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Entry version 166 (17 Jun 2020)
Sequence version 2 (11 Jan 2011)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 14

Gene

ADAMTS14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form (PubMed:31152061).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi398Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei399PROSITE-ProRule annotation1
Metal bindingi402Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi408Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCollagen degradation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.024

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 14 (EC:3.4.24.-)
Short name:
ADAM-TS 14
Short name:
ADAM-TS14
Short name:
ADAMTS-14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138316.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14899 ADAMTS14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607506 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXS8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
140766

Open Targets

More...
OpenTargetsi
ENSG00000138316

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24540

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WXS8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADAMTS14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373325

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002919023 – 252By similarityAdd BLAST230
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029191253 – 1223A disintegrin and metalloproteinase with thrombospondin motifs 14Add BLAST971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi336 ↔ 382By similarity
Disulfide bondi376 ↔ 455By similarity
Disulfide bondi415 ↔ 441By similarity
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi482 ↔ 507By similarity
Disulfide bondi493 ↔ 516By similarity
Disulfide bondi502 ↔ 535By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi564 ↔ 601By similarity
Disulfide bondi568 ↔ 606By similarity
Disulfide bondi579 ↔ 591By similarity
Glycosylationi941N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi980 ↔ 1016By similarity
Disulfide bondi984 ↔ 1021By similarity
Disulfide bondi995 ↔ 1005By similarity
Glycosylationi1027N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WXS8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WXS8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXS8

PeptideAtlas

More...
PeptideAtlasi
Q8WXS8

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXS8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75096 [Q8WXS8-1]
75097 [Q8WXS8-2]
75098 [Q8WXS8-3]
75099 [Q8WXS8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in retina and at low levels in brain, lung and placenta (PubMed:11779638). High expression in fetal tissues (PubMed:11867212).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138316 Expressed in substantia nigra and 133 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXS8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138316 Tissue enhanced (brain, gallbladder, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8WXS8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362304

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WXS8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini259 – 460Peptidase M12BPROSITE-ProRule annotationAdd BLAST202
Domaini461 – 551DisintegrinAdd BLAST91
Domaini552 – 607TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini847 – 907TSP type-1 2PROSITE-ProRule annotationAdd BLAST61
Domaini908 – 967TSP type-1 3PROSITE-ProRule annotationAdd BLAST60
Domaini968 – 1022TSP type-1 4PROSITE-ProRule annotationAdd BLAST55
Domaini1059 – 1097PLACPROSITE-ProRule annotationAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni730 – 846SpacerAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi608 – 729Cys-richAdd BLAST122
Compositional biasi875 – 878Poly-Arg4
Compositional biasi1100 – 1221Pro-richAdd BLAST122

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538 Eukaryota
ENOG410XPKZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000660_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WXS8

KEGG Orthology (KO)

