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Entry version 155 (08 May 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Carboxypeptidase A5

Gene

CPA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi196Zinc; catalyticBy similarity1
Metal bindingi199Zinc; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei254SubstrateBy similarity1
Metal bindingi323Zinc; catalyticBy similarity1
Binding sitei375SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei397Proton donor/acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M14.020

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carboxypeptidase A5 (EC:3.4.17.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:15722 CPA5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609561 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXQ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000158525

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26820

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CPA5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38257690

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000436134 – 126Activation peptideBy similarityAdd BLAST93
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000004362127 – 436Carboxypeptidase A5Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi265 ↔ 288By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Zymogen

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8WXQ8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WXQ8

PeptideAtlas

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PeptideAtlasi
Q8WXQ8

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXQ8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75078
75079 [Q8WXQ8-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q8WXQ8-1 [Q8WXQ8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is very low or not detectable.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000158525 Expressed in 68 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WXQ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXQ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020322

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125066, 19 interactors

Protein interaction database and analysis system

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IntActi
Q8WXQ8, 1 interactor

Molecular INTeraction database

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MINTi
Q8WXQ8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000420237

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8WXQ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni196 – 199Substrate bindingBy similarity4
Regioni271 – 272Substrate bindingBy similarity2
Regioni324 – 325Substrate bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2650 Eukaryota
COG2866 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161666

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000252967

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8WXQ8

KEGG Orthology (KO)

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KOi
K08781

Identification of Orthologs from Complete Genome Data

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OMAi
VHGIEYI

Database of Orthologous Groups

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OrthoDBi
524270at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8WXQ8

TreeFam database of animal gene trees

More...
TreeFami
TF317197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.340, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036990 M14A-like_propep
IPR003146 M14A_act_pep
IPR000834 Peptidase_M14

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00246 Peptidase_M14, 1 hit
PF02244 Propep_M14, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00765 CRBOXYPTASEA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00631 Zn_pept, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS00133 CARBOXYPEPT_ZN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQGTPGGGTR PGPSPVDRRT LLVFSFILAA ALGQMNFTGD QVLRVLAKDE
60 70 80 90 100
KQLSLLGDLE GLKPQKVDFW RGPARPSLPV DMRVPFSELK DIKAYLESHG
110 120 130 140 150
LAYSIMIKDI QVLLDEERQA MAKSRRLERS TNSFSYSSYH TLEEIYSWID
160 170 180 190 200
NFVMEHSDIV SKIQIGNSFE NQSILVLKFS TGGSRHPAIW IDTGIHSREW
210 220 230 240 250
ITHATGIWTA NKIVSDYGKD RVLTDILNAM DIFIELVTNP DGFAFTHSMN
260 270 280 290 300
RLWRKNKSIR PGIFCIGVDL NRNWKSGFGG NGSNSNPCSE TYHGPSPQSE
310 320 330 340 350
PEVAAIVNFI TAHGNFKALI SIHSYSQMLM YPYGRLLEPV SNQRELYDLA
360 370 380 390 400
KDAVEALYKV HGIEYIFGSI STTLYVASGI TVDWAYDSGI KYAFSFELRD
410 420 430
TGQYGFLLPA TQIIPTAQET WMALRTIMEH TLNHPY
Length:436
Mass (Da):49,036
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6EB4FFDE72F355A
GO
Isoform 2 (identifier: Q8WXQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-351: YDLAK → VRLAA
     352-436: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,364
Checksum:i9D083276FD2D6B16
GO
Isoform 3 (identifier: Q8WXQ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-436: YDLAKDAVEA...IMEHTLNHPY → MWPVGSPSTG...WRFGPSWSTP

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):44,881
Checksum:i3C8467B533BAB019
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4Q6H7C4Q6_HUMAN
Carboxypeptidase A5
CPA5
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRV5C9JRV5_HUMAN
Carboxypeptidase A5
CPA5
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZE9C9JZE9_HUMAN
Carboxypeptidase A5
CPA5
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMQ7A0A1D5RMQ7_HUMAN
Carboxypeptidase A5
CPA5
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108K → R in BAC04122 (PubMed:14702039).Curated1
Sequence conflicti117E → G in AAH39362 (PubMed:15489334).Curated1
Sequence conflicti293H → R in BAD18389 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01719179P → S1 PublicationCorresponds to variant dbSNP:rs17388190Ensembl.1
Natural variantiVAR_017192336L → S2 PublicationsCorresponds to variant dbSNP:rs11761888Ensembl.1
Natural variantiVAR_017193338E → D2 PublicationsCorresponds to variant dbSNP:rs17854248Ensembl.1
Natural variantiVAR_048596378S → G. Corresponds to variant dbSNP:rs11765961Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044866347 – 436YDLAK…LNHPY → MWPVGSPSTGPMTVASSTPS ALSSGTLGSMASCCRPHRSS PRPRRRGWRFGPSWSTP in isoform 3. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_008806347 – 351YDLAK → VRLAA in isoform 2. 1 Publication5
Alternative sequenceiVSP_008807352 – 436Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF384667 mRNA Translation: AAL37611.1
AY155229 mRNA Translation: AAO17155.1
AY155230 mRNA Translation: AAO17156.1
AK093288 mRNA Translation: BAC04122.1
AK131191 mRNA Translation: BAD18389.1
AC007938 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83757.1
BC039362 mRNA Translation: AAH39362.1
BC042996 mRNA Translation: AAH42996.1
BK000187 mRNA Translation: DAA00035.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47713.1 [Q8WXQ8-3]
CCDS5819.1 [Q8WXQ8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001120913.1, NM_001127441.1 [Q8WXQ8-1]
NP_001120914.1, NM_001127442.1 [Q8WXQ8-3]
NP_001305152.1, NM_001318223.1 [Q8WXQ8-1]
NP_525124.3, NM_080385.4 [Q8WXQ8-1]
XP_005250767.1, XM_005250710.1 [Q8WXQ8-1]
XP_005250769.1, XM_005250712.1 [Q8WXQ8-1]
XP_011515000.1, XM_011516698.1 [Q8WXQ8-1]
XP_011515003.1, XM_011516701.1 [Q8WXQ8-1]
XP_011515004.1, XM_011516702.1 [Q8WXQ8-1]
XP_011515005.1, XM_011516703.1 [Q8WXQ8-1]
XP_011515006.1, XM_011516704.1 [Q8WXQ8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393213; ENSP00000376907; ENSG00000158525 [Q8WXQ8-1]
ENST00000431780; ENSP00000393045; ENSG00000158525 [Q8WXQ8-3]
ENST00000461828; ENSP00000418183; ENSG00000158525 [Q8WXQ8-1]
ENST00000466363; ENSP00000419025; ENSG00000158525 [Q8WXQ8-1]
ENST00000474905; ENSP00000417314; ENSG00000158525 [Q8WXQ8-1]
ENST00000485477; ENSP00000420237; ENSG00000158525 [Q8WXQ8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
93979

