       1180       1190       1200
LPGALDTSSP GTQHPFAPET PIPGASWSIS PTTPGGLPWG WTQTPTPVPE 
      1210       1220 
DKGQPGEDLR HPGTSLPAAS PVT
Note: Produced by alternative promoter usage.
Length:1,223
Mass (Da):133,888
Last modified:January 11, 2011 - v2
Checksum:iEEF3229519B3170A
GO
Isoform B (identifier: Q8WXS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:1,156
Mass (Da):127,036
Checksum:i0EF756C57D635CAE
GO
Isoform C (identifier: Q8WXS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform B.
Show »
Length:1,159
Mass (Da):127,353
Checksum:i7D7B58455B6BFF31
GO
Isoform D (identifier: Q8WXS8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform A.
Show »
Length:1,226
Mass (Da):134,205
Checksum:iD218E0655F1FAF55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti868Q → R in CAC87943 (PubMed:11867212).Curated1
Sequence conflicti884Q → H in CAC87943 (PubMed:11867212).Curated1
Sequence conflicti901C → S in CAC87943 (PubMed:11867212).Curated1
Sequence conflicti923C → Y in CAC87943 (PubMed:11867212).Curated1
Sequence conflicti1024N → S in CAC87943 (PubMed:11867212).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047837179R → C. Corresponds to variant dbSNP:rs34022601Ensembl.1
Natural variantiVAR_047838590L → P3 PublicationsCorresponds to variant dbSNP:rs10823607Ensembl.1
Natural variantiVAR_047839937L → M. Corresponds to variant dbSNP:rs12774070Ensembl.1
Natural variantiVAR_0478401017S → N. Corresponds to variant dbSNP:rs10999516Ensembl.1
Natural variantiVAR_0478411049E → G. Corresponds to variant dbSNP:rs4747096Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069581 – 67Missing in isoform B and isoform C. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_005501368G → GMQG in isoform C and isoform D. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358666 mRNA Translation: AAL40229.1
AJ345098 mRNA Translation: CAC87943.1
AL355344 Genomic DNA No translation available.
AL358817 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54409.1
CH471083 Genomic DNA Translation: EAW54410.1
AF366351 mRNA Translation: AAL79814.1
CCDSiCCDS7306.1 [Q8WXS8-1]
CCDS7307.1 [Q8WXS8-4]
RefSeqiNP_542453.2, NM_080722.4 [Q8WXS8-1]
NP_631894.2, NM_139155.3 [Q8WXS8-4]
UniGeneiHs.352156

Genome annotation databases

EnsembliENST00000373207; ENSP00000362303; ENSG00000138316 [Q8WXS8-1]
ENST00000373208; ENSP00000362304; ENSG00000138316 [Q8WXS8-4]
GeneIDi140766
KEGGihsa:140766
UCSCiuc001jrg.4 human [Q8WXS8-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiATS14_HUMAN
AccessioniPrimary (citable) accession number: Q8WXS8
Secondary accession number(s): Q5T4G0
, Q5T4G1, Q8TE55, Q8TEY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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