More...
KOi
K08628

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSWIPYE

Database of Orthologous Groups

More...
OrthoDBi
79609at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXS8

TreeFam database of animal gene trees

More...
TreeFami
TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 4 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645 ADAM_CR_2
IPR006586 ADAM_Cys-rich
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857 ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00608 ACR, 1 hit
SM00209 TSP1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform A (identifier: Q8WXS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPLRALLSY LLPLHCALCA AAGSRTPELH LSGKLSDYGV TVPCSTDFRG
60 70 80 90 100
RFLSHVVSGP AAASAGSMVV DTPPTLPRHS SHLRVARSPL HPGGTLWPGR
110 120 130 140 150
VGRHSLYFNV TVFGKELHLR LRPNRRLVVP GSSVEWQEDF RELFRQPLRQ
160 170 180 190 200
ECVYTGGVTG MPGAAVAISN CDGLAGLIRT DSTDFFIEPL ERGQQEKEAS
210 220 230 240 250
GRTHVVYRRE AVQQEWAEPD GDLHNEAFGL GDLPNLLGLV GDQLGDTERK
260 270 280 290 300
RRHAKPGSYS IEVLLVVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL
310 320 330 340 350
GVHINIALVR LIMVGYRQSL SLIERGNPSR SLEQVCRWAH SQQRQDPSHA
360 370 380 390 400
EHHDHVVFLT RQDFGPSGYA PVTGMCHPLR SCALNHEDGF SSAFVIAHET
410 420 430 440 450
GHVLGMEHDG QGNGCADETS LGSVMAPLVQ AAFHRFHWSR CSKLELSRYL
460 470 480 490 500
PSYDCLLDDP FDPAWPQPPE LPGINYSMDE QCRFDFGSGY QTCLAFRTFE
510 520 530 540 550
PCKQLWCSHP DNPYFCKTKK GPPLDGTECA PGKWCFKGHC IWKSPEQTYG
560 570 580 590 600
QDGGWSSWTK FGSCSRSCGG GVRSRSRSCN NPSPAYGGRL CLGPMFEYQV
610 620 630 640 650
CNSEECPGTY EDFRAQQCAK RNSYYVHQNA KHSWVPYEPD DDAQKCELIC
660 670 680 690 700
QSADTGDVVF MNQVVHDGTR CSYRDPYSVC ARGECVPVGC DKEVGSMKAD
710 720 730 740 750
DKCGVCGGDN SHCRTVKGTL GKASKQAGAL KLVQIPAGAR HIQIEALEKS
760 770 780 790 800
PHRIVVKNQV TGSFILNPKG KEATSRTFTA MGLEWEDAVE DAKESLKTSG
810 820 830 840 850
PLPEAIAILA LPPTEGGPRS SLAYKYVIHE DLLPLIGSNN VLLEEMDTYE
860 870 880 890 900
WALKSWAPCS KACGGGIQFT KYGCRRRRDH HMVQRHLCDH KKRPKPIRRR
910 920 930 940 950
CNQHPCSQPV WVTEEWGACS RSCGKLGVQT RGIQCLLPLS NGTHKVMPAK
960 970 980 990 1000
ACAGDRPEAR RPCLRVPCPA QWRLGAWSQC SATCGEGIQQ RQVVCRTNAN
1010 1020 1030 1040 1050
SLGHCEGDRP DTVQVCSLPA CGGNHQNSTV RADVWELGTP EGQWVPQSEP
1060 1070 1080 1090 1100
LHPINKISST EPCTGDRSVF CQMEVLDRYC SIPGYHRLCC VSCIKKASGP
1110 1120 1130 1140 1150
NPGPDPGPTS LPPFSTPGSP LPGPQDPADA AEPPGKPTGS EDHQHGRATQ
1160 1170 1180 1190 1200
LPGALDTSSP GTQHPFAPET PIPGASWSIS PTTPGGLPWG WTQTPTPVPE
1210 1220
DKGQPGEDLR HPGTSLPAAS PVT
Note: Produced by alternative promoter usage.
Length:1,223
Mass (Da):133,888
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEF3229519B3170A
GO
Isoform B (identifier: Q8WXS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:1,156
Mass (Da):127,036
Checksum:i0EF756C57D635CAE
GO
Isoform C (identifier: Q8WXS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform B.Curated
Show »
Length:1,159
Mass (Da):127,353
Checksum:i7D7B58455B6BFF31
GO
Isoform D (identifier: Q8WXS8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-368: G → GMQG

Note: Produced by alternative splicing of isoform A.Curated
Show »
Length:1,226
Mass (Da):134,205
Checksum:iD218E0655F1FAF55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti868Q → R in CAC87943 (PubMed:11867212).Curated1
Sequence conflicti884Q → H in CAC87943 (PubMed:11867212).Curated1
Sequence conflicti901C → S in CAC87943 (PubMed:11867212).Curated1
Sequence conflicti923C → Y in CAC87943 (PubMed:11867212).Curated1
Sequence conflicti1024N → S in CAC87943 (PubMed:11867212).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047837179R → C. Corresponds to variant dbSNP:rs34022601Ensembl.1
Natural variantiVAR_047838590L → P3 PublicationsCorresponds to variant dbSNP:rs10823607Ensembl.1
Natural variantiVAR_047839937L → M. Corresponds to variant dbSNP:rs12774070Ensembl.1
Natural variantiVAR_0478401017S → N. Corresponds to variant dbSNP:rs10999516Ensembl.1
Natural variantiVAR_0478411049E → G. Corresponds to variant dbSNP:rs4747096Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0069581 – 67Missing in isoform B and isoform C. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_005501368G → GMQG in isoform C and isoform D. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF358666 mRNA Translation: AAL40229.1
AJ345098 mRNA Translation: CAC87943.1
AL355344 Genomic DNA No translation available.
AL358817 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54409.1
CH471083 Genomic DNA Translation: EAW54410.1
AF366351 mRNA Translation: AAL79814.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7306.1 [Q8WXS8-1]
CCDS7307.1 [Q8WXS8-4]

