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Protein

Ankyrin repeat and SOCS box protein 12

Gene

ASB12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • post-translational protein modification Source: Reactome
  • protein ubiquitination Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 12
Short name:
ASB-12
Gene namesi
Name:ASB12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198881.9
HGNCiHGNC:19763 ASB12
MIMi300891 gene
neXtProtiNX_Q8WXK4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198881
PharmGKBiPA134937084

Polymorphism and mutation databases

BioMutaiASB12
DMDMi62512181

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669471 – 309Ankyrin repeat and SOCS box protein 12Add BLAST309

Proteomic databases

PaxDbiQ8WXK4
PeptideAtlasiQ8WXK4
PRIDEiQ8WXK4
ProteomicsDBi75075

PTM databases

iPTMnetiQ8WXK4
PhosphoSitePlusiQ8WXK4

Expressioni

Gene expression databases

BgeeiENSG00000198881 Expressed in 132 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ASB12
GenevisibleiQ8WXK4 HS

Organism-specific databases

HPAiHPA049542

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.1 Publication

Protein-protein interaction databases

BioGridi126776, 28 interactors
CORUMiQ8WXK4
IntActiQ8WXK4, 11 interactors
MINTiQ8WXK4
STRINGi9606.ENSP00000355195

Structurei

3D structure databases

ProteinModelPortaliQ8WXK4
SMRiQ8WXK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 92ANK 1Add BLAST30
Repeati96 – 125ANK 2Add BLAST30
Repeati129 – 158ANK 3Add BLAST30
Repeati171 – 200ANK 4Add BLAST30
Repeati213 – 243ANK 5Add BLAST31
Domaini268 – 308SOCS boxAdd BLAST41

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148951
HOGENOMiHOG000034084
HOVERGENiHBG107089
InParanoidiQ8WXK4
KOiK10334
OMAiYNNCSPL
OrthoDBiEOG091G090M
PhylomeDBiQ8WXK4
TreeFamiTF331945

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WXK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLMDITKIF SLLQPDKEEE DTDTEEKQAL NQAVYDNDSY TLDQLLRQER
60 70 80 90 100
YKRFINSRSG WGVPGTPLRL AASYGHLSCL QVLLAHGADV DSLDVKAQTP
110 120 130 140 150
LFTAVSHGHL DCVRVLLEAG ASPGGSIYNN CSPVLTAARD GAVAILQELL
160 170 180 190 200
DHGAEANVKA KLPVWASNIA SCSGPLYLAA VYGHLDCFRL LLLHGADPDY
210 220 230 240 250
NCTDQGLLAR VPRPRTLLEI CLHHNCEPEY IQLLIDFGAN IYLPSLSLDL
260 270 280 290 300
TSQDDKGIAL LLQARATPRS LLSQVRLVVR RALCQAGQPQ AINQLDIPPM

LISYLKHQL
Length:309
Mass (Da):33,943
Last modified:April 12, 2005 - v2
Checksum:i8280C47C544D03D8
GO
Isoform 2 (identifier: Q8WXK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRIVLQLAKM

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):34,996
Checksum:iD2EA9DD3E66E73DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149L → P in BAC04888 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448651M → MRIVLQLAKM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403030 mRNA Translation: AAL57349.1
AK096896 mRNA Translation: BAC04888.1
AL356317 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05414.1
BC069436 mRNA Translation: AAH69436.1
BC069555 mRNA Translation: AAH69555.1
BC093883 mRNA Translation: AAH93883.1
BC104946 mRNA Translation: AAI04947.1
CCDSiCCDS14378.2 [Q8WXK4-2]
RefSeqiNP_569059.3, NM_130388.3 [Q8WXK4-2]
UniGeneiHs.56281

Genome annotation databases

EnsembliENST00000362002; ENSP00000355195; ENSG00000198881 [Q8WXK4-2]
GeneIDi142689
KEGGihsa:142689
UCSCiuc004dvr.3 human [Q8WXK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403030 mRNA Translation: AAL57349.1
AK096896 mRNA Translation: BAC04888.1
AL356317 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05414.1
BC069436 mRNA Translation: AAH69436.1
BC069555 mRNA Translation: AAH69555.1
BC093883 mRNA Translation: AAH93883.1
BC104946 mRNA Translation: AAI04947.1
CCDSiCCDS14378.2 [Q8WXK4-2]
RefSeqiNP_569059.3, NM_130388.3 [Q8WXK4-2]
UniGeneiHs.56281

3D structure databases

ProteinModelPortaliQ8WXK4
SMRiQ8WXK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126776, 28 interactors
CORUMiQ8WXK4
IntActiQ8WXK4, 11 interactors
MINTiQ8WXK4
STRINGi9606.ENSP00000355195

PTM databases

iPTMnetiQ8WXK4
PhosphoSitePlusiQ8WXK4

Polymorphism and mutation databases

BioMutaiASB12
DMDMi62512181

Proteomic databases

PaxDbiQ8WXK4
PeptideAtlasiQ8WXK4
PRIDEiQ8WXK4
ProteomicsDBi75075

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362002; ENSP00000355195; ENSG00000198881 [Q8WXK4-2]
GeneIDi142689
KEGGihsa:142689
UCSCiuc004dvr.3 human [Q8WXK4-1]

Organism-specific databases

CTDi142689
EuPathDBiHostDB:ENSG00000198881.9
GeneCardsiASB12
HGNCiHGNC:19763 ASB12
HPAiHPA049542
MIMi300891 gene
neXtProtiNX_Q8WXK4
OpenTargetsiENSG00000198881
PharmGKBiPA134937084
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148951
HOGENOMiHOG000034084
HOVERGENiHBG107089
InParanoidiQ8WXK4
KOiK10334
OMAiYNNCSPL
OrthoDBiEOG091G090M
PhylomeDBiQ8WXK4
TreeFamiTF331945

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

GenomeRNAii142689
PROiPR:Q8WXK4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198881 Expressed in 132 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ASB12
GenevisibleiQ8WXK4 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiASB12_HUMAN
AccessioniPrimary (citable) accession number: Q8WXK4
Secondary accession number(s): J3KP57
, Q2M3D5, Q52LK4, Q6ISF9, Q8N8F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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