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:93979

UCSC genome browser

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UCSCi
uc003vps.3 human [Q8WXQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384667 mRNA Translation: AAL37611.1
AY155229 mRNA Translation: AAO17155.1
AY155230 mRNA Translation: AAO17156.1
AK093288 mRNA Translation: BAC04122.1
AK131191 mRNA Translation: BAD18389.1
AC007938 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83757.1
BC039362 mRNA Translation: AAH39362.1
BC042996 mRNA Translation: AAH42996.1
BK000187 mRNA Translation: DAA00035.1
CCDSiCCDS47713.1 [Q8WXQ8-3]
CCDS5819.1 [Q8WXQ8-1]
RefSeqiNP_001120913.1, NM_001127441.1 [Q8WXQ8-1]
NP_001120914.1, NM_001127442.1 [Q8WXQ8-3]
NP_001305152.1, NM_001318223.1 [Q8WXQ8-1]
NP_525124.3, NM_080385.4 [Q8WXQ8-1]
XP_005250767.1, XM_005250710.1 [Q8WXQ8-1]
XP_005250769.1, XM_005250712.1 [Q8WXQ8-1]
XP_011515000.1, XM_011516698.1 [Q8WXQ8-1]
XP_011515003.1, XM_011516701.1 [Q8WXQ8-1]
XP_011515004.1, XM_011516702.1 [Q8WXQ8-1]
XP_011515005.1, XM_011516703.1 [Q8WXQ8-1]
XP_011515006.1, XM_011516704.1 [Q8WXQ8-3]

3D structure databases

SMRiQ8WXQ8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125066, 19 interactors
IntActiQ8WXQ8, 1 interactor
MINTiQ8WXQ8
STRINGi9606.ENSP00000420237

Protein family/group databases

MEROPSiM14.020

PTM databases

iPTMnetiQ8WXQ8
PhosphoSitePlusiQ8WXQ8

Polymorphism and mutation databases

BioMutaiCPA5
DMDMi38257690

Proteomic databases

jPOSTiQ8WXQ8
PaxDbiQ8WXQ8
PeptideAtlasiQ8WXQ8
PRIDEiQ8WXQ8
ProteomicsDBi75078
75079 [Q8WXQ8-2]
TopDownProteomicsiQ8WXQ8-1 [Q8WXQ8-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
93979
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393213; ENSP00000376907; ENSG00000158525 [Q8WXQ8-1]
ENST00000431780; ENSP00000393045; ENSG00000158525 [Q8WXQ8-3]
ENST00000461828; ENSP00000418183; ENSG00000158525 [Q8WXQ8-1]
ENST00000466363; ENSP00000419025; ENSG00000158525 [Q8WXQ8-1]
ENST00000474905; ENSP00000417314; ENSG00000158525 [Q8WXQ8-1]
ENST00000485477; ENSP00000420237; ENSG00000158525 [Q8WXQ8-1]
GeneIDi93979
KEGGihsa:93979
UCSCiuc003vps.3 human [Q8WXQ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93979

GeneCards: human genes, protein and diseases

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GeneCardsi
CPA5
HGNCiHGNC:15722 CPA5
HPAiHPA020322
MIMi609561 gene
neXtProtiNX_Q8WXQ8
OpenTargetsiENSG00000158525
PharmGKBiPA26820

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2650 Eukaryota
COG2866 LUCA
GeneTreeiENSGT00940000161666
HOGENOMiHOG000252967
InParanoidiQ8WXQ8
KOiK08781
OMAiVHGIEYI
OrthoDBi524270at2759
PhylomeDBiQ8WXQ8
TreeFamiTF317197

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CPA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
93979

Protein Ontology

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PROi
PR:Q8WXQ8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158525 Expressed in 68 organ(s), highest expression level in testis
ExpressionAtlasiQ8WXQ8 baseline and differential
GenevisibleiQ8WXQ8 HS

Family and domain databases

Gene3Di3.30.70.340, 1 hit
InterProiView protein in InterPro
IPR036990 M14A-like_propep
IPR003146 M14A_act_pep
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit
PF02244 Propep_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00631 Zn_pept, 1 hit
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS00133 CARBOXYPEPT_ZN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPA5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXQ8
Secondary accession number(s): G3V0G8
, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2002
Last modified: May 8, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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