NCBI Reference Sequences

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RefSeqi
NP_542453.2, NM_080722.4 [Q8WXS8-1]
NP_631894.2, NM_139155.3 [Q8WXS8-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000373207; ENSP00000362303; ENSG00000138316 [Q8WXS8-1]
ENST00000373208; ENSP00000362304; ENSG00000138316 [Q8WXS8-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
140766

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:140766

UCSC genome browser

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UCSCi
uc001jrg.4 human [Q8WXS8-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358666 mRNA Translation: AAL40229.1
AJ345098 mRNA Translation: CAC87943.1
AL355344 Genomic DNA No translation available.
AL358817 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54409.1
CH471083 Genomic DNA Translation: EAW54410.1
AF366351 mRNA Translation: AAL79814.1
CCDSiCCDS7306.1 [Q8WXS8-1]
CCDS7307.1 [Q8WXS8-4]
RefSeqiNP_542453.2, NM_080722.4 [Q8WXS8-1]
NP_631894.2, NM_139155.3 [Q8WXS8-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8WXS8, 1 interactor
STRINGi9606.ENSP00000362304

Protein family/group databases

MEROPSiM12.024

PTM databases

iPTMnetiQ8WXS8
PhosphoSitePlusiQ8WXS8

Polymorphism and mutation databases

BioMutaiADAMTS14
DMDMi317373325

Proteomic databases

jPOSTiQ8WXS8
MassIVEiQ8WXS8
PaxDbiQ8WXS8
PeptideAtlasiQ8WXS8
PRIDEiQ8WXS8
ProteomicsDBi75096 [Q8WXS8-1]
75097 [Q8WXS8-2]
75098 [Q8WXS8-3]
75099 [Q8WXS8-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29052 37 antibodies

The DNASU plasmid repository

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DNASUi
140766

Genome annotation databases

EnsembliENST00000373207; ENSP00000362303; ENSG00000138316 [Q8WXS8-1]
ENST00000373208; ENSP00000362304; ENSG00000138316 [Q8WXS8-4]
GeneIDi140766
KEGGihsa:140766
UCSCiuc001jrg.4 human [Q8WXS8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
140766
DisGeNETi140766
EuPathDBiHostDB:ENSG00000138316.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ADAMTS14
HGNCiHGNC:14899 ADAMTS14
HPAiENSG00000138316 Tissue enhanced (brain, gallbladder, placenta)
MIMi607506 gene
neXtProtiNX_Q8WXS8
OpenTargetsiENSG00000138316
PharmGKBiPA24540

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00940000158426
HOGENOMiCLU_000660_4_1_1
InParanoidiQ8WXS8
KOiK08628
OMAiHSWIPYE
OrthoDBi79609at2759
PhylomeDBiQ8WXS8
TreeFamiTF313537

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
140766 1 hit in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADAMTS14 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
140766
PharosiQ8WXS8 Tbio

Protein Ontology

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PROi
PR:Q8WXS8
RNActiQ8WXS8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138316 Expressed in substantia nigra and 133 other tissues
GenevisibleiQ8WXS8 HS

Family and domain databases

Gene3Di2.20.100.10, 4 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645 ADAM_CR_2
IPR006586 ADAM_Cys-rich
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 4 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00209 TSP1, 4 hits
SUPFAMiSSF82895 SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS14_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXS8
Secondary accession number(s): Q5T4G0
, Q5T4G1, Q8TE55, Q8TEY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: January 11, 2011
Last modified: June 17, 2020
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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