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Protein

Voltage-dependent calcium channel gamma-like subunit

Gene

TMEM37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-like subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-like subunit
Transmembrane protein 37
Gene namesi
Name:TMEM37Imported
Synonyms:PR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000171227.6
HGNCiHGNC:18216 TMEM37
neXtProtiNX_Q8WXS4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi140738
OpenTargetsiENSG00000171227
PharmGKBiPA134897608

Polymorphism and mutation databases

BioMutaiTMEM37
DMDMi296434430

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256011 – 190Voltage-dependent calcium channel gamma-like subunitAdd BLAST190

Proteomic databases

PaxDbiQ8WXS4
PeptideAtlasiQ8WXS4
PRIDEiQ8WXS4
ProteomicsDBi75094

PTM databases

PhosphoSitePlusiQ8WXS4

Expressioni

Gene expression databases

BgeeiENSG00000171227
CleanExiHS_TMEM37
ExpressionAtlasiQ8WXS4 baseline and differential
GenevisibleiQ8WXS4 HS

Organism-specific databases

HPAiHPA053794

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.By similarity

Protein-protein interaction databases

BioGridi126681, 6 interactors
IntActiQ8WXS4, 6 interactors
STRINGi9606.ENSP00000303148

Structurei

3D structure databases

ProteinModelPortaliQ8WXS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8N Eukaryota
ENOG4111WUN LUCA
GeneTreeiENSGT00390000006225
HOGENOMiHOG000111447
HOVERGENiHBG028482
InParanoidiQ8WXS4
PhylomeDBiQ8WXS4
TreeFamiTF333259

Family and domain databases

InterProiView protein in InterPro
IPR029372 Tmem37
PANTHERiPTHR31767 PTHR31767, 1 hit
PfamiView protein in Pfam
PF15108 TMEM37, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WXS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVGVQAQR PLGQRQPRRS FFESFIRTLI ITCVALAVVL SSVSICDGHW
60 70 80 90 100
LLAEDRLFGL WHFCTTTNQT ICFRDLGQAH VPGLAVGMGL VRSVGALAVV
110 120 130 140 150
AAIFGLEFLM VSQLCEDKHS QCKWVMGSIL LLVSFVLSSG GLLGFVILLR
160 170 180 190
NQVTLIGFTL MFWCEFTASF LLFLNAISGL HINSITHPWE
Length:190
Mass (Da):20,932
Last modified:May 18, 2010 - v2
Checksum:iCDDC58485DF57FD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Q → H in AAL50051 (PubMed:11738816).Curated1
Sequence conflicti70T → SVP in AAL50051 (PubMed:11738816).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361356 mRNA Translation: AAL50051.1
AC013275 Genomic DNA No translation available.
CCDSiCCDS33281.1
RefSeqiNP_899063.2, NM_183240.2
UniGeneiHs.26216

Genome annotation databases

EnsembliENST00000306406; ENSP00000303148; ENSG00000171227
GeneIDi140738
KEGGihsa:140738
UCSCiuc002tly.4 human

Similar proteinsi

Entry informationi

Entry nameiCCGL_HUMAN
AccessioniPrimary (citable) accession number: Q8WXS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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